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https://www.readbyqxmd.com/read/28699687/the-super-sickling-haemoglobin-hbs-oman-a-study-of-red-cell-sickling-k-permeability-and-associations-with-disease-severity-in-patients-heterozygous-for-hba-and-hbs-oman-hba-s-oman-genotype
#1
Halima W M Al Balushi, Yasser Wali, Maha Al Awadi, Taimoora Al-Subhi, David C Rees, John N Brewin, Anke Hannemann, John S Gibson
Studying different sickle cell genotypes may throw light on the pathogenesis of sickle cell disease (SCD). Here, the clinical profile, red cell sickling and K(+) permeability in 29 SCD patients (15 patients with severe disease and 14 with a milder form) of HbA/S-Oman genotype were analysed. The super sickling nature of this Hb variant was confirmed. The red cell membrane permeability to K(+) was markedly abnormal with elevated activities of Psickle , Gardos channel and KCl cotransporter (KCC). Results were consistent with Ca(2+) entry and Mg(2+) loss via Psickle stimulating Gardos channel and KCC activities...
July 12, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28662098/molecular-cloning-and-biochemical-characterization-of-two-cation-chloride-cotransporter-subfamily-members-of-hydra-vulgaris
#2
Anna-Maria Hartmann, Lucie I Pisella, Igor Medina, Hans Gerd Nothwang
Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl-). They are divided into K+-Cl- outward transporters (KCCs), the Na+-K+-Cl- (NKCCs) and Na+-Cl- (NCCs) inward transporters, the cation chloride cotransporter interacting protein CIP1, and the polyamine transporter CCC9. KCCs and N(K)CCs are established in the genome since eukaryotes and metazoans, respectively. Most of the physiological and functional data were obtained from vertebrate species...
2017: PloS One
https://www.readbyqxmd.com/read/28554384/synthesis-of-fibrous-and-non-fibrous-mesoporous-silica-magnetic-yolk-shell-microspheres-as-recyclable-supports-for-immobilization-of-candida-rugosa-lipase
#3
Zafar Ali, Lei Tian, Baoliang Zhang, Nisar Ali, Muhammad Khan, Qiuyu Zhang
The mesoporous yolk-shell nanoparticles (MYSNs), with a movable Fe3O4 core inside the hollow capsules, with two different morphologies (1) Fe3O4@SiO2@hollow@fibrous SiO2 (Yolk Shell-1) (2) Fe3O4@SiO2@hollow@mesoporousSiO2 (Yolk Shell-2) were fabricated as carriers for Candida rugosa lipase (CRL) immobilization, through a template-assistant selectively etching method. Firstly the hydrophilic Fe3O4 nanoparticles were synthesized according to the solvothermal method. Then, SiO2 shell was coated on the Fe3O4 nanoparticle surface by a sol-gel reaction...
August 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28436531/international-inter-rater-agreement-in-scoring-acne-severity-utilizing-cloud-based-image-sharing-of-mobile-phone-photographs
#4
Negar Foolad, Jennifer N Ornelas, Ashley K Clark, Ifrah Ali, Victoria R Sharon, Luluah Al Mubarak, Andrés Lopez, Ali Alikhan, Bishr Al Dabagh, Alireza Firooz, Smita Awasthi, Yu Liu, Chin-Shang Li, Raja K Sivamani
BACKGROUND: Cloud-based image sharing technology allows facilitated sharing of images. Cloud-based image sharing technology has not been well-studied for acne assessments or treatment preferences, among international evaluators. We evaluated inter-rater variability of acne grading and treatment recommendations among an international group of dermatologists that assessed photographs. METHODS: This is a prospective, single visit photographic study to assess inter-rater agreement of acne photographs shared through an integrated mobile device, cloud-based, and HIPAA-compliant platform...
April 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28363248/the-resting-state-functional-magnetic-resonance-imaging-regional-homogeneity-metrics-kendall-s-coefficient-of-concordance-regional-homogeneity-and-coherence-regional-homogeneity-are-valid-indicators-of-tumor-related-neurovascular-uncoupling
#5
Shruti Agarwal, Haris I Sair, Jay J Pillai
The aim of this study is to determine whether regional homogeneity (ReHo) of resting-state blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (rsfMRI) data based on Kendall's coefficient of concordance (KCC-ReHo) and coherence (Cohe-ReHo) metrics may allow detection of brain tumor-induced neurovascular uncoupling (NVU) in the sensorimotor network similar to findings in standard motor task-based BOLD fMRI (tbfMRI) activation. Twelve de novo brain tumor patients undergoing clinical fMRI exams (tbfMRI and rsfMRI) were included in this Institutional Review Board (IRB)-approved study...
May 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28276587/phosphoregulation-of-k-cl-cotransporters-during-cell-swelling-novel-insights
#6
Rachelle Frenette-Cotton, Andrée-Anne Marcoux, Alexandre P Garneau, Micheline Noel, Paul Isenring
The K(+) -Cl(-) cotransporters (KCCs) belong to the cation-Cl(-) cotransporter family and consist of 4 isoforms and many splice variants. Their main role is to promote electroneutral efflux of K(+) and Cl(-) ions across the surface of many cell types and, thereby, to regulate intracellular ion concentration, cell volume and epithelial salt movement. These transport systems are induced by an increase in cell volume and are less active at lower intracellular [Cl(-) ] (Cli ), but the mechanisms at play are still ill-defined...
March 9, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28251821/nanostructured-silica-titania-hybrid-using-dendritic-fibrous-nanosilica-as-a-photocatalyst
#7
Nisha Bayal, Rustam Singh, Vivek Polshettiwar
A new method has been developed to fabricate active TiO2 photocatalysts by tuning the morphology of the catalyst support. A sustainable solution-phase TiO2 deposition on dendritic fibrous nanosilica (DFNS) protocol is developed, which is better than the complex and expensive atomic layer deposition technique. In general, catalytic activity decreases with an increased TiO2 loading on conventional mesoporous silica because of the loss of the surface area caused by the blocking of pores. Notably, in the case of the dendritic fibrous nanosilica KCC-1 as a support, because of its open fibrous morphology, even at the highest TiO2 loading, a relatively large amount of surface area remained intact...
May 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28237886/ligand-peptide-grafted-pegylated-liposomes-using-her2-targeted-peptide-lipid-derivatives-for-targeted-delivery-in-breast-cancer-cells-the-effect-of-serine-glycine-repeated-peptides-as-a-spacer
#8
Tadaharu Suga, Yuki Fuchigami, Masayori Hagimori, Shigeru Kawakami
Ligand peptide-grafted PEGylated liposomes have been widely studied for targeted drug delivery systems. Because ligand peptides are commonly grafted using PEG as a spacer on the surface of PEGylated liposomes, the interaction between ligand peptides and their corresponding receptors can be interrupted by steric hindrance of the PEG layer. Therefore, we aimed to develop ligand peptide-lipid derivatives to enhance the targeting efficiency of ligand peptide-grafted PEGylated liposomes, and designed a new ligand peptide-lipid derivatives having serine-glycine repeats (SG)n as a spacer based on the peptide length calculated by PyMol (v0...
February 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28152000/bumetanide-increases-cl-dependent-short-circuit-current-in-late-distal-colon-evidence-for-the-presence-of-active-electrogenic-cl-absorption
#9
Lieqi Tang, Xiefan Fang, Steven P Winesett, Catherine Y Cheng, Henry J Binder, Scott A Rivkees, Sam X Cheng
Mammalian colonic epithelia consist of cells that are capable of both absorbing and secreting Cl-. The present studies employing Ussing chamber technique identified two opposing short-circuit current (Isc) responses to basolateral bumetanide in rat distal colon. Apart from the transepithelial Cl--secretory Isc in early distal colon that was inhibited by bumetanide, bumetanide also stimulated Isc in late distal colon that had not previously been identified. Since bumetanide inhibits basolateral Na+-K+-2Cl- cotransporter (NKCC) in crypt cells and basolateral K+-Cl- cotransporter (KCC) in surface epithelium, we proposed this stimulatory Isc could represent a KCC-mediated Cl- absorptive current...
2017: PloS One
https://www.readbyqxmd.com/read/28093242/the-zn-2-sensing-receptor-znr-gpr39-upregulates-colonocytic-cl-absorption-via-basolateral-kcc1-and-reduces-fluid-loss
#10
Laxmi Sunuwar, Hila Asraf, Mark Donowitz, Israel Sekler, Michal Hershfinkel
Administration of zinc, as a complement to oral rehydration solutions, effectively diminishes duration and severity of diarrhea, but it is not known whether it merely fulfills a nutritional deficiency, or if zinc has a direct role of regulating solute absorption. We show that Zn(2+) acts via a specific receptor, ZnR/GPR39, to reduce fluid loss. Intestinal fluid secretion triggered by cholera toxin (CTx) was lower in WT mice compared to ZnR/GPR39 KO. In the absence of dietary Zn(2+) we observed similar fluid accumulation in WT and ZnR/GPR39 KO mice, indicating that Zn(2+) and ZnR/GPR39 are both required for a beneficial effect of Zn(2+) in diarrhea...
April 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27998063/challenges-of-finding-novel-drugs-targeting-the-k-cl-cotransporter
#11
Eric Delpire, C David Weaver
Human disease-causing mutations and genetically modified mouse models have established the importance of KCC2 and KCC3 in nervous system physiology. These two proteins mediate the electroneutral cotransport of K(+) and Cl(-) ions across the neuronal membrane. Disruption of KCC2 function affects inhibitory synaptic transmission with consequences for epilepsy, pain perception, and potentially some neuropsychiatric disorders, whereas disruption of KCC3 affects both central and peripheral nervous systems, resulting in psychosis and peripheral neuropathy...
December 21, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27931026/feasibility-of-knife-coagulated-cut-in-gastric-endoscopic-submucosal-dissection-a-case-control-study
#12
Yohei Horikawa, Takashi Toyonaga, Hiroya Mizutamari, Nobuya Mimori, Yuhei Kato, Saki Fushimi, Syunji Okubo
BACKGROUND/AIMS: Intraoperative bleeding remains a challenge during endoscopic submucosal dissection (ESD). Forceps-coagulated cut (FCC) was found to be effective to reduce this bleeding. However, this involved frequent device replacement, and therefore, knife-coagulated cut (KCC) might ensure an easier and smoother procedure. We aimed to assess the effectiveness of KCC with Flushknife-BT at a super-low-output setting. METHODS: In this prospective study, we compared the hemostasis condition during ESD in 40 pairs of gastric lesions treated by FCC (Group F) or KCC (Group K)...
2016: Digestion
https://www.readbyqxmd.com/read/27859489/elevated-fabp1-serum-levels-are-associated-with-poorer-survival-in-acetaminophen-induced-acute-liver-failure
#13
Constantine J Karvellas, Jaime L Speiser, Mélanie Tremblay, William M Lee, Christopher F Rose
Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Serum liver-type fatty acid binding protein (FABP1) early (day 1) or late (day 3-5) levels are associated with 21-day mortality in the absence of liver transplant. Serum samples from 198 APAP-ALF patients (nested case-control study with 99 survivors, 99 nonsurvivors) were analyzed by enzyme-linked immunosorbent assay with clinical data from the US Acute Liver Failure Study Group registry (1998-2014)...
March 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27783284/age-specific-dynamics-of-corpus-callosum-development-in-children-and-its-peculiarities-in-infantile-cerebral-palsy
#14
E I Krasnoshchekova, P A Zykin, L A Tkachenko, T A Aleksandrov, V M Sereda, A N Yalfimov
The age dynamics of corpus callosum development was studied on magnetic resonance images of the brain in children aged 2-11 years without neurological abnormalities and with infantile cerebral palsy. The areas of the total corpus callosum and its segments are compared in the midsagittal images. Analysis is carried out with the use of an original formula: proportion of areas of the anterior (genu, CC2; and anterior part, CC3) and posterior (isthmus, CC6 and splenium, CC7) segments: kCC=(CC2+CC3)×CC6/CC7. The results characterize age-specific dynamics of the corpus callosum development and can be used for differentiation, with high confidence, of the brain of children without neurological abnormalities from the brain patients with infantile cerebral palsy...
October 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27740502/order-statistics-concordance-coefficient-with-applications-to-multi-channel-biosignal-analysis
#15
Weichao Xu, Zhaoguo Chen, Yun Zhang, Lianglun Cheng
In this paper, we propose a novel concordance coefficient, called order statistics concordance coefficients (OSCOC), to quantify the association among multi-channel biosignals. To uncover its properties, we compare OSCOC with other three similar indices, i.e., average Pearson's product moment correlation coefficient (APPMCC), Kendall's concordance coefficients (KCC), and average Kendall's tau (AKT), under a multivariate normal model (MNM), linear model (LM) and nonlinear model (NM). To further demonstrate its usefulness, we present an example on atrial arrhythmia analysis based on real world multi-channel cardiac signals...
October 11, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27434734/synthesis-of-manganese-incorporated-hierarchical-mesoporous-silica-nanosphere-with-fibrous-morphology-by-facile-one-pot-approach-for-efficient-catalytic-ozonation
#16
Shahzad Afzal, Xie Quan, Shuo Chen, Jing Wang, Dost Muhammad
Manganese incorporated fibrous silica nanosphere (MnOx-0.013/KCC-1) was synthesized by one step hydrothermal method for the first time and its catalytic activity for ozonation of oxalic acid was studied. For comparison, manganese loaded MCM-41 (MnOx-0.013/MCM-41) was prepared by impregnation method. Various characterizations showed that the morphological, structural and textural properties of MnOx-0.013/KCC-1 were well preserved. Ozonation and catalytic ozonation by MnOx-0.013/KCC-1 and MnOx-0.013/MCM-41 led to 4, 85 and 60% reduction in TOC respectively...
November 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27268220/a-preoperative-risk-scoring-system-to-predict-lymph-node-metastasis-in-endometrial-cancer-and-stratify-patients-for-lymphadenectomy
#17
Kazuaki Imai, Hisamori Kato, Kayoko Katayama, Kazuho Nakanishi, Aiko Kawano, Ayaka Iura, Katsuyuki Konnai, Ryo Onose, Fumiki Hirahara, Etsuko Miyagi
OBJECTIVE: This study aimed to validate the preoperative scoring system adopted in the Kanagawa Cancer Center (KCC) to stratify endometrial cancer patients for lymphadenectomy according to the risk of developing lymph node metastasis (LNM). METHODS: The records of 432 and 221 uterine cancer patients treated in the KCC and Yokohama City University (YCU), respectively, were retrospectively analyzed. The KCC classified patients for LNM risk based on tumor volume, myometrial invasion, histological grade, and serum CA125 levels, while YCU used only myometrial invasion...
August 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27191193/isolation-purification-and-partial-characterization-of-a-membrane-bound-cl-hco3-activated-atpase-complex-from-rat-brain-with-sensitivity-to-gabaaergic-ligands
#18
Sergey A Menzikov
This study describes the isolation and purification of a protein complex with [Formula: see text]-ATPase activity and sensitivity to GABAAergic ligands from rat brain plasma membranes. The ATPase complex was enriched using size-exclusion, affinity, and ion-exchange chromatography. The fractions obtained at each purification step were subjected to SDS-polyacrylamide gel electrophoresis (SDS-PAGE), which revealed four subunits with molecular mass ∼48, 52, 56, and 59 kDa; these were retained at all stages of the purification process...
February 7, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27120557/further-insight-into-the-definite-morphology-and-formation-mechanism-of-mesoporous-silica-kcc-1
#19
E Febriyanti, V Suendo, R R Mukti, A Prasetyo, A F Arifin, M A Akbar, S Triwahyono, I N Marsih, Ismunandar
The unique three-dimensional pore structure of KCC-1 has attracted significant attention and has proven to be different compared to other conventional mesoporous silica such as the MCM-41 family, SBA-15, or even MSN nanoparticles. In this research, we carefully examine the morphology of KCC-1 to define more appropriate nomenclature. We also propose a formation mechanism of KCC-1 based on our experimental evidence. Herein, the KCC-1 morphology was interpreted mainly on the basis of compiling all observation and information taken from SEM and TEM images...
June 14, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27118152/size-and-fiber-density-controlled-synthesis-of-fibrous-nanosilica-spheres-kcc-1
#20
Nisha Bayal, Baljeet Singh, Rustam Singh, Vivek Polshettiwar
We report a facile protocol for the synthesis of fibrous nano-silica (KCC-1) with controllable size and fiber density. In this work, we have shown that the particle size, fiber density, surface area and pore volume of KCC-1 can be effectively controlled and tuned by changing various reaction parameters, such as the concentrations of urea, CTAB, 1-pentanol, reaction time, temperature, solvent ratio, and even outside stirring time. For the first time, we were able to control the particle size ranging from as small as 170 nm to as large as 1120 nm...
April 27, 2016: Scientific Reports
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