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https://www.readbyqxmd.com/read/29675950/risk-factors-for-red-blood-cell-alloimmunization-in-the-recipient-epidemiology-and-donor-evaluation-study-reds-iii-database
#1
Matthew S Karafin, Matt Westlake, Ronald G Hauser, Christopher A Tormey, Philip J Norris, Nareg H Roubinian, Yanyun Wu, Darrell J Triulzi, Steve Kleinman, Jeanne E Hendrickson
Despite the significance of red blood cell (RBC) alloimmunization, the lack of standardized registries in the US has prevented the completion of large studies. Data from 3·5 years of the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) recipient database, containing information from 12 hospitals, were studied. A RBC alloantibody responder had an antibody identified at any point during the study, and a non-responder had a negative antibody screen at least 15 days post-RBC transfusion. Demographics, blood type, ICD9/10 codes, and other potential correlates were evaluated...
April 19, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29655805/metabolic-syndrome-positively-correlates-with-the-risks-of-atherosclerosis-and-diabetes-in-a-chinese-population
#2
Sung-Sheng Tsai, Yu-Sheng Lin, Szu-Tah Chen, Pao-Hsien Chu
BACKGROUND: Published studies seldom tested the weight of different waist circumference (WC) cut-off values for the diagnosis of metabolic syndrome (MetS) in predicting clinical outcomes, including cardiovascular disease and diabetes. METHODS: This is a Chinese population-based cross-sectional study screening subjects from a Health Examination Program since 1999 to 2015. The MetS identification and scores were determined either according to the Adult Treatment Panel III/American Heart Association/National Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI)- or Asian-WC cut-off points...
April 12, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29650706/pro-inflammatory-biomarkers-in-stable-versus-acutely-decompensated-heart-failure-with-preserved-ejection-fraction
#3
Abraham Abernethy, Sadi Raza, Jie-Lena Sun, Kevin J Anstrom, Russell Tracy, Johannes Steiner, Peter VanBuren, Martin M LeWinter
BACKGROUND: Underlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction (HFpEF). In this study we tested the hypothesis that pro-inflammatory biomarkers are elevated in patients with acutely decompensated HFpEF (AD-HFpEF) compared with patients with stable HFpEF (S-HFpEF). METHODS AND RESULTS: Using a post hoc analysis the serum biomarkers tumor necrosis factor-alpha, high-sensitivity C-reactive protein interleukin 6 and pentraxin 3 (PTX3) and clinical, demographic, echocardiographic-Doppler and clinical outcomes data were analyzed in HFpEF patients enrolled in NHLBI Heart Failure Research Network clinical trials which enrolled patients with either AD-HFpEF or S-HFpEF...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29649002/jak1-2-inhibition-with-baricitinib-in-the-treatment-of-autoinflammatory-interferonopathies
#4
Gina A Montealegre Sanchez, Adam Reinhardt, Suzanne Ramsey, Helmut Wittkowski, Philip J Hashkes, Yackov Berkun, Susanne Schalm, Sara Murias, Jason A Dare, Diane Brown, Deborah L Stone, Ling Gao, Thomas Klausmeier, Dirk Foell, Adriana A de Jesus, Dawn C Chapelle, Hanna Kim, Samantha Dill, Robert Colbert, Laura Failla, Bahar Kost, Michelle O'Brien, James C Reynolds, Les R Folio, Katherine R Calvo, Scott M Paul, Nargues Weir, Alessandra Brofferio, Ariane Soldatos, Angélique Biancotto, Edward W Cowen, John G Digiovanna, Massimo Gadina, Andrew J Lipton, Colleen Hadigan, Steven M Holland, Joseph Fontana, Ahmad S Alawad, Rebecca J Brown, Kristina I Rother, Theo Heller, Kristina M Brooks, Parag Kumar, Stephen R Brooks, Meryl Waldman, Harsharan K Singh, Volker Nickeleit, Maria Silk, Apurva Prakash, Jonathan M Janes, Seza Ozen, Paul G Wakim, Paul A Brogan, William L Macias, Raphaela Goldbach-Mansky
BACKGROUND: Monogenic Interferon (IFN)-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN-response-gene-signature (IRS), inflammatory organ damage and high mortality. We used the janus kinase (JAK) inhibitor baricitinib with IFN-blocking activity in vitro, to ameliorate disease. METHODS: Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 with SAVI (Stimulator of IFN genes (STING)-associated vasculopathy with onset in infancy), and 4 patients with other interferonopathies were enrolled in an Expanded Access Program...
April 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29624755/searching-for-unknown-transfusion-transmitted-hepatitis-viruses-a-bi-national-cohort-study-of-1-5-million-transfused-patients
#5
Gustaf Edgren, Henrik Hjalgrim, Klaus Rostgaard, Viktor Dahl, Kjell Titlestad, Christian Erikstrup, Agneta Wikman, Rut Norda, Ammar Majeed
BACKGROUND: Both hepatitis B and C viruses were transmitted through blood transfusion before implementation of donor screening. The existence of additional, yet unknown transfusion transmittable agents causing liver disease could have important public health implications. METHODS: Analyses were based on the Scandinavian Donations and Transfusions (SCANDAT2) database. Cox regression models were used to estimate the hazard ratio (HR) of developing chronic liver disease in recipients of blood from donors who later developed any chronic liver disease compared to recipients who received blood transfusion from healthy donors...
April 6, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29621589/identification-of-rare-heterozygous-missense-mutations-in-fanca-in-esophageal-atresia-patients-using-next-generation-sequencing
#6
Yu Feng, Runsen Chen, Min Da, Bo Qian, Xuming Mo
Esophageal atresia and tracheoesophageal fistula (EA/TEF) are relatively common malformations in newborns, but the etiology of EA/TEF remains unknown. Fanconi anemia (FA) complementation group A (FANCA) is a key component of the FA core complex and is essential for the activation of the DNA repair pathway. The middle region (amino acids 674-1208) of FANCA is required for its interaction with FAAP20. We performed targeted sequencing of this binding region of FANCA (exons 23-36) in 40 EA/TEF patients. We also investigated the effect of the p...
April 2, 2018: Gene
https://www.readbyqxmd.com/read/29605370/a-novel-missense-mutation-in-gipc3-causes-sensorineural-hearing-loss-in-an-iranian-family-revealed-by-targeted-next-generation-sequencing
#7
Samira Asgharzade, Mohammad Amin Tabatabaiefar, Javad Mohammadi-Asl, Morteza Hashemzadeh Chaleshtori
BACKGROUND: Recent studies have confirmed the utility of targeted next-generation sequencing (NGS), providing a remarkable opportunity to find variants in known disease genes, especially in genetically heterogeneous disorders such as hearing loss (HL). METHODS: After excluding mutations in the most common autosomal recessive non-syndromic HL (ARNSHL) genes via Sanger sequencing and genetic linkage analysis, we performed NGS in the proband an Iranian family with ARNSHL...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29590102/common-%C3%AE-globin-variants-modify-hematologic-and-other-clinical-phenotypes-in-sickle-cell-trait-and-disease
#8
Laura M Raffield, Jacob C Ulirsch, Rakhi P Naik, Samuel Lessard, Robert E Handsaker, Deepti Jain, Hyun M Kang, Nathan Pankratz, Paul L Auer, Erik L Bao, Joshua D Smith, Leslie A Lange, Ethan M Lange, Yun Li, Timothy A Thornton, Bessie A Young, Goncalo R Abecasis, Cathy C Laurie, Deborah A Nickerson, Steven A McCarroll, Adolfo Correa, James G Wilson, Guillaume Lettre, Vijay G Sankaran, Alex P Reiner
Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications of sickle cell disease (SCD), including stroke. However, little information exists on the association and interactions for the common African ancestral α-thalassemia mutation (-α3.7 deletion) and β-globin traits (HbS trait [SCT] and HbC trait) on important clinical phenotypes such as red blood cell parameters, anemia, and chronic kidney disease (CKD). In a community-based cohort of 2,916 African Americans from the Jackson Heart Study, we confirmed the expected associations between SCT, HbC trait, and the -α3...
March 28, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29584725/prevalence-of-metabolic-syndrome-and-its-risk-factors-in-kerala-south-india-analysis-of-a-community-based-cross-sectional-study
#9
S Harikrishnan, Smitha Sarma, G Sanjay, P Jeemon, M N Krishnan, K Venugopal, P P Mohanan, L Jeyaseelan, K R Thankappan, G Zachariah
BACKGROUND: Coronary Artery Disease (CAD) is a leading cause of death and disability in Kerala, India. Metabolic syndrome (MS) is a constellation of established risk factors for CAD. We aimed to estimate the prevalence of MS and evaluate the association between MS and CAD using a community-based sample population. METHODS: A cross-sectional community based survey was conducted in urban and rural areas of Kerala in 2011. We included 5063 individuals for analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29577553/metformin-s-impact-on-statin-associated-muscle-symptoms-an-analysis-of-accord-study-data-and-research-materials-from-the-nhlbi-biologic-specimen-and-data-repository-information-coordinating-center
#10
Nicholas W Carris, Athanasios Tsalatsanis, Srinivas M Tipparaju, Feng Cheng, Ronald R Magness, Ambuj Kumar
Statins are widely prescribed, yet statin muscle pain limits use, leading to increased cardiovascular risk. No validated therapy for statin muscle pain exists. The goal of the study was to assess if metformin was associated with reduced muscle pain. A secondary analysis of data from the ACCORD trial was performed. An ACCORD sub-study assessed patients for muscle cramps and leg/calve pain while walking, typical non-severe statin muscle pain symptoms. We compared muscle pain between patients taking a statin (n = 445) or a statin and metformin (n = 869) at baseline...
March 25, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29546996/future-research-directions-in-pneumonia-nhlbi-working-group-report
#11
Charles S Dela Cruz, Richard G Wunderink, David C Christiani, Stephania A Cormier, Kristina Crothers, Claire M Doerschuk, Scott E Evans, Daniel R Goldstein, Purvesh Khatri, Lester Kobzik, Jay K Kolls, Bruce D Levy, Mark L Metersky, Michael S Niederman, Roomi Nusrat, Carlos J Orihuela, Paula Peyrani, Alice S Prince, Julio A Ramírez, Karen M Ridge, Sanjay Sethi, Benjamin T Suratt, Jacob I Sznajder, Ephraim L Tsalik, Allan J Walkey, Sachin Yende, Neil R Aggarwal, Elisabet V Caler, Joseph P Mizgerd
Pneumonia is a complex pulmonary disease in need of new clinical approaches. While triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as ARDS and to organ dysfunction beyond the lungs and overextended time-frames after pathogen clearance, some of which increase the risk for subsequent pneumonias...
March 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29542130/addressing-gaps-in-international-blood-availability-and-transfusion-safety-in-low-and-middle-income-countries-a-nhlbi-workshop
#12
Brian Custer, Shimian Zou, Simone A Glynn, Julie Makani, Claude Tayou Tagny, Magdy El Ekiaby, Ester C Sabino, Nabajyoti Choudhury, Diana Teo, Kenrad Nelson, Emmanuel Peprah, LeShawndra Price, Michael M Engelgau
In April 2017, a workshop sponsored by the National Heart, Lung, and Blood Institute, Division of Blood Diseases and Resources, and the Center for Translation Research and Implementation Science was held to discuss blood availability and transfusion safety in low- and middle-income countries (LMICs). The purpose of the workshop was to identify research opportunities for implementation science (IS) to improve the availability of safe blood and blood components and transfusion practices in LMICs. IS describes the late stages of the translational research spectrum and studies optimal and sustainable strategies to deliver proven-effective interventions...
March 14, 2018: Transfusion
https://www.readbyqxmd.com/read/29520864/complex-association-patterns-for-inflammatory-mediators-in-induced-sputum-from-subjects-with-asthma
#13
A T Hastie, C Steele, C W Dunaway, W C Moore, B M Rector, E Ampleford, H Li, L C Denlinger, N Jarjour, D A Meyers, E R Bleecker
BACKGROUND: The release of various inflammatory mediators into the bronchial lumen is thought to reflect both the type and degree of airway inflammation, eosinophilic Th2, and Th9, or neutrophilic Th1, and Th17, in patients with asthma. AIMS: We investigated whether cytokines and chemokines differed in sputum from subjects with more severe compared with milder asthma, and if unbiased factor analysis of cytokine and chemokine groupings indicates specific inflammatory pathways...
March 9, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29518418/glutathione-and-arginine-levels-predictors-for-acetaminophen-associated-asthma-exacerbation
#14
Claudia R Morris, David T Mauger, Jung H Suh, Wanda Phipatanakul, William J Sheehan, James N Moy, Ian M Paul, Stanley J Szefler, Daniel J Jackson, Anne M Fitzpatrick
Retrospective studies have demonstrated associations between acetaminophen and exacerbations in asthma, purportedly due to reductions in the antioxidant, glutathione. In this study of young children with mild asthma treated with acetaminophen, baseline levels of glutathione were not associated with future exacerbations.
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29509491/whole-genome-sequencing-of-pharmacogenetic-drug-response-in-racially-diverse-children-with-asthma
#15
Angel Cy Mak, Marquitta J White, Walter L Eckalbar, Zachary A Szpiech, Sam S Oh, Maria Pino-Yanes, Donglei Hu, Pagé Goddard, Scott Huntsman, Joshua Galanter, Ann Chen Wu, Blanca E Himes, Soren Germer, Julia M Vogel, Karen L Bunting, Celeste Eng, Sandra Salazar, Kevin L Keys, Jennifer Liberto, Thomas J Nuckton, Thomas A Nguyen, Dara G Torgerson, Pui-Yan Kwok, Albert M Levin, Juan C Celedón, Erick Forno, Hakon Hakonarson, Patrick M Sleiman, Amber Dahlin, Kelan G Tantisira, Scott T Weiss, Denise Serebrisky, Emerita Brigino-Buenaventura, Harold J Farber, Kelley Meade, Michael A Lenoir, Pedro C Avila, Saunak Sen, Shannon M Thyne, William Rodriguez-Cintron, Cheryl A Winkler, Andrés Moreno-Estrada, Karla Sandoval, Jose R Rodriguez-Santana, Rajesh Kumar, L Keoki Williams, Nadav Ahituv, Elad Ziv, Max A Seibold, Robert B Darnell, Noah Zaitlen, Ryan D Hernandez, Esteban G Burchard
Rationale Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response. Objective To identify genetic variants important for bronchodilator drug response (BDR) in racially diverse children. Methods We performed the first whole genome sequencing (WGS) pharmacogenetics study from 1,441 children with asthma from the tails of the BDR distribution to identify genetic association with BDR. Measurements and Main Results We identified population-specific and shared genetic variants associated with BDR, including genome-wide significant (p < 3...
March 6, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29483623/upper-arm-anthropometrics-versus-dxa-scan-in-survivors-of-acute-respiratory-distress-syndrome
#16
Kitty S Chan, Marina Mourtzakis, Lisa Aronson Friedman, Victor D Dinglas, Catherine L Hough, E Wesley Ely, Peter E Morris, Ramona O Hopkins, Dale M Needham
Survivors of acute respiratory distress syndrome (ARDS) experience severe muscle wasting. Upper arm anthropometrics can provide a quick, non-invasive estimate of muscle status, but its accuracy is unknown. This study examines the accuracy of upper arm percent muscle area (UAMA) with reference measures of lean mass from dual energy X-ray absorptiometry (DXA). Data are from 120 ARDS survivors participating in a multicenter national study. Receiver operating characteristic (ROC) curves, by patient sex, demonstrated that UAMA did no better than chance in discriminating low appendicular skeletal muscle mass identified using DXA findings (c-statistics, 6 months: 0...
February 26, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29482026/determinants-of-diuretic-responsiveness-and-associated-outcomes-during-acute-heart-failure-hospitalization-an-analysis-from-the-nhlbi-heart-failure-network-clinical-trials
#17
Michael S Kiernan, Susanna R Stevens, W H Wilson Tang, Javed Butler, Kevin J Anstrom, Edo Y Birati, Justin L Grodin, Divya Gupta, Kenneth B Margulies, Shane LaRue, Victor G Dávila-Román, Adrian F Hernandez, Lisa de Las Fuentes
BACKGROUND: Poor response to loop diuretic therapy is a marker of risk during heart failure hospitalization. We sought to describe baseline determinants of diuretic response and to further explore the relationship between this response and clinical outcomes. METHODS AND RESULTS: Patient data from the National Heart, Lung, and Blood Institute Heart Failure Network ROSE-AHF and CARRESS-HF clinical trials were analyzed to determine baseline determinants of diuretic response...
March 1, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29473104/duration-of-acute-kidney-injury-in-critically-ill-patients
#18
Christine K Federspiel, Theis S Itenov, Kala Mehta, Raymond K Hsu, Morten H Bestle, Kathleen D Liu
BACKGROUND: Duration of acute kidney injury (AKI) has been recognized a risk factor for adverse outcomes following AKI. We sought to examine the relationship of AKI duration and recurrent AKI with short-term outcomes in critically ill patients who were mechanically ventilated and met criteria for the acute respiratory distress syndrome. METHODS: Participants in the NHLBI ARDS Network SAILS multicenter trial who developed AKI were included in this analysis and divided into groups based on AKI duration...
February 23, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29438772/lumen-area-change-delta-lumen-between-inspiratory-and-expiratory-ct-as-a-measure-of-severe-outcomes-in-asthma
#19
Sung Shine Shim, Mark L Schiebler, Michael D Evans, Nizar Jarjour, Ron L Sorkness, Loren Denlinger, Alfonso Rodriguez, Sally Wenzel, Eric A Hoffman, Ching-Long Lin, David S Gierada, Mario Castro, Sean B Fain
BACKGROUND: Quantitative computed tomography (QCT) biomarkers of airway morphology hold potential for understanding and monitoring regional airway remodeling in asthma. OBJECTIVE: We sought to determine if the change of airway lumen area between TLC and FRC lung volumes measured from CT imaging data was correlated with severe outcomes in asthma patients. METHODS: We studied 152 asthma patients (90 female and 62 male) and 33 normal subjects (12 female and 21 male) with QCT...
February 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29427984/controlling-the-risk-domain-in-pediatric-asthma-through-personalized-care
#20
William C Anderson, Stanley J Szefler
Strategies to control the risk domain of NHLBI EPR-3 (National Heart, Lung, and Blood Institute Expert Panel Report-3) asthma guidelines, which includes exacerbations requiring systemic corticosteroids, reduction in lung growth, and progressive loss of lung function, and treatment-related adverse effects, are evolving in children and adolescents. Increasing evidence demonstrates that children and adolescents with asthma are at risk of a reduction in lung growth, leading to lower lung function and potentially chronic obstructive pulmonary disease as adults...
February 2018: Seminars in Respiratory and Critical Care Medicine
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