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https://www.readbyqxmd.com/read/28741852/polymorphisms-of-mir-146a-mir-149-mir-196a2-and-mir-499-are-associated-with-osteoporotic-vertebral-compression-fractures-in-korean-postmenopausal-women
#1
Tae-Keun Ahn, Jung-Oh Kim, Hemant Kumar, Hyemi Choi, Min-Jae Jo, Seil Sohn, Alexander E Ropper, Nam-Keun Kim, In-Bo Han
Genetic factors have been shown to be a small but significant predictor for osteoporosis and osteoporotic fracture risk. We performed a case-control association study to determine the association between miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms and osteoporotic vertebral compression fracture (OVCF) susceptibility. In total, 286 unrelated postmenopausal Korean women (57 with OVCFs, 55 with non-OVCFs, and 174 healthy controls) were recruited. All subjects underwent dual energy X-ray absorptiometry to determine BMD at the lumbar spine and femoral neck...
July 25, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28741360/influence-of-chemical-mechanical-and-transport-processes-on-wellbore-leakage-from-geologic-co2-storage-reservoirs
#2
Susan A Carroll, Jaisree Iyer, Stuart D C Walsh
Wells are considered to be high-risk pathways for fluid leakage from geologic CO2 storage reservoirs, because breaches in this engineered system have the potential to connect the reservoir to groundwater resources and the atmosphere. Given these concerns, a few studies have assessed leakage risk by evaluating regulatory records, often self-reported, documenting leakage in gas fields. Leakage is thought to be governed largely by initial well-construction quality and the method of well abandonment. The geologic carbon storage community has raised further concerns because acidic fluids in the CO2 storage reservoir, alkaline cement meant to isolate the reservoir fluids from the overlying strata, and steel casings in wells are inherently reactive systems...
July 25, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28740971/monolithic-lithium-disilicate-complete-single-crowns-with-feather-edge-preparation-design-in-the-posterior-region-a-multicentric-retrospective-study-up-to-12-years
#3
Johannes H Schmitz, Davide Cortellini, Stefano Granata, Marco Valenti
OBJECTIVE: This retrospective study evaluated the clinical success and survival of monolithic lithium disilicate single crowns in the posterior region fabricated with feather-edge margins and cemented with resin-based self-etching cement. METHOD AND MATERIALS: In total, 627 pressed monolithic lithium disilicate restorations on posterior teeth (110 first premolars, 151 second premolars, 240 first molars, 121 second molars, 5 third molars) were placed in 335 patients...
July 20, 2017: Quintessence International
https://www.readbyqxmd.com/read/28740525/the-use-of-cholecalciferol-in-patients-with-hip-fracture
#4
Luisella Cianferotti, Simone Parri, Giorgio Gronchi, Roberto Civinini, Maria Luisa Brandi
INTRODUCTION: Major osteoporotic fractures are steadily increasing due to population aging. Programs of secondary prevention against refracture are essential to decrease morbidity and mortality and the cost for individuals and the society. Vitamin D supplementation and optimization of calcium intake are of a pivotal importance to start specific osteoporosis treatment and for its safety and efficacy. Cholecalciferol is the most widely employed drug for vitamin D supplementation. PURPOSE: Aim of this study was to assess the trends in the use of vitamin D supplements containing cholecalciferol in the population of hip fracture patients older than 65 years, resident in the region of Tuscany (Italy) in the years 2011-2015 and to describe vitamin D status in a subgroup of this individuals directly referred to a bone clinic for further evaluation after hip osteoporotic fracture...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740519/low-dose-diclofenac-in-patients-with-fragility-fractures
#5
Letizia Vannucci, Caterina Fossi, Giorgio Gronchi, Maria Luisa Brandi
Most osteoporotic patients complain of back pain one year after a fragility vertebral fracture and the frequency of chronic back pain increases with increasing age. The use of the lowest effective dose of an analgesic which is able to control symptoms seems to be a possible solution in order to limit potential side effects in multi-treated elderly patients. Non-steroidal anti-inflammatory drugs (NSAIDs) have a proven efficacy in the treatment of back pain associated with fragility vertebral fractures and diclofenac is available at low-dose subcutaneous injective formulation...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740372/pharmacological-treatment-of-osteoporosis-in-the-oldest-old
#6
REVIEW
A Vandenbroucke, F P Luyten, J Flamaing, E Gielen
The incidence of osteoporotic fractures increases with age. Consequently, the global prevalence of osteoporotic fractures will increase with the aging of the population. In old age, osteoporosis is associated with a substantial burden in terms of morbidity and mortality. Nevertheless, osteoporosis in old age continues to be underdiagnosed and undertreated. This may, at least partly, be explained by the fact that evidence of the antifracture efficacy of osteoporosis treatments comes mainly from randomized controlled trials in postmenopausal women with a mean age of 70-75 years...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28739416/comparison-of-non-invasive-assessments-of-strength-of-the-proximal-femur
#7
Fjola Johannesdottir, Erica Thrall, John Muller, Tony M Keaveny, David L Kopperdahl, Mary L Bouxsein
It is not clear which non-invasive method is most effective for predicting strength of the proximal femur in those at highest risk of fracture. The primary aim of this study was to compare the abilities of dual energy X-ray absorptiometry (DXA)-derived aBMD, quantitative computed tomography (QCT)-derived density and volume measures, and finite element analysis (FEA)-estimated strength to predict femoral failure load. We also evaluated the contribution of cortical and trabecular bone measurements to proximal femur strength...
July 21, 2017: Bone
https://www.readbyqxmd.com/read/28739300/the-critical-shoulder-angle-is-associated-with-osteoarthritis-in-the-shoulder-but-not-rotator-cuff-tears-a-retrospective-case-control-study
#8
Arnar O Bjarnison, Thomas J Sørensen, Thomas Kallemose, Kristoffer W Barfod
BACKGROUND: In 2013 Moor et al introduced the concept of the critical shoulder angle (CSA) and suggested that an abnormal CSA was a leading factor in development of rotator cuff tear (RCT) and osteoarthritis (OA) of the shoulder. This study assessed whether the CSA was associated with RCT and OA and tested the inter- and intrarater reliability of the CSA when measuring RCT and OA. MATERIALS AND METHODS: The study was performed as a retrospective case-control study...
July 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28739219/systematic-review-of-hardware-related-complications-of-deep-brain-stimulation-do-new-indications-pose-an-increased-risk
#9
Onanong Jitkritsadakul, Roongroj Bhidayasiri, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, Alfonso Fasano
INTRODUCTION: Deep Brain Stimulation (DBS) is an effective treatment extended broadly to many neurological and psychiatric disorders. Nevertheless, complications may arise during DBS procedures or following implantation due to implanted hardware. This may result in both minor and major adverse events that may necessitate hardware removal and/or compromise maximal therapeutic benefit for the patient. OBJECTIVES AND METHODS: To identify relevant literature on hardware-related complications from DBS procedures by performing a systematic review, and propose how to identify at-risk group and possible preventive approaches...
July 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28739083/assessment-of-osteoporosis-fracture-risk-preface
#10
EDITORIAL
Sanford Baim
No abstract text is available yet for this article.
July 21, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28739082/osteoporosis-risk-calculators
#11
Beatrice J Edwards
Osteoporosis is a silent disease until fractures occur, patient recognition is the greatest clinical challenge. Although more than 20 million women in the US are estimated to have established osteoporosis the majority are not appropriately identified. Bone densitometry is the current gold standard for diagnosis of osteoporosis; but may not be feasible or cost-effective to recommend for all postmenopausal women. Therefore, questionnaires incorporating risk factors have been developed to aid the clinician in identifying women with osteoporosis...
July 21, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28739081/quantitative-ultrasound-qus-in-the-management-of-osteoporosis-and-assessment-of-fracture-risk
#12
Didier Hans, Sanford Baim
The use of quantitative ultrasound (QUS) for a variety of skeletal sites, associated with the absence of technology-specific guidelines, has created uncertainty with respect to the application of QUS results to the management of individual patients in clinical practice. However, when prospectively validated (this is not the case for all QUS devices and skeletal sites), QUS is a proven, low-cost, and readily accessible alternative to dual-energy X-ray absorptiometry (DXA) measurements of bone mineral density (BMD) for the assessment of fracture risk...
July 21, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28738168/role-of-age-and-injury-mechanism-in-cervical-spine-injury-tolerance-under-head-contact-loading
#13
Narayan Yoganandan, Sajal Chirvi, Liming Voo, Frank A Pintar, Anjishnu Banerjee
OBJECTIVE: To determine the influence of age on cervical spine tolerance to injury from head contact loading using survival analysis. METHODS: This study analyzed data from previously conducted experiments using Post Mortem Human Subject specimens (PMHS). Group A tests used the upright intact head-cervical column experimental model. The inferior end of the specimen was fixed, head was balanced by a mechanical system, and natural lordosis was removed. Specimens were placed on a testing device via a load cell...
July 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28738139/association-of-history-of-dizziness-and-long-term-adverse-outcomes-with-early-vs-later-orthostatic-hypotension-assessment-times-in-middle-aged-adults
#14
Stephen P Juraschek, Natalie Daya, Andreea M Rawlings, Lawrence J Appel, Edgar R Miller, B Gwen Windham, Michael E Griswold, Gerardo Heiss, Elizabeth Selvin
Importance: Guidelines recommend assessing orthostatic hypotension (OH) 3 minutes after rising from supine to standing positions. It is not known whether measurements performed immediately after standing predict adverse events as strongly as measurements performed closer to 3 minutes. Objective: To compare early vs later OH measurements and their association with history of dizziness and longitudinal adverse outcomes. Design, Setting, and Participants: This was a prospective cohort study of middle-aged (range, 44-66 years) participants in the Atherosclerosis Risk in Communities Study (1987-1989)...
July 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28737666/the-role-of-aopp-in-age-related-bone-loss-and-the-potential-benefits-of-berry-anthocyanins
#15
REVIEW
Melissa M Melough, Xin Sun, Ock K Chun
Age-related bone loss is a major factor in osteoporosis and osteoporotic fractures among the elderly. Because bone homeostasis involves a balance between bone formation and resorption, multiple mechanisms may induce age-dependent changes in bone. Oxidative stress is one such factor that contributes to the pathology of aging-associated osteoporosis (AAO). Advanced oxidation protein products (AOPP) are a biomarker of oxidant-mediated protein damage, and can also act to increase the production of reactive oxygen species (ROS), thereby perpetuating oxidative damage...
July 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28737638/a-bone-health-intervention-for-chinese-immigrants-in-santa-clara-county
#16
Joanne Zou, Michelle DeCoux Hampton, Kate Shade, Leonard Kaku
BACKGROUND: Among Chinese immigrants, osteoporosis is undertreated, misdiagnosed, and a leading cause of fragility fractures. In orthopaedic surgery departments, prevention education and health behavior change programs are necessary to improve their bone health. PURPOSE: The purpose of this study was to examine the effectiveness of an osteoporosis prevention education program on participants' self-efficacy with regard to exercise and nutrition when provided by an orthopaedic surgery team during an annual Chinese Health Fair in Santa Clara County, CA...
July 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28737593/a-teachable-moment-after-orthopaedic-fracture-in-the-smoking-patient-a-randomized-controlled-trial
#17
Matthew D Baron, Christopher J DeFrancesco, Tiffany C Liu, Frank T Leone, Jaimo Ahn
OBJECTIVES: To assess whether education during hospitalization after an acute fracture changes patient attitudes toward smoking-related complications and to assess whether this change persists into the first outpatient follow-up visit. DESIGN: Prospective, randomized, controlled trial. SETTING: Level 1 trauma center. PATIENTS: Inpatients with fractures who identified as smokers: 40 assessed for inclusion and randomized, 30 completed inpatient assessments, and 20 completed outpatient follow-up...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28736795/identifying-characteristics-and-outcomes-that-are-associated-with-fall-related-fatalities-multi-year-retrospective-summary-of-fall-deaths-in-older-adults-from-2005-2012
#18
Sara M Deprey, Lynda Biedrzycki, Kristine Klenz
BACKGROUND: Fall-related deaths continue to be the leading cause of accidental deaths in the older adult (65+ year) population. However, many fall-related fatalities are unspecified and little is known about the fall characteristics and personal demographics at the time of the fall. Therefore, this report describes the characteristics, circumstances and injuries of falls that resulted in older adult deaths in one U.S. County and explores the variables associated with fatal injuries from falls...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28736374/-low-cement-distribution-index-is-a-risk-factor-for-refracture-of-the-adjacent-segments-after-percutaneous-vertebroplasty
#19
Zhao-Zong Fu, Zhong-Xian Chen, Ying Qin, Zhi-Qiang Feng, Xiong-Jian Jiang, Qing-Hua Xie, Yi-Tao Liu
OBJECTIVE: To investigate the impact of cement distribution index on the occurrence of refracture in the adjacent segments after percutaneous vertebroplasty. METHODS: This retrospective analysis was conducted among 143 patients who received percutaneous vertebroplasty for osteoporotic vertebral compression fracture between April, 2011 and April, 2014. Of the 134 patients with complete follow-up data, 18 had adjacent segment fracture within 1 year following the surgeries (re-fracture group), and 116 patients without new fracture served as the control group...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736122/treatment-of-tibial-nonunion-with-posterolateral-bone-grafting
#20
Michael J Foster, Robert V O'Toole, Theodore T Manson
OBJECTIVES: Posterolateral bone grafting to treat nonunions of the distal two-thirds of the tibia avoids the often traumatized and more tenuous anterior soft-tissue envelope. Few modern reports of its effectiveness are available. We assessed whether posterolateral bone grafting leads to high union and low complication rates. METHODS: We conducted a retrospective review at a Level I trauma center. Our study group was 59 patients with distal two-thirds tibial fractures treated with posterolateral bone grafting...
May 3, 2017: Injury
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