Camille N Kotton, Nassim Kamar, David Wojciechowski, Michael Eder, Helmut Hopfer, Parmjeet Randhawa, Martina Sester, Patrizia Comoli, Helio Tedesco Silva, Greg Knoll, Daniel C Brennan, Jennifer Trofe-Clark, Lars Pape, David Axelrod, Bryce Kiberd, Germaine Wong, Hans H Hirsch
BK polyomavirus (BKPyV) remains a significant challenge after kidney transplantation. International experts reviewed current evidence and updated recommendations according to Grading of Recommendations, Assessment, Development, and Evaluations (GRADE). Risk factors for BKPyV-DNAemia and biopsy-proven BKPyV-nephropathy include recipient older age, male sex, donor BKPyV-viruria, BKPyV-seropositive donor/-seronegative recipient, tacrolimus, acute rejection, and higher steroid exposure. To facilitate early intervention with limited allograft damage, all kidney transplant recipients should be screened monthly for plasma BKPyV-DNAemia loads until month 9, then every 3 mo until 2 y posttransplant (3 y for children)...
April 12, 2024: Transplantation