keyword
MENU ▼
Read by QxMD icon Read
search

commitment signals in relation

keyword
https://www.readbyqxmd.com/read/28089422/low-magnitude-mechanical-signals-and-the-spine-a-review-of-current-and-future-applications
#1
REVIEW
Martin H Pham, Zorica Buser, Jeffrey C Wang, Frank L Acosta
Animal and human studies demonstrate the anabolic properties of low-magnitude mechanical stimulation (LMMS) in its ability to improve bone formation by enhancing the proliferation of mesenchymal stem cells and their subsequent commitment down an osteoblastic lineage. Response to mechanical strains as low as 10μɛ have been seen, illustrating the sensitivity of mechanosensory cells to mechanotransduction pathways. Applications to the spine include treatment of osteoporosis in preparation for instrumented fusion, fracture reduction in spinal cord injury patients to slow bone mineral density loss, and bone tissue engineering and enhancement of bone-implant osseointegration for pseudarthrosis and hardware failure...
January 12, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28078846/mir-2861-is-involved-in-osteogenic-commitment-of-human-periodontal-ligament-stem-cells-grown-onto-3d-scaffold
#2
F Diomede, I Merciaro, S Martinotti, M F X B Cavalcanti, S Caputi, E Mazzon, O Trubiani
miR-2861 endorsing osteoblast differentiation through the overexpression of Runt-related transcription factor 2 (RUNX2) protein has been recently described. In this study we evaluated: the performance of living construct, composed by human Periodontal Ligament Stem Cells (hPDLSCs) and 3D scaffold (EXg), and the behaviour of miR-2861/RUNX2 expression pathway on the osteogenic commitment. Human PDLSCs were seeded with and without EXg scaffold and cultured under basal and osteogenic conditions. Morphological features, adhesiveness and differentiation abilities were analysed using scanning electron and confocal laser scanning microscopy...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28068307/transitional-b-cells-commit-to-marginal-zone-b-cell-fate-by-taok3-mediated-surface-expression-of-adam10
#3
Hamida Hammad, Matthias Vanderkerken, Philippe Pouliot, Kim Deswarte, Wendy Toussaint, Karl Vergote, Lana Vandersarren, Sophie Janssens, Ioanna Ramou, Savvas N Savvides, Jody J Haigh, Rudi Hendriks, Manfred Kopf, Katleen Craessaerts, Bart de Strooper, John F Kearney, Daniel H Conrad, Bart N Lambrecht
Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3(-/-) mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner...
January 9, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28004780/adam17-egfr-axis-promotes-transglutaminase-dependent-skin-barrier-formation-through-phosholipase-c-%C3%AE-1-and-protein-kinase-c-pathways
#4
Cristina Wolf, Yawen Qian, Matthew A Brooke, David P Kelsell, Claus-Werner Franzke
The vitally important skin barrier is formed by extensive cross-linking activity of transglutaminases (TGs) during terminal epidermal differentiation. We have previously shown that epidermal deficiency of a disintegrin and metalloproteinase 17 (ADAM17), the principal EGFR ligand sheddase, results in postnatal skin barrier defects in mice due to impeded TG activity. However, the mechanism by which ADAM17/EGFR signalling maintains TG activity during epidermal differentiation remains elusive. Here we demonstrate that ADAM17-dependent EGFR signalling promotes TG activity in keratinocytes committed to terminal differentiation by direct induction of TG1 expression...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28003483/adenovirus-serotype-5-vaccination-results-in-suboptimal-cd4-t-helper-1-responses-in-mice
#5
Junghwa Lee, Masao Hashimoto, Se Jin Im, Koichi Araki, Hyun-Tak Jin, Carl W Davis, Bogumila T Konieczny, Gregory A Spies, M Juliana McElrath, Rafi Ahmed
: Adenovirus serotype 5 (Ad5) is one of the most widely used viral vectors and is known to generate potent T cell responses. While many previous studies have characterized Ad5-induced CD8 T cell responses, there is a relative lack of detailed studies analysing CD4 T cells elicited by Ad5 vaccination. Herein, we immunized mice with Ad5 vectors encoding lymphocytic choriomeningitis virus (LCMV)-glycoprotein (GP) and examined GP-specific CD4 T cell responses elicited by Ad5 vectors compared to those induced by an acute LCMV infection...
December 21, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27990620/role-of-peroxynitrite-induced-activation-of-poly-adp-ribose-polymerase-parp-in-circulatory-shock-and-related-pathological-conditions
#6
REVIEW
Badar Ul Islam, Safia Habib, Syed Amaan Ali, Moinuddin, Asif Ali
Peroxynitrite is a powerful oxidant, formed from the reaction of nitric oxide and superoxide. It is known to interact and modify different biological molecules such as DNA, lipids and proteins leading to alterations in their structure and functions. These events elicit various cellular responses, including cell signaling, causing oxidative damage and committing cells to apoptosis or necrosis. This review discusses nitrosative stress-induced modification in the DNA molecule that results in the formation of 8-nitroguanine and 8-oxoguanine, and its role in disease conditions...
December 19, 2016: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/27981736/frontal-theta-activation-associated-with-error-detection-in-toddlers-influence-of-familial-socioeconomic-status
#7
Ángela Conejero, Sonia Guerra, Alicia Abundis-Gutiérrez, M Rosario Rueda
Error detection is one of the functions of the executive attention network, a brain system involved in executive control that includes the anterior cingulate cortex and other prefrontal regions. Despite the key role of this function in a wide range of life outcomes, very limited research has examined the early development of the network and whether its functional efficacy is related to environmental factors. Electrophysiological studies with adults have shown oscillatory activity in theta (4-7 Hz) range arising from medial frontal cortex that follows the detection of self-committed or observed errors...
December 15, 2016: Developmental Science
https://www.readbyqxmd.com/read/27920747/social-influence-and-different-types-of-red-light-behaviors-among-cyclists
#8
Federico Fraboni, Víctor Marín Puchades, Marco De Angelis, Gabriele Prati, Luca Pietrantoni
Accident analysis and studies on traffic revealed that cyclists' violation of red-light regulation is one typical infringement committed by cyclists. Furthermore, an association between cyclists' crash involvement and red-light violations has been found across different countries. The literature on cyclists' psychosocial determinants of red-light violation is still scarce. The present study, based on the classification of cyclists' red-light behavior in risk-taking (ignoring the red-light and traveling through the junction without stopping), opportunistic (waiting at red-lights but being too impatient to wait for green signal and subsequently crossing the junction), and law-obeying (stopping to obey the red-light), adopted an eye-observational methodology to investigate differences in cyclists' crossing behavior at intersections, in relation to traffic light violations and the presence of other cyclists...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27911036/properties-of-embryoid-bodies
#9
REVIEW
Joshua M Brickman, Palle Serup
Embryoid bodies (EBs) have been popular in vitro differentiation models for pluripotent stem cells for more than five decades. Initially, defined as aggregates formed by embryonal carcinoma cells, EBs gained more prominence after the derivation of karyotypically normal embryonic stem cells from early mouse blastocysts. In many cases, formation of EBs constitutes an important initial step in directed differentiation protocols aimed at generated specific cell types from undifferentiated stem cells. Indeed state-of-the-art protocols for directed differentiation of cardiomyocytes still rely on this initial EB step...
December 2, 2016: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/27909258/prioritizing-and-funding-the-uganda-nutrition-action-plan
#10
Amanda Pomeroy-Stevens, Alexis D'Agostino, Nancy Adero, Hannah Foehringer Merchant, Abel Muzoora, Ezekiel Mupere, Edgar Agaba, Lidan Du
BACKGROUND: In 2010, Uganda began developing its first multisectoral nutrition plan, the Uganda Nutrition Action Plan (UNAP), to reduce malnutrition. While the UNAP signals high-level commitment to addressing nutrition, knowledge gaps remain about how to successfully implement such a plan. OBJECTIVE: We tracked the UNAP's influence on the process of priority setting and funding for nutrition from 2013 to 2015. METHODS: This study used a longitudinal mixed methods design to track qualitative and budgetary changes related to UNAP processes nationally as well as in 2 study districts...
December 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/27877072/cultured-human-periosteum-derived-cells-can-differentiate-into-osteoblasts-in-a-perioxisome-proliferator-activated-receptor-gamma-mediated-fashion-via-bone-morphogenetic-protein-signaling
#11
Jin-Eun Chung, Jin-Ho Park, Jeong-Won Yun, Young-Hoon Kang, Bong-Wook Park, Sun-Chul Hwang, Yeong-Cheol Cho, Iel-Yong Sung, Dong Kyun Woo, June-Ho Byun
The differentiation of mesenchymal stem cells towards an osteoblastic fate depends on numerous signaling pathways, including activation of bone morphogenetic protein (BMP) signaling components. Commitment to osteogenesis is associated with activation of osteoblast-related signal transduction, whereas inactivation of this signal transduction favors adipogenesis. BMP signaling also has a critical role in the processes by which mesenchymal stem cells undergo commitment to the adipocyte lineage. In our previous study, we demonstrated that an agonist of the perioxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipocyte differentiation, stimulates osteoblastic differentiation of cultured human periosteum-derived cells...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27862226/histone-h4-methyltransferase-suv420h2-maintains-fidelity-of-osteoblast-differentiation
#12
Farzaneh Khani, Roman Thaler, Christopher R Paradise, David R Deyle, Marianne Kruijthof-de Julio, Mario Galindo, Jonathan A Gordon, Gary S Stein, Amel Dudakovic, Andre J van Wijnen
Osteogenic lineage commitment and progression is controlled by multiple signaling pathways (e.g., WNT, BMP, FGF) that converge on bone-related transcription factors. Access of osteogenic transcription factors to chromatin is controlled by epigenetic regulators that generate post-translational modifications of histones ("histone code"), as well as read, edit and/or erase these modifications. Our understanding of the biological role of epigenetic regulators in osteoblast differentiation remains limited. Therefore, we performed next-generation RNA sequencing (RNA-seq) and established which chromatin-related proteins are robustly expressed in mouse bone tissues (e...
November 9, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27859962/concise-review-geminin-a-tale-of-two-tails-dna-replication-and-transcriptional-epigenetic-regulation-in-stem-cells
#13
REVIEW
Alexandra L Patmanidi, Spyridon Champeris Tsaniras, Dimitris Karamitros, Christina Kyrousi, Zoi Lygerou, Stavros Taraviras
Molecular mechanisms governing maintenance, commitment, and differentiation of stem cells are largely unexploited. Molecules involved in the regulation of multiple cellular processes are of particular importance for stem cell physiology, as they integrate different signals and coordinate cellular decisions related with self-renewal and fate determination. Geminin has emerged as a critical factor in DNA replication and stem cell differentiation in different stem cell populations. Its inhibitory interaction with Cdt1, a member of the prereplicative complex, ensures the controlled timing of DNA replication and, consequently, genomic stability in actively proliferating cells...
November 11, 2016: Stem Cells
https://www.readbyqxmd.com/read/27848246/mir-2861-is-involved-in-osteogenic-commitment-of-human-periodontal-ligament-stem-cells-grown-onto-3d-scaffold
#14
F Diomede, I Merciaro, S Martinotti, M Cavalcanti, S Caputi, E Mazzon, O Trubiani
miR-2861 endorsing osteoblast differentiation through the overexpression of Runt-related transcription factor 2 (RUNX2) protein has been recently described. In this study we evaluated: the performance of living construct, composed by human Periodontal Ligament Stem Cells (hPDLSCs) and 3D scaffold (EXg), and the behaviour of miR-2861/RUNX2 expression pathway on the osteogenic commitment. Human PDLSCs were seeded with and without EXg scaffold and cultured under basal and osteogenic conditions. Morphological features, adhesiveness and differentiation abilities were analysed using scanning electron and confocal laser scanning microscopy...
November 16, 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27771457/identification-of-nf-%C3%AE%C2%BAb-inhibitors-following-shenfu-injection-and-bioactivity-integrated-uplc-q-tof-ms-and-screening-for-related-anti-inflammatory-targets-in-vitro-and-in-silico
#15
Pan Li, Bin Lv, Xiaoqing Jiang, Ting Wang, Xianghui Ma, Nianwei Chang, Xiaoying Wang, Xiumei Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Shenfu injection (SFI) is a commercial medicinal product approved by the China Food and Drug Administration that is widely used in the treatment of stroke and coronary heart disease. However, the material basis and the mechanism of SFI are not fully understood. AIM OF THE STUDY: With network pharmacology analysis, our research committed to identify the anti-inflammatory ingredients and mechanism of SFI by combining high-throughput screening...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27758858/enhancer-of-zeste-homolog-2-inhibition-stimulates-bone-formation-and-mitigates-bone-loss-caused-by-ovariectomy-in-skeletally-mature-mice
#16
Amel Dudakovic, Emily T Camilleri, Scott M Riester, Christopher R Paradise, Martina Gluscevic, Thomas M O'Toole, Roman Thaler, Jared M Evans, Huihuang Yan, Malayannan Subramaniam, John R Hawse, Gary S Stein, Martin A Montecino, Meghan E McGee-Lawrence, Jennifer J Westendorf, Andre J van Wijnen
Perturbations in skeletal development and bone degeneration may result in reduced bone mass and quality, leading to greater fracture risk. Bone loss is mitigated by bone protective therapies, but there is a clinical need for new bone-anabolic agents. Previous work has demonstrated that Ezh2 (enhancer of zeste homolog 2), a histone 3 lysine 27 (H3K27) methyltransferase, suppressed differentiation of osteogenic progenitors. Here, we investigated whether inhibition of Ezh2 can be leveraged for bone stimulatory applications...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27736777/genome-wide-association-study-of-cell-mediated-response-in-dogs-naturally-infected-by-leishmania-infantum
#17
Luís F S Batista, Yuri T Utsunomiya, Thaís B F Silva, Raíssa A Dias, Thaise Y Tomokane, Acácio D Pacheco, Vânia L R da Matta, Fernando T Silveira, Mary Marcondes, Cáris M Nunes, Márcia D Laurenti
A genome-wide association study (GWAS) could unravel the complexity of the cell-mediated immunity (CMI) to canine leishmaniasis (CanL). Therefore, we scanned 110,165 single-nucleotide polymorphisms (SNPs), aiming to identify chromosomal regions associated with the leishmanin skin test (LST), lymphocyte proliferation assay (LPA), and cytokine responses to further understand the role played by CMI in the outcome of natural Leishmania infantum infection in 189 dogs. Based on LST and LPA, four CMI profiles were identified (LST(-)/LPA(-), LST(+)/LPA(-), LST(-)/LPA(+), and LST(+)/LPA(+)), which were not associated with subclinically infected or diseased dogs...
December 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27711125/memory-distortion-and-its-avoidance-an-event-related-potentials-study-on-false-recognition-and-correct-rejection
#18
Sara Cadavid, Maria Soledad Beato
Memory researchers have long been captivated by the nature of memory distortions and have made efforts to identify the neural correlates of true and false memories. However, the underlying mechanisms of avoiding false memories by correctly rejecting related lures remains underexplored. In this study, we employed a variant of the Deese/Roediger-McDermott paradigm to explore neural signatures of committing and avoiding false memories. ERP were obtained for True recognition, False recognition, Correct rejection of new items, and, more importantly, Correct rejection of related lures...
2016: PloS One
https://www.readbyqxmd.com/read/27699898/adipose-tissue-regulates-insulin-sensitivity-role-of-adipogenesis-de-novo-lipogenesis-and-novel-lipids
#19
U Smith, B B Kahn
Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces insulin resistance in peripheral insulin target tissues. Several mechanisms have been identified related to cross-talk between adipose tissue, skeletal muscle and liver. These mechanisms involve both increased free fatty acid release and altered secretion of adipokines from adipose tissue. A major determinant of metabolic health is the ability of subcutaneous adipose tissue (SAT) to store excess fat rather than allowing it to accumulate in ectopic depots including liver (i...
November 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27694305/in-vitro-germ-cell-differentiation-from-embryonic-stem-cells-of-mice-induction-control-by-bmp4-signaling
#20
Zohreh Makoolati, Mansoureh Movahedin, Mehdi Forouzandeh-Moghadam
The present study aims to confirm and analyze germ-cell related patterns and specific gene expressions at a very early stage of cell commitment. Following the XY cytogenetic confirmation of the CCE mouse embryonic stem cells (mESCs) line, cells were cultured to form embrioid bodies (EBs). Expression pattern assessment of the Mvh, Stra8, α6 and β1 integrin genes in ESC and 1-3-day-old EB showed that all genes except α6 integrin were expressed in the ESC. The mean calibration of Mvh, Stra8 and α6 integrin expression significantly increased upon EB formation compared to the ESCs...
September 30, 2016: Bioscience Reports
keyword
keyword
78125
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"