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https://www.readbyqxmd.com/read/27810501/novel-tuberculosis-susceptibility-candidate-genes-revealed-by-the-reconstruction-and-analysis-of-associative-networks
#1
Elena Yu Bragina, Evgeny S Tiys, Alexey A Rudko, Vladimir A Ivanisenko, Maxim B Freidin
Tuberculosis (TB) is a common infectious disease caused by M. tuberculosis. The risk of the disease is dependent on complex interactions between host genetics and environmental factors. Accumulated genomic data, along with novel methodological approaches such as associative networks, facilitate studies into the inherited basis of TB. In the current study, we carried out the reconstruction and analysis of an associative network representing molecular interactions between proteins and genes associated with TB...
October 31, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27744082/quantitative-diffusion-tensor-imaging-analysis-of-low-grade-gliomas-from-pre-clinical-application-to-patient-care
#2
Tamara Ius, Luca Turella, Giada Pauletto, Miriam Isola, Marta Maieron, Giovanni Sciacca, Riccardo Budai, Serena D'Agostini, Roberto Eleopra, Miran Skrap
BACKGROUND: Pre-operative diffusion tensor tractography (DTT) has recently been utilized to aid in the mapping of functional pathways in order to limit damage associated with resection of low-grade gliomas. OBJECTIVE: To assess the predictive capacity of DTT as a biomarker of post-operative motor outcomes in patients with low-grade gliomas (LGGs) involving the corticospinal tract (CST). CST parameters obtained using a quantitative fiber-tracking approach were used to investigate the reliability of the DTT biomarker by comparing their values in the tumoral (Tcst) and healthy (Hcst) hemispheres...
October 12, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27699886/topical-cidofovir-for-recalcitrant-verrucae-in-individuals-with-severe-combined-immunodeficiency-after-hematopoietic-stem-cell-transplantation
#3
Sarah E Henrickson, James R Treat
Verrucae vulgaris in patients with severe combined immunodeficiency (SCID) after hematopoietic stem cell transplantation (HCST) can be challenging to manage. We describe two brothers with X-linked SCID who had severe, persistent verrucae that did not respond to traditional topical therapies, including liquid nitrogen, imiquimod, salicylic acid, sinecatechins, 40% urea, and 5-fluorourcil. Both brothers had full response to topical 3% cidofovir, which should be considered in recalcitrant warts in individuals with SCID after HSCT...
October 4, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27499838/refractory-ascites-with-liver-fibrosis-developed-in-late-phase-allogeneic-hematopoietic-stem-cell-transplantation-report-of-three-patients
#4
Hiroki Hosoi, Kenji Warigaya, Shogo Murata, Toshiki Mushino, Kodai Kuriyama, Akinori Nishikawa, Shinobu Tamura, Kazuo Hatanaka, Nobuyoshi Hanaoka, Yasuteru Muragaki, Shinichi Murata, Hideki Nakakuma, Takashi Sonoki
We report cases of three patients of refractory ascites without other fluid retention that occurred around five months after allogeneic hematopoietic stem cell transplantation (allo-HSCT). All three patients expired and postmortem examinations revealed unexpected liver fibrosis lacking histological evidences of graft-versus-host-disease (GVHD). The three patients showed normal hepatic function and size before transplantation. During their clinical courses, serum biochemistry test showed no elevation of hepatic enzymes and bilirubin; however, imaging studies demonstrated hepatic atrophy at the onset of ascites...
May 10, 2016: Hematology Reports
https://www.readbyqxmd.com/read/27165415/assessing-the-nutritional-quality-of-diets-of-canadian-children-and-adolescents-using-the-2014-health-canada-surveillance-tool-tier-system
#5
Mahsa Jessri, Stephanie K Nishi, Mary R L'Abbe
BACKGROUND: Health Canada's Surveillance Tool (HCST) Tier System was developed in 2014 with the aim of assessing the adherence of dietary intakes with Eating Well with Canada's Food Guide (EWCFG). HCST uses a Tier system to categorize all foods into one of four Tiers based on thresholds for total fat, saturated fat, sodium, and sugar, with Tier 4 reflecting the unhealthiest and Tier 1 the healthiest foods. This study presents the first application of the HCST to examine (i) the dietary patterns of Canadian children, and (ii) the applicability and relevance of HCST as a measure of diet quality...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27139367/-bone-marrow-transplant-in-patients-with-sickle-cell-anaemia-experience-in-one-centre
#6
Marina García Morin, Elena Cela, Carmen Garrido, Eduardo Bardón Cancho, Alejandra Aguado Del Hoyo, Cristina Pascual, Ana Pérez-Corral, Cristina Beléndez
INTRODUCTION: Sickle cell disease (SCD), despite the improvement in the medical management, is still associated with severe morbidity and decreased survival. Allogenic hematopoietic stem cell transplantation (Allo-HSCT) currently provides the only curative therapy. A report is presented on our experience in children with SCD, who underwent Allo-HSCT in a single centre. MATERIAL AND METHOD: A single centre descriptive study was conducted on patients with SCD who underwent a bone marrow transplant from an HLA-identical sibling donor between January 2010 and December 2014...
April 29, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/26990469/cyclosporine-induced-sebaceous-hyperplasia-in-a-hematopoetic-stem-cell-transplant-patient-delayed-onset-of-a-common-adverse-event
#7
Reason Wilken, Maxwell A Fung, Vivian Y Shi, Michelle Y Cheng, Forum Patel, Hawa Sultani, Emanual Maverakis
Cyclosporine-induced sebaceous hyperplasia (SH) is a well-documented entity, occurring in up to 30% of renal transplant patients treated with cyclosporine and has also been reported to occur following heart or hematopoetic stem cell transplantation (HCST). Cyclosporine has a stimulatory effect on undifferentiated sebocytes, resulting in the clinical and histologic findings in these patients. Sebaceous hyperplasia most commonly presents as asymptomatic papules over the face, chest, or groin. Herein we describe a case of a 27-year-old man who developed facial sebaceous hyperplasia five months after completing cyclosporine therapy for cutaneous graft versus host disease (GVHD) following HSCT...
January 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/26290712/a-whole-genomic-scan-to-detect-selection-signatures-between-berkshire-and-korean-native-pig-breeds
#8
Zewdu Edea, Kwan-Suk Kim
BACKGROUND: Scanning of the genome for selection signatures between breeds may play important role in understanding the underlie causes for observable phenotypic variations. The discovery of high density single nucleotide polymorphisms (SNPs) provide a useful starting point to perform genome-wide scan in pig populations in order to identify loci/candidate genes underlie phenotypic variation in pig breeds and facilitate genetic improvement programs. However, prior to this study genomic region under selection in commercially selected Berkshire and Korean native pig breeds has never been detected using high density SNP markers...
2014: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/26137657/human-herpes-virus-6-following-pediatric-allogeneic-hematopoietic-stem-cell-transplantation
#9
Yael Shachor-Meyouhas, Alla Fesenko, Zipi Kra-Oz, Irina Zaidman, Moran Szwarcwort-Cohen, Einat Shafran, Imad Kassis
BACKGROUND: Human herpes virus-6 (HHV-6) reactivation after hematopoietic stem cell transplantation (HSCT) is well known and has been linked with several clinical manifestations. The significance of HHV-6 viremia and related complications in this setting is still unclear. OBJECTIVE: To estimate the incidence of HHV-6 reactivation and associated morbidity in children undergoing allogeneic HSCT. METHODS: Blood samples obtained weekly (for cytomegalovirus surveillance) from children who underwent allogeneic HCST during the period January 2006-June 2010 were retrospectively tested for the presence of HHV-6 DNA using standard real-time polymerase chain reaction (PCR) assay...
May 2015: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/25993291/immunohistochemical-analysis-of-the-natural-killer-cell-cytotoxicity-pathway-in-human-abdominal-aortic-aneurysms
#10
Irene Hinterseher, Charles M Schworer, John H Lillvis, Elizabeth Stahl, Robert Erdman, Zoran Gatalica, Gerard Tromp, Helena Kuivaniemi
Our previous analysis using genome-wide microarray expression data revealed extreme overrepresentation of immune related genes belonging the Natural Killer (NK) Cell Mediated Cytotoxicity pathway (hsa04650) in human abdominal aortic aneurysm (AAA). We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies...
May 18, 2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25881755/peripheral-blood-cd38-bright-cd8-effector-memory-t-cells-predict-acute-graft-versus-host-disease
#11
Pooja Khandelwal, Adam Lane, Vijaya Chaturvedi, Erika Owsley, Stella M Davies, Daniel Marmer, Alexandra H Filipovich, Michael B Jordan, Rebecca A Marsh
Acute graft-versus-host disease (aGVHD) is mediated by allogeneic T cell responses. We hypothesized that increases of peripheral blood-activated CD8+ effector memory T (TEM) cells would be observed after hematopoietic stem cell transplantation (HSCT) before onset of aGVHD symptoms. Blood was collected twice weekly after HSCT for 7 weeks in 49 consecutive pediatric and adult HSCT recipients. Samples were incubated with fluorochrome-conjugated antibodies against CD45, CD3, CD8, CD38, CD45RA, and CCR7 and analyzed using flow cytometry...
July 2015: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/25880102/the-number-of-t-cell-allo-epitopes-associates-with-cd4-and-cd8-t-cell-infiltration-in-pediatric-cutaneous-gvhd
#12
Kirsten A Thus, Astrid G S van Halteren, Titus A P de Hond, Marijke R van Dijk, Robin Q H Kloos, Arjan C Lankester, Marc B Bierings, Eric Spierings
Risk factors for graft-versus-host disease (GVHD) following allogeneic hematopoietic stem-cell transplantation (HCST) include: HLA mismatches, sex-mismatch, and stem-cell source. We retrospectively analyzed if HLA- and sex-mismatching quantitatively affects the composition of GVHD-induced T-cell infiltrates. We quantified absolute numbers of CD4+ and CD8+ T cells present in tissue sections from skin biopsies of 23 pediatric HSCT-recipients with GVHD. HSCT with a sex-mismatched unrelated donor was associated with an increased number of CD4+ T cells when compared to a sex-matched unrelated donor (p=0...
June 2015: Cellular Immunology
https://www.readbyqxmd.com/read/25487697/innate-immune-response-is-differentially-dysregulated-between-bipolar-disease-and-schizophrenia
#13
Angelica de Baumont, Mariana Maschietto, Leandro Lima, Dirce Maria Carraro, Eloisa Helena Olivieri, Alex Fiorini, Luiz André Nardin Barreta, Joana Almeida Palha, Paulo Belmonte-de-Abreu, Carlos Alberto Moreira Filho, Helena Brentani
Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions with a neurodevelopmental component. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. Also, image studies provide evidence for a shared neurobiological basis, contributing to a dimensional diagnostic approach. This study aimed to identify the molecular mechanisms that differentiate SZ and BD patients from health controls but also that distinguish both from health individuals. Comparison of gene expression profiling in post-mortem brains of both disorders and health controls (30 cases), followed by a further comparison between 29 BD and 29 SZ revealed 28 differentially expressed genes...
February 2015: Schizophrenia Research
https://www.readbyqxmd.com/read/25058083/autologous-hematopoietic-stem-cell-transplantation-vs-intravenous-pulse-cyclophosphamide-in-diffuse-cutaneous-systemic-sclerosis-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Jacob M van Laar, Dominique Farge, Jacob K Sont, Kamran Naraghi, Zora Marjanovic, Jérôme Larghero, Annemie J Schuerwegh, Erik W A Marijt, Madelon C Vonk, Anton V Schattenberg, Marco Matucci-Cerinic, Alexandre E Voskuyl, Arjan A van de Loosdrecht, Thomas Daikeler, Ina Kötter, Marc Schmalzing, Thierry Martin, Bruno Lioure, Stefan M Weiner, Alexander Kreuter, Christophe Deligny, Jean-Marc Durand, Paul Emery, Klaus P Machold, Francoise Sarrot-Reynauld, Klaus Warnatz, Daniel F P Adoue, Joël Constans, Hans-Peter Tony, Nicoletta Del Papa, Athanasios Fassas, Andrea Himsel, David Launay, Andrea Lo Monaco, Pierre Philippe, Isabelle Quéré, Éric Rich, Rene Westhovens, Bridget Griffiths, Riccardo Saccardi, Frank H van den Hoogen, Willem E Fibbe, Gérard Socié, Alois Gratwohl, Alan Tyndall
IMPORTANCE: High-dose immunosuppressive therapy and autologous hematopoietic stem cell transplantation (HSCT) have shown efficacy in systemic sclerosis in phase 1 and small phase 2 trials. OBJECTIVE: To compare efficacy and safety of HSCT vs 12 successive monthly intravenous pulses of cyclophosphamide. DESIGN, SETTING, AND PARTICIPANTS: The Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3, multicenter, randomized (1:1), open-label, parallel-group, clinical trial conducted in 10 countries at 29 centers with access to a European Group for Blood and Marrow Transplantation-registered transplant facility...
June 25, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/24837891/similar-survival-for-patients-undergoing-reduced-intensity-total-body-irradiation-tbi-versus-myeloablative-tbi-as-conditioning-for-allogeneic-transplant-in-acute-leukemia
#15
John L Mikell, Edmund K Waller, Jeffrey M Switchenko, Sravanti Rangaraju, Zahir Ali, Michael Graiser, William A Hall, Amelia A Langston, Natia Esiashvili, H Jean Khoury, Mohammad K Khan
PURPOSE: Hematopoietic stem cell transplantation (HSCT) is the mainstay of treatment for adults with acute leukemia. Total body irradiation (TBI) remains an important part of the conditioning regimen for HCST. For those patients unable to tolerate myeloablative TBI (mTBI), reduced intensity TBI (riTBI) is commonly used. In this study we compared outcomes of patients undergoing mTBI with those of patients undergoing riTBI in our institution. METHODS AND MATERIALS: We performed a retrospective review of all patients with acute leukemia who underwent TBI-based conditioning, using a prospectively acquired database of HSCT patients treated at our institution...
June 1, 2014: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/24662420/etiology-clinical-features-and-outcomes-of-pre-engraftment-and-post-engraftment-bloodstream-infection-in-hematopoietic-sct-recipients
#16
C Gudiol, C Garcia-Vidal, M Arnan, I Sánchez-Ortega, B Patiño, R Duarte, J Carratalà
We conducted an observational study to assess the etiology, clinical features and outcomes of bloodstream infection (BSI) in 172 hematopoietic SCT (HCST) recipients. One hundred episodes of BSI in the pre-engraftment period (early onset) were compared with 89 episodes in the post-engraftment phase (late onset). More patients with late-onset BSI received an allogeneic HSCT, had GVHD and had received corticosteroids, whereas patients with early-onset BSI were more likely to have neutropenia, severe mucositis and a central venous catheter (CVC) in place...
June 2014: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/24551291/chromosomal-and-genetic-imbalances-in-chinese-patients-with-rhabdomyosarcoma-detected-by-high-resolution-array-comparative-genomic-hybridization
#17
Chunxia Liu, Dongliang Li, Jianming Hu, Jinfang Jiang, Wei Zhang, Yunzhao Chen, Xiaobin Cui, Yan Qi, Hong Zou, Wenjie Zhang, Feng Li
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children. Although associations between ARMS tumorigenesis and PAX3, PAX7, and FKHR are well recognized, the complete genetic etiology underlying RMS pathogenesis and progression remains unclear. Chromosomal copy number variations (CNVs) and the involved genes may play important roles in the pathogenesis and progression of human malignancies. Using high-resolution array comparative genomic hybridization (aCGH), we examined 20 formalin-fixed, paraffin-embedded (FFPE) RMS tumors to explore the involvement of the relevant chromosomal regions with resident genes in RMS tumorigenesis...
2014: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/23888242/treatment-of-oral-mucositis-in-hematologic-patients-undergoing-autologous-or-allogeneic-transplantation-of-peripheral-blood-stem-cells-a-prospective-randomized-study-with-a-mouthwash-containing-camelia-sinensis-leaf-extract
#18
Giovanni Carulli, Melania Rocco, Alessia Panichi, Chiara Feira Chios, Ester Ciurli, Chiara Mannucci, Elisabetta Sordi, Francesco Caracciolo, Federico Papineschi, Edoardo Benedetti, Mario Petrini
Oral mucositis is an important side effect of hematopoietic stem cell transplantation (HCST), mainly due to toxicity of conditioning regimens. It produces significant pain and morbidity. The present study reports a prospective, randomized, non-blinded study testing the efficacy of a new mouthwash, called Baxidil Onco(®) (Sanitas Farmaceutici Srl, Tortona, Italy) in 60 hematologic patients undergoing HCST (28 autologous, 32 allogeneic). Baxidil Onco(®), used three times a day from Day -1 to Day +30, in addition to standard prophylactic schedules, was administered to 14 patients undergoing autologous and 14 patients undergoing allogeneic HCST...
January 25, 2013: Hematology Reports
https://www.readbyqxmd.com/read/23826127/structure-of-the-human-telomeric-stn1-ten1-capping-complex
#19
Christopher Bryan, Cory Rice, Michael Harkisheimer, David C Schultz, Emmanuel Skordalakes
The identification of the human homologue of the yeast CST in 2009 posed a new challenge in our understanding of the mechanism of telomere capping in higher eukaryotes. The high-resolution structure of the human Stn1-Ten1 (hStn1-Ten1) complex presented here reveals that hStn1 consists of an OB domain and tandem C-terminal wHTH motifs, while hTen1 consists of a single OB fold. Contacts between the OB domains facilitate formation of a complex that is strikingly similar to the replication protein A (RPA) and yeast Stn1-Ten1 (Ten1) complexes...
2013: PloS One
https://www.readbyqxmd.com/read/23801913/long-term-follow-up-report-of-cardiac-toxicity-in-patients-with-multiple-myeloma-treated-with-tandem-autologous-hematopoietic-stem-cell-transplantation
#20
Mirta Kozelj, Samo Zver, Vesna Zadnik
BACKGROUND: Tandem autologous hematopoietic stem cell transplantation (ta-HSCT) is a standard treatment for multiple myeloma (MM). Patients receive a high-dose cyclophosphamide (CY), followed by two myeloablative cycles of melphalan (MEL). There are scarce data about long term cardiotoxicity. PATIENTS AND METHODS: We studied 12 patients (62.25 ± 8.55 years) six years after the completion of MM treatment with ta-HCST. Late cardiotoxic effects were evaluated clinically and echocardiographically...
June 2013: Radiology and Oncology
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