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https://www.readbyqxmd.com/read/28087756/fine-mapping-of-genes-determining-extrafusal-fiber-properties-in-murine-soleus-muscle
#1
Andrew Carroll, Riyan Cheng, Elaina Collie-Duguid, Caroline Meharg, Michael E Scholz, Steven N Fiering, Jennifer L Fields, Abraham A Palmer, Arimantas Lionikas
INTRODUCTION: Muscle fiber cross-sectional area (CSA) and proportion of different fiber types are important determinants of muscle function and overall metabolism. Genetic variation plays a substantial role in phenotypic variation of these traits, however, the underlying genes remain poorly understood. AIMS: This study aimed to map quantitative trait loci (QTL) affecting differences in soleus muscle fiber traits between the LG/J and SM/J mouse strains. METHODS: Fiber number, CSA, and proportion of oxidative type I fibers were assessed in the soleus of 334 genotyped male and female mice of the F34 generation of advanced intercross lines (AIL) derived from the LG/J and SM/J strains...
January 13, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28072725/laparoscopic-revision-surgery-for-gastroesophageal-reflux-disease
#2
Haydar Celasin, Volkan Genc, Suleyman Utku Celik, Ahmet Gökhan Turkcapar
Laparoscopic antireflux surgery is a frequently performed procedure for the treatment of gastroesophageal reflux in surgical clinics. Reflux can recur in between 3% and 30% of patients on whom antireflux surgery has been performed, and so revision surgery can be required due to recurrent symptoms or dysphagia in approximately 3% to 6% of the patients. The objective of this study is to evaluate the mechanism of recurrences after antireflux surgery and to share our results after revision surgery in recurrent cases...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070269/musculoskeletal-diagnostic-ultrasound-imaging-for-thickness-measurement-of-four-principal-muscles-of-the-cervical-spine-a-reliability-and-agreement-study
#3
Cecilie Krage Øverås, Birgitte Lawaetz Myhrvold, Gro Røsok, Eli Magnesen
BACKGROUND: The reliability of musculoskeletal diagnostic ultrasound imaging (MSK-DUSI) for the evaluation of neck musculature has been sparsely documented in the research literature. Until now, research has featured a limited number of subjects and only few studies have tested for both inter- and intra-reliability using appropriate methodology. METHODS: Four examiners conducted an inter- and intra-rater reliability and agreement study. Fifty females with and without neck pain (NP) between the ages of 20-70 were recruited from October 2014 to April 2015...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28039497/synergistic-effects-of-fenbendazole-and-metronidazole-against-giardia-muris-in-swiss-mice-naturally-infected
#4
Renata Coltro Bezagio, Cristiane Maria Colli, Liara Izabela Lopes Romera, Érika Cristina Ferreira, Ana Lúcia Falavigna-Guilherme, Mônica Lúcia Gomes
In this study were proposed different protocols for the treatment of mice naturally infected with Giardia muris. Male Swiss mice were divided into seven groups, with five animals each, in a blind, controlled, randomized by drawing lots and once-repeated experiment. Parasite detection and cure control were performed using the Faust method and search by trophozoites in the intestinal mucosa. Clinical parameters (weight, water and feed consumption, elimination of excreta, aspect of the fur and feces) were also evaluated...
December 30, 2016: Parasitology Research
https://www.readbyqxmd.com/read/28026895/self-fertilization-long-distance-flash-invasion-and-biogeography-shape-the-population-structure-of-pseudosuccinea-columella-at-the-worldwide-scale
#5
M Lounnas, A C Correa, A A Vázquez, A Dia, J S Escobar, A Nicot, J Arenas, R Ayaqui, M P Dubois, T Gimenez, A Gutiérrez, C González-Ramírez, O Noya, L Prepelitchi, N Uribe, C Wisnivesky-Colli, M Yong, P David, E S Loker, P Jarne, J P Pointier, S Hurtrez-Boussès
Population genetic studies are efficient for inferring the invasion history based on a comparison of native and invasive populations, especially when conducted at species scale. An expected outcome in invasive populations is variability loss, and this is especially true in self-fertilizing species. We here focus on the self-fertilizing Pseudosuccinea columella, an invasive hermaphroditic freshwater snail that has greatly expanded its geographic distribution and that acts as intermediate host of Fasciola hepatica, the causative agent of human and veterinary fasciolosis...
December 27, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28005757/correction-of-pterygium-colli-in-turner-syndrome-a-clinical-report-and-review-of-the-surgical-management
#6
Richard Ben Lou, Petros Konofaos, Robert D Wallace
The aim of surgery for pterygium colli (PC) is to correct the contour deformity, redistribute or remove the horizontal excess of skin, address the abnormal posterior hairline, avoid excessive scarring, and prevent recurrence. The purpose of this study is to review the available methods to correct the deformity and highlight a recent patient performed by the senior author. A modified bilateral Z-plasty technique was used for correcting PC on a 5-year-old African American girl diagnosed with Turner syndrome. The patient had an uneventful postoperative period and satisfactory functional and esthetic results were demonstrated at 1 year follow-up...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27999235/drug-resistant-tuberculosis-in-naples-2008-2013
#7
Annalisa Del Giudice, Alessandro Mustazzolu, Angelo Iacobino, Rossella Perna, Riccardo Smeraglia, Rachele Marino, Lanfranco Fattorini, Giulia Santoro
BACKGROUND: Drug-resistant tuberculosis (TB) is a serious threat in industrialized countries, but information from Southern Italy is lacking. Here, we present the results of a retrospective study of TB cases diagnosed in 2008-2013 in Naples, the largest city in Southern Italy. METHODS: Six hundred ninety Mycobacterium tuberculosis strains were isolated at the Ospedali dei Colli of Naples, and resistance to first-line and second-line drugs was determined. RESULTS: Multidrug-resistant (MDR) TB increased from 2008 to 2013, with 77...
October 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27999154/pectinate-ligament-dysplasia-in-the-border-collie-hungarian-vizsla-and-golden-retriever
#8
James A C Oliver, Abel B Ekiri, Cathryn S Mellersh
Pectinate ligament dysplasia (PLD) is significantly associated with primary closed angle glaucoma (PCAG) in several dog breeds. Gonioscopy screening for PLD is advised in breeds in which PLD and PCAG are particularly prevalent in order that affected dogs may be eliminated from the breeding population. The Border Collie (BC), Hungarian Vizsla (HV) and Golden Retriever (GR) breeds are currently under investigation for PLD by the British Veterinary Association/Kennel Club/International Sheep Dog Society (BVA/KC/ISDS) Eye Scheme...
December 20, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27992655/use-of-20-intravenous-lipid-emulsion-for-the-treatment-of-loperamide-toxicosis-in-a-collie-homozygous-for-the-abcb1-1%C3%A2-mutation
#9
Whitney M Long, Virginia B Sinnott, Kiko Bracker, Danielle Thomas
OBJECTIVE: To describe the successful treatment of loperamide toxicosis in a dog using intravenous lipid emulsion (ILE). CASE SUMMARY: An 8-month-old male neutered Rough Collie weighing 20.0 kg was given a total dose of 0.75 mg/kg loperamide over 3 days as treatment for diarrhea. The dog was subsequently evaluated for signs of dull mentation, anxiety, ptyalism and ataxia, thought to be a result of loperamide intoxication. The dog was treated with a 1.5 mL/kg IV bolus of 20% ILE solution followed by 0...
December 19, 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27990259/anterior-single-odontoid-screw-placement-for-type-ii-odontoid-fractures-our-modified-surgical-technique-and-initial-results-in-a-cohort-study-of-15-patients
#10
Binod Bhattarai, Sunil Munakomi, Karuna Tamrakar, Pramod Kumar Chaudhary
Objective: Anterior odontoid screw fixation for type II odontoid fracture is the ideal management option. However in the context of unavailability of an O-arm or neuro-navigation and poor images from the available C-arm may be an obstacle to ideal trajectory and placement of the odontoid screw. We herein detail  our surgical technique so as to ensure a correct trajectory and subsequent good fusion in Type II odontoid fractures. This may be advantageous  in clinical set ups lacking state of the art facilities...
2016: F1000Research
https://www.readbyqxmd.com/read/27986516/effects-of-withdrawal-from-repeated-phencyclidine-administration-on-behavioural-function-and-brain-arginine-metabolism-in-rats
#11
Logan T Knox, Yu Jing, Jamal Bawazier-Edgecombe, Nicola D Collie, Hu Zhang, Ping Liu
Phencyclidine (PCP) induces behavioural changes in humans and laboratory animals that resemble positive and negative symptoms, and cognitive impairments in schizophrenia. It has been shown repeated treatment of PCP leading to persistent symptoms even after the drug discontinuation, and there is a growing body of evidence implicating altered arginine metabolism in the pathogenesis of schizophrenia. The present study investigated the effects of withdrawal from repeated daily injection of PCP (2mg/kg) for 12 consecutive days on animals'behavioural performance and arginine metabolism in the hippocampus and prefrontal cortex in male young adult rats...
December 13, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27969771/tct-42-transcatheter-echo-guided-mitral-valve-repair-with-neochord-implantation-for-posterior-leaflet-disease-results-from-neochord-independent-international-registry
#12
Andrea Colli, Laura Besola, Eleonora Bizzotto, Erica Manzan, Fabio Zucchetta, Demetrio Pittarello, Kestutis Rucinskas, Andrius Aidietis, Vilius Janusauskas, Diana Zakarkaite, Agne Drasutiene, Douglas Gibson, Bernd Danner, Horst Sievert, Katarzyna Kurnicka, Krzystof Wrobel, Stefano Salizzoni, Mauro Rinaldi, Krzystof Wrobel, Carlo Savini, Davide Pacini, Mariano Cefarelli, Gino Gerosa
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27965094/isoform-specific-regulation-of-osteogenic-factors-by-polypeptide-n-acetylgalactosaminyltransferases-1-and-4
#13
Juan Tang, Hanxi Zheng, Ling Chen, Shangshang Gao, Xiaorui Shi, Jingjing Liu, Lan Xu
The family of UDP-GalNAc polypeptide: N-Acetylgalactosaminlytransfersases (ppGalNAcTs) catalyzes the initial step of O-linked protein glycosylation. Mucin-type O-glycoproteins are abundant in the bone and may play an important role in osteogenesis. Herein, we examined the effects of ppGalNAc-T isoforms on osteogenesis of MC3T3-E1 pre-osteoblasts. We found that ppGalNAc-T1 and -T4 isoforms were highly expressed during osteogenesis of MC3T3-E1 and their knockdown by short hairpin RNA (shRNA) decreased osteoblast formation and bone mineralization...
December 11, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27941298/degenerative-myelopathy-in-the-collie-breed-a-retrospective-immunohistochemical-analysis-of-superoxide-dismutase-1-in-an-affected-rough-collie-and-a-molecular-epidemiological-survey-of-the-sod1-c-118g-a-mutation-in-japan
#14
Moeko Kohyama, Masato Kitagawa, Hiroaki Kamishina, Yui Kobatake, Akira Yabuki, Mariko Sawa, Shusaku Kakita, Osamu Yamato
Canine degenerative myelopathy (DM) is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds. A DM-associated mutation of the canine superoxide dismutase 1 (SOD1) gene, designated as c.118G>A (p.E40K), has been implicated as one of pathogenetic determinants of the disease in many breeds, but it remains to be determined whether the c.118G>A mutation is responsible for development or progression of DM in Collies. Previously, a Rough Collie was diagnosed clinically and histopathologically as having DM in Japan, suggesting the possibility that the Collie breed may be predisposed to DM due to the high frequency of c...
December 12, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27940330/in-the-shadows-phylogenomics-and-coalescent-species-delimitation-unveil-cryptic-diversity-in-a-cerrado-endemic-lizard-squamata-tropidurus
#15
Fabricius M C B Domingos, Guarino R Colli, Alan Lemmon, Emily Moriarty Lemmon, Luciano B Beheregaray
The recognition of cryptic diversity within geographically widespread species is gradually becoming a trend in the highly speciose Neotropical biomes. The statistical methods to recognise such cryptic lineages are rapidly advancing, but have rarely been applied to genomic-scale datasets. Herein, we used phylogenomic data to investigate phylogenetic history and cryptic diversity within Tropidurus itambere, a lizard endemic to the Cerrado biodiversity hotspot. We applied a series of phylogenetic methods to reconstruct evolutionary relationships and a coalescent Bayesian species delimitation approach (BPP) to clarify species limits...
December 9, 2016: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/27917507/evidence-of-a-genomic-insertion-in-intron-2-of-sod1-causing-allelic-drop-out-during-routine-diagnostic-testing-for-canine-degenerative-myelopathy
#16
M E Turba, R Loechel, E Rombolà, G Gandini, F Gentilini
Degenerative myelopathy is a severe and progressive neurodegenerative disease and, in the majority of breeds, is associated with the c.118G>A substitution in exon 2 of the canine superoxide dismutase 1 (SOD1) gene. Our laboratories have been engaged in determining the cause of many discordant findings between the parental and the offspring genotypes found by different laboratories. In both cases, the discordant findings refer to actual heterozygous dogs that had been typed as homozygous for the variant allele...
December 4, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27904957/neck-pain-and-acute-dysphagia
#17
João Simões, José Romão, Anita Cunha, Sofia Paiva, António Miguéis
The acute tendinitis of the longus colli muscle is an unusual diagnosis in the cases of acute dysphagia with cervical pain. Is a self-limiting condition caused by abnormal calcium hydroxyapatite deposition in the prevertebral space and can cause pharyngeal swelling with impaired swallow. It is absolutely critical to make the differential diagnosis with deep cervical infections in order to avoid invasive treatments.
November 30, 2016: Dysphagia
https://www.readbyqxmd.com/read/27879369/response-assessment-criteria-and-their-applications-in-lymphoma-part-2
#18
REVIEW
Mateen C Moghbel, Erik Mittra, Andrea Gallamini, Ryan Niederkohr, Delphine L Chen, Katherine Zukotynski, Helen Nadel, Lale Kostakoglu
Interim and end-of-treatment PET/CT have become central to the evaluation of Hodgkin and non-Hodgkin lymphoma. This review article seeks to aid clinical decision making by providing an overview of available data on the diagnostic and prognostic value of PET/CT imaging for response assessment and pretransplant evaluation in lymphoma. The relative strengths and limitations of these techniques in various disease subtypes and clinical scenarios are explored, along with their current standards for reporting and latest developments...
January 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27875056/opioid-nsaid-and-otc-analgesic-medications-for-dental-procedures-pearl-network-findings
#19
Ying Jo Wong, James Keenan, Keith Hudson, Henry Bryan, Frederick Naftolin, Van P Thompson, Ronald G Craig, Don Vena, Damon Collie, Hongyu Wu, Abigail G Matthews, Ashley C Grill, Frederick A Curro
OBJECTIVE: Dental treatment is often categorized as a moderately or severely painful experience; however, no clinical data reported by the patient and dentist currently exists to support this degree of pain. This has contributed possibly to the overprescribing of analgesics, in particular the opioid class of medications. The primary objective of the study was to document the dentists' postprocedural prescriptions and recommendations for analgesic medications and their effectiveness for a 5-day period...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27867408/reliability-of-a-measurement-method-for-the-cross-sectional-area-of-the-longus-colli-using-real-time-ultrasound-imaging
#20
Cliona O'Riordan, Pepijn Van De Ven, John Nelson, Karen McCreesh, Amanda Clifford
OBJECTIVE: Real-time ultrasound imaging is an established objective outcome measurement with proven reliability. However, it is still largely biased by user-ability. Published research in the area of real-time ultrasound imaging reliability in the cervical region and in particular the deep cervical flexors is quite sparse. The purpose of this investigation was to examine if a novice ultrasound user could agree favourably with an experienced ultrasound sonographer in measuring the cross-sectional area of the longus colli...
August 2016: Ultrasound: Journal of the British Medical Ultrasound Society
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