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https://www.readbyqxmd.com/read/29453521/safety-and-feasibility-of-breast-lesion-localization-using-magnetic-seeds-magseed-a-multi-centre-open-label-cohort-study
#1
James R Harvey, Yit Lim, John Murphy, Miles Howe, Julie Morris, Amit Goyal, Anthony J Maxwell
PURPOSE: Wire localization has several disadvantages, notably wire migration and difficulty scheduling the procedure close to surgery. Radioactive seed localization overcomes these disadvantages, but implementation is limited due to radiation safety requirements. Magnetic seeds potentially offer the logistical benefits and transcutaneous detection equivalence of a radioactive seed, with easier implementation. This study was designed to evaluate the feasibility and safety of using magnetic seeds for breast lesion localization...
February 16, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29452816/transnasal-humidified-rapid-insufflation-ventilatory-exchange-for-oxygenation-of-children-during-apnoea-a-prospective-randomised-controlled-trial
#2
T Riva, T H Pedersen, S Seiler, N Kasper, L Theiler, R Greif, M Kleine-Brueggeney
BACKGROUND: Transnasal humidified rapid insufflation ventilatory exchange (THRIVE) comprises the administration of heated, humidified, and blended air/oxygen mixtures via nasal cannula at rates of ≥2 litres kg -1 min -1 . The aim of this randomized controlled study was to evaluate the length of the safe apnoea time using THRIVE with two different oxygen concentrations (100% vs 30% oxygen) compared with standard low-flow 100% oxygen administration. METHODS: Sixty patients, aged 1-6 yr, weighing 10-20 kg, undergoing general anaesthesia for elective surgery, were randomly allocated to receive one of the following oxygen administration methods during apnoea: 1) low-flow 100% oxygen at 0...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29451431/study-protocol-of-hypoalgesic-effects-of-low-frequency-and-burst-modulated-alternating-currents-on-healthy-individuals
#3
Érika Patrícia Rampazo da Silva, Viviane Ribeiro da Silva, Anabelly Sato Bernardes, Fabio Massao Matuzawa, Richard Eloin Liebano
The aim of the study will be to compare different types of analgesic electrical currents in relation to the pressure pain threshold and sensory comfort in healthy individuals. A total of 100 individuals will be randomly assigned to four groups: transcutaneous electrical nerve stimulation, interferential current, Aussie current or placebo. The electrical stimulation will be administered with a strong level for 30 min and to the placebo group, the electrodes will be positioned while the equipment will remain switched off...
February 16, 2018: Pain Management
https://www.readbyqxmd.com/read/29447711/no-355-physiologic-basis-of-pain-in-labour-and-delivery-an-evidence-based-approach-to-its-management
#4
Julie Bonapace, Guy-Paul Gagné, Nils Chaillet, Raymonde Gagnon, Emmanuelle Hébert, Sarah Buckley
OBJECTIVE: To review the evidence relating to nonpharmacological approaches in the management of pain during labour and delivery. To formulate recommendations for the usage of nonpharmacological approaches to pain management. OPTIONS: Nonpharmacological methods available for pain management during labour and delivery exist. These should be included in the counselling and care of women. EVIDENCE: PubMed and Medline were searched for articles in French and English on subjects related to "breastfeeding," "pain," "epidural," "anaesthesia," "analgesia," "labour," "labor," and combined with "gate control theory," "alternative therapies," "massage," "position," "mobility," "TENS," "bathing," "DNIC," "acupuncture," "acupressure," "sterile water injection," "higher center," "control mind," "cognitive structuring," "holistic health," "complementary therapy(ies)," "breathing," "relaxation," "mental imagery," "visualization," "mind focusing," "hypnosis," "auto-hypnosis," "sophrology," "mind and body interventions," "music," "odors," "biofeedback," "Lamaze," "Bonapace," "prenatal training," "gymnastic," "chanting," "haptonomy," "environment," "transcutaneous electrical stimulus-stimulation," "antenatal education," "support," "continuous support," "psychosocial support," "psychosomatic medicine," "supportive care," "companion," "intrapartum care," "nurse," "midwife(ves)," "father," "doula," "caregiver," " hormones," "oxytocin," "endorphin," "prolactin," "catecholamine," "adrenaline," and "noradrenaline" from 1990 to December 2015...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29444807/hypoxic-challenge-testing-fitness-to-fly-in-children-with-complex-congenital-heart-disease
#5
Nitha N Naqvi, Victoria L Doughty, Luke Starling, Rodney C Franklin, Simon Ward, Piers E F Daubeney, Ian M Balfour-Lynn
OBJECTIVE: Commercial airplanes fly with an equivalent cabin fraction of inspired oxygen of 0.15, leading to reduced oxygen saturation (SpO 2 ) in passengers. How this affects children with complex congenital heart disease (CHD) is unknown. We conducted Hypoxic Challenge Testing (HCT) to assess need for inflight supplemental oxygen. METHODS: Children aged <16 years had a standard HCT. They were grouped as (A) normal versus abnormal baseline SpO 2 (≥95% vs <95%) and (B) absence versus presence of an actual/potential right-to-left (R-L) shunt...
February 14, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29442536/a-new-surgical-technique-for-excision-of-orbital-cavernous-hemangioma-a-15-year-experience
#6
Abbas Bagheri, Reza Jafari, Hosein Salour, Maryam Aletaha, Shahin Yazdani, Sepehr Baghi
PURPOSE: To present a new surgical technique for excision of orbital cavernous hemangiomas (CHs). METHODS: This retrospective case series study included patients with orbital CH who were operated from 2001 to 2016 at our referral center. Epidemiologic data, symptoms, signs, and images were reviewed from patients' files with at least one year of follow-up. Surgical results and complications were documented. We used the "index finger dissection" technique without grasping the tumor for release of adhesions and its removal...
February 14, 2018: Orbit
https://www.readbyqxmd.com/read/29439703/characterizing-the-transcutaneous-electrical-recruitment-of-lower-leg-afferents-in-healthy-adults-implications-for-non-invasive-treatment-of-overactive-bladder
#7
Eshani Sharan, Kelly Hunter, Magdy Hassouna, Paul B Yoo
BACKGROUND: As a potential new treatment for overactive bladder (OAB), we investigated the feasibility of non-invasively activating multiple nerve targets in the lower leg. METHODS: In healthy participants, surface electrical stimulation (frequency = 20 Hz, pulse width = 200 μs) was used to target the tibial nerve, saphenous nerve, medial plantar nerve, and lateral plantar nerve. At each location, the stimulation amplitude was increased to define the thresholds for evoking (1) cutaneous sensation, (2) target nerve recruitment and (3) maximum tolerance...
February 13, 2018: BMC Urology
https://www.readbyqxmd.com/read/29439307/ultrasound-combined-transcutaneous-electrical-nerve-stimulation-ultratens-versus-phonophoresis-of-piroxicam-php-in-symptomatic-knee-osteoarthritis-a-randomized-double-blind-controlled-trial
#8
Jariya Boonhong, Phitsanu Suntornpiyapan
BACKGROUND: Ultrasound combined with transcutaneous electrical nerve stimulation (UltraTENS) and phonophoresis of piroxicam (PhP) are combined modality therapy that frequently used in musculoskeletal pain including knee osteoarthritis (OA). But it is lack of a good clinical trial to prove and compare their effects. OBJECTIVE: To compare the effects of UltraTENS with PhP on mild to moderate degree of symptomatic knee OA. METHODS: Sixty-one patients (55 women), mean age of 63...
February 2, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29437598/bilateral-transcutaneous-electrical-nerve-stimulation-improves-lower-limb-motor-function-in-subjects-with-chronic-stroke-a-randomized-controlled-trial
#9
Patrick W H Kwong, Gabriel Y F Ng, Raymond C K Chung, Shamay S M Ng
BACKGROUND: Transcutaneous electrical nerve stimulation (TENS) has been used to augment the efficacy of task-oriented training (TOT) after stroke. Bilateral intervention approaches have also been shown to be effective in augmenting motor function after stroke. The purpose of this study was to compare the efficacy of bilateral TENS combined with TOT versus unilateral TENS combined with TOT in improving lower-limb motor function in subjects with chronic stroke. METHODS AND RESULTS: Eighty subjects were randomly assigned to bilateral TENS+TOT or to unilateral TENS+TOT and underwent 20 sessions of training over a 10-week period...
February 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29432663/transcutaneous-bilirubinometry-should-be-carried-out-in-newborn-infants-at-least-seven-hours-after-phototherapy-finishes
#10
Agah Akin, S Umit Sarici, Murat Ozcan, Melis Akpinar, Demet Altun, Yuksel Yasartekin, Muhittin A Serdar, Dilek Sarici
Bilirubin rebound, which is a reincrease in serum bilirubin levels after the cessation of phototherapy, may develop due to variations in the rates of bilirubin production and clearance. The most commonly used method for testing bilirubin rebound is measuring total serum bilirubin (TSB) levels, because transcutaneous bilirubin (TcB) gives false negative results in newborn infants receiving phototherapy or when phototherapy has just finished. However, TcB is a more preferable method, because TSB is invasive and time consuming...
February 12, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29429820/direct-bone-conduction-stimulation-ipsilateral-effect-of-different-transducer-attachments-in-active-transcutaneous-devices
#11
Cristina Rigato, Sabine Reinfeldt, Bo Håkansson, Karl-Johan Fredén Jansson, Erik Renvall, Måns Eeg-Olofsson
Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the contact to bone has not been addressed yet. The aim of this study is therefore to compare how different attachment methods of the transducer to the bone for direct stimulation affect the ear canal sound pressure and vibration transmission to the ipsilateral cochlea...
January 31, 2018: Hearing Research
https://www.readbyqxmd.com/read/29426587/transcutaneous-electrical-nerve-stimulation-and-interferential-current-demonstrate-similar-effects-in-relieving-acute-and-chronic-pain-a-systematic-review-with-meta-analysis
#12
REVIEW
Camila Cadena de Almeida, Vinicius Z Maldaner da Silva, Gerson Cipriano Júnior, Richard Eloin Liebano, Joao Luiz Quagliotti Durigan
BACKGROUND: Transcutaneous electrical nerve stimulation and interferential current have been widely used in clinical practice. However, a systematic review comparing their effects on pain relief has not yet been performed. OBJECTIVES: To investigate the effects of transcutaneous electrical nerve stimulation and interferential current on acute and chronic pain. METHODS: We use Pubmed, Embase, LILACS, PEDro and Cochrane Central Register of Controlled Trials as data sources...
February 2, 2018: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29421065/capsaicin-sensitive-cutaneous-primary-afferents-convey-electrically-induced-itch-in-humans
#13
Hjalte H Andersen, Antoinette I M van Laarhoven, Frederik D Justesen, Jacob B Pedersen, Laurits L Sørensen, Line P Jensen, Lars Arendt-Nielsen
Specially designed transcutaneous electrical stimulation paradigms can be used to provoke experimental itch. However, it is unclear which primary afferent fibers are activated and whether they represent pathophysiologically relevant, C-fiber mediated itch. Since low-threshold mechano-receptors have recently been implicated in pruriception we aimed to characterize the peripheral primary afferent subpopulation conveying electrically evoked itch in humans (50Hz stimulation, 100μs square pulses, stimulus-response function to graded stimulus intensity)...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29420830/acellular-therapeutic-approach-for-heart-failure-in%C3%A2-vitro-production-of-extracellular-vesicles-from-human-cardiovascular-progenitors
#14
Nadia El Harane, Anaïs Kervadec, Valérie Bellamy, Laetitia Pidial, Hany J Neametalla, Marie-Cécile Perier, Bruna Lima Correa, Léa Thiébault, Nicolas Cagnard, Angéline Duché, Camille Brunaud, Mathilde Lemitre, Jeanne Gauthier, Alexandra T Bourdillon, Marc P Renault, Yeranuhi Hovhannisyan, Solenne Paiva, Alexandre R Colas, Onnik Agbulut, Albert Hagège, Jean-Sébastien Silvestre, Philippe Menasché, Nisa K E Renault
Aims: We have shown that extracellular vesicles (EVs) secreted by embryonic stem cell-derived cardiovascular progenitor cells (Pg) recapitulate the therapeutic effects of their parent cells in a mouse model of chronic heart failure (CHF). Our objectives are to investigate whether EV released by more readily available cell sources are therapeutic, whether their effectiveness is influenced by the differentiation state of the secreting cell, and through which mechanisms they act. Methods and results: The total EV secreted by human induced pluripotent stem cell-derived cardiovascular progenitors (iPSC-Pg) and human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) were isolated by ultracentrifugation and characterized by Nanoparticle Tracking Analysis, western blot, and cryo-electron microscopy...
February 6, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29415556/patterns-of-use-survival-and-prognostic-factors-in-patients-receiving-home-mechanical-ventilation-in-western-australia-a-single-centre-historical-cohort-study
#15
Geak Poh Tan, Nigel McArdle, Satvinder Singh Dhaliwal, Jane Douglas, Clare Siobhan Rea, Bhajan Singh
Home mechanical ventilation (HMV) is used in a wide range of disorders associated with chronic hypoventilation. We describe the patterns of use, survival and predictors of death in Western Australia. We identified 240 consecutive patients (60% male; mean age 58 years and body mass index 31 kg m-2) referred for HMV between 2005 and 2010. The patients were grouped into four categories: motor neurone disorders (MND; 39%), pulmonary disease (PULM; 25%, mainly chronic obstructive pulmonary disease), non-MND neuromuscular and chest wall disorders (NMCW; 21%) and the obesity hypoventilation syndrome (OHS; 15%)...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29408222/mechanistic-investigation-of-transcutaneous-protein-delivery-using-solid-in-oil-nanodispersion-a-case-study-with-phycocyanin
#16
Safrina Dyah Hardiningtyas, Rie Wakabayashi, Momoko Kitaoka, Yoshiro Tahara, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya
Phycocyanin (PC), a water-soluble protein-chromophore complex composed of hexameric (αβ)6 subunits, has important biological functions in blue-green algae as well as pharmacological activities in biomedicine. We have previously developed a solid-in-oil (S/O) nanodispersion method to deliver biomacromolecules through the skin, although the transcutaneous mechanism has not yet been fully elucidated. To study the mechanism of transcutaneous protein delivery, we therefore enabled S/O nanodispersion by coating PC with hydrophobic surfactants and evaluated how the proteinaceous macromolecules formulated in an oil phase might permeate the skin...
February 3, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29404360/access-site-complications-in-transcutaneous-aortic-valve-replacement-frequency-outcomes-prevention-and-treatment
#17
REVIEW
Samuel Latham, Tamunoinemi Bob-Manuel, Arindam Sharma, Amit Nanda, Devareshi Ardeshna, Rami N Khouzam
Aortic stenosis (AS) is a common cause of valvular heart disease with heavy disease burden in elderly patients. It is present in almost 7% of patients older than 65. The mortality rate increases significantly once it becomes symptomatic with average life expectancy of around 1-year. Symptoms include angina, syncope, or heart failure. This requires either surgical or transcutaneous replacement. Transcutaneous aortic valve replacement (TAVR) use has increased in recent years from high risk patients to now even including intermediate risk patients...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29398576/a-distinct-biomarker-of-continuous-transcutaneous-vagus-nerve-stimulation-treatment-in-major-depressive-disorder
#18
Yiheng Tu, Jiliang Fang, Jin Cao, Zengjian Wang, Joel Park, Kristen Jorgenson, Courtney Lang, Jun Liu, Guolei Zhang, Yanping Zhao, Bing Zhu, Peijing Rong, Jian Kong
BACKGROUND: Major depression is the fourth leading cause of disability worldwide and poses a socioeconomic burden worldwide. Transcutaneous vagus nerve stimulation (tVNS) is a promising noninvasive clinical device that may reduce the severity of major depression. However, the neural mechanism underlying continuous tVNS has not yet been elucidated. OBJECTIVE: We aimed to explore the effect of hypothalamic subregion functional connectivity (FC) changes during continuous tVNS treatment on major depressive disorder (MDD) patients and to identify the potential biomarkers for treatment outcomes...
January 31, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29398209/comparison-of-preseptal-and-retroseptal-transconjunctival-approaches-in-patients-with-isolated-fractures-of-the-orbital-floor
#19
Salem Barcic, Michael Blumer, Harald Essig, Paul Schumann, Daniel B Wiedemeier, Martin Rücker, Thomas Gander
Transconjunctival approach has become a standard procedure to access fractures of orbit and the infraorbital rim. The transconjunctival incision can be performed pre- or retroseptally. Both approaches have been described combined with modifications such as transcaruncular or detachment of the lateral canthus for wider exposure of the orbital walls and rim. Particularly concerning aesthetics, the transconjunctival approach shows advantages compared to the transcutaneous incisions, such as the transciliary and infraorbital access...
December 24, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29397746/solid-in-oil-peptide-nanocarriers-for-transcutaneous-cancer-vaccine-delivery-against-melanoma
#20
Rie Wakabayashi, Masato Sakuragi, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto
Cancer vaccines represent a prophylactic or therapeutic method of suppressing cancer by activating the adaptive immune system. The immune response is initiated by the delivery of tumor antigens to antigen presenting cells (APCs). The use of peptides, as vaccine antigens, is advantageous especially in the availability and productivity of pure and defined antigens. However, their limited immunogenicity remains a major drawback and therefore the utilization of nanocarriers as a means of delivering antigens to target cells and/or the addition of immune stimulants have been investigated as an efficient peptide-based cancer vaccine...
February 5, 2018: Molecular Pharmaceutics
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