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https://www.readbyqxmd.com/read/28431272/specific-microrna-mrna-regulatory-network-of-colon-cancer-invasion-mediated-by-tissue-kallikrein-related-peptidase-6
#1
Earlphia Sells, Ritu Pandey, Hwudaurw Chen, Bethany A Skovan, Haiyan Cui, Natalia A Ignatenko
Metastatic colon cancer is a major cause of deaths among colorectal cancer (CRC) patients. Elevated expression of kallikrein 6 (KLK6), a member of a kallikrein subfamily of peptidase S1 family serine proteases, has been reported in CRC and is associated with low patient survival rates and poor disease prognosis. We knocked down KLK6 expression in HCT116 colon cancer cells to determine the significance of KLK6 expression for metastatic dissemination and to identify the KLK6-associated microRNAs (miRNAs) signaling networks in metastatic colon cancer...
April 18, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28427524/kallistatin-suppresses-cancer-development-by-multi-factorial-actions
#2
REVIEW
Julie Chao, Pengfei Li, Lee Chao
Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein and a serine proteinase inhibitor. Kallistatin via its two structural elements regulates differential signaling cascades, and thus a wide spectrum of biological functions. Kallistatin's active site is essential for: inhibiting tissue kallikrein's activity; stimulating endothelial nitric oxide synthase and sirtuin 1 expression and activation; and modulating the synthesis of the microRNAs, miR-34a, miR-21 and miR-203. Kallistatin's heparin-binding site is crucial for antagonizing the signaling pathways of vascular endothelial growth factor, tumor necrosis factor-α, Wnt, transforming growth factor-β and epidermal growth factor...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28418858/the-mir-124-p63-feedback-loop-modulates-colorectal-cancer-growth
#3
Kuijie Liu, Hongliang Yao, Sanlin Lei, Li Xiong, Haizhi Qi, Ke Qian, Jiqiang Liu, Peng Wang, Hua Zhao
Among the diverse co-regulatory relationships between transcription factors (TFs) and microRNAs (miRNAs), feedback loops have received the most extensive research attention. The co-regulation of TFs and miRNAs plays an important role in colorectal cancer (CRC) growth. Here, we show that miR-124 can regulate two isoforms of p63, TAp63 and ΔNp63, via iASPP, while p63 modulates signal transducers and activators of transcription 1 (STAT1) expression by targeting miR-155. Moreover, STAT1 acts as a regulator of CRC growth by targeting miR-124...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28405738/evaluation-of-mir-506-and-mir-4316-expression-in-early-and-non-invasive-diagnosis-of-colorectal-cancer
#4
Paweł Krawczyk, Tomasz Powrózek, Tomasz Olesiński, Adam Dmitruk, Joanna Dziwota, Dariusz Kowalski, Janusz Milanowski
PURPOSE: Examination of the entire colon by colonoscopy remains the golden standard for screening of colorectal cancer (CRC). However, patients are reluctant to perform invasive colonoscopies because of interference with their intimacy. Therefore, the potential use of non-invasive analysis of microRNAs expression in liquid biopsy as a novel biomarker for early CRC has investigated in several studies. In this study, we analyzed the expression of two novel microRNAs: miR-506 and miR-4316, which have never been examined in CRC...
April 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28401648/current-status-and-perspectives-regarding-lna-anti-mir-oligonucleotides-and-microrna-mir-21-inhibitors-as-a-potential-therapeutic-option-in-treatment-of-colorectal-cancer
#5
Reza Nedaeinia, Amir Avan, Mehdi Ahmadian, Sasan Nedaee Nia, Maryam Ranjbar, Mohammadreza Sharifi, Mohammad Goli, Ahmad Piroozmand, Esmail Nourmohammadi, Mostafa Manian, Gordon A Ferns, Majid Ghayour-Mobarhan, Rasoul Salehi
Colorectal cancer (CRC) is among the leading causes of cancer-related death, principally due to its metastatic spread and multifactorial chemoresistance. The therapeutic failure can also be explained by inter- or intra-tumor genetic heterogeneity and tumor stromal content. Thus, the identification of novel prognostic biomarkers and therapeutic options are warranted in the management of CRC patients. There are data showing that microRNA-21 is elevated in different types of cancer, particularly colon adenocarcinoma and that this is association with a poor prognosis...
April 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28396317/4pd-functionalized-dendrimers-a-flexible-tool-for-in-vivo-gene-silencing-of-tumor-educated-myeloid-cells
#6
Serena Zilio, Jennifer L Vella, Adriana C De la Fuente, Pirouz M Daftarian, Donald T Weed, Angel Kaifer, Ilaria Marigo, Kevin Leone, Vincenzo Bronte, Paolo Serafini
Myeloid cells play a key role in tumor progression and metastasis by providing nourishment and immune protection, as well as facilitating cancer invasion and seeding to distal sites. Although advances have been made in understanding the biology of these tumor-educated myeloid cells (TEMCs), their intrinsic plasticity challenges our further understanding of their biology. Indeed, in vitro experiments only mimic the in vivo setting, and current gene-knockout technologies do not allow the simultaneous, temporally controlled, and cell-specific silencing of multiple genes or pathways...
April 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28392396/p53-target-mir-29c-3p-suppresses-colon-cancer-cell-invasion-and-migration-through-inhibition-of-phldb2
#7
Geng Chen, Tong Zhou, Yang Li, Zhenxiang Yu, Liankun Sun
miR-29c-3p is a potential tumor suppressor microRNA that is reportedly downregulated in several types of human cancers, but its role in colon cancer remains to be elucidated. Meanwhile, TP53, one of the most important tumor suppressors, is highly mutated in colon cancer. In the attempt to connect p53 and miR-29c-3p, we found that the upstream of miR-29c-3p gene contains a functional p53 consensus responsive element that is driven by p53 transcriptional factor activity, suggesting miR-29c-3p as a direct p53 target gene...
May 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28383996/nfe2l2-nrf2-activity-is-linked-to-mitochondria-and-amp-activated-protein-kinase-signaling-in-cancers-through-mir-181c-mitochondria-encoded-cytochrome-c-oxidase-regulation
#8
Kyeong-Ah Jung, Sujin Lee, Mi-Kyoung Kwak
AIMS: The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NFE2L2/NRF2) pathway contributes to the environmental resistance of cancers by enhancing the antioxidant capacity. Here, we explored the potential connection between NFE2L2/NRF2 and mitochondrial function in cancers. RESULTS: Global miRNA expression analysis of HT29 and HCT116 human colon cancer cells identified that NFE2L2/NRF2 silencing upregulated miR-181c through nuclear factor-κB signaling, and this increase was associated with the reduction in mitochondria-encoded cytochrome c oxidase subunit-1 (MT-CO1), a catalytic core subunit of the complex IV of the electron transport chain (ETC)...
April 6, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28381168/long-non-coding-rna-colon-cancer-associated-transcript-1-functions-as-a-competing-endogenous-rna-to-regulate-cyclin-dependent-kinase-1-expression-by-sponging-mir-490-3p-in-hepatocellular-carcinoma-progression
#9
Chunqing Dou, Liyuan Sun, Xin Jin, Mingming Han, Bao Zhang, Tao Li
Hepatocellular carcinoma is an aggressive neoplasm and is one of the most common human cancers. Recently, long non-coding RNAs have been demonstrated to participate in pathogenesis of many diseases including the progression in several cancers. In this study, we found that the long non-coding RNA colon cancer-associated transcript 1 was upregulated in hepatocellular carcinoma tissues (p < 0.05), and high colon cancer-associated transcript 1 expression level was positively associated with tumor volume (p < 0...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28370854/ephb3-targeted-regulation-of-mir-149-in-the-migration-and-invasion-of-human-colonic-carcinoma-hct116-and-sw620-cells
#10
Guodong Zhang, Xiaozhu Liu, Yinfeng Li, Yan Wang, Huankun Liang, Kangyan Li, Laiqing Li, Cuicui Chen, Wenqiao Sun, Shoulei Ren, Pengfei Zhu, Licheng Zhang
microRNAs play key roles during various crucial cell processes such as proliferation, migration, invasion and apoptosis. Also, microRNAs have been shown to possess oncogenic and tumor-suppressive functions in human cancers. Here, we describe the regulation and function of miR-149 in colorectal cancer cell lines. miR-149 expression patterns were detected in human colorectal cell lines and tissue samples, and then focused on its role in regulation of cell growth, migration, invasion, and its target gene identification...
March 2017: Cancer Science
https://www.readbyqxmd.com/read/28358427/h19-promotes-the-migration-and-invasion-of-colon-cancer-by-sponging-mir-138-to-upregulate-the-expression-of-hmga1
#11
Qingqiang Yang, Xin Wang, Chunyan Tang, Xuan Chen, Jianjun He
Colon cancer is the most common digestive system malignancy, along with high mortality rate, familial transmissibility and hepatic metastasis. Our study investigated the role of long non-coding RNA H19 in colon cancer. We found that H19 was overexpressed in colon cancer tissues and cell lines, the interference of H19 by short hairpin RNA (shRNA) effectively decreased the migration and invasion of colon cancer cells (HT-29 and RKO). Besides, miR-138 was predicted a target of H19, and low expression of miR-138 was found in colon cancer tissues and cells...
March 29, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28356122/integrated-analysis-identifies-microrna-195-as-a-suppressor-of-hippo-yap-pathway-in-colorectal-cancer
#12
Min Sun, Haibin Song, Shuyi Wang, Chunxiao Zhang, Liang Zheng, Fangfang Chen, Dongdong Shi, Yuanyuan Chen, Chaogang Yang, Zhenxian Xiang, Qing Liu, Chen Wei, Bin Xiong
BACKGROUND: With persistent inconsistencies in colorectal cancer (CRC) miRNAs expression data, it is crucial to shift toward inclusion of a "pre-laboratory" integrated analysis to expedite effective precision medicine and translational research. Aberrant expression of hsa-miRNA-195 (miR-195) which is distinguished as a clinically noteworthy miRNA has previously been observed in multiple cancers, yet its role in CRC remains unclear. METHODS: In this study, we performed an integrated analysis of seven CRC miRNAs expression datasets...
March 29, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28348518/combination-of-endothelial-monocyte-activating-polypeptide-ii-with-temozolomide-suppress-malignant-biological-behaviors-of-human-glioblastoma-stem-cells-via-mir-590-3p-macc1-inhibiting-pi3k-akt-mtor-signal-pathway
#13
Wei Zhou, Libo Liu, Yixue Xue, Jian Zheng, Xiaobai Liu, Jun Ma, Zhen Li, Yunhui Liu
This study aims to investigate the effect of Endothelial-Monocyte-Activating Polypeptide-II (EMAP-II) combined with temozolomide (TMZ) upon glioblastoma stem cells (GSCs) and its possible molecular mechanisms. In this study, combination of EMAP-II with TMZ inhibited cell viability, migration and invasion in GSCs, and autophagy inhibitor 3-methyl adenine (3-MA) and chloroquine (CQ) partly reverse the anti-proliferative effect of the combination treatment. Autophagic vacuoles were formed in GSCs after the combination therapy, accompanied with the up-regulation of LC3-II and Beclin-1 as well as the down-regulation of p62/SQSTM1...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28347230/inhibition-of-microrna-21-via-locked-nucleic-acid-anti-mir-suppressed-metastatic-features-of-colorectal-cancer-cells-through-modulation-of-programmed-cell-death-4
#14
Reza Nedaeinia, Mohammadreza Sharifi, Amir Avan, Mohammad Kazemi, Abdolreza Nabinejad, Gordon A Ferns, Majid Ghayour-Mobarhan, Rasoul Salehi
Colorectal cancer is among the most lethal of malignancies, due to its propensity to metastatic spread and multifactorial-chemoresistance. The latter property supports the need to identify novel therapeutic approaches for the treatment of colorectal cancer. MicroRNAs are endogenous non-coding small RNA molecules that function as post-transcriptional regulators of gene expression. Recently, programmed cell death 4 has been identified as a protein that increases during apoptosis. This gene is among the potential targets of miR-21 (OncomiR)...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28341962/tumour-suppressor-ep300-a-modulator-of-paclitaxel-resistance-and-stemness-is-downregulated-in-metaplastic-breast-cancer
#15
Muhammad Asaduzzaman, Stephanie Constantinou, Haoxiang Min, John Gallon, Meng-Lay Lin, Poonam Singh, Selina Raguz, Simak Ali, Sami Shousha, R Charles Coombes, Eric W-F Lam, Yunhui Hu, Ernesto Yagüe
PURPOSE: We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells. Upstream in the pathway, three miRs (miR-106b, miR-93 and miR-25) target EP300, a transcriptional activator of E-cadherin. Upregulation of these miRs leads to the downregulation of EP300 and E-cadherin with initiation of an EMT. However, miRs regulate the expression of many genes, and the contribution to EMT by miR targets other than EP300 cannot be ruled out...
March 24, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28327152/trim8-restores-p53-tumour-suppressor-function-by-blunting-n-myc-activity-in-chemo-resistant-tumours
#16
Francesca Mastropasqua, Flaviana Marzano, Alessio Valletti, Italia Aiello, Giuseppe Di Tullio, Annalisa Morgano, Sabino Liuni, Elena Ranieri, Luisa Guerrini, Giuseppe Gasparre, Elisabetta Sbisà, Graziano Pesole, Antonio Moschetta, Mariano Francesco Caratozzolo, Apollonia Tullo
BACKGROUND: TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to chemotherapeutic drugs. The mechanisms that regulate TRIM8, especially in cancers like clear cell Renal Cell Carcinoma (ccRCC) and colorectal cancer (CRC) where it is low expressed, are still unknown. However, recent studies suggest the potential involvement of some microRNAs belonging to miR-17-92 and its paralogous clusters, which could include TRIM8 in a more complex pathway...
March 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28322989/role-of-micrornas-in-endocrine-cancer-metastasis
#17
Cilene Rebouças Lima, Cibele Crastequini Gomes, Marinilce Fagundes Santos
The deregulation of transcription and processing of microRNAs (miRNAs), as well as their function, has been involved in the pathogenesis of several human diseases, including cancer. Despite advances in therapeutic approaches, cancer still represents one of the major health problems worldwide. Cancer metastasis is an aggravating factor in tumor progression, related to increased treatment complexity and a worse prognosis. After more than one decade of extensive studies of miRNAs, the fundamental role of these molecules in cancer progression and metastasis is beginning to be elucidated...
March 18, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28303484/alterations-in-microrna-expression-associated-with-alcohol-consumption-in-rectal-cancer-subjects
#18
Lila E Mullany, Jennifer S Herrick, Roger K Wolff, John R Stevens, Martha L Slattery
PURPOSE: Alcohol consumption has been purported to influence many diseases. MicroRNAs (miRNAs) may be influenced by compounds found in alcohol. In this investigation, we test the hypothesis that total alcohol, beer, wine, and hard liquor influence miRNA expression. METHODS: We studied 1447 colorectal (CR) cancer cases with normal CR mucosa and carcinoma miRNA expression data along with alcohol consumption data. We analyzed long-term and long-term and current (LTC) alcohol use for beer, liquor, and wine with miRNA expression between paired carcinoma and normal colon and rectal tissues, adjusting for multiple comparisons using the positive false discovery rate q-value...
March 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28296190/microrna-1254-inhibits-the-migration-of-colon-adenocarcinoma-cells-by-targeting-psmd10
#19
Yi-Min Chu, Hai-Xia Peng, Ying Xu, Da-Ming Yang, Feng-Li Zhou, Rong Kuai Ji Li, Yong Lin
BACKGROUND AND AIMS: MicroRNA-1254 (miR-1254) has not been studied in colorectal cancer (CRC) to date. In the current study, we investigate the inhibitory mechanism of miR-1254 in CRC tumorigenesis. METHODS: Differential miR-1254 expression was examined using real-time-PCR in CRC and control tissues. Whether miR-1254 levels correlated with colon adenocarcinoma cell proliferation and migration was determined using the CCK-8 and transwell assays. RNA sequencing was used to identify differentially expressed genes downstream of miR-1254...
March 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28293146/rs35301225-polymorphism-in-mir-34a-promotes-development-of-human-colon-cancer-by-deregulation-of-3-utr-in-e2f1-in-chinese-population
#20
Haiqiang Jiang, Fengyuan Ge, Beina Hu, Lamei Wu, Huijian Yang, Huiyun Wang
BACKGROUND: Previous reports have revealed that down-regulation of miR-34a expression can promote colorectal cancer (CRC) cell growth by targeting cell cycle-related transcriptional factor E2F1. To date, the function of the single nucleotide polymorphism (SNP) located in the mature region of miR-34a has not been investigated. METHODS: We performed a case-control study including 685 CRC patients and 618 cancer-free controls. Genotyping, real-time PCR assay, cell transfection, and the dual luciferase reporter assay were used in our study...
2017: Cancer Cell International
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