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https://www.readbyqxmd.com/read/29225436/perspective-late-stage-t4-translation-research-and-implementation-science-the-national-heart-lung-and-blood-institute-strategic-vision
#1
EDITORIAL
George A Mensah, Cheryl Anne Boyce, LeShawndra N Price, Helena O Mishoe, Michael M Engelgau
In August 2016, the National Heart, Lung, and Blood Institute (NHLBI) released its Strategic Vision for charting a course for research over the next decade. This vision was the culmination of an unprecedented process that engaged diverse stakeholders from across the United States and around the globe. The process resulted in four mission-oriented goals and eight strategic objectives that provide an overall framework for advancing research in heart, lung, and blood diseases and sleep disorders. In this perspective, we address opportunities that NHLBI has identified to advance late-stage (T4) translation research, implementation science, health inequities research, global health research, and related research workforce development...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29168253/genomewide-association-study-of-hla-alloimmunization-in-previously-pregnant-blood-donors
#2
Mark Seielstad, Grier P Page, Nathan Gaddis, Marion Lanteri, Tzong-Hae Lee, Ram Kakaiya, Lisa F Barcellos, Lindsey A Criswell, Darrell Triulzi, Philip J Norris, Michael P Busch
BACKGROUND: Alloimmunization through blood transfusion, transplantation, or circulating fetal cells during pregnancy is a significant concern. Some exposed individuals make alloantibodies while others do not, implying variation in genetic risk factors. STUDY DESIGN AND METHODS: We conducted a genomewide association study (GWAS) of 9,427,497 single-nucleotide polymorphisms (SNPs) to identify genetic variants for HLA alloimmunization in previously pregnant blood donors with (n = 752) and without (n = 753) HLA Class I or II alloantibodies...
November 22, 2017: Transfusion
https://www.readbyqxmd.com/read/29149222/personalized-medicine-and-hispanic-health-improving-health-outcomes-and-reducing-health-disparities-a-national-heart-lung-and-blood-institute-workshop-report
#3
M Larissa Avilés-Santa, John Heintzman, Nangel M Lindberg, Rafael Guerrero-Preston, Kenneth Ramos, Ana L Abraído-Lanza, Jonca Bull, Adolph Falcón, Mary Ann McBurnie, Ernest Moy, George Papanicolaou, Ileana L Piña, Jennifer Popovic, Shakira F Suglia, Miguel A Vázquez
Persons of Hispanic/Latino descent may represent different ancestries, ethnic and cultural groups and countries of birth. In the U.S., the Hispanic/Latino population is projected to constitute 29% of the population by 2060. A personalized approach focusing on individual variability in genetics, environment, lifestyle and socioeconomic determinants of health may advance the understanding of some of the major factors contributing to the health disparities experienced by Hispanics/Latinos and other groups in the U...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/29130351/the-gene-therapy-resource-program-a-decade-of-dedication-to-translational-research-by-the-national-heart-lung-and-blood-institute
#4
Terence R Flotte, Eric Daniels, Janet Benson, Jenee M Bevett-Rose, Kenneth Cornetta, Margaret Diggins, Julie Johnston, Susan Sepelak, Johannes Van Der Loo, James M Wilson, Cheryl L McDonald
Over a ten-year period, the Gene Therapy Resource Program (GTRP) of the National Heart Lung and Blood Institute (NHLBI) has provided a set of core services to investigators to facilitate the clinical translation of gene therapy. These services have included a preclinical (research-grade) vector production core; current Good Manufacturing Practice (cGMP) clinical-grade vector cores for recombinant adeno-associated virus (rAAV) and lentivirus vectors; a pharmacology and toxicology core; and a coordinating center to manage program logistics and to provide regulatory and financial support to early phase clinical trials...
November 12, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29128648/a-hypertension-emergency-department-intervention-aimed-at-decreasing-disparities-design-of-a-randomized-clinical-trial
#5
Heather M Prendergast, Marina Del Rios, Renee Petzel-Gimbar, Daniel Garside, Sara Heinert, Sandra Escobar-Schulz, Pavitra Kotini-Shah, Michael Brown, Jinsong Chen, Joseph Colla, Marian Fitzgibbon, Ramon A Durazo-Arvizu, Martha Daviglus
Effective interventions to identify and treat uncontrolled hypertension (HTN), particularly in underrepresented populations that use the emergency department (ED) for primary care, are critically needed. Uncontrolled HTN contributes significantly to cardiovascular morbidity and mortality and is more frequently encountered among patients presenting to the ED as compared to the primary care setting. EDs serve as the point of entry into the health care system for high-risk patient populations, including minority and low-income patients...
November 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29123142/genomic-and-epidemiological-characterisation-of-a-dengue-virus-outbreak-among-blood-donors-in-brazil
#6
Nuno R Faria, Antonio Charlys da Costa, José Lourenço, Paula Loureiro, Maria Esther Lopes, Roberto Ribeiro, Cecilia Salete Alencar, Moritz U G Kraemer, Christian J Villabona-Arenas, Chieh-Hsi Wu, Julien Thézé, Kamran Khan, Shannon E Brent, Camila Romano, Eric Delwart, Brian Custer, Michael P Busch, Oliver G Pybus, Ester C Sabino
Outbreaks caused by Dengue, Zika and Chikungunya viruses can spread rapidly in immunologically naïve populations. By analysing 92 newly generated viral genome sequences from blood donors and recipients, we assess the dynamics of dengue virus serotype 4 during the 2012 outbreak in Rio de Janeiro. Phylogenetic analysis indicates that the outbreak was caused by genotype II, although two isolates of genotype I were also detected for the first time in Rio de Janeiro. Evolutionary analysis and modelling estimates are congruent, indicating a reproduction number above 1 between January and June, and at least two thirds of infections being unnoticed...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122942/a-special-report-on-the-nhlbi-initiative-to-study-cellular-and-molecular-mechanisms-of-arterial-stiffness-and-its-association-with-hypertension
#7
Young S Oh, Dan E Berkowitz, Richard A Cohen, C Alberto Figueroa, David G Harrison, Jay D Humphrey, Douglas F Larson, Jane A Leopold, Robert P Mecham, Nelson Ruiz-Opazo, Lakshmi Santhanam, Francesca Seta, John Y J Shyy, Zhongjie Sun, Philip S Tsao, Jessica E Wagenseil, Zorina S Galis
No abstract text is available yet for this article.
November 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29103858/mental-stress-peripheral-vascular-reactivity-is-elevated-in-women-with-coronary-vascular-dysfunction-results-from-the-nhlbi-sponsored-cardiac-autonomic-nervous-system-cans-study
#8
Puja K Mehta, Melody Hermel, Michael D Nelson, Galen Cook-Wiens, Elizabeth A Martin, Ayman A Alkhoder, Janet Wei, Margo Minissian, Chrisandra L Shufelt, Sailaja Marpuri, David Hermel, Amit Shah, Michael R Irwin, David S Krantz, Amir Lerman, C Noel Bairey Merz
BACKGROUND: Women with chest pain, ischemia, and no obstructive coronary artery disease often have coronary vascular dysfunction (CVaD). Peripheral vascular reactivity to mental stress may contribute mechanistic understanding of stress-induced ischemia in women with CVaD. METHODS: 62 women (41 CVaD and 21 controls) underwent mental stress testing (MST) with anger recall, mental arithmetic, and forehead cold pressor (COP) challenge. Emotional arousal was measured (Likert scale)...
October 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29100885/a-phase-ii-clinical-trial-of-low-dose-inhaled-carbon-monoxide-in-idiopathic-pulmonary-fibrosis
#9
Ivan O Rosas, Hilary J Goldberg, Harold R Collard, Souheil El-Chemaly, Kevin Flaherty, Gary M Hunninghake, Joseph A Lasky, David J Lederer, Roberto Machado, Fernando J Martinez, Rie Maurer, Danielle Teller, Imre Noth, Elizabeth Peters, Ganesh Raghu, Joe G N Garcia, Augustine M K Choi
BACKGROUND: Preclinical studies have demonstrated that low-dose carbon monoxide (CO) can abrogate experimental lung fibrosis. To test the therapeutic role of inhaled CO, we designed a clinical study in patients with idiopathic pulmonary fibrosis (IPF). METHODS: We conducted a multicenter, phase IIa, double-blinded, sham-controlled, clinical trial. Patients with IPF were randomized to treatment with inhaled CO at 100 to 200 parts per million or to inhaled 21% oxygen for 2 h daily, twice weekly, for 12 weeks...
October 31, 2017: Chest
https://www.readbyqxmd.com/read/29099655/multimarker-assessment-of-diastolic-dysfunction-in-metabolic-syndrome-patients
#10
Mihaela Mocan, Florin Anton, Șoimița Suciu, Rodica Răhăian, Sorin Nicu Blaga, Anca Daniela Fărcaș
BACKGROUND: Metabolic syndrome (MetS) has been associated with left ventricular diastolic dysfunction (LVDD) with preserved systolic function. This study aims at identifying the predictive factors for LVDD in MetS patients. METHODS: The studied group comprised 72 consecutive hospitalized patients (2010-2011) diagnosed with MetS based on AHA/NHLBI/IDF 2009 definition, free of cardiovascular disease (36.11% males, age 59.19 ± 5.26 years), who underwent echocardiographic examination...
November 3, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29098718/outgrowing-the-laboratory-diagnosis-of-type-1-von-willebrand-disease-a-two-decade-study
#11
Mouhamed Yazan Abou-Ismail, Gbolahan O Ogunbayo, Michelle Secic, Peter A Kouides
Von Willebrand Factor (VWF) levels are known to increase with age in the general population, but that effect is unclear in von Willebrand disease (VWD) patients. Thus, it is important to assess the trends of VWF levels with age, and the extent and rate of their normalization in patients with VWD. In a retrospective cohort study, we reviewed the medical records of 126 patients between 1996 and 2016 who met the NHLBI diagnostic criteria for type 1 VWD or "Low VWF" (LVWF). We followed all their historically documented VWF antigen (VWF:Ag), VWF activity (VWF:RCo), and Factor VIII (FVIII) levels longitudinally over time, correlating data with clinical setting at time of testing...
November 3, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29092746/comparing-associations-of-different-metabolic-syndrome-definitions-with-ischemic-stroke-in-chinese-elderly-population
#12
Qian Liu, Yan-Xun Li, Zhi-Hao Hu, Xiao-Yan Jiang, Shu-Juan Li, Xiao-Feng Wang
OBJECTIVES: Studies have showed the associations between different definitions of metabolic syndrome (MetS) and risk of ischemic stroke were inconsistent. In this study, we compared associations of different MetS definitions with ischemic stroke in Chinese elderly population. METHODS: A total of 1713 individuals aged 70-84years from Rugao Longevity and Ageing Study were analyzed. The MetS was defined by four different criteria: Chinese Adult Dyslipidemia Prevention Guide, International Diabetes Federation (IDF), Updated ATPIII (Updated ATPIII) by American heart association/American heart, lung and blood institute (AHA/NHLBI), and Joint Interim Statement(JIS) recommended by IDF and the American heart association/American national institutes of health/American heart, lung and blood institute (AHA/NIH/NHLBI)...
October 29, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29092064/perspectives-on-polycystic-ovary-syndrome-is-polycystic-ovary-syndrome-research-underfunded
#13
Soumia Brakta, Daria Lizneva, Kateryna Mykhalchenko, Adonis Imam, Walidah Walker, Michael P Diamond, Ricardo Azziz
Context: The Polycystic Ovary Syndrome (PCOS) is a common endocrine-metabolic abnormality with a worldwide prevalence of 4%-21%, depending on diagnostic criteria. The National Institutes of Health (NIH) is the largest single funding agency in the world, invests nearly $30.0 billion annually in biomedical research. Evidence Acquisition: Utilizing the NIH RePorter system we searched for all grants awarded by the NIH for PCOS and three other disorders with comparable degrees of morbidity, and similar or lower mortality and prevalences (i...
September 19, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29074945/analysis-commons-a-team-approach-to-discovery-in-a-big-data-environment-for-genetic-epidemiology
#14
Jennifer A Brody, Alanna C Morrison, Joshua C Bis, Jeffrey R O'Connell, Michael R Brown, Jennifer E Huffman, Darren C Ames, Andrew Carroll, Matthew P Conomos, Stacey Gabriel, Richard A Gibbs, Stephanie M Gogarten, Namrata Gupta, Cashell E Jaquish, Andrew D Johnson, Joshua P Lewis, Xiaoming Liu, Alisa K Manning, George J Papanicolaou, Achilleas N Pitsillides, Kenneth M Rice, William Salerno, Colleen M Sitlani, Nicholas L Smith, Susan R Heckbert, Cathy C Laurie, Braxton D Mitchell, Ramachandran S Vasan, Stephen S Rich, Jerome I Rotter, James G Wilson, Eric Boerwinkle, Bruce M Psaty, L Adrienne Cupples
No abstract text is available yet for this article.
October 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29073364/genetic-immunological-and-environmental-basis-of-sarcoidosis
#15
David R Moller, Ben A Rybicki, Nabeel Y Hamzeh, Courtney G Montgomery, Edward S Chen, Wonder Drake, Andrew Fontenot
Sarcoidosis is a multisystem disease with tremendous heterogeneity in disease manifestations, severity and clinical course that varies among different ethnic and racial groups. To better understand this disease and to improve the outcomes of patients, an NHLBI workshop was convened to assess the current state of knowledge, gaps and research needs across the clinical, genetic, environmental and immunologic arenas. We also explored to what extent the interplay of the genetic, environmental and immunologic factors could explain the different phenotypes and outcomes of sarcoidosis patients, including the chronic phenotypes that have the greatest health care burden...
October 26, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29073361/high-risk-sarcoidosis-current-concepts-and-research-imperatives
#16
William H Sauer, Barney J Stern, Robert Baughman, Daniel A Culver, Walter Royal
Sarcoidosis is a disease with heterogeneous manifestations and outcomes, varying in part based on organ involvement. Specifically, sarcoidosis patients at risk for poor outcomes include individuals with treatment-resistant pulmonary sarcoidosis, including fibrotic pulmonary disease and pulmonary hypertension, as well as those with cardiac, neurologic and multi-organ disease. The limited but available data relating to these high-risk sarcoidosis patients, defined as those patients with presentations requiring medical intervention to avoid progressive disability or premature death, was evaluated as part of the National Heart Lung and Blood Institute's (NHLBI) workshop to improve understanding of these disease manifestations...
October 26, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29064539/guidezilla-extension-catheter-for-percutaneous-interventional-therapy-of-complex-lesions-via-a-transradial-approach-case-series-from-a-single-center-experience
#17
Chen-Yang Chen, Yi-Yuan Huang, Liang Tang, Xin-Qun Hu, Zhen-Fei Fang, Sheng-Hua Zhou
BACKGROUND: Guide catheter extension systems have become one of the most powerful tools for addressing complex lesions during percutaneous coronary intervention (PCI), but data on a new-generation rapid exchange extension catheter - the Guidezilla catheter - are limited. Summarized herein reports on experience using the Guidezilla catheter for complex coronary lesions via a transradial approach at the documented institution an evaluation of its safety and efficacy. METHODS: A total of 25 patients (19 males and 6 females) who underwent PCI via the radial approach with the Guidezilla catheter for adequate back-up support and to facilitate equipment delivery were enrolled...
October 24, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29048937/executive-summary-of-the-nhlbi-workshop-report-leveraging-current-scientific-advances-to-better-understand-sarcoidosis-variability-and-improve-outcomes
#18
Lisa A Maier, Elliott D Crouser, William J Martin, Jerry Eu
Sarcoidosis is a systemic granulomatous disease that primarily affects the lung; it is associated with significant disparities, more commonly impacting those in the prime of their lives, age 20-50, with a second peak after age 60, Blacks, and women. However, the burden of disease, the ability to diagnose and prognose organ involvement and course, as well as specific treatment and management options, and disease pathogenesis remain poorly understood. As a result, the National Heart Lung and Blood Institute (NHLBI) undertook a sarcoidosis workshop "Leveraging Current Scientific Advancements to Understand Sarcoidosis Variability and Improve Outcomes" to help address these issues by defining the scientific and clinical priorities to improve sarcoidosis care...
October 19, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29044499/identification-of-the-first-homozygous-1-bp-deletion-in-gdf9-gene-leading-to-primary-ovarian-insufficiency-by-using-targeted-massively-parallel-sequencing
#19
M M França, M F A Funari, M Y Nishi, A M Narcizo, S Domenice, E M F Costa, A M Lerario, B B Mendonca
Targeted massively parallel sequencing (TMPS) has been used in genetic diagnosis for Mendelian disorders. In the past few years, the TMPS has identified new and already described genes associated with primary ovarian insufficiency phenotype. Here, we performed a targeted gene sequencing to find a genetic diagnosis in idiopathic cases of Brazilian POI cohort. A custom SureSelect(XT) DNA target enrichment panel was designed and the sequencing was performed on Illumina NextSeq sequencer. We identified one homozygous 1-bp deletion variant (c...
October 16, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/29030328/studying-acute-coronary-syndrome-through-the-world-wide-web-experiences-and-lessons
#20
Angelo A Alonzo
This study details my viewpoint on the experiences, lessons, and assessments of conducting a national study on care-seeking behavior for heart attack in the United States utilizing the World Wide Web. The Yale Heart Study (YHS) was funded by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH). Grounded on two prior studies, the YHS combined a Web-based interview survey instrument; ads placed on the Internet; flyers and posters in public libraries, senior centers, and rehabilitation centers; information on chat rooms; a viral marketing strategy; and print ads to attract potential participants to share their heart attack experiences...
October 13, 2017: JMIR Research Protocols
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