keyword
MENU ▼
Read by QxMD icon Read
search

National Heart, Lung, and Blood Institute

keyword
https://www.readbyqxmd.com/read/29790628/metabolic-syndrome-and-its-components-are-associated-with-increased-chronic-kidney-disease-risk-evidence-from-a-meta-analysis-on-11-109-003-participants-from-66-studies
#1
Shahab Alizadeh, Mahsa Ahmadi, Behnam Ghorbani Nejad, Abolghassem Djazayeri, Sakineh Shab-Bidar
BACKGROUND & AIMS: Observational studies examining the relationship between metabolic syndrome and the risk of chronic kidney disease (CKD) have reported inconclusive results. This meta-analysis was performed to resolve these controversies. METHODS: The MEDLINE, EMBASE, and PubMed databases were systematically searched from their inception until March 2016 to identify all relevant studies. Risk estimates and their corresponding 95% confidence intervals (CIs) for the associations of MetS and its components with CKD risk were extracted and pooled using a random-effects model...
May 23, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#2
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29770297/current-status-and-future-perspectives-of-the-pumpkin-trial
#3
REVIEW
Iki Adachi
Similar to the adult experience, the use of continuous-flow ventricular assist devices (VADs) has been increasing in the pediatric population. According to the PediMACS registry, continuous-flow VAD currently accounts for >60% of the durable device implantations in the U.S. Nonetheless, the continuous-flow VADs currently in use are designed for adults; this inevitably causes the patient-device size mismatch issue, especially when applied for small children. Pulsatile VADs, therefore, represent the only practical option for this group of patients despite the known risk profile of pulsatile VADs...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29770169/dietary-total-antioxidant-capacity-and-dietary-polyphenol-intake-and-prevalence-of-metabolic-syndrome-in-polish-adults-a-nationwide-study
#4
Małgorzata Elżbieta Zujko, Anna Waśkiewicz, Anna Maria Witkowska, Danuta Szcześniewska, Tomasz Zdrojewski, Krystyna Kozakiewicz, Wojciech Drygas
Specific classes and subclasses of polyphenols have been studied for their potential effects on noncommunicable diseases, but studies on association between dietary polyphenol intake (DPI) and dietary total antioxidant capacity (DTAC) and MetS (metabolic syndrome) are scarce. Therefore, the aim of this study was to determine associations between DTAC and DPI and the prevalence of MetS and its components in the Polish adult population. Subjects (5690) were participants of the Polish National Multicentre Health Examination Survey (WOBASZ II study) performed in 2013-2014...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29769802/who-height-charts-can-be-safely-substituted-when-calculating-bp-z-scores-in-a-north-american-clinic-setting
#5
Celia J Rodd, Daniel L Metzger, Atul K Sharma
Objectives: The Public Health Agency of Canada has officially adopted growth charts from the World Health Organization (WHO); nevertheless, North American blood pressure (BP) Z-scores and percentiles still depend on height Z-scores based on growth charts from the US Centers for Disease Control (CDC), which may differ significantly, particularly in toddlers. Since many practitioners simply replace CDC height scores with WHO equivalents for diagnosing hypertension, we explore the impact of this substitution on BP Z-scores in real-world BPs measured on more than 22,000 children aged 2 to 18 years...
May 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29753517/liberal-versus-restrictive-intravenous-fluid-therapy-for-early-septic-shock-rationale-for-a-randomized-trial
#6
Wesley H Self, Matthew W Semler, Rinaldo Bellomo, Samuel M Brown, Bennett P deBoisblanc, Matthew C Exline, Adit A Ginde, Colin K Grissom, David R Janz, Alan E Jones, Kathleen D Liu, Stephen P J Macdonald, Chadwick D Miller, Pauline K Park, Lora A Reineck, Todd W Rice, Jay S Steingrub, Daniel Talmor, Donald M Yealy, Ivor S Douglas, Nathan I Shapiro
Prompt intravenous fluid therapy is a fundamental treatment for patients with septic shock. However, the optimal approach for administering intravenous fluid in septic shock resuscitation is unknown. Two competing strategies are emerging: a liberal fluids approach, consisting of a larger volume of initial fluid (50 to 75 mL/kg [4 to 6 L in an 80-kg adult] during the first 6 hours) and later use of vasopressors, versus a restrictive fluids approach, consisting of a smaller volume of initial fluid (≤30 mL/kg [≤2 to 3 L]), with earlier reliance on vasopressor infusions to maintain blood pressure and perfusion...
May 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29746147/female-sex-and-gender-in-lung-sleep-health-and-disease-increased-understanding-of-basic-biological-pathophysiological-and-behavioral-mechanisms-leading-to-better-health-for-female-patients-with-lung-disease
#7
MeiLan K Han, Emilio Arteaga-Solis, John Blenis, Ghada Bourjeily, Deborah J Clegg, Dawn DeMeo, Jeanne Duffy, Ben Gaston, Nicola M Heller, Anna Hemnes, Elizabeth Petri Henske, Raksha Jain, Tim Lahm, Lisa H Lancaster, Joyce Lee, Marianne J Legato, Sherry McKee, Reena Mehra, Alison Morris, Y S Prakash, Martin R Stampfli, Rashmi Gopal-Srivastava, Aaron D Laposky, Antonello Punturieri, Lora Reineck, Xenia Tigno, Janine Clayton
Female sex/gender is an under-characterized variable in studies related to lung development and disease. Notwithstanding, many aspects of lung and sleep biology and pathobiology are impacted by female sex and female reproductive transitions. These may manifest as differential gene expression or peculiar organ development. Some conditions are more prevalent in women, such as asthma and insomnia, or in the case of LAM, are seen almost exclusively in women. In other diseases, presentation differs such as the higher frequency of exacerbations experienced by women with COPD or greater cardiac morbidity among women with sleep disordered breathing...
May 10, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29735474/the-detroit-young-adult-asthma-project-proposal-for-a-multicomponent-technology-intervention-for-african-american-emerging-adults-with-asthma
#8
Karen MacDonell, Sylvie Naar, Wanda Gibson-Scipio, Jean-Marie Bruzzese, Bo Wang, Aaron Brody
BACKGROUND: Racial and ethnic minority youth have poorer asthma status than white youth, even after controlling for socioeconomic variables. Proper use of asthma controller medications is critical in reducing asthma mortality and morbidity. The clinical consequences of poor asthma management include increased illness complications, excessive functional morbidity, and fatal asthma attacks. There are significant limitations in research on interventions to improve asthma management in racial minority populations, particularly minority adolescents and young adults, although illness management tends to deteriorate after adolescence during emerging adulthood, the unique developmental period beyond adolescence but before adulthood...
May 7, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29727365/evaluating-muscle-mass-in-survivors-of-acute-respiratory-distress-syndrome-a-1-year-multicenter-longitudinal-study
#9
Kitty S Chan, Marina Mourtzakis, Lisa Aronson Friedman, Victor D Dinglas, Catherine L Hough, E Wesley Ely, Peter E Morris, Ramona O Hopkins, Dale M Needham
OBJECTIVES: Rapid muscle wasting occurs during acute respiratory failure, resulting in muscle weakness and functional impairments. This study examines survivors' body composition in the year after acute respiratory distress syndrome and tests associations of patient characteristics, hospital exposures, and survivors' strength and physical functioning with whole body percent lean mass. DESIGN: Prospective cohort study with 6- and 12-month follow-up. SETTING: National study enrolling patients from five study centers...
May 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29724236/patient-consent-to-publication-and-data-sharing-in-industry-and-nih-funded-clinical-trials
#10
O'Mareen Spence, Richie Onwuchekwa Uba, Seongbin Shin, Peter Doshi
BACKGROUND: Participants are recruited into clinical trials under the assumption that the research will contribute to medical knowledge. Therefore, non-publication trials-and, more recently, lack of data sharing-are widely considered to violate the trust of trial participants. Existing practices regarding patient consent to publication and data sharing have not been evaluated. Analyzing informed consent forms (ICFs), we studied what trial participants were told regarding investigators' intention to contribute to medical knowledge, publish trial results, and share de-identified trial data...
May 3, 2018: Trials
https://www.readbyqxmd.com/read/29718371/metabolic-syndrome-and-its-components-in-southern-kazakhstan-a-cross-sectional-study
#11
Assel Sadykova, Zhanar S Shalkharova, Zhanat N Shalkharova, Karlygash Sadykova, Kamshat Madenbay, Mira Zhunissova, Gulnaz Nuskabayeva, Saltanat Askarova, Andrej M Grjibovski
Background: The study aimed to assess the prevalence of metabolic syndrome (MetS) and its components in southern Kazakhstan. Methods: A total of 965 adults, ages 20-74 y, participated in a cross-sectional study. MetS was defined using National Education Cholesterol Education Program Adult Treatment Panel III (NCEP), American Heart Association/National Heart, Lung and Blood Institute (AHA) and International Diabetes Federation (IDF) criteria. Social variations in the prevalence of components of MetS were assessed using Poisson regression...
April 27, 2018: International Health
https://www.readbyqxmd.com/read/29716847/implementation-research-to-address-the-united-states-health-disadvantage-report-of-a-national-heart-lung-and-blood-institute-workshop
#12
Michael M Engelgau, K M Venkat Narayan, Majid Ezzati, Luis A Salicrup, Deshiree Belis, Laudan Y Aron, Robert Beaglehole, Alain Beaudet, Peter A Briss, David A Chambers, Marion Devaux, Kevin Fiscella, Michael Gottlieb, Unto Hakkinen, Rain Henderson, Anselm J Hennis, Judith S Hochman, Stephen Jan, Walter J Koroshetz, Johan P Mackenbach, M G Marmot, Pekka Martikainen, Mark McClellan, David Meyers, Polly E Parsons, Clas Rehnberg, Darshak Sanghavi, Stephen Sidney, Anna Maria Siega-Riz, Sharon Straus, Steven H Woolf, Stephanie Constant, Tony L Creazzo, Janet M de Jesus, Nara Gavini, Norma B Lerner, Helena O Mishoe, Cheryl Nelson, Emmanuel Peprah, Antonello Punturieri, Uchechukwu Sampson, Rachael L Tracy, George A Mensah
Four decades ago, U.S. life expectancy was within the same range as other high-income peer countries. However, during the past decades, the United States has fared worse in many key health domains resulting in shorter life expectancy and poorer health-a health disadvantage. The National Heart, Lung, and Blood Institute convened a panel of national and international health experts and stakeholders for a Think Tank meeting to explore the U.S. health disadvantage and to seek specific recommendations for implementation research opportunities for heart, lung, blood, and sleep disorders...
April 28, 2018: Global Heart
https://www.readbyqxmd.com/read/29710187/prevalence-and-severity-of-high-blood-pressure-among-children-based-on-the-2017-american-academy-of-pediatrics-guidelines
#13
Atul K Sharma, Daniel L Metzger, Celia J Rodd
Importance: Based on the new 2017 blood pressure guidelines, the prevalence of high blood pressure (BP) among adults has increased from 32% to 46%. Based on new norms and diagnostic thresholds that better align with adult definitions, new clinical practice guidelines were also published for children. The American Academy of Pediatrics clinical practice guidelines for the management of elevated BP in children replace the 2004 fourth report from the National, Heart, Lung, and Blood Institute...
April 23, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29707832/dealing-with-competing-risks-in-clinical-trials-how-to-choose-the-primary-efficacy-analysis
#14
James F Troendle, Eric S Leifer, Lauren Kunz
We investigate different primary efficacy analysis approaches for a 2-armed randomized clinical trial when interest is focused on a time to event primary outcome that is subject to a competing risk. We extend the work of Friedlin and Korn (2005) by considering estimation as well as testing and by simulating the primary and competing events' times from both a cause-specific hazards model as well as a joint subdistribution-cause-specific hazards model. We show that the cumulative incidence function can provide useful prognostic information for a particular patient but is not advisable for the primary efficacy analysis...
April 29, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29705495/weight-labeling-and-disordered-eating-among-adolescent-girls-longitudinal-evidence-from-the-national-heart-lung-and-blood-institute-growth-and-health-study
#15
Jeffrey M Hunger, A Janet Tomiyama
PURPOSE: Weight stigma is implicated in disordered eating, but much of this research focuses on forms of stigma such as weight-based teasing. METHODS: In a large cohort of adolescent girls (N = 2,036), we tested the hypothesis that being labeled as "too fat" by others predicts subsequent greater disordered eating cognitions and behaviors. RESULTS: Compared with girls who did not report weight labeling, girls who were labeled at age 14 showed an increase in unhealthy weight control behaviors and disordered eating cognitions over the subsequent 5 years...
April 25, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29698329/trends-in-health-disparities-health-inequity-and-social-determinants-of-health-research-a-17-year-analysis-of-ninr-nci-nhlbi-and-nimhd-funding
#16
Shawn M Kneipp, Todd A Schwartz, Denise J Drevdahl, Mary K Canales, Sheila Santacroce, Hudson P Santos, Ruth Anderson
BACKGROUND: The theoretical landscape of health disparities research now emphasizes health inequities and the role that social determinants of health (SDOH) play in creating and perpetuating them. Whether National Institutes of Health (NIH) funding patterns reflect this theoretical shift is unknown. OBJECTIVES: The aim of this study was to examine the National Institute of Nursing Research's (NINR) funding for research focused on health disparities, health inequities, and SDOH, relative to other key NIH institutes...
May 2018: Nursing Research
https://www.readbyqxmd.com/read/29661561/clinically-actionable-hypercholesterolemia-and-hypertriglyceridemia-in-children-with-nonalcoholic-fatty-liver-disease
#17
Kathryn E Harlow, Jonathan A Africa, Alan Wells, Patricia H Belt, Cynthia A Behling, Ajay K Jain, Jean P Molleston, Kimberly P Newton, Philip Rosenthal, Miriam B Vos, Stavra A Xanthakos, Joel E Lavine, Jeffrey B Schwimmer
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines. STUDY DESIGN: This multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29655805/metabolic-syndrome-positively-correlates-with-the-risks-of-atherosclerosis-and-diabetes-in-a-chinese-population
#18
Sung-Sheng Tsai, Yu-Sheng Lin, Szu-Tah Chen, Pao-Hsien Chu
BACKGROUND: Published studies seldom tested the weight of different waist circumference (WC) cut-off values for the diagnosis of metabolic syndrome (MetS) in predicting clinical outcomes, including cardiovascular disease and diabetes. METHODS: This is a Chinese population-based cross-sectional study screening subjects from a Health Examination Program since 1999 to 2015. The MetS identification and scores were determined either according to the Adult Treatment Panel III/American Heart Association/National Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI)- or Asian-WC cut-off points...
April 12, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29582077/association-of-e-cigarette-use-with-smoking-cessation-among-smokers-who-plan-to-quit-after-a-hospitalization-a-prospective-study
#19
Nancy A Rigotti, Yuchiao Chang, Hilary A Tindle, Sara M Kalkhoran, Douglas E Levy, Susan Regan, Jennifer H K Kelley, Esa M Davis, Daniel E Singer
Background: Many smokers report using e-cigarettes to help them quit smoking, but whether e-cigarettes aid cessation efforts is uncertain. Objective: To determine whether e-cigarette use after hospital discharge is associated with subsequent tobacco abstinence among smokers who plan to quit and are advised to use evidence-based treatment. Design: Secondary data analysis of a randomized controlled trial. (ClinicalTrials.gov: NCT01714323 [parent trial])...
March 27, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29573768/factors-influencing-the-implementation-of-screening-and-brief-interventions-for-alcohol-use-in-primary-care-practices-a-systematic-review-protocol
#20
Frederico Rosário, Maria Inês Santos, Kathryn Angus, Leo Pas, Niamh Fitzgerald
INTRODUCTION: Alcohol is a leading risk factor contributing to the global burden of disease. National and international agencies recommend evidence-based screening and brief interventions in primary care settings in order to reduce alcohol consumption. However, the majority of primary care professionals do not routinely deliver such interventions. OBJECTIVE: To identify factors influencing general practitioners/family physicians' and primary care nurses' routine delivery of alcohol screening and brief intervention in adults...
January 31, 2018: Acta Médica Portuguesa
keyword
keyword
78167
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"