Rim Charfi, Mohamed Mongi Bacha, Myriam Ben Fadhal, Khouloud Ferchichi, Hanene El Jebari, Emna Gaies, Anis Klouz, Ezzeddine Abderrahim, Fathi Ben Hamida, Taieb Ben Abdallah, Sameh Trabelsi, Yosr Gorgi, Imen Sfar
INTRODUCTION: Tacrolimus, exhibits interindividual pharmacokinetic variability and a narrow therapeutic index. The influence of the CYP3A5 6986A>G single nucleotide polymorphism (SNP) on this variability remains a topic of debate. AIM: To assess the impact of the aforementioned SNP on tacrolimus area under curve (AUC0-12h), adverse drug reactions (ADRs), and kidney graft outcomes. METHODS: Blood samples were collected from Tunisian kidney transplants over a five-year period during either the early (<3 months) or late (>3 months) post-transplant phases...
October 5, 2023: La Tunisie Médicale