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İnhaler anesthetics

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https://www.readbyqxmd.com/read/29764007/anesthetic-considerations-during-surgical-intervention-in-woake-s-syndrome-a-case-report
#1
So Ron Choi, Jeong Ho Kim, Kyoung Lin Chae, Seung Cheol Lee, Sang Yoong Park
Woake's syndrome (WS) is a recurrent nasal polyposis, accompanied by broadening of the nose, frontal sinus aplasia, dyscrinia, and bronchiectasis. There has been no previous report on anesthetic management in patients with WS. We describe a case involving a 13-year-old male patient with WS who was scheduled for septorhinoplasty for necrotic ethmoiditis. Anesthesia was induced and maintained with propofol and remifentanil using a target-controlled infusion device. The anesthetic considerations of this rare syndrome and the advantages of an intravenous infusion method over local and volatile anesthesia for these patients are discussed...
May 15, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29750301/sevoflurane-suppresses-proliferation-by-upregulating-microrna-203-in-breast-cancer-cells
#2
Jiaying Liu, Longqiu Yang, Xia Guo, Guangli Jin, Qimin Wang, Dongdong Lv, Junli Liu, Qiu Chen, Qiong Song, Baolin Li
Rapid proliferation is one of the critical characteristics of breast cancer. However, the underlying regulatory mechanism of breast cancer cell proliferation is largely unclear. The present study indicated that sevoflurane, one of inhalational anesthetics, could significantly suppress breast cancer cell proliferation by arresting cell cycle at G1 phase. Notably, the rescue experiment indicated that miR-203 was upregulated by sevoflurane and mediated the function of sevoflurane on suppressing the breast cancer cell proliferation...
May 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29734080/the-anesthetic-action-of-some-polyhalogenated-ethers-monte-carlo-method-based-qsar-study
#3
Mlađan Golubović, Milan Lazarević, Dragan Zlatanović, Dane Krtinić, Viktor Stoičkov, Bojan Mladenović, Dragan J Milić, Dušan Sokolović, Aleksandar M Veselinović
Up to this date, there has been an ongoing debate about the mode of action of general anesthetics, which have postulated many biological sites as targets for their action. However, postoperative nausea and vomiting are common problems in which inhalational agents may have a role in their development. When a mode of action is unknown, QSAR modelling is essential in drug development. To investigate the aspects of their anesthetic, QSAR models based on the Monte Carlo method were developed for a set of polyhalogenated ethers...
April 13, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29728856/elevated-expression-of-dj-1-encoded-by-the-human-park7-gene-protects-neuronal-cells-from-sevoflurane-induced-neurotoxicity
#4
Yajie Zhang, Yu Li, Xuechang Han, Xu Dong, Xiangbiao Yan, Qunzhi Xing
Sevoflurane, an inhaled ether general anesthetic agent, exerts a variety of neurotoxic effects, including oxidative stress, mitochondrial dysfunction, and neuronal apoptosis. However, the underlying molecular mechanisms remain to be elucidated. DJ-1 is a protein that exerts neuroprotective effects against different kinds of stress through multiple pathways. This study aimed to investigate the neuroprotective effects of DJ-1 against sevoflurane-induced neurotoxicity. Here, we found that sevoflurane treatment significantly increased DJ-1 expression in human neuroblastoma M17 cells in a dose-dependent manner at both the mRNA and protein levels...
May 4, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29721820/hypothermic-total-liquid-ventilation-after-experimental-aspiration-associated-acute-respiratory-distress-syndrome
#5
Jérôme Rambaud, Fanny Lidouren, Michaël Sage, Matthias Kohlhauer, Mathieu Nadeau, Étienne Fortin-Pellerin, Philippe Micheau, Luca Zilberstein, Nicolas Mongardon, Jean-Damien Ricard, Megumi Terada, Patrick Bruneval, Alain Berdeaux, Bijan Ghaleh, Hervé Walti, Renaud Tissier
BACKGROUND: Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital cardiac arrest is frequently associated with early-onset pneumonia, which may lead to acute respiratory distress syndrome (ARDS). Here, our objective was to determine whether hypothermic TLV could be safe or even beneficial in an aspiration-associated ARDS animal model...
May 2, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29683966/intracranial-space-occupying-lesion-inducing-intracranial-hypertension-increases-the-encephalographic-effects-of-isoflurane-in-a-swine-model
#6
Tadayoshi Kurita, Shingo Kawashima, Koji Morita, Yoshiki Nakajima
BACKGROUND: Patients with a brain tumor are susceptible to the hypnotic effect of anesthetics depending on the tumor's size. We investigated whether intracranial space-occupying lesions (ICSOLs) inducing intracranial hypertension increase isoflurane's effect on electroencephalographic (EEG) results. MATERIALS AND METHODS: After anesthetic induction with isoflurane, 11 swine were studied with regard to isoflurane's effect on EEGs at 0.5% to 2.0% inhalational concentration at sequential stages: baseline 1, ICSOL 1, baseline 2, ICSOL 2, baseline 3...
April 20, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29680394/the-clinical-effects-of-a-low-dose-dexmedetomidine-constant-rate-infusion-in-isoflurane-anesthetized-cats
#7
B T Simon, E M Scallan, C D Coursey, W M Kiehl, E J Moore
The aim of this study was to evaluate the effects of a low dose dexmedetomidine constant rate infusion (CRI) on cardiopulmonary function, inhalant anesthetic concentration and recovery in isoflurane anesthetized cats. In a prospective, randomized, blinded, controlled design, 12 cats undergoing anesthesia for ovariohysterectomy were administered hydromorphone (0.1mg/kg) intramuscularly, propofol (4.3-7.8mg/kg) intravenously and maintained with isoflurane. During isoflurane anesthesia, the cats were administered either a dexmedetomidine loading dose (0...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29674333/intravenous-and-intratracheal-thyrotropin-releasing-hormone-and-its-analog-taltirelin-reverse-opioid-induced-respiratory-depression-in-isoflurane-anesthetized-rats
#8
James D Boghosian, Anita Luethy, Joseph F Cotten
Thyrotropin releasing hormone (TRH) is a tripeptide hormone and a neurotransmitter widely-expressed in the CNS that regulates thyroid function and that maintains physiologic homeostasis. Following injection in rodents, TRH has multiple effects including increased blood pressure and breathing. We tested the hypothesis that TRH and its long-acting analog, taltirelin, will reverse morphine-induced respiratory depression in anesthetized rats following intravenous(IV) or intratracheal(IT) administration. TRH (1 mg/kg plus 5 mg/kg/hour IV) and talitrelin (1 mg/kg IV), when administered to rats pretreated with morphine (5 mg/kg IV), increased ventilation from 50±6 to 131±7% and 45±6 to 168±13% (percent baseline; n=4±SEM), primarily through increased breathing rates (from 76+/-9 to 260±14% and 66±8 to 318±37%)...
April 19, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29673528/genomics-and-proteomic-techniques
#9
Jonathan Z Pan
Although general anesthesia induced by inhaled anesthetics produces definitive phenotypes (e.g., loss of mobility, amnesia, analgesia), the underlying targets of these drugs are still not clear. Genomics and proteomic techniques are discussed for measurement of global transcriptional and translational changes after inhaled anesthetic exposures. The current discussion focuses primarily on the genomic and proteomic technical methodology. We also include a discussion of network and pathway analyses for data interpretation after identification of the targets...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29672287/early-administration-of-magnesium-sulfate-during-open-fetal-myelomeningocele-repair-reduces-the-dose-of-inhalational-anesthesia
#10
Roopali Donepudi, Melissa Huynh, Kenneth J Moise, Ramesha Papanna, Anthony Johnson, Mary Austin, KuoJen Tsao, Ranu Jain
INTRODUCTION: Optimal uterine relaxation is achieved through higher minimum alveolar concentration (MAC) of inhalational anesthetics, increasing risks to mother and fetus. Our objective was to determine if earlier administration of magnesium sulfate would reduce the requirement of inhalational anesthetics in fetal myelomeningocele repair. MATERIALS AND METHODS: Prospective observational study of fetal myelomeningocele repair was performed from September 2011 to August 2017...
April 19, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29658097/anesthetized-by-chloroform-before-hanging
#11
Amal Nishantha Vadysinghe, Murugaphillai Sivasubramanium
We present a unique case of suicidal hanging. The deceased was a 31-year-old male who was found hanging from a tree in a dense thicket, with his lower limbs in contact with the ground (partial suspension). There was an apparatus similar to a facial mask placed around his nose and mouth. A strong chemical smell was emanating from the apparatus, which was identified as chloroform (Formyl trichloride/CHCl3 ). A ligature with a soft cloth beneath it was around his neck. A ligature mark was present around the neck...
April 16, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29628584/evaluation-of-the-hemodynamic-response-of-intravenous-clonidine-versus-ropivacaine-scalp-block-to-insertion-of-scalp-pins-in-neurosurgical-patients
#12
Saraswathi Nagappa, Sandhya Kalappa, Raghavendra Biligiri Sridhara
Background: The application of the skull-pin head-holder, used to stabilize the head during neurosurgical procedures, produces an intense nociceptive stimulus and results in abrupt increases in blood pressure and cerebral blood flow under general anesthesia. Different anesthetic and pharmacologic techniques, including local anesthetics, narcotics, antihypertensives, and deepening of anesthesia with inhalation anesthetics, have been used to blunt this deleterious effect with variable success...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628557/intraocular-pressure-changes-during-laparoscopic-surgery-in-trendelenburg-position-in-patients-anesthetized-with-propofol-based-total-intravenous-anesthesia-compared-to-sevoflurane-anesthesia-a-comparative-study
#13
Gagandeep Kaur, Mamta Sharma, Poonam Kalra, Shobha Purohit, Kanchan Chauhan
Background: Intraocular pressure (IOP) is increased during laparoscopic surgery with Trendelenburg position and may contribute to deleterious effects on optic nerve in susceptible patients. Aims: The primary objective of this study is to compare the effects of propofol-based total intravenous anesthesia (TIVA) with those of sevoflurane anesthesia on IOP in patients undergoing lower abdominal laparoscopic surgery in Trendelenburg position. Secondary objectives are to compare hemodynamic changes, mean arterial pressure (MAP), end-tidal CO2 , and peak inspiratory pressure changes...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29627934/inhibition-of-microrna-23-contributes-to-the-isoflurane-mediated-cardioprotection-against-oxidative-stress
#14
Hai-Jian Liu, Bin Liu
Isoflurane is one of the most frequently used volatile anesthetics in clinical practice for inhalational anesthesia. It is widely studied that isoflurane mediates cardioprotection during multiple pathological processes. However, the precise mechanisms have not been fully elucidated. Neonatal cardiomyocytes were isolated and cultured, followed by treatments with isoflurane at 0, 50, 100 or 200 µM. Rat cardiomyoblast cell line, H9c2, was treated with H2 O2 . Expression of miR-23 was measured by qRT-PCR. The cell survival rate of H9c2 in response to H2 O2 treatments was evaluated by MTT assay...
April 7, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29627444/inhalational-anesthetics-accelerate-desensitization-of-acid-sensing-ion-channels
#15
Linda Lehmke, Mark Coburn, Manfred Möller, Rosmarie Blaumeiser-Debarry, Pia Lenzig, Dominik Wiemuth, Stefan Gründer
Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by extracellular acidification. Inhibiting ASICs is neuroprotective in mouse models of ischemic stroke. As inhalational anesthetics interact with many ion channels and as some of them have neuroprotective effects, we hypothesized that inhalational anesthetics modulate ASICs. We expressed different homo- and heteromeric ASICs heterologously in Xenopus oocytes. We co-applied with acidic pH the halogenated inhalational anesthetics sevoflurane, desflurane, and isoflurane and the noble gases xenon and argon at concentrations that are roughly equivalent to their minimal alveolar concentrations and analyzed their effect on current kinetics and amplitude...
April 5, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29622309/anesthetic-agents-commonly-used-by-oral-and-maxillofacial-surgeons
#16
REVIEW
Kyle J Kramer, Jason W Brady
Oral and maxillofacial surgeons have a variety of anesthetic agents that can be used to provide anesthesia safely and efficiently in the office-based environment. However, it is critical to have a thorough understanding of the particulars for each agent. Commonly used anesthetic agents, administered either individually or in combination, include diazepam, midazolam, propofol, ketamine, opioid agonists such as fentanyl or remifentanil, dexmedetomidine, and inhalational agents, including nitrous oxide and sevoflurane...
May 2018: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/29620198/isoflurane%C3%A2-induced-postoperative-cognitive-dysfunction-is-mediated-by-hypoxia%C3%A2-inducible-factor%C3%A2-1%C3%AE-%C3%A2-dependent-neuroinflammation-in-aged-rats
#17
Yiyun Cao, Zhengqian Li, Lijun Ma, Cheng Ni, Lunxu Li, Ning Yang, Chengmei Shi, Xiangyang Guo
Elderly patients are at high risk of developing postoperative cognitive dysfunction (POCD) after prolonged exposure to inhaled anesthetics. However, the pathogenesis of POCD remains unknown. Hypoxia‑inducible factor‑1α (HIF‑1α) is activated by inhaled anesthetics. The aim of the present study was to determine the role of HIF‑1α in isoflurane‑induced neuroinflammation and the resulting cognitive impairment. Following a 4‑h exposure to 1.5% isoflurane in 20‑month‑old rats, increased expression of HIF‑1α protein, activation of nuclear factor (NF)‑κB signaling and increased expression of TNF‑1α were observed in the hippocampus of isoflurane‑exposed rats compared with the control group...
April 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29605588/genotoxic-effect-of-lippia-alba-mill-n-e-brown-essential-oil-on-fish-oreochromis-niloticus-and-mammal-mus-musculus
#18
Edgar Hell Kampke, Maria Eduarda de Souza Barroso, Franciane Martins Marques, Marcio Fronza, Rodrigo Scherer, Mayara Fumiere Lemos, Bianca Prandi Campagnaro, Levy Carvalho Gomes
"Erva cidreira" (Lippia alba (Mill.) N. E. Brown) is popular for its therapeutic properties, especially its sedative properties. Such properties led to the discovery of the anesthetic action of Lippia alba essential oil in fish culture. The objective of this study was to evaluate the genotoxic effect of Lippia alba essential oil in fish and mammals. The oil was extracted by hydrodistillation with a Clevenger apparatus and analyzed by gas chromatography coupled to mass spectrometry (GC-MS), where the compounds linalool, eucalyptol, γ-muurolene, and caryophyllene were identified as the most abundant compounds...
March 26, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29588456/inhalational-anesthetics-induce-neuronal-protein-aggregation-and-affect-er-trafficking
#19
Matthew Coghlan, Elizabeth Richards, Sadiq Shaik, Pablo Rossi, Ramesh Babu Vanama, Saumel Ahmadi, Christelle Petroz, Mark Crawford, Jason T Maynes
Anesthetic agents have been implicated in the causation of neurological and cognitive deficits after surgery, the exacerbation of chronic neurodegenerative disease, and were recently reported to promote the onset of the neurologic respiratory disease Congenital Central Hypoventilation Syndrome (CCHS), related to misfolding of the transcription factor Phox2B. To study how anesthetic agents could affect neuronal function through alterations to protein folding, we created neuronal cell models emulating the graded disease severity of CCHS...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29588040/hcn-and-k-2p-channels-in-anesthetic-mechanisms-research
#20
Paul M Riegelhaupt, Gareth R Tibbs, Peter A Goldstein
The ability of a diverse group of agents to produce general anesthesia has long been an area of intense speculation and investigation. Over the past century, we have seen a paradigm shift from proposing that the anesthetized state arises from nonspecific interaction of anesthetics with the lipid membrane to the recognition that the function of distinct, and identifiable, membrane-embedded proteins is dramatically altered in the presence of intravenous and inhaled agents. Among proteinaceous targets, metabotropic and ionotropic receptors garnered much of the attention over the last 30 years, and it is only relatively recently that voltage-gated ion channels have clearly and rigorously been shown to be important molecular targets...
2018: Methods in Enzymology
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