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National Heart, Lung, and Blood Institute

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https://www.readbyqxmd.com/read/28636425/ats-nhlbi-asthma-copd-overlap-aco-workshop-report
#1
Prescott G Woodruff, Maarten van den Berge, Richard C Boucher, Christopher Brightling, Esteban G Burchard, Stephanie A Christenson, MeiLan K Han, Michael J Holtzman, Monica Kraft, David A Lynch, Fernando D Martinez, Helen K Reddel, Don D Sin, George R Washko, Sally E Wenzel, Antonello Punturieri, Michelle M Freemer, Robert A Wise
Asthma and COPD are highly prevalent chronic obstructive lung diseases with an associated high burden of disease. Asthma, which is often allergic in origin, frequently begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, and dyspnea. Patients with COPD, in contrast, are usually current or former smokers who present after the age of 40 years with symptoms (often persistent), including dyspnea and a productive cough. Based on age and smoking history, it is often easy to distinguish between asthma and COPD...
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28633205/advancing-the-science-of-myocardial-recovery-with-mechanical-circulatory-support-a-working-group-of-the-national-heart-lung-and-blood-institute
#2
EDITORIAL
Stavros G Drakos, Francis D Pagani, Martha S Lundberg, Timothy J Baldwin
The medical burden of heart failure (HF) has spurred interest in clinicians and scientists to develop therapies to restore the function of a failing heart. To advance this agenda, the National Heart, Lung, and Blood Institute (NHLBI) convened a Working Group of experts from June 2 to 3, 2016, in Bethesda, Maryland, to develop NHLBI recommendations aimed at advancing the science of cardiac recovery in the setting of mechanical circulatory support (MCS). MCS devices effectively reduce volume and pressure overload that drives the cycle of progressive myocardial dysfunction, thereby triggering structural and functional reverse remodeling...
July 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28625502/a-computable-phenotype-improves-cohort-ascertainment-in-a-pediatric-pulmonary-hypertension-registry
#3
Alon Geva, Jessica L Gronsbell, Tianxi Cai, Tianrun Cai, Shawn N Murphy, Jessica C Lyons, Michelle M Heinz, Marc D Natter, Nandan Patibandla, Jonathan Bickel, Mary P Mullen, Kenneth D Mandl
OBJECTIVES: To compare registry and electronic health record (EHR) data mining approaches for cohort ascertainment in patients with pediatric pulmonary hypertension (PH) in an effort to overcome some of the limitations of registry enrollment alone in identifying patients with particular disease phenotypes. STUDY DESIGN: This study was a single-center retrospective analysis of EHR and registry data at Boston Children's Hospital. The local Informatics for Integrating Biology and the Bedside (i2b2) data warehouse was queried for billing codes, prescriptions, and narrative data related to pediatric PH...
June 15, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28623181/allele-level-hla-matching-for-umbilical-cord-blood-transplantation-for-non-malignant-diseases-in-children-a-retrospective-analysis
#4
Mary Eapen, Tao Wang, Paul A Veys, Jaap J Boelens, Andrew St Martin, Stephen Spellman, Carmem Sales Bonfim, Colleen Brady, Andrew J Cant, Jean-Hugues Dalle, Stella M Davies, John Freeman, Katherine C Hsu, Katharina Fleischhauer, Chantal Kenzey, Joanne Kurtzberg, Gerard Michel, Paul J Orchard, Annalisa Paviglianiti, Vanderson Rocha, Michael R Veneris, Fernanda Volt, Robert Wynn, Stephanie J Lee, Mary M Horowitz, Eliane Gluckman, Annalisa Ruggeri
BACKGROUND: The standard for selecting unrelated umbilical cord blood units for transplantation for non-malignant diseases relies on antigen-level (lower resolution) HLA typing for HLA-A and HLA-B, and allele-level for HLA-DRB1. We aimed to study the effects of allele-level matching at a higher resolution-HLA-A, HLA-B, HLA-C, and HLA-DRB1, which is the standard used for adult unrelated volunteer donor transplantation for non-malignant diseases-for umbilical cord blood transplantation...
June 13, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28619198/cardiovascular-disease-in-incarcerated%C3%A2-populations
#5
REVIEW
Emily A Wang, Nicole Redmond, Cheryl R Dennison Himmelfarb, Becky Pettit, Marc Stern, Jue Chen, Susan Shero, Erin Iturriaga, Paul Sorlie, Ana V Diez Roux
Currently, 2.2 million individuals are incarcerated, and more than 11 million have been released from U.S. correctional facilities. Individuals with a history of incarceration are more likely to be of racial and ethnic minority populations, poor, and have higher rates of cardiovascular risk factors, especially smoking and hypertension. Cardiovascular disease is a leading cause of death among incarcerated individuals, and those recently released have a higher risk of being hospitalized and dying of cardiovascular disease compared with the general population, even after accounting for differences in racial identity and socioeconomic status...
June 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28614402/providing-researchers-with-online-access-to-nhlbi-biospecimen-collections-the-results-of-the-first-six-years-of-the-nhlbi-biolincc-program
#6
Carol A Giffen, Elizabeth L Wagner, John T Adams, Denise M Hitchcock, Lisbeth A Welniak, Sean P Brennan, Leslie E Carroll
The National Heart, Lung, and Blood Institute (NHLBI), within the United States' National Institutes of Health (NIH), established the Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) in 2008 to develop the infrastructure needed to link the contents of the NHLBI Biorepository and the NHLBI Data Repository, and to promote the utilization of these scientific resources by the broader research community. Program utilization metrics were developed to measure the impact of BioLINCC on Biorepository access by researchers, including visibility, program efficiency, user characteristics, scientific impact, and research types...
2017: PloS One
https://www.readbyqxmd.com/read/28605260/cellular-therapies-for-treatment-of-radiation-injury-report-from-a-nih-niaid-and-irsn-workshop
#7
Andrea L DiCarlo, Radia Tamarat, Carmen I Rios, Marc Benderitter, Christine W Czarniecki, Theresa C Allio, Francesca Macchiarini, Bert W Maidment, Jean-Rene Jourdain
In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there exists the real possibility that safety of nuclear power reactors could be compromised by natural (such as the tsunami and subsequent Fukushima accident in Japan in March, 2011) or accidental (Three Mile Island, 1979 and Chernobyl, 1986) events...
June 12, 2017: Radiation Research
https://www.readbyqxmd.com/read/28600386/associations-of-age-and-sex-with-marfan-phenotype-the-national-heart-lung-and-blood-institute-gentac-genetically-triggered-thoracic-aortic-aneurysms-and-cardiovascular-conditions-registry
#8
Mary J Roman, Richard B Devereux, Liliana R Preiss, Federico M Asch, Kim A Eagle, Kathryn W Holmes, Scott A LeMaire, Cheryl L Maslen, Dianna M Milewicz, Shaine A Morris, Siddharth K Prakash, Reed E Pyeritz, William J Ravekes, Ralph V Shohet, Howard K Song, Jonathan W Weinsaft
BACKGROUND: The associations of age and sex with phenotypic features of Marfan syndrome have not been systematically examined in a large cohort of both children and adults. METHODS AND RESULTS: We evaluated 789 Marfan patients enrolled in the National Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions) Registry (53% male; mean age 31 [range: 1-86 years]). Females aged ≥15 and males aged ≥16 years were considered adults based on average age of skeletal maturity...
June 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28591813/the-energy-expenditure-benefits-of-reallocating-sedentary-time-with-physical-activity-a-systematic-review-and-meta-analysis
#9
Aviroop Biswas, Paul I Oh, Guy E Faulkner, Alis Bonsignore, Maureen T Pakosh, David A Alter
Background: We compared direct and daily cumulative energy expenditure (EE) differences associated with reallocating sedentary time to physical activity in adults for meaningful EE changes. Methods: Peer-reviewed studies in PubMed, Medline, EMBASE, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews were searched from inception to March 2017. Randomized and non-randomized interventions with sedentary time and EE outcomes in adults were included...
June 7, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28580435/the-national-heart-lung-and-blood-institute-small-business-program-a-comprehensive-ecosystem-for-biomedical-product-development
#10
Kurt W Marek
Small companies working to develop products in the cardiovascular space face numerous challenges, from regulatory, intellectual property, and reimbursement barriers to securing funds to keep the lights on and reach the next development milestone. Most small companies that spin out from universities have the scientific knowledge, but product development expertise and business acumen are also needed to be successful. Other challenges include reduced interest in early stage technologies (Pharma & Biotech 2015 in Review, EP Vantage) and limited deal flow for cardiovascular products (Gormley B...
December 2016: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28572916/ipscs-are-safe
#11
Hualong Yan, Yun-Bo Shi, Jing Huang
Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came from the observations that genomic alterations exist in iPSCs. Using next generation sequencing of clonal skin fibroblasts and the iPSC clones derived from the same skin fibroblasts, Dr. Liu and his colleagues in the National Human Genome Research Institute, National Institutes of Health (NIH), USA, in collaboration with Dr...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28550403/healthcare-utilization-and-costs-in-ards-survivors-a-1-year-longitudinal-national-us-multicenter-study
#12
A Parker Ruhl, Minxuan Huang, Elizabeth Colantuoni, Taruja Karmarkar, Victor D Dinglas, Ramona O Hopkins, Dale M Needham
PURPOSE: To evaluate (1) post-discharge healthcare utilization and estimated costs in ARDS survivors, and (2) the association between patient and intensive care-related variables, and 6-month patient status, with subsequent hospitalization and costs. METHODS: Longitudinal cohort study enrolling from four ARDSNet trials in 44 US hospitals. Healthcare utilization was collected via structured interviews at 6 and 12 months post-ARDS, and hospital costs estimated via the Medical Expenditure Panel Survey...
May 26, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28546354/angiogenesis-research-extramural-portfolio-supported-by-the-national-heart-lung-and-blood-institute-2008-2015
#13
Yunling Gao, Dennis V Stanley, Valerie C Robinson, Diane M Reid, Zorina S Galis
No abstract text is available yet for this article.
May 26, 2017: Circulation Research
https://www.readbyqxmd.com/read/28546353/meeting-report-for-the-2017-national-institutes-of-health-national-heart-lung-and-blood-institute-progenitor-cell-biology-consortium-cardiovascular-bioengineering-workshop-and-symposium
#14
https://www.readbyqxmd.com/read/28538439/nonlinear-imputation-of-pao2-fio2-from-spo2-fio2-among-mechanically-ventilated-patients-in-the-icu-a-prospective-observational-study
#15
Samuel M Brown, Abhijit Duggal, Peter C Hou, Mark Tidswell, Akram Khan, Matthew Exline, Pauline K Park, David A Schoenfeld, Ming Liu, Colin K Grissom, Marc Moss, Todd W Rice, Catherine L Hough, Emanuel Rivers, B Taylor Thompson, Roy G Brower
OBJECTIVES: In the contemporary ICU, mechanically ventilated patients may not have arterial blood gas measurements available at relevant timepoints. Severity criteria often depend on arterial blood gas results. Retrospective studies suggest that nonlinear imputation of PaO2/FIO2 from SpO2/FIO2 is accurate, but this has not been established prospectively among mechanically ventilated ICU patients. The objective was to validate the superiority of nonlinear imputation of PaO2/FIO2 among mechanically ventilated patients and understand what factors influence the accuracy of imputation...
May 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28535286/invited-commentary-is-strenuous-activity-good-for-you-the-legacy-of-ralph-paffenbarger
#16
Lewis H Kuller
Ralph Paffenbarger, Jr, MD, DrPH (1922-2007), was initially trained as an infectious disease epidemiologist at the Johns Hopkins School of Hygiene and Public Health (now the Bloomberg School of Public Health). He was the first Epidemiology Intelligence Service officer in the first Epidemiology Intelligence Service class. He joined the National Heart Institute (now the National Heart, Lung, and Blood Institute) in its very early days and later became a faculty member at Stanford University and Harvard University...
June 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28530520/cardiovascular-disease-and-gout-real-world-experience-evaluating-patient-characteristics-treatment-patterns-and-health-care-utilization
#17
Michael H Pillinger, Sripal Bangalore, Alyssa B Klein, Scott Baumgartner, Robert Morlock
BACKGROUND: Gout, hyperuricemia, and cardiovascular disease (CVD) are prevalent conditions in the United States, and while they share common risk factors such as obesity, hypertension, hypercholesterolemia, and type 2 diabetes mellitus, relatively little is known about what patient and disease characteristics may link CVD with hyperuricemia and gout and how the presence of both diseases affects management decisions differently than for patients with gout alone. OBJECTIVE: To identify differences in patient characteristics, patterns of urate-lowering therapy (ULT) use, and gout control in gout patients with and without cardiovascular comorbidity...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28530113/refining-current-scientific-priorities-identifying-new-scientific-gaps-in-hiv-related-heart-lung-blood-and-sleep-hlbs-research
#18
Homer L TwiggIII, Ronald Crystal, Judith Currier, Paul M Ridker, Nancy Berliner, Hans-Peter Kiem, George Rutherford, Shimian Zou, Simone Glynn, Renee Wong, Emmanuel Peprah, Michael Engelgau, Tony L Creazzo, Sandra Colombini-Hatch, Elisabet Caler
The National Heart, Lung and Blood Institute (NHLBI) AIDS Program's goal is to provide direction and support for research and training programs in areas of HIV-related heart, lung, blood and sleep (HLBS) diseases. To better define NHLBI current HIV-related scientific priorities and with the goal of identifying new scientific priorities and gaps in HIV-related HLBS research, a wide group of investigators gathered for a scientific NHLBI HIV Working Group on December 14-15, 2015, in Bethesda, MD. The core objectives of the Working Group included discussions on: 1) HIV-related HLBS comorbidities in the antiretroviral era; 2) HIV cure; 3) HIV prevention; and 4) mechanisms to implement new scientific discoveries in an efficient and timely manner so as to have the most impact on people living with HIV (PLWH)...
May 20, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28528703/does-fitness-improve-the-cardiovascular-risk-profile-in-obese-subjects
#19
H Halland, M T Lønnebakken, S Saeed, H Midtbø, D Cramariuc, E Gerdts
BACKGROUND AND AIMS: Good cardiorespiratory fitness has been suggested to reduce the risk of cardiovascular disease in obesity. We explored the association of fitness with the prevalences of major cardiovascular risk factor like hypertension (HT), diabetes and metabolic syndrome (MetS) in overweight and obese subjects. METHODS AND RESULTS: Clinical data from 491 participants in the FAT associated CardiOvasculaR dysfunction (FATCOR) study were analyzed. Physical fitness was assessed by ergospirometry, and subjects with at least good level of performance for age and sex were classified as fit...
June 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28521801/why-are-some-people-more-fit-than-others-correlates-and-determinants-of-cardiorespiratory-fitness-in-adults-protocol-for-a-systematic-review
#20
Nita Perumal, Gert B M Mensink, Thomas Keil, Jonas David Finger
BACKGROUND: Cardiorespiratory fitness (CRF) is a physical condition that is now well established as a predictor of numerous adverse health outcomes, independent of physical activity levels. In order to be able to improve CRF at the population level and to develop effective interventions and public health programmes, it is important to understand why some people are more fit than others. Therefore, the primary aim of the systematic review described in this protocol is to examine individual and interpersonal factors that are correlated with or determine CRF among adults...
May 18, 2017: Systematic Reviews
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