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JOURNAL ARTICLE
Caroline Diguisto, Elfreda Baker, Simon Stanworth, Peter W Collins, Rachel E Collis, Marian Knight
INTRODUCTION: Pregnant women with a fibrinogen level <2 g/L represent a high-risk group that is associated with severe postpartum hemorrhage and other complications. Women who would qualify for fibrinogen therapy are not yet identified. MATERIAL AND METHODS: A population-based cross-sectional study was conducted using the UK Obstetric Surveillance System between November 2017 and October 2018 in any UK hospital with a consultant-led maternity unit. Any woman pregnant or immediately postpartum with a fibrinogen <2 g/L was included...
March 22, 2024: Acta Obstetricia et Gynecologica Scandinavica
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JOURNAL ARTICLE
Yonas Getaye Tefera, Michael Di Donato, Luke R Sheehan, Shannon Gray, Suzanne Nielsen, Ting Xia, Alex Collie
OBJECTIVE: This study aims to characterise the approaches to collecting, coding, and reporting healthcare and medicines data within Australian workers' compensation schemes. METHODS: We conducted a cross-sectional survey of data and information professionals in major Australian workers' compensation jurisdictions. Questionnaires were developed with input from key informants and a review of existing documentation. RESULTS: Twenty-five participants representing regulators (40%) and insurers (60%) with representation from all Australian jurisdictions were included...
March 18, 2024: Journal of Occupational and Environmental Medicine
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JOURNAL ARTICLE
A R Felisbino Neto, D F C Souza, R A Campos, S Albertini, M R Bastos, B G Freitas, M H A Colli, F M Elliff, J N S Sales, P S Baruselli
This study evaluated the efficacy of the administration of different doses of equine chorionic gonadotropin (eCG; 0 IU, 200 IU, or 300 IU) at the time of the progesterone device removal in 2-year-old Nelore (Bos indicus) heifers synchronized for fixed-timed artificial insemination (FTAI). On day 0 (D0), a total of 398 heifers received 2 mg of oestradiol benzoate i.m., 0.53 mg of cloprostenol i.m., and an eight-day previously used (second use) intravaginal device containing 1 g of progesterone (P4)...
March 2024: Reproduction in Domestic Animals
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JOURNAL ARTICLE
Antonia Rizzuto, Jacopo Andreuccetti, Umberto Bracale, Vania Silvestri, Emanuele Pontecorvi, Stefano Reggio, Carlo Sagnelli, Roberto Peltrini, Angela Amaddeo, Cristina Bozzarello, Giusto Pignata, Diego Cuccurullo, Francesco Corcione
BACKGROUND: Colovesical fistulas (CVFs) pose a challenge in diverticulitis, affecting 4% to 20% of sigmoid colon cases. Complicated diverticular disease contributes significantly, accounting for 60%-70% of all CVFs. Existing studies on laparoscopic CVF management lack clarity on its effectiveness in diverticular cases compared to open surgery. This study redefines paradigms by assessing the potentiality, adequacy, and utility of laparoscopy in treating CVFs due to complicated diverticular disease, marking a paradigm shift in surgical approaches...
2024: Frontiers in Surgery
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JOURNAL ARTICLE
Chong Sun, Hongfei Xiang, Xiaolin Wu, Bohua Chen, Zhu Guo
BACKGROUND: Anterior cervical discectomy and fusion surgery (ACDF) is a common technique in treating degenerative cervical spondylosis. This study is to evaluate the changes of cervical muscles after ACDF and analyze the correlation between related muscle changes and clinical efficacy. METHODS: Sixty-five postoperative patients (single-level ACDF) with cervical spondylotic myelopathy from January 2013 to December 2022 were analyzed. The measured parameters include: the axial section of longus colli cross-sectional area (AxCSA), the volume of cervical longus, the ratio of long and short diameter line (RLS), the cervical extensor cross-sectional area (CESA), the vertebral body area (VBA), and the CESA/VBA...
March 16, 2024: Journal of Orthopaedic Surgery and Research
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JOURNAL ARTICLE
Pilar Okenve-Ramos, Rory Gosling, Monika Chojnowska-Monga, Kriti Gupta, Samuel Shields, Haifa Alhadyian, Ceryce Collie, Emilia Gregory, Natalia Sanchez-Soriano
Natural ageing is accompanied by a decline in motor, sensory, and cognitive functions, all impacting quality of life. Ageing is also the predominant risk factor for many neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. We need to therefore gain a better understanding of the cellular and physiological processes underlying age-related neuronal decay. However, gaining this understanding is a slow process due to the large amount of time required to age mammalian or vertebrate animal models...
March 13, 2024: PLoS Biology
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JOURNAL ARTICLE
Callum G Jones, Aurelie Vanderlinden, Ola Rominiyi, Spencer J Collis
Glioblastoma is an aggressive, incurable brain cancer with poor five-year survival rates of around 13% despite multimodal treatment with surgery, DNA-damaging chemoradiotherapy and the recent addition of Tumour Treating Fields (TTFields). As such, there is an urgent need to improve our current understanding of cellular responses to TTFields using more clinically and surgically relevant models, which reflect the profound spatial heterogeneity within glioblastoma, and leverage these biological insights to inform the rational design of more effective therapeutic strategies incorporating TTFields...
February 21, 2024: Cancers
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JOURNAL ARTICLE
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David Wagner, Jarrod J Walsh, David Watson, Beth Williamson
The optimization of an allosteric fragment, discovered by differential scanning fluorimetry, to an in vivo MAT2a tool inhibitor is discussed. The structure-based drug discovery approach, aided by relative binding free energy calculations, resulted in AZ'9567 ( 21 ), a potent inhibitor in vitro with excellent preclinical pharmacokinetic properties. This tool showed a selective antiproliferative effect on methylthioadenosine phosphorylase (MTAP) KO cells, both in vitro and in vivo, providing further evidence to support the utility of MAT2a inhibitors as potential anticancer therapies for MTAP-deficient tumors...
March 11, 2024: Journal of Medicinal Chemistry
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JOURNAL ARTICLE
Kalai Selvi T, A Sumaiya Begum, P Poonkuzhali, R Aarthi
This research focuses on improving the detection and classification of brain tumors using a method called Brain Tumor Classification using Dual-Discriminator Conditional Generative Adversarial Network (DDCGAN) for MRI images. The proposed system is implemented in the MATLAB programming language. In this study, images of the brain are taken from a dataset and processed to remove noise and enhance image quality. The brain pictures are taken from Brats MRI image dataset. The images are preprocessed using Structural interval gradient filtering to remove noises and improve the quality of the image...
March 10, 2024: Electromagnetic Biology and Medicine
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JOURNAL ARTICLE
Luke F Ellis, Arthur K House, Kiyoko Shimura, Mika Frances
OBJECTIVE: The aim of this study was to determine if variations in Hounsfield units (HU) are present within the elbow between asymptomatic dogs of two breeds of dogs susceptible to elbow dysplasia. STUDY DESIGN: Guide Dogs and Border Collies that presented for routine computed tomography (CT) screening for elbow dysplasia prior to breeding were evaluated. All dogs had no documented history of lameness. Dogs diagnosed with CT as being free of elbow dysplasia were included...
March 6, 2024: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
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JOURNAL ARTICLE
Daisuke Honda, Michihiro Hide, Tomoo Fukuda, Keisuke Koga, Eishin Morita, Shinichi Moriwaki, Yoshihiro Sasaki, Yusuke Suzuki, Phil Collis, Douglas T Johnston, Dianne Tomita, Bhavisha Desai, Isao Ohsawa
BACKGROUND: Berotralstat is a once-daily oral inhibitor of plasma kallikrein for the prophylaxis of hereditary angioedema (HAE) in patients ≥12 years. APeX-J aimed to evaluate the efficacy and safety of berotralstat in Japan. METHODS: APeX-J was a Phase III trial comprising 3 parts (NCT03873116). Part 1 was a randomized, placebo-controlled evaluation of berotralstat 150 or 110 mg over 24 weeks. Part 2 was a 28-week dose-blinded phase in which berotralstat-treated patients continued the same dose and placebo patients were re-randomized to berotralstat 150 or 110 mg...
March 2024: World Allergy Organization Journal
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JOURNAL ARTICLE
Fariba Mohseni, Nahid Rahmani, Mohammad Ali Mohseni Bandpei, Iraj Abdollahi
BACKGROUND: Ultrasonography (US) has been suggested to assess the morphology and function of cervical muscles; but little is known about the reliability of the US measures in patients with cervical disc herniation (CDH). The purpose of this study was to evaluate within-day inter and intra-rater and between-day intra-rater reliability of US to measure dimensions of deep cervical muscles in patients with unilateral CDH. METHODS: Thirty patients with unilateral CDH participated...
January 2024: Journal of Bodywork and Movement Therapies
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JOURNAL ARTICLE
Marie Moinet, Rose M Collis, Lynn Rogers, Megan L Devane, Patrick J Biggs, Rebecca Stott, Jonathan Marshall, Richard Muirhead, Adrian L Cookson
Escherichia coli are widely used by water quality managers as Fecal Indicator Bacteria, but current quantification methods do not differentiate them from benign, environmental Escherichia species such as E. marmotae (formerly named cryptic clade V) or E. ruysiae (cryptic clades III and IV). Reliable and specific techniques for their identification are required to avoid confounding microbial water quality assessments. To address this, a multiplex droplet digital PCR (ddPCR) assay targeting lipB (E. coli and E...
March 1, 2024: Journal of Microbiological Methods
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REVIEW
Olalekan Lee Aiyegbusi, Samantha Cruz Rivera, Jessica Roydhouse, Paul Kamudoni, Yvonne Alder, Nicola Anderson, Robert Mitchell Baldwin, Vishal Bhatnagar, Jennifer Black, Andrew Bottomley, Michael Brundage, David Cella, Philip Collis, Elin-Haf Davies, Alastair K Denniston, Fabio Efficace, Adrian Gardner, Ari Gnanasakthy, Robert M Golub, Sarah E Hughes, Flic Jeyes, Scottie Kern, Bellinda L King-Kallimanis, Antony Martin, Christel McMullan, Rebecca Mercieca-Bebber, Joao Monteiro, John Devin Peipert, Juan Carlos Quijano-Campos, Chantal Quinten, Khadija Rerhou Rantell, Antoine Regnault, Maxime Sasseville, Liv Marit Valen Schougaard, Roya Sherafat-Kazemzadeh, Claire Snyder, Angela M Stover, Rav Verdi, Roger Wilson, Melanie J Calvert
Patient-reported outcomes (PROs) are increasingly used in healthcare research to provide evidence of the benefits and risks of interventions from the patient perspective and to inform regulatory decisions and health policy. The use of PROs in clinical practice can facilitate symptom monitoring, tailor care to individual needs, aid clinical decision-making and inform value-based healthcare initiatives. Despite their benefits, there are concerns that the potential burden on respondents may reduce their willingness to complete PROs, with potential impact on the completeness and quality of the data for decision-making...
March 2024: Nature Medicine
#35
JOURNAL ARTICLE
Nina R Kieves, Abigail Shoben, Arielle Pechette Markley
OBJECTIVES: Our aim was to determine risk factors for developing stifle injuries in canine agility athletes. We hypothesized that increased weight, increased frequency of competing, and greater number of runs/day would increase risk. STUDY DESIGN: Internet based survey, n = 4,197. METHODS: Individuals with at least one dog who had competed in agility in the past 3 years were eligible. Injury history was defined as an injury to the stifle that kept the dog from participating in agility for >1 week...
2024: Frontiers in Veterinary Science
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JOURNAL ARTICLE
Brianna L Collie, Nicole B Lyons, Christopher F O'Neil, Walter A Ramsey, Edward B Lineen, Carl I Schulman, Kenneth G Proctor, Jonathan P Meizoso, Nicholas Namias, Enrique Ginzburg
BACKGROUND: Thromboprophylaxis after blunt splenic trauma is complicated by the risk of bleeding, but the risk after angioembolization is unknown. We hypothesized that earlier thromboprophylaxis initiation was associated with increased bleeding complications without mitigating venous thromboembolism events. METHODS: All blunt trauma patients who underwent splenic angioembolization within 24 hours of arrival were identified from the American College of Surgeons Trauma Quality Improvement Program datasets from 2017 to 2019...
February 27, 2024: Surgery
#37
JOURNAL ARTICLE
Sarah Hoedemakers, Nicola Riccardo Pugliese, Jan Stassen, Arnaud Vanoppen, Jade Claessens, Tin Gojevic, Youri Bekhuis, Maarten Falter, Sara Moura Ferreira, Sebastiaan Dhont, Nicolò De Biase, Lavinia Del Punta, Valerio Di Fiore, Marco De Carlo, Cristina Giannini, Andrea Colli, Raluca Elena Dulgheru, Jolien Geers, Alaaddin Yilmaz, Guido Claessen, Philippe Bertrand, Steven Droogmans, Patrizio Lancellotti, Bernard Cosyns, Frederik H Verbrugge, Lieven Herbots, Stefano Masi, Jan Verwerft
BACKGROUND: Recent guidelines redefined exercise pulmonary hypertension as a mean pulmonary artery pressure/cardiac output (mPAP/CO) slope >3 mm Hg·L-1 ·min-1 . A peak systolic pulmonary artery pressure >60 mm Hg during exercise has been associated with an increased risk of cardiovascular death, heart failure rehospitalization, and aortic valve replacement in aortic valve stenosis. The prognostic value of the mPAP/CO slope in aortic valve stenosis remains unknown...
February 27, 2024: Circulation
#38
JOURNAL ARTICLE
Paula P Schnurr, Jessica L Hamblen, Jonathan Wolf, Rachael Coller, Claire Collie, Matthew A Fuller, Paul E Holtzheimer, Ursula Kelly, Ariel J Lang, Kate McGraw, Joshua C Morganstein, Sonya B Norman, Katie Papke, Ismene Petrakis, David Riggs, James A Sall, Brian Shiner, Ilse Wiechers, Marija S Kelber
DESCRIPTION: The U.S. Department of Veterans Affairs (VA) and Department of Defense (DoD) worked together to revise the 2017 VA/DoD Clinical Practice Guideline for the Management of Posttraumatic Stress Disorder and Acute Stress Disorder. This article summarizes the 2023 clinical practice guideline (CPG) and its development process, focusing on assessments and treatments for which evidence was sufficient to support a recommendation for or against. METHODS: Subject experts from both departments developed 12 key questions and reviewed the published literature after a systematic search using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) method...
March 2024: Annals of Internal Medicine
#39
JOURNAL ARTICLE
S E Gray, M Di Donato, L R Sheehan, R Iles, A Collie
PURPOSE: To describe the volume, timing and provider of mental health services provided to workers with accepted low back pain (LBP) claims, and to identify determinants of service volume and time to first mental health service. METHODS: Using claim and service-level workers' compensation data from four Australian states (Queensland, South Australia, Western Australia, Victoria) for LBP claims with at least one mental health service lodged between 1 July 2011 and 30 June 2015...
February 24, 2024: Journal of Occupational Rehabilitation
#40
JOURNAL ARTICLE
Bogdan Alin Vlaic, Augustin Vlaic, Isa-Rita Russo, Licia Colli, Michael William Bruford, Antonia Odagiu, Pablo Orozco-terWengel, Climgen Consortium
Animal husbandry is one of man's oldest occupations. It began with the domestication of animals and developed continuously, in parallel with the evolution of human society. The selection and improvement of goats in Romania was not a clearly defined objective until around 1980. In recent years, with the increasing economic value given to goats, breeding programs are becoming established. In Romania, a few goat genetic studies using microsatellites and mtDNA have been carried out; however, a systematic characterization of the country's goat genomic resources remains missing...
February 7, 2024: Animals: An Open Access Journal From MDPI
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