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Calcium Sensor Receptor

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https://www.readbyqxmd.com/read/29768523/extracellular-calcium-increases-fibroblast-growth-factor-2-gene-expression-via-extracellular-signal-regulated-kinase-1-2-and-protein-kinase-a-signaling-in-mouse-dental-papilla-cells
#1
Sousuke Kanaya, Binlu Xiao, Yukihiko Sakisaka, Mizuki Suto, Kentaro Maruyama, Masahiro Saito, Eiji Nemoto
We previously reported that elevated extracellular calcium (Ca2+) levels increase bone morphogenetic protein 2 expression in human dental pulp (hDP) cells. However, it is unknown whether extracellular Ca2+ affects the expression of other growth factors such as fibroblast growth factor 2 (FGF2). The present study aimed to examine the effect of extracellular Ca2+ on FGF2 gene expression in hDP and immortalized mouse dental papilla (mDP) cells. Cells were stimulated with 10 mM CaCl2 in the presence or absence of cell signaling inhibitors...
May 14, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29752624/g%C3%AE-%C3%AE-snare-interactions-and-their-behavioral-effects
#2
Simon Alford, Heidi Hamm, Shelagh Rodriguez, Zack Zurawski
Presynaptic terminals possess interlocking molecular mechanisms that control exocytosis. An example of such complexity is the modulation of release by presynaptic G Protein Coupled Receptors (GPCRs). GPCR ubiquity at synapses-GPCRs are present at every studied presynaptic terminal-underlies their critical importance in synaptic function. GPCRs mediate presynaptic modulation by mechanisms including via classical Gα effectors, but membrane-delimited actions of Gβγ can also alter probability of release by altering presynaptic ionic conductances...
May 11, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29723786/design-synthesis-and-biological-activities-of-2-3-dihydroquinazolin-4-1h-one-derivatives-as-trpm2-inhibitors
#3
Han Zhang, Huan Liu, Xiao Luo, Yuxi Wang, Yuan Liu, Hongwei Jin, Zhenming Liu, Wei Yang, Peilin Yu, Liangren Zhang, Lihe Zhang
Transient receptor potential melastatin 2 (TRPM2), a Ca2+ -permeable cationic channel, plays critical roles in insulin release, cytokine production, body temperature regulation and cell death as a reactive oxygen species (ROS) and temperature sensor. However, few TRPM2 inhibitors have been reported, especially TRP-subtype selective inhibitors, which hampers the investigation and validation of TRPM2 as a drug target. To discover novel TRPM2 inhibitors, 3D similarity-based virtual screening method was employed, by which 2,3-dihydroquinazolin-4(1H)-one derivative H1 was identified as a TRPM2 inhibitor...
April 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29658714/activation-of-trpv3-by-wood-smoke-particles-and-roles-in-pneumotoxicity
#4
Cassandra Deering-Rice, Nam Nguyen, Zhenyu Lu, James Cox, Darien Shapiro, Erin G Romero, Virginia K Mitchell, Katherine L Burrell, John M Veranth, Christopher A Reilly
Wood/biomass smoke particulate materials (WBSPM) are pneumotoxic, but mechanisms by which these materials affect lung cells are not fully understood. We previously identified transient receptor potential (TRP) ankyrin-1 as a sensor for electrophiles in WBSPM and hypothesized that other TRP channels expressed by lung cells might also be activated by WBSPM, contributing to pneumotoxicity. Screening TRP channel activation by WBSPM using calcium flux assays revealed TRPV3 activation by materials obtained from burning multiple types of wood under fixed conditions...
April 16, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29657822/increasing-cell-device-adherence-using-cultured-insect-cells-for-receptor-based-biosensors
#5
Daigo Terutsuki, Hidefumi Mitsuno, Takeshi Sakurai, Yuki Okamoto, Agnès Tixier-Mita, Hiroshi Toshiyoshi, Yoshio Mita, Ryohei Kanzaki
Field-effect transistor (FET)-based biosensors have a wide range of applications, and a bio-FET odorant sensor, based on insect (Sf21) cells expressing insect odorant receptors (ORs) with sensitivity and selectivity, has emerged. To fully realize the practical application of bio-FET odorant sensors, knowledge of the cell-device interface for efficient signal transfer, and a reliable and low-cost measurement system using the commercial complementary metal-oxide semiconductor (CMOS) foundry process, will be indispensable...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29626166/cascades-of-homeostatic-dysregulation-promote-incubation-of-cocaine-craving
#6
Junshi Wang, Masago Ishikawa, Yue Yang, Mami Otaka, James Y Kim, George R Gardner, Michael T Stefanik, Mike Milovanovic, Yanhua H Huang, Johannes W Hell, Marina E Wolf, Oliver M Schlüter, Yan Dong
In human drug users, cue-induced drug craving progressively intensifies after drug abstinence, promoting drug relapse. This time-dependent progression of drug craving is recapitulated in rodent models, in which rats exhibit progressive intensification of cue-induced drug seeking after withdrawal from drug self-administration, a phenomenon termed incubation of drug craving. While recent results suggest that functional alterations of the nucleus accumbens (NAc) contribute to incubation of drug craving, it remains poorly understood how NAc function evolves after drug withdrawal to progressively intensify drug seeking...
April 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29590557/response-of-catecholaminergic-neurons-in-the-mouse-hindbrain-to-glucoprivic-stimuli-is-astrocyte-dependent
#7
Richard C Rogers, David H McDougal, Sue Ritter, Emily Qualls-Creekmore, Gerlinda E Hermann
Hindbrain catecholamine (CA) neurons are required for critical autonomic, endocrine, and behavioral counter-regulatory responses (CRRs) to hypoglycemia. Recent studies suggest that CRR initiation depends on hindbrain astrocyte glucose sensors (39, 64). To test the proposition that hindbrain CA responses to glucoprivation are astrocyte dependent, we utilized transgenic mice in which the calcium reporter construct (GCaMP5) was expressed selectively in tyrosine hydroxylase neurons (TH-GCaMP5). We conducted live-cell calcium imaging studies on tissue slices containing the nucleus of the solitary tract (NST) or the ventrolateral medulla (VLM); critical CRR initiation sites...
March 28, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29589513/x-ray-crystallography-of-trp-channels
#8
Appu K Singh, Luke L McGoldrick, Kei Saotome, Alexander I Sobolevsky
Transient receptor potential (TRP) ion channels are molecular sensors of a large variety of stimuli including temperature, mechanical stress, voltage, small molecules including capsaicin and menthol, and lipids such as phosphatidylinositol 4,5-bisphosphate (PIP2 ). Since the same TRP channels may respond to different physical and chemical stimuli, they can serve as signal integrators. Many TRP channels are calcium permeable and contribute to Ca2+ homeostasis and signaling. Although the TRP channel family was discovered decades ago, only recently have the structures of many of these channels been solved, largely by cryo-electron microscopy (cryo-EM)...
March 28, 2018: Channels
https://www.readbyqxmd.com/read/29584660/the-different-facets-of-extracellular-calcium-sensors-old-and-new-concepts-in-calcium-sensing-receptor-signalling-and-pharmacology
#9
REVIEW
Andrea Gerbino, Matilde Colella
The current interest of the scientific community for research in the field of calcium sensing in general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still increasing number of papers published on this topic. The extracellular calcium-sensing receptor is the best-known G-protein-coupled receptor (GPCR) able to sense external Ca2+ changes. Widely recognized as a fundamental player in systemic Ca2+ homeostasis, the CaR is ubiquitously expressed in the human body where it activates multiple signalling pathways...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29584409/the-structural-basis-of-calcium-dependent-inactivation-of-the-transient-receptor-potential-vanilloid-5-channel
#10
Fedir M Bokhovchuk, Neil Bate, Nadezhda V Kovalevskaya, Benjamin T Goult, Chris A E M Spronk, Geerten W Vuister
The Transient Receptor Potential Vanilloid Channel subfamily member 5 (TRPV5) is a highly selective calcium ion channel predominately expressed in the kidney epithelium that plays an essential role in calcium reabsorption from renal infiltrate. In order to maintain Ca2+ homeostasis, TRPV5 possesses a tightly regulated negative feedback mechanism, where the ubiquitous Ca2+-binding protein Calmodulin (CaM) directly binds to the intracellular TRPV5 C-terminus, thus regulating TRPV5. Here we report on the characterisation of the TRPV5 C-terminal CaM binding site and its interaction with CaM at an atomistic level...
March 27, 2018: Biochemistry
https://www.readbyqxmd.com/read/29582401/trpv4-a-sensor-for-homeostasis-and-pathological-events-in-the-cns
#11
REVIEW
Hemant Kumar, Soo-Hong Lee, Kyoung-Tae Kim, Xiang Zeng, Inbo Han
Transient receptor potential vanilloid type 4 (TRPV4) was originally described as a calcium-permeable nonselective cation channel. TRPV4 is now recognized as a polymodal ionotropic receptor: it is a broadly expressed, nonselective cation channel (permeable to calcium, potassium, magnesium, and sodium) that plays an important role in a multitude of physiological processes. TRPV4 is involved in maintaining homeostasis, serves as an osmosensor and thermosensor, can be activated directly by endogenous or exogenous chemical stimuli, and can be activated or sensitized indirectly via intracellular signaling pathways...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29568892/effect-of-electro-acupuncture-on-the-bdnf-trkb-pathway-in-the-spinal-cord-of-cci-rats
#12
Wen-Zhan Tu, Si-Si Li, Xia Jiang, Xin-Ru Qian, Guan-Hu Yang, Peng-Peng Gu, Bin Lu, Song-He Jiang
Microglia, which comprise a sensor for pathological events in the central nervous system, may be triggered by nerve injury and transformed from a quiescent state into an activated state; ionised calcium binding adaptor molecule 1 (Iba1) is a sensitive marker associated with activated microglia. Accumulated evidence suggests that spinal activated microglia and the brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signalling pathway play major roles in the production and development of neuropathic pain...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29553526/using-a-microfluidics-device-for-mechanical-stimulation-and-high-resolution-imaging-of-c-elegans
#13
Holger Fehlauer, Adam L Nekimken, Anna A Kim, Beth L Pruitt, Miriam B Goodman, Michael Krieg
One central goal of mechanobiology is to understand the reciprocal effect of mechanical stress on proteins and cells. Despite its importance, the influence of mechanical stress on cellular function is still poorly understood. In part, this knowledge gap exists because few tools enable simultaneous deformation of tissue and cells, imaging of cellular activity in live animals, and efficient restriction of motility in otherwise highly mobile model organisms, such as the nematode Caenorhabditis elegans. The small size of C...
February 19, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29543918/chlamydia-trachomatis-inclusion-membrane-protein-mrca-interacts-with-the-inositol-1-4-5-trisphosphate-receptor-type-3-itpr3-to-regulate-extrusion-formation
#14
Phu Hai Nguyen, Erika I Lutter, Ted Hackstadt
Chlamydia trachomatis is an obligate intracellular bacterium that replicates within a vacuole termed an inclusion. At the end of their intracellular developmental cycle, chlamydiae are released either by lysis of the host cell or extrusion of the intact inclusion. The inclusion membrane is extensively modified by the insertion of type III secreted inclusion membrane proteins, Incs, which contribute to inclusion membrane structure and facilitate host-pathogen interactions. An interaction was identified between the inclusion membrane protein, MrcA, and the Ca2+ channel inositol-1,4,5-trisphosphate receptor, type 3 (ITPR3)...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29480205/inhibition-of-trpc1-dependent-store-operated-calcium-entry-improves-synaptic-stability-and-motor-performance-in-a-mouse-model-of-huntington-s-disease
#15
Jun Wu, Daniel Ryskamp, Lutz Birnbaumer, Ilya Bezprozvanny
BACKGROUND: Huntington disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. We previously discovered that mutant Huntingtin sensitizes type 1 inositol 1,4,5-trisphosphate receptor (InsP3R1) to InsP3. This causes calcium leakage from the endoplasmic reticulum (ER) and a compensatory increase in neuronal store-operated calcium (nSOC) entry. We previously demonstrated that supranormal nSOC leads to synaptic loss in striatal medium spiny neurons (MSNs) in YAC128 HD mice...
2018: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/29456142/the-feronia-receptor-kinase-maintains-cell-wall-integrity-during-salt-stress-through-ca-2-signaling
#16
Wei Feng, Daniel Kita, Alexis Peaucelle, Heather N Cartwright, Vinh Doan, Qiaohong Duan, Ming-Che Liu, Jacob Maman, Leonie Steinhorst, Ina Schmitz-Thom, Robert Yvon, Jörg Kudla, Hen-Ming Wu, Alice Y Cheung, José R Dinneny
Cells maintain integrity despite changes in their mechanical properties elicited during growth and environmental stress. How cells sense their physical state and compensate for cell-wall damage is poorly understood, particularly in plants. Here we report that FERONIA (FER), a plasma-membrane-localized receptor kinase from Arabidopsis, is necessary for the recovery of root growth after exposure to high salinity, a widespread soil stress. The extracellular domain of FER displays tandem regions of homology with malectin, an animal protein known to bind di-glucose in vitro and important for protein quality control in the endoplasmic reticulum...
March 5, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29449563/cinacalcet-mediated-activation-of-the-camkk%C3%AE-lkb1-ampk-pathway-attenuates-diabetic-nephropathy-in-db-db-mice-by-modulation-of-apoptosis-and-autophagy
#17
Ji Hee Lim, Hyung Wook Kim, Min Young Kim, Tae Woo Kim, Eun Nim Kim, Yaeni Kim, Sungjin Chung, Young Soo Kim, Bum Soon Choi, Yong-Soo Kim, Yoon Sik Chang, Hye Won Kim, Cheol Whee Park
Apoptosis and autophagy are harmoniously regulated biological processes for maintaining tissue homeostasis. AMP-activated protein kinase (AMPK) functions as a metabolic sensor to coordinate cellular survival and function in various organs, including the kidney. We investigated the renoprotective effects of cinacalcet in high-glucose treated human glomerular endothelial cells (HGECs), murine podocytes and C57BLKS/J-db/db mice. In cultured HGECs and podocytes, cinacalcet decreased oxidative stress and apoptosis and increased autophagy that were attributed to the increment of intracellular Ca2+ concentration and the phosphorylation of Ca2+ /calmodulin-dependent protein kinase kinaseβ (CaMKKβ)-Liver kinase B1 (LKB1)-AMPK and their downstream signals including the phosphorylation of endothelial nitric oxide synthase (eNOS) and increases in superoxide dismutases and B cell leukemia/lymphoma 2/BCL-2-associated X protein expression...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29411421/tanycytes-and-hypothalamic-control-of-energy-metabolism
#18
REVIEW
Francis J P Ebling, Jo E Lewis
Studies from a number of areas of neuroendocrinology indicate that hypothalamic tanycytes play a key role in control of energy metabolism. First, profound annual changes in gene expression have been identified in these unusual glial cells in seasonal mammals, for example in genes relating to the transport and metabolism of thyroid hormone into the hypothalamus. The consequent changes in local thyroid hormone availability in the hypothalamus have been shown experimentally to regulate annual cycles in energy intake, storage and expenditure in seasonal species...
June 2018: Glia
https://www.readbyqxmd.com/read/29363587/intracellular-cavity-of-sensor-domain-controls-allosteric-gating-of-trpa1-channel
#19
Lucie Zimova, Viktor Sinica, Anna Kadkova, Lenka Vyklicka, Vlastimil Zima, Ivan Barvik, Viktorie Vlachova
Transient receptor potential ankyrin 1 (TRPA1) is a temperature-sensitive ion channel activated by various pungent and irritant compounds that can produce pain in humans. Its activation involves an allosteric mechanism whereby electrophilic agonists evoke interactions within cytosolic domains and open the channel pore through an integrated nexus formed by intracellular membrane proximal regions that are densely packed beneath the lower segment of the S1-S4 sensor domain. Studies indicate that this part of the channel may contain residues that form a water-accessible cavity that undergoes changes in solvation during channel gating...
January 23, 2018: Science Signaling
https://www.readbyqxmd.com/read/29342202/cells-containing-aragonite-crystals-mediate-responses-to-gravity-in-trichoplax-adhaerens-placozoa-an-animal-lacking-neurons-and-synapses
#20
Tatiana D Mayorova, Carolyn L Smith, Katherine Hammar, Christine A Winters, Natalia B Pivovarova, Maria A Aronova, Richard D Leapman, Thomas S Reese
Trichoplax adhaerens has only six cell types. The function as well as the structure of crystal cells, the least numerous cell type, presented an enigma. Crystal cells are arrayed around the perimeter of the animal and each contains a birefringent crystal. Crystal cells resemble lithocytes in other animals so we looked for evidence they are gravity sensors. Confocal microscopy showed that their cup-shaped nuclei are oriented toward the edge of the animal, and that the crystal shifts downward under the influence of gravity...
2018: PloS One
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