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https://www.readbyqxmd.com/read/28332127/a-review-of-zoonotic-infection-risks-associated-with-the-wild-meat-trade-in-malaysia
#1
REVIEW
Jennifer Caroline Cantlay, Daniel J Ingram, Anna L Meredith
The overhunting of wildlife for food and commercial gain presents a major threat to biodiversity in tropical forests and poses health risks to humans from contact with wild animals. Using a recent survey of wildlife offered at wild meat markets in Malaysia as a basis, we review the literature to determine the potential zoonotic infection risks from hunting, butchering and consuming the species offered. We also determine which taxa potentially host the highest number of pathogens and discuss the significant disease risks from traded wildlife, considering how cultural practices influence zoonotic transmission...
March 22, 2017: EcoHealth
https://www.readbyqxmd.com/read/28330585/molecular-detection-of-leptospirosis-and-melioidosis-co-infection-a-case-report
#2
Mohammad Ridhuan Mohd Ali, Amira Wahida Mohamad Safiee, Padmaloseni Thangarajah, Mohd Hashairi Fauzi, Alwi Muhd Besari, Nabilah Ismail, Chan Yean Yean
Leptospirosis and melioidosis are important tropical infections caused by Leptospira and Burkholdheria pseudomallei, respectively. As both infections share similar clinical manifestations yet require different managements, complementary laboratory tests are crucial for the diagnosis. We describe a case of Leptospira and B. pseudomallei co-infection in a diabetic 40-year-old woman with history of visit to a freshwater camping site in northern Malaysia. To our knowledge, this is the first case of such double-infection, simultaneously demonstrated by molecular approach...
March 15, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28329123/prevalence-of-chagas-disease-in-the-latin-american-born-population-of-los-angeles
#3
Sheba K Meymandi, Colin J Forsyth, Jonathan Soverow, Salvador Hernandez, Daniel Sanchez, Susan P Montgomery, Mahmoud Traina
Background.: According to an estimate from the Centers for Disease Control and Prevention (CDC), Chagas disease (CD) may affect 1.31% of Latin American immigrants in the United States, with >300 000 cases. However, there is a lack of real-world data to support this estimate. Little is known about the actual prevalence of this neglected tropical disease in the United States, and the bulk of those infected are undiagnosed. Methods.: From April 2008 to May 2014, we screened 4,755 Latin American-born residents of Los Angeles County...
February 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28327791/a-tale-of-two-neglected-tropical-infections-using-gis-to-assess-the-spatial-and-temporal-overlap-of-schistosomiasis-and-leprosy-in-a-region-of-minas-gerais-brazil
#4
David Alexander Phillips, José Antonio Ferreira, Deidra Ansah, Herica Sa Teixeira, Uriel Kitron, Thelma de Filippis, Marcelo H de Alcântara, Jessica K Fairley
BACKGROUND: Despite public health efforts to reduce the global burden of leprosy, gaps remain in the knowledge surrounding transmission of infection. Helminth co-infections have been associated with a shift towards the lepromatous end of the disease spectrum, potentially increasing transmission in co-endemic areas. OBJECTIVES: Using this biologically plausible association, we conducted a geographic information systems (GIS) study to investigate the spatial associations of schistosomiasis and leprosy in an endemic area of Minas Gerais (MG), Brazil...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28321210/production-of-ramoplanin-and-ramoplanin-analogs-by-actinomycetes
#5
Mercedes de la Cruz, Ignacio González, Craig A Parish, Russell Onishi, José R Tormo, Jesús Martín, Fernando Peláez, Debbie Zink, Noureddine El Aouad, Fernando Reyes, Olga Genilloud, Francisca Vicente
Ramoplanin is a glycolipodepsipeptide antibiotic obtained from fermentation of Actinoplanes sp. ATCC 33076 that exhibits activity against clinically important multi-drug-resistant, Gram-positive pathogens including vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-intermediate resistant Clostridium difficile. It disrupts bacterial cell wall through a unique mechanism of action by sequestering the peptidoglycan intermediate Lipid II and therefore does not show cross-resistance with other antibiotics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28320726/glucantime%C3%A2-causes-oxidative-stress-derived-dna-damage-in-balb-c-mice-infected-by-leishmania-leishmania-infantum
#6
Vanessa Ribeiro Moreira, Luís Cláudio Lima de Jesus, Rossy-Eric Pereira Soares, Luis Douglas Miranda Silva, Bruno Araújo Serra Pinto, Maria Norma Melo, Antonio Marcus de Andrade Paes, Silma Regina Ferreira Pereira
Leishmaniasis is a neglected tropical disease caused by over 20 species of the protozoan parasite Leishmania Regarding treatment, Glucantime® is the first-choice drug recommended by the World Health Organization for the treatment of all types of leishmaniasis. However, the mechanisms of action and toxicity of pentavalent antimonials, including genotoxic effetcs, remain unclear. Therefore, the mechanism by which Glucantime® causes DNA damage was investigated in BALB/c mice infected by Leishmania (Leishmania) infantum and treated with Glucantime® (20 mg/kg for 20 days)...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28319196/h-channels-in-embryonic-biomphalaria-glabrata-cell-membranes-putative-roles-in-snail-host-schistosome-interactions
#7
Brandon J Wright, Utibe Bickham-Wright, Timothy P Yoshino, Meyer B Jackson
The human blood fluke Schistosoma mansoni causes intestinal schistosomiasis, a widespread neglected tropical disease. Infection of freshwater snails Biomphalaria spp. is an essential step in the transmission of S. mansoni to humans, although the physiological interactions between the parasite and its obligate snail host that determine success or failure are still poorly understood. In the present study, the B. glabrata embryonic (Bge) cell line, a widely used in vitro model for hemocyte-like activity, was used to investigate membrane properties, and assess the impact of larval transformation proteins (LTP) on identified ion channels...
March 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28316881/occurrence-of-concurrent-infections-with-multiple-serotypes-of-dengue-viruses-during-2013-2015-in-northern-kerala-india
#8
Manchala Nageswar Reddy, Ranjeet Dungdung, Lathika Valliyott, Rajendra Pilankatta
BACKGROUND: Dengue is a global human public health threat, causing severe morbidity and mortality. The occurrence of sequential infection by more than one serotype of dengue virus (DENV) is a major contributing factor for the induction of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS), two major medical conditions caused by DENV infection. However, there is no specific drug or vaccine available against dengue infection. There are reports indicating the increased incidence of concurrent infection of dengue in several tropical and subtropical regions...
2017: PeerJ
https://www.readbyqxmd.com/read/28316426/genotyping-of-benzimidazole-resistant-and-susceptible-isolates-of-haemonchus-contortus-from-sheep-by-allele-specific-pcr
#9
Karthik Mohanraj, Subhra Subhadra, Aravindan Kalyanasundaram, Manikkavasagan Ilangopathy, Muthusamy Raman
Extensive and indiscriminate use of the benzimidazole class of drugs has led to the onset of anthelmintic resistance. In tropical countries like India, Haemonchus contortus is the most pathogenic parasite infecting sheep and goats. The widespread presence of resistant helminths (especially H. contortus) threatens the livestock farming. The use of various drugs has led to single nucleotide polymorphism that causes specific amino acid substitutions in β-tubulin protein of H. contortus to confer resistance. This emphasizes the need for a survey on the present status of resistance in India...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28315039/ecology-and-feeding-habits-drive-infection-of-water-bugs-with-mycobacterium-ulcerans
#10
Solange Meyin A Ebong, Gabriel E García-Peña, Dominique Pluot-Sigwalt, Laurent Marsollier, Philippe Le Gall, Sara Eyangoh, Jean-François Guégan
Mycobacterium ulcerans (MU), the causative agent of Buruli ulcer, is present in a wide spectrum of environments, including terrestrial and aquatic ecosystems in tropical regions. The most promising studies on the epidemiological risk of this disease suggest that some ecological settings may favor infection of animals with MU including human. A species' needs and impacts on resources and the environment, i.e., its ecological niche, may influence its susceptibility to be infected by this microbial form. For example, some Naucoridae may dive in fresh waters to prey upon infected animals and thus may get infected with MU...
March 17, 2017: EcoHealth
https://www.readbyqxmd.com/read/28303006/short-course-high-dose-rifampicin-achieves-wolbachia-depletion-predictive-of-curative-outcomes-in-preclinical-models-of-lymphatic-filariasis-and-onchocerciasis
#11
Ghaith Aljayyoussi, Hayley E Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metugene, Darren A N Cook, Andrew Steven, Raman Sharma, Ana F Guimaraes, Rachel H Clare, Andrew Cassidy, Kelly L Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D Turner, Mark J Taylor, Stephen A Ward
Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (Brugia malayi, Wuchereria bancrofti) or onchocerciasis (Onchocerca volvulus) is doxycycline. The target of doxycycline is the essential endosymbiont, Wolbachia. Four to six weeks doxycycline therapy achieves >90% depletion of Wolbachia in worm tissues leading to blockade of embryogenesis, adult sterility and premature death 18-24 months post-treatment...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302096/mathematical-analysis-of-a-lymphatic-filariasis-model-with-quarantine-and-treatment
#12
Peter M Mwamtobe, Simphiwe M Simelane, Shirley Abelman, Jean M Tchuenche
BACKGROUND: Lymphatic filariasis is a globally neglected tropical parasitic disease which affects individuals of all ages and leads to an altered lymphatic system and abnormal enlargement of body parts. METHODS: A mathematical model of lymphatic filariaris with intervention strategies is developed and analyzed. Control of infections is analyzed within the model through medical treatment of infected-acute individuals and quarantine of infected-chronic individuals...
March 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28301479/ligb-subunit-vaccine-confers-sterile-immunity-against-challenge-in-the-hamster-model-of-leptospirosis
#13
Neida L Conrad, Flávia W Cruz McBride, Jéssica D Souza, Marcelle M Silveira, Samuel Félix, Karla S Mendonça, Cleiton S Santos, Daniel A Athanazio, Marco A Medeiros, Mitermayer G Reis, Odir A Dellagostin, Alan J A McBride
Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact on rural and poor urban communities, particularly in developing countries. This has led to major investment in antipoverty vaccines that focus on diseases that influence public health and thereby productivity. While the true, global, impact of leptospirosis is unknown due to the lack of adequate laboratory diagnosis, the WHO estimates that incidence has doubled over the last 15 years to over 1 million cases that require hospitalization every year...
March 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28298600/dengue-virus-ns2b-ns3-protease-inhibitors-exploiting-the-prime-side
#14
Kuan-Hung Lin, Akbar Ali, Linah Rusere, Djade I Soumana, Nese Kurt Yilmaz, Celia A Schiffer
The mosquito-transmitted dengue virus (DENV) infects millions of people in tropical and sub-tropical regions. Maturation of DENV particles requires proper cleavage of the viral polyprotein, including processing 8 of the 13 substrate cleavage sites by dengue NS2B-S3 protease. With no available direct-acting antiviral targeting DENV, NS2-S3 protease is a promising target for inhibitor design. Current design efforts focus on the nonprime side of the DENV protease active site, resulting in highly hydrophilic and nonspecific scaffolds...
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28298599/bushmeat-hunting-and-zoonotic-transmission-of-simian-t-lymphotropic-virus-1-in-tropical-west-and-central-africa
#15
Arsène Mossoun, Sébastien Calvignac-Spencer, Augustin E Anoh, Maude S Pauly, Daniel A Driscoll, Adam O Michel, Lavry Grah Nazaire, Stefan Pfister, Pascale Sabwe, Ulla Thiesen, Barbara R Vogler, Lidewij Wiersma, Jean-Jacques Muyembe-Tamfum, Stomy Karhemere, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Barbara Fruth, Roman M Wittig, Fabian H Leendertz, Grit Schubert
Simian T-lymphotropic virus 1 (STLV-1) enters human populations through contact with non-human primate (NHP) bushmeat. We tested whether differences in the extent of contact to STLV-1 infected NHP bushmeat foster regional differences in prevalence of human HTLV-1. Using serological and PCR assays, we screened humans and NHP at two sub-Saharan African sites where subsistence hunting was expected to be less (Taï region, Côte d'Ivoire, CIV) or more developed (Bandundu region, Democratic Republic of the Congo, DRC)...
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28295964/respiratory-virus-infection-after-allogeneic-hematopoietic-stem-cell-transplant-in-a-tropical-center-predictive-value-of-the-immunodeficiency-scoring-index
#16
Lin Wang, John Allen, Colin Diong, Yeow-Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Francesca Lim, Lynette Oon, Thuan-Tong Tan, Yeh-Ching Linn, Ban-Hock Tan
BACKGROUND: Respiratory virus infection (RVI) is a prevalent infection in patients after allogeneic hematopoietic stem cell transplant (allo-HSCT) and can result in significant morbidity and mortality. Ability to assess the potential severity of RVI is important in the management of such patients. METHODS: We reviewed the cases of RVI in allo-HSCT recipients and explored the predictive value of the immunodeficiency scoring index (ISI) established for respiratory syncytial virus (RSV) and its applicability for RVI caused by other respiratory viruses...
March 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28295400/paper-based-point-of-care-testing-for-cost-effective-diagnosis-of-acute-flavivirus-infections
#17
F Bedin, L Boulet, E Voilin, G Theillet, A Rubens, C Rozand
Flavivirus infections are a serious healthcare concern in tropical and subtropical countries. Although well-established laboratory tests can provide early diagnosis of acute dengue or Zika infections, access to these tests is limited in developing countries, presenting an urgent need to develop simple, rapid, and robust diagnostic tools. Microfluidic Paper-based Analytical Devices (µPAD), are typically rapid, cost-effective, user-friendly, and they can be used as diagnostic tools for the diagnosis of these infections at Point of Care settings...
March 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28295235/cutaneous-manifestations-of-subcutaneous-and-systemic-fungal-infections-in-tropical-regions-a-retrospective-study-from-a-referral-center-in-southern-taiwan
#18
Wen-Chien Tsai, Chih-Hung Lee, Wei-Min Wu, Shang-Hung Lin, Yi-Chien Yang, Yu-Wen Cheng, Ji-Chen Ho, Kwei-Lan Liu
BACKGROUND: Deep cutaneous fungal infections, including subcutaneous mycoses and systemic fungal infection with cutaneous involvement, cause significant morbidity and mortality in light of increasing immunocompromised patients and global warming. Although a few studies reviewed deep fungal infections in temperate regions, a relevant study in tropical regions is lacking. We evaluated features of deep cutaneous fungal infections in southern Taiwan among the tropical regions. METHODS: We retrospectively reviewed all histopathological specimens with deep cutaneous fungal infections in a single referral center from 2001 to 2014 and successfully identified 23 cases...
March 13, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28295179/platelets-and-infections-in-the-resource-limited-countries-with-a-focus-on-malaria-and-viral-haemorrhagic-fevers
#19
REVIEW
Jecko Thachil
Infections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and simpler methods of diagnosis and interventions are required...
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28293169/brain-metabolism-changes-in-patients-infected-with-htlv-1
#20
Manuel Schütze, Luiz C F Romanelli, Daniela V Rosa, Anna B F Carneiro-Proietti, Rodrigo Nicolato, Marco A Romano-Silva, Michael Brammer, Débora M de Miranda
The Human T-cell leukemia virus type-I (HTLV-1) is the causal agent of HTLV-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP). HAM/TSP is the result of demyelination and cell death in the spinal cord and disruption of the blood-brain barrier (BBB), mediated by a virus-induced inflammatory response. In this study, we applied Positron Emission Tomography with 18F-fluordeoxyglucose (18F-FDG PET) to evaluate brain metabolism in a group of 47 patients infected with HTLV-1, and 18 healthy controls. Patients were divided into three groups according to their neurological symptoms...
2017: Frontiers in Molecular Neuroscience
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