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Rui Huang, Sanfang Tu, Lan Deng, Qian Kang, Chaoyang Song, Yuhua Li
OBJECTIVES: We retrospectively compared the prophylactic effect of basiliximab and antithymocyte globulin (ATG) after haploidentical hematopoietic stem cell transplantation (HSCT) in patients with leukemia. METHODS: Haploidentical HSCT using basiliximab for graft-versus-host disease (GVHD) prophylaxis in 10 patients with leukemia was retrospectively compared to ATG for GVHD prophylaxis in 24 patients. RESULTS: All the patients achieved neutrophil engraftment...
July 2015: Hematology (Amsterdam, Netherlands)
Keiko Okada, Yoshiko Nakano, Kai Yamasaki, Chika Tanaka, Hiroyuki Fujisaki, Yuko Osugi, Junichi Hara
HLA-haploidentical 2 or 3-loci mismatched families are alternative donors for high-risk patients without HLA-matched donors. We retrospectively reviewed our case series of HLA-halpoidentical hematopoietic stem cell transplantations (haplo-HSCTs). Between Jul 2005 and Dec 2012, 25 patients (median age, 8 y; 13 ALL, 8 AML, 4 others) received haplo-HSCTs because of a worsening prognosis (i.e. induction failure, non-CR, or relapse after prior HSCT). Disease status was CR in 8 and non-CR in 17 patients. The 17 patients received myeloablative conditioning, while the 8 were given reduced-intensity conditioning because of their conditions (e...
January 2014: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
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