Claudio Tripodo, Valeria Cancila, Gaia Morello, Giorgio Bertolazzi, Allison Si-Yu Chan, Giulia Bastianello, Daniel Paysan, Patrick William Jaynes, Giovanna Schiavoni, Fabrizio Mattei, Silvia Piconese, Maria Revuelta, Francesco Noto, Adele De Ninno, Ilenia Cammarata, Fabio Pagni, Saradha Venkatachalapathy, Sabina Sangaletti, Arianna Di Napoli, Davide Vacca, Silvia Lonardi, Luisa Lorenzi, Andrés J M Ferreri, Beatrice Belmonte, Gabriele Varano, Mario Paolo Colombo, Silvio Bicciato, Giorgio Inghirami, Leandro Cerchietti, Maurilio Ponzoni, Roberta Zappasodi, Fabio Facchetti, Marco Foiani, Stefano Casola, Anand D Jeyasekharan
The germinal center (GC) dark zone (DZ) and light zone (LZ) regions spatially separate expansion and diversification from selection of antigen-specific B-cells to ensure antibody affinity maturation and B cell memory. The DZ and LZ differ significantly in their immune composition despite the lack of a physical barrier, yet the determinants of this polarization are poorly understood. This study provides novel insights into signals controlling asymmetric T-cell distribution between DZ and LZ regions. We identify spatially-resolved DNA damage response and chromatin compaction molecular features that underlie DZ T-cell exclusion...
March 18, 2024: Research Square