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National Heart, Lung, and Blood Institute

Guido Grassi
The Systolic Blood Pressure Intervention Trial (SPRINT), sponsored by the National Heart, Lung and Blood Institute in the USA, allocated 9361 hypertensive patients (mean age 68 years) to two systolic blood pressure treatment targets (either < 120mmHg or < 140mmHg). Although SPRINT intended to enrol hypertensive patients at high cardiovascular risk, it specifically excluded patients with diabetes mellitus or prior stroke. SPRINT was stopped earlier than planned, after a mean follow-up of 3.26 years, on the recommendation of its data and safety monitoring board, and data were published on 9 November 2015...
September 2016: Journal of Hypertension
Kazuhiro Osawa, Rine Nakanishi, Matthew Budoff
Coronary artery calcification (CAC) is an established marker of subclinical atherosclerosis and an independent predictor of future coronary heart disease in the asymptomatic primary prevention population, particularly in the intermediate risk cohort. CAC also helps in reclassifying those patients and their risk of cardiovascular events into higher or lower risk categories. MESA (Multi-Ethnic Study of Atherosclerosis) is a National Heart, Lung, and Blood Institute-sponsored population-based medical research study involving 6,814 men and women from 6 U...
September 2016: Global Heart
Roberta Bruhn, Elizabeth Moreno, Ester C Sabino, Naura Aparecida F Ferreira, Anna Barbara F Carneiro-Proietti, Maria Esther D Lopes, Divaldo Sampaio, Paula Loureiro, Brian Custer, Thelma T Goncalez
BACKGROUND: There has been increased worldwide emphasis on the many benefits of human immunodeficiency virus (HIV) serostatus awareness for both infection prevention and improved treatment outcomes. Previous studies indicate that donors may use blood donation to be tested; the objectives of this analysis were to assess, among donors with previously undisclosed risk behavior in the 12 months before donation, the frequency of those who have previously been tested for HIV and the demographic and behavioral factors associated with such testing...
September 9, 2016: Transfusion
Jane Scott, Wayne Wang
A new Trans NIH K12 Program in Emergency Care Research was funded in late July 2016 and is funded by the National Heart, Lung and Blood Institute (NHLBI), the National Institute of Mental Health (NIMH) and National Institute of Nursing Research (NINR). The new program seeks to widen the scientific domain of emergency care research to include mental health and nursing research. This article is protected by copyright. All rights reserved.
October 6, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
Emily M Bucholz, Neel M Butala, Shuangge Ma, Sharon-Lise T Normand, Harlan M Krumholz
Background Thirty-day risk-standardized mortality rates after acute myocardial infarction are commonly used to evaluate and compare hospital performance. However, it is not known whether differences among hospitals in the early survival of patients with acute myocardial infarction are associated with differences in long-term survival. Methods We analyzed data from the Cooperative Cardiovascular Project, a study of Medicare beneficiaries who were hospitalized for acute myocardial infarction between 1994 and 1996 and who had 17 years of follow-up...
October 6, 2016: New England Journal of Medicine
Reza Shekarriz-Foumani, Faezeh Khodaie
CONTEXT: Breast cancer has been considered as one of the most common types of cancer among the women worldwide, and patients with breast neoplasms have been reported with high prevalence of low serum 25-hydroxyvitamin D levels. OBJECTIVES: Our aim was to evaluate the correlation of plasma 25-hydroxyvitamin D deficiency with breast neoplasms risk among women. DATA SOURCES: PubMed database was searched with MeSH (medical subject headings) keywords "vitamin D AND breast neoplasms" which was restricted by original articles written only in English and published from January 1, 2014...
June 2016: Iranian Journal of Cancer Prevention
Alex Dayton, Eric C Exner, John D Bukowy, Timothy J Stodola, Theresa Kurth, Meredith Skelton, Andrew S Greene, Allen W Cowley
Despite the striking differences between male and female physiology, female physiology is understudied. In response, the National Institutes of Health is promulgating new policies to increase the use of female organisms in preclinical research. Females are commonly believed to have greater variability than males because of the estrous cycle, but recent studies call this belief into question. Effects of estrous cycling on mean arterial pressure were assessed in female Dahl S rats using telemetry and vaginal cytometry and found that estrous cycling did not affect mean arterial pressure magnitude or variance...
November 2016: Hypertension
Leah Kern, Janet Crow, Christine B Williams, Eyla Boies, Sheila Gahagan, Kyung E Rhee
In 2011, the National Heart Lung and Blood Institute recommended universal lipid screening (ULS) in 9- to 11-year-old children. This study aimed to determine whether a quality improvement (QI) initiative increased ULS. Data were abstracted from the electronic medical record to compare screening behaviors 1 year preimplementation and postimplementation. A focus group was conducted to examine physicians' attitudes. In preimplementation and postimplementation years, the number of 9- to 11-year-olds seen for well-child checks were 356 and 357, respectively...
September 23, 2016: Clinical Pediatrics
Neil D Patel, Andrew Newburn, Michael E Brier, Deepa H Chand
The National Heart, Lung, and Blood Institute recommends that children older than 3 years seen in the medical setting have their blood pressure (BP) measured. The authors aimed to determine whether BPs are measured at well-child visits and whether elevated readings are recognized. A retrospective chart review of 3- to 18-year-old children seen for well-child visits was performed. Age, sex, weight, height, BP, extremity measured, and type of intervention were collected. BP was measured in 777 of 805 patients (97%)...
September 23, 2016: Journal of Clinical Hypertension
Guido Grassi
The Systolic Blood Pressure Intervention Trial (SPRINT), sponsored by the National Heart, Lung and Blood Institute in the USA, allocated 9361 hypertensive patients (mean age 68 years) to two systolic blood pressure treatment targets (either < 120mmHg or < 140mmHg). Although SPRINT intended to enrol hypertensive patients at high cardiovascular risk, it specifically excluded patients with diabetes mellitus or prior stroke. SPRINT was stopped earlier than planned, after a mean follow-up of 3.26 years, on the recommendation of its data and safety monitoring board, and data were published on 9 November 2015...
September 2016: Journal of Hypertension
Joanne Kotsopoulos, Victoria Sopik, Barry Rosen, Isabel Fan, John R McLaughlin, Harvey Risch, Ping Sun, Steven A Narod, Mohammad R Akbari
Recent studies suggest that mutations in the partner and localizer of BRCA2 (PALB2) gene may predispose to ovarian cancer. It is of importance to clarify the prevalence and penetrance of PALB2 mutations in an unselected population so that clinical recommendations for prevention can be implemented. We evaluated the prevalence of germline mutations in PALB2 among 1421 epithelial ovarian cancer patients and 4300 European controls from the National Heart, Lung, and Blood Institute's Exome Sequencing Project dataset...
September 8, 2016: Familial Cancer
Mary Emma Gorham Bigelow, Brian G Jamieson, Chi On Chui, Yufei Mao, Kyeong-Sik Shin, Tony Jun Huang, Po-Hsun Huang, Liqiang Ren, Bishow Adhikari, Jue Chen, Erin Iturriaga
The commercialization of new point of care technologies holds great potential in facilitating and advancing precision medicine in heart, lung, blood, and sleep (HLBS) disorders. The delivery of individually tailored health care to a patient depends on how well that patient's health condition can be interrogated and monitored. Point of care technologies may enable access to rapid and cost-effective interrogation of a patient's health condition in near real time. Currently, physiological data are largely limited to single-time-point collection at the hospital or clinic, whereas critical information on some conditions must be collected in the home, when symptoms occur, or at regular intervals over time...
2016: IEEE Journal of Translational Engineering in Health and Medicine
May Bakir, Michael D Nelson, Erika Jones, Quanlin Li, Janet Wei, Behzad Sharif, Margo Minissian, Chrisandra Shufelt, George Sopko, Carl J Pepine, C Noel Bairey Merz
BACKGROUND: Women with signs and symptoms of ischemia, no obstructive coronary artery disease, and preserved left ventricular ejection fraction enrolled in the National Heart Lung and Blood Institute (NHLBI) sponsored Women's Ischemia Syndrome Evaluation (WISE) study have an unexpectedly high rate of subsequent heart failure (HF) hospitalization. We sought to verify and characterize the HF hospitalizations. METHODS: A retrospective chart review was performed on 223 women with signs and symptoms of ischemia, undergoing coronary angiography for suspected coronary artery disease followed for 6±2...
November 15, 2016: International Journal of Cardiology
William Virgil Brown, Abhimanyu Garg, Phillip Gorden, Robert Shamburek
Lipodystrophy comes in several forms, some involving the complete failure to develop adipose tissue and others with a partial absence in various bodily distributions. All appear to have a major genetic basis, and all involve a high frequency of lipoprotein disorders. High triglycerides and low high-density lipoprotein cholesterol are the usual findings that raise interesting questions as to how such abnormalities characteristic of obesity can be caused by genetic variants that produce a paucity of adiposity...
July 2016: Journal of Clinical Lipidology
Agathi Ntzouvani, Elisabeth Fragopoulou, Demosthenes Panagiotakos, Christos Pitsavos, Smaragdi Antonopoulou
BACKGROUND: Given the increasing rate of overweight and the burden of metabolic syndrome (MetS) on cardiovascular disease development, better understanding of the syndrome is of great importance. Therefore, the objectives were to examine whether interleukin-6 (IL-6) and adiponectin are associated with MetS, and whether this association is mediated by components of the MetS. METHODS: During 2011-2012, 284 individuals (159 men, 53 ± 9 years, 125 women 52 ± 9 years) without cardiovascular disease, type 1 diabetes mellitus, high-grade inflammatory disease, living in the greater Athens area, Greece, participated in clinical examination...
August 27, 2016: Lipids in Health and Disease
Marine Azevedo Da Silva, Beverley Balkau, Ronan Roussel, Jean Tichet, Frédéric Fumeron, Guy Fagherazzi, Hermann Nabi
OBJECTIVE: To examine longitudinal associations between antidepressant medication use and the metabolic syndrome (MetS). METHODS: 5014 participants (49.8% were men) from the D.E.S.I.R. cohort study, aged 30-65 years at baseline in 1994-1996, were followed over 9 years at 3-yearly intervals (1997-1999, 2000-2002, and 2003-2005). Antidepressant use and MetS, defined by the National Cholesterol Education Program Adult Treatment Panel III criteria (NCEP-ATP III) and the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) criteria, were assessed concurrently at four medical examinations...
August 21, 2016: Psychoneuroendocrinology
David Jernigan, Jonathan Noel, Jane Landon, Nicole Thornton, Tim Lobstein
BACKGROUND AND AIMS: Youth alcohol consumption is a major global public health concern. Previous reviews have concluded that exposure to alcohol marketing was associated with earlier drinking initiation and higher alcohol consumption among youth. This review examined longitudinal studies published since those earlier reviews. METHODS: Peer-reviewed articles were identified in medical, scientific and social science databases, supplemented by examination of reference lists...
August 26, 2016: Addiction
Loren C Denlinger, Brenda R Phillips, Sima Ramratnam, Kristie Ross, Nirav R Bhakta, Juan Carlos Cardet, Mario Castro, Stephen P Peters, Wanda Phipatanakul, Shean Aujla, Leonard B Bacharier, Eugene R Bleecker, Suzy A A Comhair, Andrea Coverstone, Mark DeBoer, Serpil C Erzurum, Sean B Fain, Merritt Fajt, Anne M Fitzpatrick, Jonathan Gaffin, Benjamin Gaston, Annette T Hastie, Gregory A Hawkins, Fernando Holguin, Anne-Marie Irani, Elliot Israel, Bruce D Levy, Ngoc Ly, Deborah A Meyers, Wendy C Moore, Ross Myers, Maria Theresa D Opina, Michael C Peters, Mark L Schiebler, Ronald L Sorkness, W Gerald Teague, Sally E Wenzel, Prescott G Woodruff, David T Mauger, John V Fahy, Nizar N Jarjour
RATIONALE: Reducing asthma exacerbation frequency is an important criterion for approval of asthma therapies, but the clinical features of exacerbation prone asthma (EPA) remain incompletely defined. OBJECTIVE: Describe the clinical, physiological, inflammatory and co-morbidity factors associated with EPA. METHODS: Baseline data from the NHLBI Severe Asthma Research Program-3 were analyzed. An exacerbation was defined as a burst of systemic corticosteroids lasting ≥3 days...
August 24, 2016: American Journal of Respiratory and Critical Care Medicine
Dae Hyun Kim, Caroline A Kim, Sebastian Placide, Lewis A Lipsitz, Edward R Marcantonio
Background: Frailty assessment may inform surgical risk and prognosis not captured by conventional surgical risk scores. Purpose: To evaluate the evidence for various frailty instruments used to predict mortality, functional status, or major adverse cardiovascular and cerebrovascular events (MACCEs) in older adults undergoing cardiac surgical procedures. Data Sources: MEDLINE and EMBASE (without language restrictions), from their inception to 2 May 2016...
August 23, 2016: Annals of Internal Medicine
Farnaz Vahidnia, Susan L Stramer, Debra Kessler, Beth Shaz, German Leparc, David E Krysztof, Simone A Glynn, Brian Custer
PURPOSE: Blood donors are considered to be one of the healthiest populations, but relatively little is known about their perceived quality of life. The objective was to examine HRQOL in donors infected with HIV, HBV, HCV or HTLV and a comparison group. METHODS: Donors with confirmed viral infection (cases) and donors who tested false-positive (controls) participated in a multicenter study of US blood donors (2010-2013), funded by the National Heart, Lung and Blood Institute (NHLBI)...
August 17, 2016: Quality of Life Research
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