keyword
https://read.qxmd.com/read/38493318/transplant-renal-artery-stenosis-a-case-report-and-literature-review
#21
JOURNAL ARTICLE
Nasser Simforoosh, Amirhossein Nayebzade, Meisam Ghaedi
Transplant renal artery stenosis is the most common vascular complication that turns out following kidney transplantation and can lead to graft dysfunction and even its loss. The present report, describes A patient with end-stage renal disease who underwent living related renal transplantation. He had oliguria and creatinine rise in the post-operative course but all doppler ultrasonography (DUS) during the 2 months post-operation for the renal graft showed a normal mean resistive index in the graft renal artery...
March 17, 2024: Urology Journal
https://read.qxmd.com/read/38490642/the-use-of-extracorporeal-photopheresis-in-solid-organ-transplantation-current-status-and-future-directions
#22
REVIEW
Markus J Barten, Andrew Fisher, Alexandre Hertig
Prevention and management of allograft rejection urgently require more effective therapeutic solutions. Current immunosuppressive therapies used in solid organ transplantation, while effective in reducing the risk of acute rejection, are associated with substantial adverse effects. There is therefore a need for agents that can provide immunomodulation supporting graft tolerance, while minimizing the need for immunosuppression. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy currently recommended in international guidelines as an adjunctive treatment for the prevention and management of organ rejection in heart (HTx) and lung (LTx) transplantation...
March 13, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38484785/safety-and-efficacy-of-early-corticosteroid-withdrawal-in-liver-transplant-recipients-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Jongman Kim, Jae-Won Joh, Kwang-Woong Lee, Dong Lak Choi, Hee-Jung Wang
BACKGROUNDS/AIMS: Prolonged use of steroids after liver transplantation (LT) significantly increases the risk of diabetes or cardiovascular disease, which can adversely affect patient outcomes. Our study evaluated the effectiveness and safety of early steroid withdrawal within the first year following LT. METHODS: This study was conducted as an open-label, multicenter, randomized controlled trial. Liver transplant recipients were randomly assigned to one of the following two groups: Group 1, in which steroids were withdrawn two weeks posttransplantation, and Group 2, in which steroids were withdrawn three months posttransplantation...
March 15, 2024: Annals of Hepato-Biliary-Pancreatic Surgery
https://read.qxmd.com/read/38483692/downstaging-hepatocellular-carcinoma-with-checkpoint-inhibitor-therapy-improves-access-to-curative-liver-transplant
#24
JOURNAL ARTICLE
Margaret C Liu, Blanca Lizaola-Mayo, Channa R Jayasekera, Amit K Mathur, Nitin Katariya, Bashar Aqel, Thomas J Byrne, David M H Chascsa
PURPOSE: Liver transplantation is curative for hepatocellular carcinoma (HCC). Checkpoint inhibitor therapy (CPIT) has been used in unresectable HCC, but recent advances have demonstrated CPIT as an innovative method of downstaging advanced HCC with the caveat that CPIT prior to transplantation has risks including irreversible graft rejection. We report the outcomes of Mayo Clinic Arizona patients who underwent downstaging with CPIT. METHODS: This retrospective chart review was conducted for Mayo Clinic Arizona patients who were diagnosed with HCC who underwent downstaging with CPIT with the goal of meeting criteria for transplantation...
March 14, 2024: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/38479703/endomyocardial-biopsy-in-clinical-practice-the-diagnostic-yield-and-insights-from-a-5-year-single-center-experience
#25
JOURNAL ARTICLE
Mutaz Karameh, Karen Meir, Abed Qadan, Orit Pappo, Dotan Cohen, Ronen Durst, Offer Amir, Rabea Asleh
BACKGROUND AND AIMS: Endomyocardial biopsy (EMB) is a diagnostic tool for evaluating various cardiac conditions, such as myocarditis and myocardial infiltrative diseases. It is also the gold standard screening technique for detecting allograft rejection after heart transplantation. Despite advances in noninvasive imaging modalities for myocardial tissue characterization, EMB is still necessary for making a definitive diagnosis and determining treatment for certain conditions. Herein, we report our recent experience using EMB and its diagnostic yield...
March 11, 2024: Hellenic Journal of Cardiology: HJC
https://read.qxmd.com/read/38472084/experience-with-tandem-pre-dilution-online-hemodiafiltration-and-centrifugal-plasma-exchange-in-pretransplant-desensitization-for-abo-incompatible-kidney-transplantation-a-case-report
#26
JOURNAL ARTICLE
Kazuki Masuda, Toshihide Naganuma, Takuya Torigoe, Kazuya Kabei, Yuichi Machida, Tomoaki Iwai, Yoshiaki Takemoto, Junji Uchida
BACKGROUND: In the use of therapeutic plasma exchange (TPE) as antibody removal therapy for ABO-incompatible (ABOi) kidney transplantation, it is technically possible to perform online hemodiafiltration (OHDF) and TPE simultaneously for patients who are receiving OHDF. In this study, we report tandem therapy of pre-dilution OHDF and centrifugal plasma exchange (cTPE), instead of membrane plasma exchange, which is the mainstay of TPE in Japan. METHODS: A total of 14 sessions of tandem cTPE and pre-dilution OHDF were performed as preoperative antibody removal therapy for 6 ABOi kidney transplant recipients...
March 11, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38467591/targeting-macrophages-in-organ-transplantation-a-step-toward-personalized-medicine
#27
JOURNAL ARTICLE
Macee C Owen, Benjamin J Kopecky
Organ transplantation remains the most optimal strategy for patients with end-stage organ failure. However, prevailing methods of immunosuppression are marred by adverse side effects, and allograft rejection remains common. It is imperative to identify and comprehensively characterize the cell types involved in allograft rejection, and develop therapies with greater specificity. There is increasing recognition that processes mediating allograft rejection are the result of interactions between innate and adaptive immune cells...
March 12, 2024: Transplantation
https://read.qxmd.com/read/38467426/acute-aromatase-inhibition-impairs-neural-and-behavioral-auditory-scene-analysis-in-zebra-finches
#28
JOURNAL ARTICLE
Marcela Fernández-Vargas, Matheus Macedo-Lima, Luke Remage-Healey
Auditory perception can be significantly disrupted by noise. To discriminate sounds from noise, auditory scene analysis (ASA) extracts the functionally relevant sounds from acoustic input. The zebra finch communicates in noisy environments. Neurons in their secondary auditory pallial cortex (caudomedial nidopallium; NCM) can encode song from background chorus, or scenes, and this capacity may aid behavioral ASA. Furthermore, song processing is modulated by the rapid synthesis of neuroestrogens when hearing conspecific song...
March 11, 2024: ENeuro
https://read.qxmd.com/read/38467375/immunosuppression-withdrawal-in-living-donor-renal-transplant-recipients-following-induction-with-anti-thymocyte-globulin-and-rituximab-results-of-a-prospective-clinical-trial
#29
JOURNAL ARTICLE
James F Markmann, Bryna E Burrell, Jonathan S Bromberg, Choli Hartono, Dixon B Kaufman, Andrew M Possselt, Ali Naji, Nancy D Bridges, Cynthia Breeden, Sai Kanaparthi, Jorge Pardo, Heather Kopetskie, Kristen Mason, Noha Lim, Sindhu Chandran
Durable tolerance in kidney transplant recipients remains an important but elusive goal. We hypothesized that adding B cell depletion to T cell depletion would generate an immune milieu post-reconstitution dominated by immature transitional B cells, favoring tolerance. The Immune Tolerance Network ITN039ST RESTARRT was a prospective multicenter pilot study of live donor kidney transplant recipients who received induction with rabbit anti-thymocyte globulin and rituximab, and initiated immunosuppression withdrawal (ISW) at 26 weeks...
March 9, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38466262/high-dose-individualized-antithymocyte-globulin-with-therapeutic-drug-monitoring-in-high-risk-cord-blood-transplant
#30
JOURNAL ARTICLE
Rick Admiraal, A Birgitta Versluijs, Alwin D R Huitema, Lysette Ebskamp, Amelia Lacna, C T Klaartje de Kanter, Marc B Bierings, Jaap Jan Boelens, Caroline A Lindemans, Stefan Nierkens
BACKGROUND: Graft-versus-host disease (GvHD) and rejection are main limitations of cord blood transplantation (CBT), more so in patients with severe inflammation or previous rejections. While rigorous T-cell depletion with antithymocyte globulin (ATG) is needed to prevent GvHD and rejection, overexposure to ATG leads to slow T-cell recovery after transplantation, especially in CBT. OBJECTIVE: To evaluate high-dose, upfront ATG with individualized dosing and therapeutic drug monitoring (TDM) in pediatric CBT for patients at high risk for GvHD and rejection...
February 23, 2024: Cytotherapy
https://read.qxmd.com/read/38465753/the-effects-of-the-cyp3a5-3-variant-on-tacrolimus-pharmacokinetics-and-outcomes-in-tunisian-kidney-transplant-recipients
#31
JOURNAL ARTICLE
Rim Charfi, Mohamed Mongi Bacha, Myriam Ben Fadhal, Khouloud Ferchichi, Hanene El Jebari, Emna Gaies, Anis Klouz, Ezzeddine Abderrahim, Fathi Ben Hamida, Taieb Ben Abdallah, Sameh Trabelsi, Yosr Gorgi, Imen Sfar
INTRODUCTION: Tacrolimus, exhibits interindividual pharmacokinetic variability and a narrow therapeutic index. The influence of the CYP3A5 6986A>G single nucleotide polymorphism (SNP) on this variability remains a topic of debate. AIM: To assess the impact of the aforementioned SNP on tacrolimus area under curve (AUC0-12h), adverse drug reactions (ADRs), and kidney graft outcomes. METHODS: Blood samples were collected from Tunisian kidney transplants over a five-year period during either the early (<3 months) or late (>3 months) post-transplant phases...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38465633/impact-of-cumulative-6%C3%A2-mg-kg-antithymocyte-globulin-on-early-posttransplant-outcomes-in-kidney-transplant-recipients-with-delayed-graft-function
#32
JOURNAL ARTICLE
Van Anh Vu, Suverta Bhayana, Helen Sweiss, Nohely Castro, Reed Hall, Joelle Nelson
Introduction: Delayed graft function in kidney transplant is associated with an increased risk of rejection and graft loss. Use of rabbit antithymocyte globulin induction in delayed graft function has been correlated with less rejection compared to basiliximab, but optimal dosing remains unknown. Program Evaluation Aims: The purpose of this evaluation was to retrospectively assess the short-term effectiveness and tolerability of a clinical protocol that increased the net state of immunosuppression in delayed graft function kidney transplant recipients using cumulative 6 mg/kg rabbit antithymocyte globulin induction...
March 11, 2024: Progress in Transplantation
https://read.qxmd.com/read/38464256/defining-the-t-cell-transcriptional-landscape-in-pediatric-liver-transplant-rejection-at-single-cell-resolution
#33
Anna L Peters, Erica A K DePasquale, Gousia Begum, Krishna M Roskin, E Steve Woodle, David A Hildeman
Acute cellular rejection (ACR) affects >80% of pediatric liver transplant recipients within 5 years, and late ACR is associated with graft failure. Traditional anti-rejection therapy for late ACR is ineffective and has remained unchanged for six decades. Although CD8+ T cells promote late ACR, little has been done to define their specificity and gene expression. Here, we used single-cell sequencing and immune repertoire profiling (10X Genomics) on 30 cryopreserved 16G liver biopsies from 14 patients (5 pre-transplant or with no ACR, 9 with ACR)...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38463582/new-onset-tachycardia-bradycardia-syndrome-following-acute-non-medullary-brainstem-infarction
#34
Jingmin Zhao, Yu Gao, Zhengxian Jin, Yujing Huang, Kwee-Yum Lee, Guangxun Shen
Tachycardia-bradycardia syndrome (TBS) is a variant of sick sinus syndrome (SSS) characterized by alternating tachycardia and bradycardia. A few cases of SSS secondary to structural lesions in the medulla have been reported, but there has never been a reported case of the rare sign akin to TBS following acute non-medullary brainstem infarction. Furthermore, new-onset cardiac arrhythmias in stroke often presented in one continuous pattern - either as bradycardia or tachycardia, but instances of an alternating fashion have been rarely reported...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38462861/outcomes-of-haematopoietic-stem-cell-transplantation-in-beta-thalassemia-major-with-fully-matched-parents-as-donor
#35
JOURNAL ARTICLE
Asghar Ali Kerio, Nighat Shahbaz, Tariq Azam Khattak, Tariq Ghafoor, Muhammad Farhan, Hashim Khan
OBJECTIVE: To determine the outcome of beta thalassemia major (BTM) patients undergoing haematopoietic stem cells (HSCT), with fully matched parents as donors vs. matched sibling donors (MSD). STUDY DESIGN: Observational Study. Place and Duration of the Study: Department of Clinical Haematology and Bone Marrow Transplantation Centre, Rawalpindi, Pakistan, from January 2013 to July 2023. METHODOLOGY: Group A consisted of BTM patients who underwent HSCT with fully matched siblings as donors, and Group B consisted of BTM patients who underwent HSCT with fully matched parents as donors...
March 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38460620/sex-specific-patterns-of-donor-derived-cell-free-dna-in-heart-transplant-rejection-an-analysis-from-the-genomic-research-alliance-for-transplantation-graft
#36
JOURNAL ARTICLE
Ersilia M DeFilippis, Benjamin Sweigart, Kiran K Khush, Palak Shah, Sean Agbor-Enoh, Hannah A Valantine, Amanda R Vest
INTRODUCTION: Non-invasive methods for surveillance of acute rejection are increasingly used in heart transplantation (HT), including donor-derived cell-free DNA (dd-cfDNA). As other cardiac biomarkers differ by sex, we hypothesized that there may be sex-specific differences in performance of dd-cfDNA for detection of acute rejection. The purpose of the current study was to examine patterns of dd-cfDNA seen in quiescence and acute rejection in males and female transplant recipients. METHODS: Patients enrolled in the Genomic Research Alliance for Transplantation (GRAfT) who were ≥18 years at the time of HT were included...
March 7, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38453157/experience-with-pembrolizumab-in-a-renal-transplant-patient-with-advanced-lung-cancer-a-case-report-and-review
#37
JOURNAL ARTICLE
Laura Fernández Madrigal, Victoria García Samblás, Laura Sánchez Escudero
The treatment of non-small cell lung cancer (NSCLC) has undergone a change because of the advancement of new therapies, like immune checkpoint inhibitors (ICIs), including pembrolizumab. A 64-year-old woman received a kidney transplant in 2012 because of chronic kidney disease secondary to glomerulosclerosis, diagnosed in 2020 with stage IV NSCLC because of metastasis in the contralateral lung, with programmed death ligand 1programmed death ligand 1 expression of 98%, starting treatment with ICIs, despite presenting a graft rejection risk around 40%...
March 8, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38450843/the-effect-of-primary-renal-disease-upon-outcomes-after-renal-transplant
#38
JOURNAL ARTICLE
Shona Garland, Kairi Pullerits, Chukwuma A Chukwu, Rajkumar Chinnadurai, Rachel Middleton, Philip A Kalra
BACKGROUND: This study investigated whether nature of primary renal disease affects clinical outcomes after renal transplantation at a single center in the United Kingdom. METHODS: This was a retrospective cohort study of 961 renal transplant recipients followed up at a large renal center from 2000 to 2020. Separation of diseases responsible for end-stage kidney disease included glomerulonephritis, diabetic kidney disease, hypertensive nephropathy, autosomal dominant polycystic kidney disease, unknown cause, other causes and chronic pyelonephritis...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38450290/basics-and-art-of-immunosuppression-in-liver-transplantation
#39
REVIEW
Shekhar Poudel, Subhash Gupta, Sanjiv Saigal
Liver transplantation is one of the most challenging areas in the medical field. Despite that, it has already been established as a standard treatment option, especially in decompensated cirrhosis and selected cases of hepatocellular carcinoma and acute liver failure. Complications due to graft rejection, including mortality and morbidity, have greatly improved over time due to better immunosuppressive agents and management protocols. Currently, immunosuppression in liver transplant patients makes use of the best possible combinations of effective agents to achieve optimal immunosuppression for long-term graft survival...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38449096/avascular-necrosis-in-kidney-transplant-recipients-is-associated-with-an-increased-risk-of-patient-death
#40
JOURNAL ARTICLE
Sonam Dolma, Fauzia Osman, Emily Zona, Angelie Santos, Fahad Aziz, Neetika Garg, Maha Mohamed, Didier Mandelbrot, Sandesh Parajuli
Introduction: Avascular necrosis is a debilitating osseous complication in transplant recipients. Project Aim: This program evaluation sought to describe risk factors and adverse outcomes of avascular necrosis in kidney transplant recipients. Design: This was a retrospective evaluation of all recipients of kidneys and simultaneous pancreas and kidneys between 2001 and 2018 from a single center. Controls were selected based on the incidence density, sampling at a 1:3 ratio based on the post-transplant interval...
March 6, 2024: Progress in Transplantation
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