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National Heart, Lung, and Blood Institute

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https://www.readbyqxmd.com/read/27887664/translating-sickle-cell-guidelines-into-practice-for-primary-care-providers-with-project-echo
#1
Lisa M Shook, Christina B Farrell, Karen A Kalinyak, Stephen C Nelson, Brandon M Hardesty, Angeli G Rampersad, Kay L Saving, Wanda J Whitten-Shurney, Julie A Panepinto, Russell E Ware, Lori E Crosby
BACKGROUND: Approximately 100,000 persons with sickle cell disease (SCD) live in the United States, including 15,000 in the Midwest. Unfortunately, many patients experience poor health outcomes due to limited access to primary care providers (PCPs) who are prepared to deliver evidence-based SCD care. Sickle Treatment and Outcomes Research in the Midwest (STORM) is a regional network established to improve care and outcomes for individuals with SCD living in Indiana, Illinois, Michigan, Minnesota, Ohio, and Wisconsin...
2016: Medical Education Online
https://www.readbyqxmd.com/read/27859323/no-association-between-frequent-apheresis-donation-and-risk-of-fractures-a-retrospective-cohort-analysis-from-sweden
#2
Katrine Grau, Senthil K Vasan, Klaus Rostgaard, Walter Bialkowski, Rut Norda, Henrik Hjalgrim, Gustaf Edgren
BACKGROUND: Citrate anticoagulation during apheresis induces transient alterations in calcium homeostasis. It is unknown whether the repeated, transient alterations in calcium homeostasis experienced by repeated apheresis donors affects bone turnover to increase fracture risk. Our aim was to investigate the risk of osteoporotic and nonosteoporotic fracture among voluntary, frequent apheresis donors. STUDY DESIGN AND METHODS: All apheresis donors were identified from the Scandinavian Donations and Transfusions database (SCANDAT2), which includes information on over 1...
November 18, 2016: Transfusion
https://www.readbyqxmd.com/read/27856459/challenges-and-opportunities-in-linking-long-noncoding-rnas-to-cardiovascular-lung-and-blood-diseases
#3
REVIEW
Jane E Freedman, Joseph M Miano
The new millennium heralds an unanticipated surge of genomic information, most notably an expansive class of long noncoding RNAs (lncRNAs). These transcripts, which now outnumber all protein-coding genes, often exhibit the same characteristics as mRNAs (RNA polymerase II-dependent, 5' methyl-capped, multiexonic, polyadenylated); yet, they do not encode for stable, well-conserved proteins. Elucidating the function of all relevant lncRNAs in heart, vasculature, lung, and blood is essential for generating a complete interactome in these tissues...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27856456/inflammatory-obesity-phenotypes-gender-effects-and-subclinical-atherosclerosis-in-african-americans-the-jackson-heart-study
#4
Albert Lin, Mary E Lacy, Charles Eaton, Adolfo Correa, Wen-Chih Wu
OBJECTIVE: Reasons for variations in atherosclerotic burden among individuals with similar levels of obesity are poorly understood, especially in African Americans. This study examines whether high-sensitivity C-reactive protein (hsCRP) is useful for discriminating between benign and high-risk obesity phenotypes for subclinical atherosclerosis in African Americans. APPROACH AND RESULTS: Participants from the Jackson Heart Study (n=4682) were stratified into 4 phenotypes based on the presence of National Heart and Lung and Blood Institute definition of obesity or obesity-equivalent (body mass index ≥30 or body mass index 25-30 with waist circumference >102 cm in men and >88 cm in women) and inflammation by hsCRP ≥2 mg/L...
December 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27836022/the-nhlbi-revive-it-study-understanding-its-discontinuation-in-the-context-of-current-left-ventricular-assist-device-therapy
#5
EDITORIAL
Francis D Pagani, Keith D Aaronson, Robert Kormos, Douglas L Mann, Cathie Spino, Neal Jeffries, Wendy C Taddei-Peters, Donna M Mancini, Dennis M McNamara, Kathleen L Grady, John Gorcsan, Ralph Petrucci, Allen S Anderson, Henry A Glick, Michael A Acker, J Eduardo Rame, Daniel J Goldstein, Salpy V Pamboukian, Marissa A Miller, J Timothy Baldwin
The National Institutes of Health National Heart, Lung, and Blood Institute convened a working group in March 2008 to discuss how therapies for heart failure (HF) might be best advanced using clinical trials involving left ventricular assist devices (LVAD). This group opined that the field was ready for a trial to assess the use of long-term ventricular assist device therapy in patients who are less ill than patients currently eligible for destination therapy, which resulted in the Randomized Evaluation of VAD InterVEntion before Inotropic Therapy (REVIVE-IT) pilot study...
November 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27810273/latino-immigrants-depressive-symptoms-and-cognitive-behavioral-therapy-a-systematic-review
#6
REVIEW
Maria Pineros-Leano, Janet M Liechty, Lissette M Piedra
BACKGROUND: In order to address the needs of the growing Latino immigrant population, this study aimed to systematically review peer-reviewed articles of intervention studies that used cognitive behavioral therapy to treat depressive symptoms among Latino immigrants in the U.S. METHODS: We searched PsycINFO, PubMed, and Medline databases from January 1995 through July 2016 as part of a registered review protocol (PROSPERO) following PRISMA guidelines. Inclusion criteria were intervention studies that used cognitive behavioral techniques to treat depressive symptoms among a predominantly U...
October 24, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27796857/turning-failure-into-success-trials-of-the-heart-failure-clinical-research-network
#7
REVIEW
Emer Joyce, Michael M Givertz
The Heart Failure Clinical Research Network (HFN) was established in 2008 on behalf of the NIH National Heart, Lung and Blood Institute, with the primary goal of improving outcomes in heart failure (HF) by designing and conducting high-quality concurrent clinical trials testing interventions across the spectrum of HF. Completed HFN trials have answered several important and relevant clinical questions concerning the safety and efficacy of different decongestive and adjunctive vasodilator therapies in hospitalized acute HF, phosphodiesterase-5 inhibition and nitrate therapies in HF with preserved ejection fraction, and the role of xanthine oxidase inhibition in hyperuricemic HF...
December 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27789558/recommended-dietary-pattern-to-achieve-adherence-to-the-american-heart-association-american-college-of-cardiology-aha-acc-guidelines-a-scientific-statement-from-the-american-heart-association
#8
Linda Van Horn, Jo Ann S Carson, Lawrence J Appel, Lora E Burke, Christina Economos, Wahida Karmally, Kristie Lancaster, Alice H Lichtenstein, Rachel K Johnson, Randal J Thomas, Miriam Vos, Judith Wylie-Rosett, Penny Kris-Etherton
In 2013, the American Heart Association and American College of Cardiology published the "Guideline on Lifestyle Management to Reduce Cardiovascular Risk," which was based on a systematic review originally initiated by the National Heart, Lung, and Blood Institute. The guideline supports the American Heart Association's 2020 Strategic Impact Goals for cardiovascular health promotion and disease reduction by providing more specific details for adopting evidence-based diet and lifestyle behaviors to achieve those goals...
October 27, 2016: Circulation
https://www.readbyqxmd.com/read/27783918/a-randomized-trial-of-long-term-oxygen-for-copd-with-moderate-desaturation
#9
(no author information available yet)
Background Long-term treatment with supplemental oxygen has unknown efficacy in patients with stable chronic obstructive pulmonary disease (COPD) and resting or exercise-induced moderate desaturation. Methods We originally designed the trial to test whether long-term treatment with supplemental oxygen would result in a longer time to death than no use of supplemental oxygen among patients who had stable COPD with moderate resting desaturation (oxyhemoglobin saturation as measured by pulse oximetry [Spo2], 89 to 93%)...
October 27, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27777974/lymphocyte-activation-gene-3-and-coronary-artery-disease
#10
Diana Golden, Antonina Kolmakova, Sunitha Sura, Anthony T Vella, Ani Manichaikul, Xin-Qun Wang, Suzette J Bielinski, Kent D Taylor, Yii-Der Ida Chen, Stephen S Rich, Annabelle Rodriguez
BACKGROUND: The lipoprotein scavenger receptor BI (SCARB1) rs10846744 noncoding variant is significantly associated with atherosclerotic disease independently of traditional cardiovascular risk factors. We identified a potentially novel connection between rs10846744, the immune checkpoint inhibitor lymphocyte activation gene 3 (LAG3), and atherosclerosis. METHODS: In vitro approaches included flow cytometry, lipid raft isolation, phosphosignaling, cytokine measurements, and overexpressing and silencing LAG3 protein...
October 20, 2016: JCI Insight
https://www.readbyqxmd.com/read/27773665/pulmonary-effects-of-immediate-versus-deferred-antiretroviral-therapy-in-hiv-positive-individuals-a-nested-substudy-within-the-multicentre-international-randomised-controlled-strategic-timing-of-antiretroviral-treatment-start-trial
#11
Ken M Kunisaki, Dennis E Niewoehner, Gary Collins, Bitten Aagaard, Nafisah B Atako, Elzbieta Bakowska, Amanda Clarke, Giulio Maria Corbelli, Ernest Ekong, Sean Emery, Elizabeth B Finley, Eric Florence, Rosa M Infante, Cissy M Kityo, Juan Sierra Madero, Daniel E Nixon, Ellen Tedaldi, Jørgen Vestbo, Robin Wood, John E Connett
BACKGROUND: Observational data have been conflicted regarding the potential role of HIV antiretroviral therapy (ART) as a causative factor for, or protective factor against, COPD. We therefore aimed to investigate the effect of immediate versus deferred ART on decline in lung function in HIV-positive individuals. METHODS: We did a nested substudy within the randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial at 80 sites in multiple settings in 20 high-income and low-to-middle-income countries...
October 20, 2016: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27754014/me-02-3-extending-sprint-results-to-diabetics
#12
Guido Grassi
The Systolic Blood Pressure Intervention Trial (SPRINT), sponsored by the National Heart, Lung and Blood Institute in the USA, allocated 9361 hypertensive patients (mean age 68 years) to two systolic blood pressure treatment targets (either < 120mmHg or < 140mmHg). Although SPRINT intended to enrol hypertensive patients at high cardiovascular risk, it specifically excluded patients with diabetes mellitus or prior stroke. SPRINT was stopped earlier than planned, after a mean follow-up of 3.26 years, on the recommendation of its data and safety monitoring board, and data were published on 9 November 2015...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27741976/coronary-artery-calcification
#13
REVIEW
Kazuhiro Osawa, Rine Nakanishi, Matthew Budoff
Coronary artery calcification (CAC) is an established marker of subclinical atherosclerosis and an independent predictor of future coronary heart disease in the asymptomatic primary prevention population, particularly in the intermediate risk cohort. CAC also helps in reclassifying those patients and their risk of cardiovascular events into higher or lower risk categories. MESA (Multi-Ethnic Study of Atherosclerosis) is a National Heart, Lung, and Blood Institute-sponsored population-based medical research study involving 6,814 men and women from 6 U...
September 2016: Global Heart
https://www.readbyqxmd.com/read/27716930/self-reported-historic-human-immunodeficiency-virus-hiv-testing-in-a-brazilian-blood-donor-hiv-case-control-study
#14
Roberta Bruhn, Elizabeth Moreno, Ester C Sabino, Naura Aparecida F Ferreira, Anna Barbara F Carneiro-Proietti, Maria Esther D Lopes, Divaldo Sampaio, Paula Loureiro, Brian Custer, Thelma T Goncalez
BACKGROUND: There has been increased worldwide emphasis on the many benefits of human immunodeficiency virus (HIV) serostatus awareness for both infection prevention and improved treatment outcomes. Previous studies indicate that donors may use blood donation to be tested; the objectives of this analysis were to assess, among donors with previously undisclosed risk behavior in the 12 months before donation, the frequency of those who have previously been tested for HIV and the demographic and behavioral factors associated with such testing...
September 9, 2016: Transfusion
https://www.readbyqxmd.com/read/27709731/seeking-applicants-for-new-trans-nih-k12-program-in-emergency-care-research
#15
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27705249/life-expectancy-after-myocardial-infarction-according-to-hospital-performance
#16
Emily M Bucholz, Neel M Butala, Shuangge Ma, Sharon-Lise T Normand, Harlan M Krumholz
Background Thirty-day risk-standardized mortality rates after acute myocardial infarction are commonly used to evaluate and compare hospital performance. However, it is not known whether differences among hospitals in the early survival of patients with acute myocardial infarction are associated with differences in long-term survival. Methods We analyzed data from the Cooperative Cardiovascular Project, a study of Medicare beneficiaries who were hospitalized for acute myocardial infarction between 1994 and 1996 and who had 17 years of follow-up...
October 6, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27703645/the-correlation-of-plasma-25-hydroxyvitamin-d-deficiency-with-risk-of-breast-neoplasms-a-systematic-review
#17
Reza Shekarriz-Foumani, Faezeh Khodaie
CONTEXT: Breast cancer has been considered as one of the most common types of cancer among the women worldwide, and patients with breast neoplasms have been reported with high prevalence of low serum 25-hydroxyvitamin D levels. OBJECTIVES: Our aim was to evaluate the correlation of plasma 25-hydroxyvitamin D deficiency with breast neoplasms risk among women. DATA SOURCES: PubMed database was searched with MeSH (medical subject headings) keywords "vitamin D AND breast neoplasms" which was restricted by original articles written only in English and published from January 1, 2014...
June 2016: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27672030/breaking-the-cycle-estrous-variation-does-not-require-increased-sample-size-in-the-study-of-female-rats
#18
Alex Dayton, Eric C Exner, John D Bukowy, Timothy J Stodola, Theresa Kurth, Meredith Skelton, Andrew S Greene, Allen W Cowley
Despite the striking differences between male and female physiology, female physiology is understudied. In response, the National Institutes of Health is promulgating new policies to increase the use of female organisms in preclinical research. Females are commonly believed to have greater variability than males because of the estrous cycle, but recent studies call this belief into question. Effects of estrous cycling on mean arterial pressure were assessed in female Dahl S rats using telemetry and vaginal cytometry and found that estrous cycling did not affect mean arterial pressure magnitude or variance...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27663965/increasing-universal-lipid-screening-among-9-to-11-year-old-children-through-a-quality-improvement-initiative
#19
Leah Kern, Janet Crow, Christine B Williams, Eyla Boies, Sheila Gahagan, Kyung E Rhee
In 2011, the National Heart Lung and Blood Institute recommended universal lipid screening (ULS) in 9- to 11-year-old children. This study aimed to determine whether a quality improvement (QI) initiative increased ULS. Data were abstracted from the electronic medical record to compare screening behaviors 1 year preimplementation and postimplementation. A focus group was conducted to examine physicians' attitudes. In preimplementation and postimplementation years, the number of 9- to 11-year-olds seen for well-child checks were 356 and 357, respectively...
September 23, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27659546/pediatric-hypertension-are-pediatricians-following-guidelines
#20
Neil D Patel, Andrew Newburn, Michael E Brier, Deepa H Chand
The National Heart, Lung, and Blood Institute recommends that children older than 3 years seen in the medical setting have their blood pressure (BP) measured. The authors aimed to determine whether BPs are measured at well-child visits and whether elevated readings are recognized. A retrospective chart review of 3- to 18-year-old children seen for well-child visits was performed. Age, sex, weight, height, BP, extremity measured, and type of intervention were collected. BP was measured in 777 of 805 patients (97%)...
September 23, 2016: Journal of Clinical Hypertension
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