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Chad A Galloway, Sonal Dalvi, Audra M A Shadforth, Shuko Suzuki, Molly Wilson, David Kuai, Ali Hashim, Leslie A MacDonald, David M Gamm, Damien G Harkin, Ruchira Singh
Purpose: RPE cell transplantation as a potential treatment for AMD has been extensively investigated; however, in AMD, ultrastructural damage affects both the RPE and its underlying matrix support, the Bruch's membrane (BrM). An RPE monolayer supported by a surrogate scaffold could thus provide a more effective approach to cell-based therapy for AMD. Toward this goal, we aimed to establish a functional human induced pluripotent stem cell-derived (hiPSC)-RPE monolayer on a Bombyx mori silk fibroin (BMSF) scaffold...
June 1, 2018: Investigative Ophthalmology & Visual Science
Roberto Cocchetto, Luigi Canullo, Renato Celletti
Several studies have clearly shown that osseointegrated implants, when inserted in growing bone, such as in adolescents, do not follow the eruptive path of adjacent teeth; instead, they act like ankylosed teeth, remaining in a stationary position for the lifetime, thus developing a progressive infraposition of the implant-supported crown. However, further studies have demonstrated that similar changes also occur in adult patients, although mostly in a small amount and over long time spans. Here the case of a female patient aged 35 years is presented, in which infraposition of the maxillary central incisor developed in a very short time (15 months)...
July 2018: International Journal of Oral & Maxillofacial Implants
Claudio Gatti, Fulvio Gatti, Maurizio Silvestri, Francesco Mintrone, Roberto Rossi, Gabriele Tridondani, Giacomo Piacentini, Paola Borrelli
PURPOSE: To compare the peri-implant radiographic crestal bone changes around implants placed at the subcrestal or crestal level. MATERIALS AND METHODS: Systemically healthy patients with at least two missing teeth requiring implant-supported fixed prosthetic restorations were enrolled in the study. Implants were randomly placed either 1 mm subcrestally or at the bone crest level. Radiographic examination was performed using the long-cone parallel technique and customized film holders...
July 2018: International Journal of Oral & Maxillofacial Implants
Carola Siebert, Dominik Rieder, Jochen Eggert, Manfred Gerhard Wichmann, Siegfried Martin Heckmann
PURPOSE: The aim of this study was to assess and compare the esthetic outcome of tissue-level (TL) and bone-level (BL) implants that had been placed as single implants in the anterior maxilla. MATERIALS AND METHODS: Between 2001 and 2008, patients were treated using TL implants (Straumann). From 2008 until 2012, patients received the newly developed BL implant (Straumann). All patients with a single anterior maxillary implant who came to check-ups regularly were contacted and invited to take part in the study...
July 2018: International Journal of Oral & Maxillofacial Implants
George Alexandre de Barros Lucena, Rafael Scaf de Molon, Antonio J Moretti, Jamil Awad Shibli, Delane Maria Rêgo
PURPOSE: The objective of this investigation was to assess the microbiologic contamination in the inner surface of titanium implants prior to prosthetic abutment placement. MATERIALS AND METHODS: The study population consisted of partially edentulous individuals who had previously received at least one internal hexagon titanium dental implant. A bacterial sample of the inner surface of the individual dental implant was taken after surgical reopening for healing abutment placement...
July 2018: International Journal of Oral & Maxillofacial Implants
Lucia Fernandez-Estevan, Javier Montero, Eduardo J Selva Otaolaurruchi, Maria Fernanda Sola Ruiz
PURPOSE: To quantify the rate of maintenance interventions of mandibular prostheses: complete dentures and overdentures retained by two implants, with either internal hex or external hex connections. MATERIALS AND METHODS: This study analyzed patients with edentulous mandibles treated with distinct treatment protocols: a control group received complete dentures; a second group received Locator-retained overdentures supported by two external hex connection implants; and a third group received overdentures supported by internal hex connection implants...
July 2018: International Journal of Oral & Maxillofacial Implants
Peter Gehrke, Thorsten Sing, Carsten Fischer, Sebastian Spintzyk, Jürgen Geis-Gerstorfer
PURPOSE: Central manufacturing of two-piece computer-aided design/computer-aided manufacture (CAD/CAM) zirconia abutments may provide a higher accuracy of internal and external adaptation at the expense of delayed restoration delivery. The aim of this study was to compare the fit of two-part zirconia abutments that were either fabricated centrally with the DEDICAM system or at a local laboratory. The field of interest was the marginal, external, and internal luting gap between the titanium insert and CAD/CAM zirconia coping...
July 2018: International Journal of Oral & Maxillofacial Implants
Rubén Agustín-Panadero, Ana Roig-Vanaclocha, Antonio Fons-Font, María Fernanda Solá-Ruíz
PURPOSE: The aim of this study was to evaluate the mechanical behavior of implant-supported cemented restorations placed on two types of abutment design, with and without a prosthetic finish line, evaluating fracture resistance and the type of fracture produced in the abutment-crown complex. MATERIALS AND METHODS: Eighty zirconia restorations supported by tapered implants were divided into two groups: group I, with 40 zirconia crowns cemented onto individualized zirconia abutments with a chamfered finish line (1 mm deep); and group II, with 40 zirconia crowns cemented onto individualized zirconia abutments without a finish line...
July 2018: International Journal of Oral & Maxillofacial Implants
Zdzisław A Bogucki
BACKGROUND: Patients with xerostomia have difficulties using dentures. Application of denture adhesives (DAs) can improve the stabilization of prostheses. OBJECTIVES: The aim of the study was to determine the retention capability of complete maxillary dentures in patients with xerostomia, determined with and without the use of prosthetic DAs. MATERIAL AND METHODS: This study evaluated the retention force of prostheses in a group of 60 patients diagnosed with xerostomia...
July 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
P F Manicone, P C Passarelli, S Bigagnoli, R Pastorino, A Manni, G Pasquantonio, A D'Addona
OBJECTIVE: The aim of this study was to find out the rates of survival and success of implant rehabilitation, and the influence of some risk indicators on the medium- and long-term prognosis. PATIENTS AND METHODS: Of the 102 patients eligible for this study rehabilitated with dental implants during the years 2009-2015, 75 patients with 156 implants of different implant systems placed and loaded by the same team were recalled. For each subject, pocket-probing depth, bleeding on probing, plaque buildup, mobility of the fixtures, and the presence/absence of prosthetic complications were recorded...
July 2018: European Review for Medical and Pharmacological Sciences
Matthew T Houdek
No abstract text is available yet for this article.
July 13, 2018: Clinical Orthopaedics and related Research
Anwesha Biswas, Jessy Mariam, Mamta Kombrabail, Satya Narayan, G Krishnamoorthy, Ruchi Anand
Fob1 protein plays an important role in aging and maintains genomic stability by avoiding clashes between the replication and transcription machinery. It facilitates polar arrest by binding to replication fork barrier (RFB) sites, present within the nontranscribed spacer region of the ribosomal DNA. Here, we investigate the mechanism of unidirectional arrest by creating multiple prosthetic forks within the RFB, with fluorescent adenine analogue 2-aminopurine incorporated site-specifically in both the "permissible" and "nonpermissible" directions...
October 31, 2017: ACS Omega
Miguel Clemente, Joaquim Mendes, André Moreira, Afonso Pinhão Ferreira, José Manuel Amarante
INTRODUCTION: A wind instrumentalist was diagnosed with a periapical lesion on tooth 21. The prosthetic rehabilitation options were considered with respect to the embouchure mechanism of the saxophonist. The underlying mechanism associated with the embouchure of the saxophone player was observed in this particular case in order to understand if asymmetrical forces were transmitted to the upper central incisors. Periapical lesions can be harmful to the oral health of musicians. The treatment options thus have to be taken into consideration with special focus on the need for oral rehabilitation on the anterior maxilla...
July 18, 2018: Dentistry journal
Charles Mve Mvondo, Marta Pugliese, Jean Claude Ambassa, Alessandro Giamberti, Emanuele Bovio, Ellen Dailor
BACKGROUND:  The management of patients with mechanical heart valves remains a major concern in populations with limited resources and medical facilities. This study reports the clinical outcomes of patients who underwent mechanical valve implantation in a sub-Saharan center over an 8-year period. METHODS:  A total of 291 mechanical valves were implanted in 233 patients in our institution between February 2008 and June 2016. A total of 117 patients underwent mitral valve replacement (MVR, 50...
July 18, 2018: Thoracic and Cardiovascular Surgeon
Stephen Parel
As the number of seniors in the United States continues to rise, edentulism remains a serious ailment affecting many elderly patients. Though many seniors are taking fuller dentitions into their later years due to a greater emphasis on oral health maintenance than in the past, this growing population still often requires creative edentulous treatment solutions from skilled clinicians. Fortunately, with the evolution of implant dentistry various possibilities are available to treat edentulous aging patients with removable and/or fixed options...
July 2018: Compendium of Continuing Education in Dentistry
Udatta Kher, Ali Tunkiwala, Priya Bijlani
The conventional approach for fabrication of a definitive prosthesis for full-arch implant cases requires multiple visits. This article presents a case series highlighting the efficacy of a novel time-saving technique for full-arch implant prosthodontics. The technique is indicated for cases in which an immediate fixed provisional restoration has been delivered on the day of implant placement or within 72 hours of implant placement or for cases where the clinician has made an esthetically and functionally acceptable provisional restoration before starting the prosthetic phase for the definitive restoration...
July 2018: Compendium of Continuing Education in Dentistry
Houman Bahmani Jalali, Mohammad Mohammadi Aria, Ugur Meric Dikbas, Sadra Sadeghi, Baskaran Ganesh Kumar, Mehmet Sahin, Ibrahim Halil Kavakli, Cleva W Ow-Yang, Sedat Nizamoğlu
Light-induced stimulation of neurons via photoactive surfaces offers rich opportunities for the development of therapeutic methods and high-resolution retinal prosthetic devices. Quantum dots serve as an attractive building block for such surfaces, as they can be easily functionalized to match the biocompatibility and charge transport requirements of cell stimulation. Although indium-based colloidal quantum dots with Type-I band alignment have attracted significant attention as a non-toxic alternative to cadmium-based ones, little attention has been paid to their photovoltaic potential as Type-II heterostructures...
July 18, 2018: ACS Nano
Irene Katharina Sigmund, Katsiaryna Yermak, Carsten Perka, Andrej Trampuz, Nora Renz
BACKGROUND: Alpha defensin was proposed as a new biomarker in synovial fluid for the diagnostic workup of failed joint prostheses. To our knowledge, no comparative study of the performance of the quantitative enzyme-linked immunosorbent assay (ELISA) and qualitative lateral flow alpha defensin test has been reported. QUESTIONS/PURPOSES: (1) Using the proposed European Bone and Joint Infection Society (EBJIS) criteria for defining periprosthetic joint infection (PJI), is there a difference in the diagnostic accuracy of quantitative ELISA and qualitative lateral flow alpha defensin tests? (2) Is there a difference in the performance of the two alpha defensin tests when using three definition classification systems (Musculoskeletal Infection Society [MSIS], Infectious Diseases Society of America [IDSA], and proposed EBJIS)? METHODS: In this retrospective study of samples collected earlier as part of a related longitudinal study, we included patients in whom aspiration of the prosthetic hip or knee was performed as routine investigation before every revision arthroplasty...
August 2018: Clinical Orthopaedics and related Research
(no author information available yet)
This document announces the addition of 31 Healthcare Common Procedure Coding System (HCPCS) codes to the Required Prior Authorization List of Durable Medical Equipment, Prosthetics, Orthotics, and Supplies (DMEPOS) Items that require prior authorization as a condition of payment. Prior authorization for these codes will be implemented nationwide.
June 5, 2018: Federal Register
Nader Makki, Xu Ghao, Bryan Whitson, Satya Shreenivas, Juan Crestanello, Scott Lilly
BACKGROUND: Precise quantification of paravalvular aortic regurgitation (PAR) is challenging. Aortic regurgitation index (AR index) has been validated in transcatheter aortic valve replacement (TAVR) cohorts; however, accuracy is limited by heart rate dependency. Diastolic pressure time (DPT) index has been suggested as an alternative and also predicts mortality after TAVR. We chose to evaluate the left ventricular diastolic filling slope (LVDFS) as a surrogate of AR, and suggest it is less heart rate dependent than the AR index and comparable to DPT index...
July 18, 2018: Catheterization and Cardiovascular Interventions
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