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https://www.readbyqxmd.com/read/29031705/laparoscopic-repair-of-large-hiatal-hernia-without-the-need-for-esophageal-lengthening-with-low-morbidity-and-rare-symptomatic-recurrence
#1
Farzaneh Banki, Chandni Kaushik, David Roife, Kyle G Mitchell, Charles C Miller
The aim of this study was to assess symptomatic recurrence in patients who underwent a laparoscopic repair of large hiatal hernia without an esophageal lengthening procedure. Patients who underwent a laparoscopic repair of a large hiatal hernia from September 2009 to September 2015 by a single surgeon were identified in the retrospective review. The patients were followed up prospectively by the operating surgeon using a structured questionnaire, administered by telephone, to assess the symptoms. Symptomatic recurrence was defined as the requirement for a reoperative procedure for symptomatic recurrent hiatal hernia...
May 29, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29026548/erythromelanosis-follicularis-faciei-et-colli-with-reticulated-hyperpigmentation-of-the-extremities
#2
Fahad Mohammad Al-Saif, Abdullah Ali Baqays, Hadeel Fahad AlSaif, Ahmed Abdullah Alhumidi
Erythromelanosis follicularis faciei et colli (EFFC) is a distinct, rare, and underdiagnosed condition of unknown etiology that is characterized by well-demarcated erythema, hyperpigmentation, and follicular papules. The pigmentation is usually on both maxillary, preauricular regions, and the cheeks. We report a case of a 12-year-old boy with EFFC that was associated with reticulated pigmentation of the extremities.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29025962/therapeutic-hypothermia-in-acute-traumatic-spinal-cord-injury
#3
James Collis
Therapeutic hypothermia is already widely acknowledged as an effective neuroprotective intervention, especially within the acute care setting in relation to conditions such as cardiac arrest and neonatal encephalopathy. Its multifactorial mechanisms of action, including lowering metabolic rate and reducing acute inflammatory cellular processes, ultimately provide protection for central nervous tissue from continuing injury following ischaemic or traumatic insult. Its clinical application within acute traumatic spinal cord injury would therefore seem very plausible, it having the potential to combat the pathophysiological secondary injury processes that can develop in the proceeding hours to days following the initial injury...
October 12, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29023692/lower-socioeconomic-status-is-independently-associated-with-shorter-survival-in-hodgkin-lymphoma-patients-an-analysis-from-the-brazilian-hodgkin-lymphoma-registry
#4
Irene Biasoli, Nelson Castro, Marcia Delamain, Talita Silveira, James Farley, Belinda Pinto Simões, Cristiana Solza, Monica Praxedes, Otávio Baiocchi, Rafael Gaiolla, Fernanda Franceschi, Caroline Bonamin Sola, Carla Boquimpani, Nelma Clementino, Guilherme Fleury Perini, Kátia Pagnano, Giovana Steffenello, Jacques Tabacof, Gilberto de Freitas Colli, Andrea Soares, Carmino de Souza, Carlos Sérgio Chiattone, Ronir Raggio Luiz, Cristiane Milito, José Carlos Morais, Nelson Spector
Socioeconomic status (SES) is a well-known determinant of outcomes in cancer. The purpose of this study was to analyze the impact of the SES on the outcomes of Hodgkin lymphoma (HL) patients from the Brazilian Prospective HL Registry. SES stratification was done using an individual asset/education-based household index. A total of 624 classical HL patients with diagnosis from January/2009 to December/2014, and treated with ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine), were analyzed. The median follow-up was 35...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29019817/early-claim-modifiable-factors-associated-with-return-to-work-self-efficacy-among-workers-injured-at-work-are-there-differences-between-psychological-and-musculoskeletal-injuries
#5
Oliver Black, Malcolm R Sim, Alexander Collie, Peter Smith
OBJECTIVE: The objective of this study was to investigate modifiable early-injury factors which are associated with self-efficacy to return-to-work (RTW-SE) and explore whether these factors are different for people with psychological or upper-body musculoskeletal (UB-MSK) injuries. METHODS: The study used a sample of workers with a UB-MSK (N = 244) or psychological (N = 113) injury who were off work. Differences between injury types were investigated across variables related to: (1) communication with RTW stakeholders; and (2) components of the job itself...
October 10, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29018980/phonographic-detection-of-mechanical-heart-valve-thrombosis
#6
Simone Tosoni, Vincenzo Tarzia, Andrea Colli, Gino Gerosa, Andrea Bagno
The formation of thrombotic deposits affects the functionality of mechanical prosthetic heart valves; as a consequence, mechanical valves thrombosis needs early diagnosis to prevent thromboembolic events. This paper compares the acoustic signals produced by two commercial bileaflet mechanical heart valves in the closing phase to detect the presence of thrombi. The closing sounds were recorded in vitro by means of a phonocardiographic device under different hydrodynamic conditions. Thrombotic deposits of different weight and shape were applied onto the valve leaflet and the annular housing, until the movement of one leaflet was completely blocked...
October 10, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28993667/the-global-distribution-of-tetrapods-reveals-a-need-for-targeted-reptile-conservation
#7
Uri Roll, Anat Feldman, Maria Novosolov, Allen Allison, Aaron M Bauer, Rodolphe Bernard, Monika Böhm, Fernando Castro-Herrera, Laurent Chirio, Ben Collen, Guarino R Colli, Lital Dabool, Indraneil Das, Tiffany M Doan, Lee L Grismer, Marinus Hoogmoed, Yuval Itescu, Fred Kraus, Matthew LeBreton, Amir Lewin, Marcio Martins, Erez Maza, Danny Meirte, Zoltán T Nagy, Cristiano de C Nogueira, Olivier S G Pauwels, Daniel Pincheira-Donoso, Gary D Powney, Roberto Sindaco, Oliver J S Tallowin, Omar Torres-Carvajal, Jean-François Trape, Enav Vidan, Peter Uetz, Philipp Wagner, Yuezhao Wang, C David L Orme, Richard Grenyer, Shai Meiri
The distributions of amphibians, birds and mammals have underpinned global and local conservation priorities, and have been fundamental to our understanding of the determinants of global biodiversity. In contrast, the global distributions of reptiles, representing a third of terrestrial vertebrate diversity, have been unavailable. This prevented the incorporation of reptiles into conservation planning and biased our understanding of the underlying processes governing global vertebrate biodiversity. Here, we present and analyse the global distribution of 10,064 reptile species (99% of extant terrestrial species)...
October 9, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28985567/genetic-and-functional-drivers-of-diffuse-large-b%C3%A2-cell-lymphoma
#8
Anupama Reddy, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, Annika Pasanen, Leo Meriranta, Marja-Liisa Karjalainen-Lindsberg, Peter Nørgaard, Mette Pedersen, Anne O Gang, Estrid Høgdall, Tayla B Heavican, Waseem Lone, Javeed Iqbal, Qiu Qin, Guojie Li, So Young Kim, Jane Healy, Kristy L Richards, Yuri Fedoriw, Leon Bernal-Mizrachi, Jean L Koff, Ashley D Staton, Christopher R Flowers, Ora Paltiel, Neta Goldschmidt, Maria Calaminici, Andrew Clear, John Gribben, Evelyn Nguyen, Magdalena B Czader, Sarah L Ondrejka, Angela Collie, Eric D Hsi, Eric Tse, Rex K H Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, William W L Choi, Andrew M Evens, Monika Pilichowska, Manju Sengar, Nishitha Reddy, Shaoying Li, Amy Chadburn, Leo I Gordon, Elaine S Jaffe, Shawn Levy, Rachel Rempel, Tiffany Tzeng, Lanie E Happ, Tushar Dave, Deepthi Rajagopalan, Jyotishka Datta, David B Dunson, Sandeep S Dave
Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity poses a major barrier to understanding the genetic basis of the disease and its response to therapy. Here, we performed an integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of 1,001 DLBCL patients to comprehensively define the landscape of 150 genetic drivers of the disease. We characterized the functional impact of these genes using an unbiased CRISPR screen of DLBCL cell lines to define oncogenes that promote cell growth...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28977505/beating-heart-mitral-valve-repair-with-neochordae-implantation-real-time-monitoring-of-haemodynamic-recovery
#9
Andrea Colli, Eleonora Bizzotto, Demetrio Pittarello, Gino Gerosa
Transapical off-pump mitral valve repair with neochord implantation has been approved for patients presenting with severe mitral regurgitation due to leaflet prolapse or flail. The procedure is performed under real-time 2D and 3D transoesophageal echocardiography for both implantation and neochordae tension adjustment allowing real-time monitoring of haemodynamic recovery.
July 13, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28971337/a-hill-gastropexy-combined-with-nissen-fundoplication-appears-equivalent-to-a-collis-nissen-in-the-management-of-short-esophagus
#10
Oliver C Bellevue, Brian E Louie, Zeljka Jutric, Alexander S Farivar, Ralph W Aye
INTRODUCTION: A Collis gastroplasty combined with a Nissen fundoplication is commonly used when a shortened esophagus is encountered. An alternative combines intra-abdominal fixation of the gastroesophageal junction via a Hill gastropexy with a Nissen fundoplication to maintain length and avoid juxtaposing acid-secreting tissue against the diseased esophagus. METHODS: A retrospective case-controlled analysis of 106 consecutive patients with short esophagus undergoing Hill-Nissen (HN) or Collis-Nissen (CN) was compared to a cohort of 105 matched patients without short esophagus undergoing primary Nissen fundoplication (NF)...
October 2, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28969328/viscoelastometry-guided-fresh-frozen-plasma-infusion-for-postpartum-haemorrhage-obs2-an-observational-study
#11
P W Collins, R Cannings-John, D Bruynseels, S Mallaiah, J Dick, C Elton, A Weeks, J Sanders, N Aawar, J Townson, K Hood, J Hall, K Harding, R Gauntlett, R Collis
Background: Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. Based on data from trauma studies, empirical infusions of fresh frozen plasma (FFP) are often given during severe PPH if coagulation tests are unavailable. This study observed a cohort of women with moderate/severe PPH in whom FFP infusion was guided by the use of viscoelastometric point-of-care testing (VE-POCT) and clinical assessment. Methods: Women were enrolled into this observational study when blood loss was measured or suspected to be about 1000 mL...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28969312/viscoelastometric-guided-early-fibrinogen-concentrate-replacement-during-postpartum-haemorrhage-obs2-a-double-blind-randomized-controlled-trial
#12
P W Collins, R Cannings-John, D Bruynseels, S Mallaiah, J Dick, C Elton, A D Weeks, J Sanders, N Aawar, J Townson, K Hood, J E Hall, R E Collis
Background: Postpartum haemorrhage (PPH) can be exacerbated by haemostatic failure. We hypothesized that early fibrinogen replacement, guided by viscoelastometric testing, reduces blood product usage and bleed size. Methods: Women with PPH 1000-1500 ml were enrolled. If Fibtem A5 was ≤15 mm and bleeding continued, subjects were randomized to fibrinogen concentrate or placebo. The primary outcome compared the number of units of red blood cells, plasma, cryoprecipitate and platelets transfused...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28964511/the-nature-and-burden-of-occupational-injury-among-first-responder-occupations-a-retrospective-cohort-study-in-australian-workers
#13
Shannon E Gray, Alex Collie
INTRODUCTION: Workers in first responder (FR) occupations are at heightened risk for workplace injury given their exposure to physical/psychological hazards. This study sought to (1) characterise the occupational risk of injury; (2) determine factors associated with injury; and (3) characterise the burden of injury-related disability in police, ambulance officers, fire/emergency workers, compared with other occupations. METHODS: A retrospective cohort of 2,439,624 claims occurring between July 2003 and June 2012 was extracted from the Australian National Dataset for Compensation-Based Statistics...
September 23, 2017: Injury
https://www.readbyqxmd.com/read/28964121/effects-of-mechanical-feedback-on-the-stability-of-cardiac-scroll-waves-a-bidomain-electro-mechanical-simulation-study
#14
P Colli Franzone, L F Pavarino, S Scacchi
In this work, we investigate the influence of cardiac tissue deformation on re-entrant wave dynamics. We have developed a 3D strongly coupled electro-mechanical Bidomain model posed on an ideal monoventricular geometry, including fiber direction anisotropy and stretch-activated currents (SACs). The cardiac mechanical deformation influences the bioelectrical activity with two main mechanical feedback: (a) the geometric feedback (GEF) due to the presence of the deformation gradient in the diffusion coefficients and in a convective term depending on the deformation rate and (b) the mechano-electric feedback (MEF) due to SACs...
September 2017: Chaos
https://www.readbyqxmd.com/read/28936190/oxytocin-and-opioid-receptor-gene-polymorphisms-associated-with-greeting-behavior-in-dogs
#15
Enikő Kubinyi, Melinda Bence, Dora Koller, Michele Wan, Eniko Pergel, Zsolt Ronai, Maria Sasvari-Szekely, Ádám Miklósi
Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between alleles and behavioral variables might be breed-specific...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28932445/structural-elucidation-of-a-hy-droxy-cineole-product-obtained-from-cytochrome-p450-monooxygenase-cyp101j2-catalysed-transformation-of-1-8-cineole
#16
Gavin E Collis, Birgit Unterweger, Geoff J Dumsday, Craig M Forsyth
1,8-Cineole is an abundant natural product that has the potential to be transformed into other building blocks that could be suitable alternatives to petroleum-based chemicals. Mono-hydroxy-lation of 1,8-cineole can potentially occur at eight different carbon sites around the bicyclic ring system. Using cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae B2, the hy-droxy-lation can be regioselectively directed at the C atom adjacent to the methyl-substituted quaternary bridgehead atom of 1,8-cineole...
July 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28927976/quality-of-life-outcomes-in-children-with-hirschsprung-disease
#17
Lucy Collins, Brennan Collis, Misel Trajanovska, Rija Khanal, John M Hutson, Warwick J Teague, Sebastian K King
BACKGROUND: Morbidity following repair of Hirschsprung disease (HD) is common. However, quality of life (QoL) results focused on HD children are contradictory. We aimed to measure QoL outcomes in HD children using validated questionnaires. METHODS: Patients with HD, managed at a large tertiary pediatric institution between 2004 and 2013, were identified. Parents completed validated questionnaires. Results were compared with published healthy population controls...
September 2, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28904785/genomic-timetree-and-historical-biogeography-of-caribbean-island-ameiva-lizards-pholidoscelis-teiidae
#18
Derek B Tucker, Stephen Blair Hedges, Guarino R Colli, Robert Alexander Pyron, Jack W Sites
The phylogenetic relationships and biogeographic history of Caribbean island ameivas (Pholidoscelis) are not well-known because of incomplete sampling, conflicting datasets, and poor support for many clades. Here, we use phylogenomic and mitochondrial DNA datasets to reconstruct a well-supported phylogeny and assess historical colonization patterns in the group. We obtained sequence data from 316 nuclear loci and one mitochondrial marker for 16 of 19 extant species of the Caribbean endemic genus Pholidoscelis...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28895788/association-between-serum-unmetabolized-folic-acid-concentrations-and-folic-acid-from-fortified-foods
#19
Cecília Zanin Palchetti, Clóvis Paniz, Eduardo de Carli, Dirce M Marchioni, Célia Colli, Josiane Steluti, Christine M Pfeiffer, Zia Fazili, Elvira Maria Guerra-Shinohara
OBJECTIVE: To investigate the association between serum unmetabolized folic acid (UMFA) concentrations and folic acid from fortified foods and nutrients known as dietary methyl-group donors (folate, methionine, choline, betaine and vitamins B2, B6 and B12) in participants exposed to mandatory fortification of wheat and maize flours with folic acid. METHODS: Cross-sectional study carried out with 144 healthy Brazilian participants, both sexes, supplement nonusers...
September 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28881018/urinary-incontinence-in-bitches-under-primary-veterinary-care-in-england-prevalence-and-risk-factors
#20
D G O'Neill, A Riddell, D B Church, L Owen, D C Brodbelt, J L Hall
OBJECTIVES: To estimate prevalence and demographic risk factors for urinary incontinence in bitches under primary veterinary care in England. METHODS: The study population included all bitches within the VetCompass database from September 1, 2009 to July 7, 2013. Electronic patient records were searched for urinary incontinence cases and additional demographic and clinical information was extracted. RESULTS: Of 100,397 bitches attending 119 clinics in England, an estimated 3108 were diagnosed with urinary incontinence...
September 7, 2017: Journal of Small Animal Practice
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