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Weichao Xu, Zhaoguo Chen, Yun Zhang, Lianglun Cheng
In this paper, we propose a novel concordance coefficient, called order statistics concordance coefficients (OSCOC), to quantify the association among multi-channel biosignals. To uncover its properties, we compare OSCOC with other three similar indices, i.e., average Pearson's product moment correlation coefficient (APPMCC), Kendall's concordance coefficients (KCC), and average Kendall's tau (AKT), under a multivariate normal model (MNM), linear model (LM) and nonlinear model (NM). To further demonstrate its usefulness, we present an example on atrial arrhythmia analysis based on real world multi-channel cardiac signals...
October 11, 2016: IEEE Journal of Biomedical and Health Informatics
Shahzad Afzal, Xie Quan, Shuo Chen, Jing Wang, Dost Muhammad
Manganese incorporated fibrous silica nanosphere (MnOx-0.013/KCC-1) was synthesized by one step hydrothermal method for the first time and its catalytic activity for ozonation of oxalic acid was studied. For comparison, manganese loaded MCM-41 (MnOx-0.013/MCM-41) was prepared by impregnation method. Various characterizations showed that the morphological, structural and textural properties of MnOx-0.013/KCC-1 were well preserved. Ozonation and catalytic ozonation by MnOx-0.013/KCC-1 and MnOx-0.013/MCM-41 led to 4, 85 and 60% reduction in TOC respectively...
November 15, 2016: Journal of Hazardous Materials
Kazuaki Imai, Hisamori Kato, Kayoko Katayama, Kazuho Nakanishi, Aiko Kawano, Ayaka Iura, Katsuyuki Konnai, Ryo Onose, Fumiki Hirahara, Etsuko Miyagi
OBJECTIVE: This study aimed to validate the preoperative scoring system adopted in the Kanagawa Cancer Center (KCC) to stratify endometrial cancer patients for lymphadenectomy according to the risk of developing lymph node metastasis (LNM). METHODS: The records of 432 and 221 uterine cancer patients treated in the KCC and Yokohama City University (YCU), respectively, were retrospectively analyzed. The KCC classified patients for LNM risk based on tumor volume, myometrial invasion, histological grade, and serum CA125 levels, while YCU used only myometrial invasion...
August 2016: Gynecologic Oncology
Sergey A Menzikov
This study describes the isolation and purification of a protein complex with Cl(-)/HCO3(-)-ATPase activity and sensitivity to GABAAergic ligands from rat brain plasma membranes. The ATPase complex was enriched using size-exclusion, affinity, and ion-exchange chromatography. The fractions obtained at each purification step were subjected to denaturing gel electrophoresis (SDS-PAGE), which revealed four subunits with molecular mass ∼48, 52, 56 and 59 kDa; these were retained at all stages of the purification process...
May 18, 2016: Preparative Biochemistry & Biotechnology
E Febriyanti, V Suendo, R R Mukti, A Prasetyo, A F Arifin, M A Akbar, S Triwahyono, I N Marsih, Ismunandar
The unique three-dimensional pore structure of KCC-1 has attracted significant attention and has proven to be different compared to other conventional mesoporous silica such as the MCM-41 family, SBA-15, or even MSN nanoparticles. In this research, we carefully examine the morphology of KCC-1 to define more appropriate nomenclature. We also propose a formation mechanism of KCC-1 based on our experimental evidence. Herein, the KCC-1 morphology was interpreted mainly on the basis of compiling all observation and information taken from SEM and TEM images...
June 14, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Nisha Bayal, Baljeet Singh, Rustam Singh, Vivek Polshettiwar
We report a facile protocol for the synthesis of fibrous nano-silica (KCC-1) with controllable size and fiber density. In this work, we have shown that the particle size, fiber density, surface area and pore volume of KCC-1 can be effectively controlled and tuned by changing various reaction parameters, such as the concentrations of urea, CTAB, 1-pentanol, reaction time, temperature, solvent ratio, and even outside stirring time. For the first time, we were able to control the particle size ranging from as small as 170 nm to as large as 1120 nm...
2016: Scientific Reports
Aakanksha Singhvi, Bingqian Liu, Christine J Friedman, Jennifer Fong, Yun Lu, Xin-Yun Huang, Shai Shaham
Neurons receive input from the outside world or from other neurons through neuronal receptive endings (NREs). Glia envelop NREs to create specialized microenvironments; however, glial functions at these sites are poorly understood. Here, we report a molecular mechanism by which glia control NRE shape and associated animal behavior. The C. elegans AMsh glial cell ensheathes the NREs of 12 neurons, including the thermosensory neuron AFD. KCC-3, a K/Cl transporter, localizes specifically to a glial microdomain surrounding AFD receptive ending microvilli, where it regulates K(+) and Cl(-) levels...
May 5, 2016: Cell
Shuaishuai Xu, Ruozhen Gong
STUDY DESIGN: Retrospective study. OBJECTIVE: To investigate whether clivodens angle (CDA) could diagnose basilar invagination (BI) at computed tomography (CT). SUMMARY OF BACKGROUND DATA: Over the years, multiple craniometric methods such as Chamberlain line, McGregor line, McRae line, Wackenheim clivus baseline, and Welcher basal angle have been described for evaluation of craniovertebral junction anomalies, initially with radiography and later with CT...
September 2016: Spine
A Hannemann, D C Rees, S Tewari, J S Gibson
Sickle cell disease (SCD) in patients of HbSC genotype is considered similar, albeit milder, to that in homozygous HbSS individuals--but with little justification. In SCD, elevated red cell cation permeability is critical as increased solute loss causes dehydration and encourages sickling. Recently, we showed that the KCl cotransporter (KCC) activity in red cells from HbSC patients correlated significantly with disease severity, but that in HbSS patients did not. Two transporters involved in red cell dehydration, the conductive channels Psickle and the Gardos channel, behaved similarly in red cells from the two genotypes, but were significantly less active in HbSC patients...
November 2015: EBioMedicine
Daisuke Sano, Mariko Kawakami, Kyoko Fujita, Machiko Kimura, Yukiko Yamashita, Yukari Ishiguro, Goshi Nishimura, Hideki Matsuda, Mamoru Tsukuda
No abstract text is available yet for this article.
April 2016: Oncology Reports
Daisuke Sano, Hideki Matsuda, Yukari Ishiguro, Goshi Nishimura, Mariko Kawakami, Mamoru Tsukuda
No abstract text is available yet for this article.
April 2016: Oncology Reports
Tahani M Ahmad, Mary-Louise Greer, Thomas D Walters, Oscar M Navarro
OBJECTIVE: The objective of this study was to assess the diagnostic agreement between bowel sonography and MR enterography in children with suspected or confirmed inflammatory bowel disease (IBD). SUBJECTS AND METHODS: We prospectively studied 33 children undergoing clinically indicated MR enterography. Bowel sonography was performed within 2 hours before MR enterography. The reliability of each modality was assessed by computing the interreader kappa agreement on nine inflammatory markers in eight bowel segments and the interreader intraclass correlation coefficients (ICC) in each bowel segment...
January 2016: AJR. American Journal of Roentgenology
Yohei Miyagi
Kanagawa Prefecture and its department of hospital business established the Kanagawa Cancer Research and Information Association (KCRIA) in 2006, and the Kanagawa Cancer Center (KCC) and related institutes have started to collect and distribute patient-derived cancer-related biomaterials to researchers. The tumor tissue center of KCC is collecting frozen tumor tissues, formalin-fixed and paraffin-embedded (FFPE) tumor tissues, serum of patients before treatment, and genomic DNA of peripheral white blood cells...
January 2015: Rinsho Byori. the Japanese Journal of Clinical Pathology
A Yoshida, S Nakano, T Suzuki, K Ihara, T Higashiyama, I Mori
K(+) /Cl(-) cotransporters (KCCs) are known to be crucial in the control of neuronal electrochemical Cl(-) gradient. However, the role of these proteins in glial cells remains largely unexplored despite a number of studies showing expression of KCC proteins in glial cells of many species. Here, we show that the Caenorhabditis elegans K(+) /Cl(-) cotransporter KCC-3 is expressed in glial-like cells and regulates the thermosensory behavior through modifying temperature-evoked activity of a thermosensory neuron...
April 2016: Genes, Brain, and Behavior
Fiona C Brown, Ashlee J Conway, Loretta Cerruti, Janelle E Collinge, Catriona McLean, James S Wiley, Ben T Kile, Stephen M Jane, David J Curtis
We used an N-ethyl-N-nitrosurea-based forward genetic screen in mice to identify new genes and alleles that regulate erythropoiesis. Here, we describe a mouse line expressing an activated form of the K-Cl cotransporter Slc12a4 (Kcc1), which results in a semi-dominant microcytosis of red cells. A missense mutation from methionine to lysine in the cytoplasmic tail of Kcc1 impairs phosphorylation of adjacent threonines required for inhibiting cotransporter activity. We bred Kcc1(M935K) mutant mice with a humanized mouse model of sickle cell disease to directly explore the relevance of the reported increase in KCC activity in disease pathogenesis...
December 24, 2015: Blood
Amteshwar Singh Jaggi, Aalamjeet Kaur, Anjana Bali, Nirmal Singh
Sodium potassium chloride co-transporter (NKCC) belongs to cation-dependent chloride co-transporter family, whose activation allows the entry of Na(+), K(+) and 2Cl(-) inside the cell. It acts in concert with K(+) Cl(-) co-transporter (KCC), which extrudes K(+) and Cl(-) ions from cell. NKCC1 is widely distributed throughout the body, while NKCC2 is exclusively present in kidney. Protein kinase A, protein kinase C, Ste20-related proline-alanine-rich kinase, oxidative stress responsive kinases, With No K=lysine kinase and protein phosphatase type 1 control the phosphorylation/dephosphorylation of key threonine residues of in regulatory domain of NKCC1...
2015: Current Neuropharmacology
Jennifer Ornelas, Lorraine Rosamilia, Larissa Larsen, Negar Foolad, Quinlu Wang, Chin-Shang Li, Raja K Sivamani
IMPORTANCE: Isotretinoin remains an effective treatment for severe acne. Despite its effectiveness, it includes many side effects, of which cheilitis is the most common. OBJECTIVE: To develop an objective grading scale for assessment of isotretinoin-associated cheilitis. DESIGN: Cross-sectional clinical grading study. SETTING: UC Davis Dermatology clinic. PARTICIPANTS: Subjects were older than 18 years old and actively treated with oral isotretinoin...
2016: Journal of Dermatological Treatment
Soundharrajan Ilavenil, Hyung Soo Park, Mayakrishnan Vijayakumar, Mariadhas Valan Arasu, Da Hye Kim, Sivanesan Ravikumar, Ki Choon Choi
The aim of the study was to isolate and characterize the lactic acid bacteria (LAB) from animal manure. Among the thirty LAB strains, four strains, namely, KCC-25, KCC-26, KCC-27, and KCC-28, showed good cell growth and antifungal activity and were selected for further characterization. Biochemical and physiology properties of strains confirmed that the strains are related to the Lactobacillus sp.; further, the 16S rRNA sequencing confirmed 99.99% sequence similarity towards Lactobacillus plantarum. The strains exhibited susceptibility against commonly used antibiotics with negative hemolytic property...
2015: TheScientificWorldJournal
Hui Juan Chen, Rongfeng Qi, Xiang Kong, Jiqiu Wen, Xue Liang, Zhe Zhang, Xue Li, Guang Ming Lu, Long Jiang Zhang
To investigate the effect of hemodialysis (HD) on cognitive dysfunction in patients with end-stage renal disease (ESRD) using resting-state functional MR imaging (rs-fMRI) with regional homogeneity (ReHo) and functional connectivity algorithms. The rs-fMRI data were acquired in 58 ESRD patients (HD patients, n = 32, 22 male and 10 female, mean age 36.5 ± 9.6 years; non-HD ESRD patients, n = 26, 16 male and 10 female, mean years of 35.6 ± 8.2) and 32 healthy controls (22 male and 10 female, mean years of 32...
October 2015: Metabolic Brain Disease
Kristopher T Kahle, Arjun R Khanna, Seth L Alper, Norma C Adragna, Peter K Lauf, Dandan Sun, Eric Delpire
K(+)-Cl(-) cotransporters (KCCs) were originally characterized as regulators of red blood cell (RBC) volume. Since then, four distinct KCCs have been cloned, and their importance for volume regulation has been demonstrated in other cell types. Genetic models of certain KCCs, such as KCC3, and their inhibitory WNK-STE20/SPS1-related proline/alanine-rich kinase (SPAK) serine-threonine kinases, have demonstrated the evolutionary necessity of these molecules for nervous system cell volume regulation, structure, and function, and their involvement in neurological disease...
August 2015: Trends in Molecular Medicine
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