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Obesity and asthma

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https://www.readbyqxmd.com/read/28648831/glucagon-like-peptide-1-a-potential-anti-inflammatory-pathway-in-obesity-related-asthma
#1
REVIEW
Dan-Vinh Nguyen, Angela Linderholm, Angela Haczku, Nicholas Kenyon
Alterations in arginine metabolism and accelerated formation of advanced glycation end-products (AGEs), crucial mechanisms in obesity-related asthma, can be modulated by glucagon-like peptide 1 (GLP-1). L-arginine dysregulation in obesity promotes inflammation and bronchoconstriction. Prolonged hyperglycemia, dyslipidemia, and oxidative stress leads to production of AGEs, that bind to their receptor (RAGE) further potentiating inflammation. By binding to its widely distributed receptor, GLP-1 blunts the effects of RAGE activation and arginine dysregulation...
June 22, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28647509/a-review-of-acalypha-indica-l-euphorbiaceae-as-traditional-medicinal-plant-and-its-therapeutic-potential
#2
REVIEW
Nor Syahiran Zahidin, Syafiqah Saidin, Razauden Mohamed Zulkifli, Ida Idayu Muhamad, Harisun Ya'akob, Hadi Nur
ETHNOPHARMACOLOGICAL RELEVANCE: Acalypha indica is an herbal plant that grows in wet, temperate and tropical region, primarily along the earth's equator line. This plant is considered by most people as a weed and can easily be found in these regions. Although this plant is a weed, Acalypha indica has been acknowledged by local people as a useful source of medicine for several therapeutic treatments. They consume parts of the plant for many therapeutics purposes such as anthelmintic, anti-ulcer, bronchitis, asthma, wound healing, anti-bacterial and other applications...
June 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28645880/biomarkers-of-airway-and-systemic-inflammation-in-obese-asthmatic-paediatric-patients
#3
H T Nacaroglu, O B Gayret, M Erol, O Buke, O Zengi, M Tasdemir, Z Tasdemir, O Yigit
BACKGROUND: It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment. OBJECTIVE: This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation. METHODS: The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey...
June 20, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28635907/-the-problem-of-obstructive-sleep-apnea-syndrome-in-asthmatic-patients
#4
E G Sheludko, D E Naumov, Yu M Perelman, V P Kolosov
Asthma and obstructive sleep apnea syndrome (OSAS) are one of the most common chronic respiratory diseases. These have common risk factors that include obesity, gastroesophageal reflux disease (GERD) and impaired nasal breathing (allergic rhinitis, sinusitis). At the same time, experimental evidence demonstrates common pathophysiological mechanisms of these diseases, such as involvement in the process of the respiratory tract, a systemic inflammatory response, and implementation of neuromechanical reflexes...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28634898/role-of-obesity-in-asthma-mechanisms-and-management-strategies
#5
REVIEW
Hayley A Scott, Lisa G Wood, Peter G Gibson
PURPOSE OF REVIEW: Obesity is a commonly reported comorbidity in asthma, particularly in severe asthma. Obese asthmatics are highly symptomatic with a poor quality of life, despite using high-dose inhaled corticosteroids. While the clinical manifestations have been documented, the aetiologies of obese-asthma remain unclear. RECENT FINDINGS: Several potential mechanisms have been proposed, including poor diet quality, physical inactivity and consequent accrual of excess adipose tissue...
August 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28632874/screening-for-obesity-in-children-and-adolescents-us-preventive-services-task-force-recommendation-statement
#6
David C Grossman, Kirsten Bibbins-Domingo, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Based on year 2000 Centers for Disease Control and Prevention growth charts, approximately 17% of children and adolescents aged 2 to 19 years in the United States have obesity, and almost 32% of children and adolescents are overweight or have obesity. Obesity in children and adolescents is associated with morbidity such as mental health and psychological issues, asthma, obstructive sleep apnea, orthopedic problems, and adverse cardiovascular and metabolic outcomes (eg, high blood pressure, abnormal lipid levels, and insulin resistance)...
June 20, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28625577/risk-factors-for-chronic-cough-among-14-669-individuals-from-the-general-population
#7
Yunus Çolak, Børge G Nordestgaard, Lars C Laursen, Shoaib Afzal, Peter Lange, Morten Dahl
BACKGROUND: Risk factors for chronic cough in the general population have not been described systematically. We identified and ranked chronic cough risk factors at the individual and community level using data from 14669 individuals from the Copenhagen General Population Study. METHODS: Severity of chronic cough was assessed using the Leicester Cough Questionnaire(LCQ). We ranked chronic cough risk factors based on magnitude of age-adjusted odds ratios(ORs) at the individual level and of the population attributable risks(PARs) at the community level...
June 15, 2017: Chest
https://www.readbyqxmd.com/read/28624608/obesity-s-impact-on-asthma-extends-to-diagnostic-criteria
#8
Njira Lugogo, Cynthia L Green, Noah Agada, Siyi Zhang, Susanne Meghdadpour, Run Zhou, Siyun Yang, Kevin J Anstrom, Elliot Israel, Richard Martin, Robert F Lemanske, Homer Boushey, Stephen C Lazarus, Stephen I Wasserman, Mario Castro, William Calhoun, Stephen P Peters, Emily DiMango, Vernon Chinchilli, Nikolina Icitovic, Susan Kunselman, Tonya S King, Monica Kraft
BACKGROUND: The use of inflammatory biomarkers to delineate the type of lung inflammation present in asthma is increasingly common. However, the impact of obesity on these markers is unknown. OBJECTIVES: We aimed to determine the impact of obesity on conventional markers of inflammation in asthma. METHODS: We performed secondary analysis of data from 652 patients previously enrolled in two ACRN trials. We performed linear correlations between biomarkers and logistic regression analysis to determine the predictive value of IgE, blood eosinophils and FeNO in relationship to sputum eosinophils (>2%), as well as to determine if cut points existed that would maximize the sensitivity and specificity for predicting sputum eosinophilia in the three weight groups...
June 14, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28624607/obese-asthmatics-have-decreased-surfactant-protein-a-levels-mechanisms-and-implications
#9
Njira Lugogo, Dave Francisco, Kenneth J Addison, Akarsh Manne, William Pederson, Jennifer L Ingram, Cynthia L Green, Benjamin T Suratt, James J Lee, Mary E Sunday, Monica Kraft, Julie G Ledford
BACKGROUND: Eosinophils are prominent in some individuals with asthma and are elevated in the submucosa in a subgroup of obese asthmatics. Surfactant protein-A (SP-A) modulates host responses to infectious and environmental insults. OBJECTIVE: To determine if SP-A levels are altered in obese asthma patients compared to a control group and to determine the implications of these alterations in SP-A levels in asthma. METHODS: Bronchoalveolar lavage fluid from 23 lean, 12 overweight and 20 obese subjects were examined for SP-A...
June 14, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28606587/asthma-control-status-in-pregnancy-bmi-and-maternal-vitamin-d-levels
#10
Hooman Mirzakhani, George O'Connor, Leonard B Bacharier, Robert S Zeiger, Michael X Schatz, Scott T Weiss, Augusto A Litonjua
Higher maternal 25OHD levels at early pregnancy could reduce the associated risk of uncontrolled asthma status during pregnancy. Obesity might attenuate this effect and is a predictor of uncontrolled status during pregnancy.
June 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28604080/association-of-childhood-obesity-and-the-immune-system-a-systematic-review-of-reviews
#11
Roya Kelishadi, Mohammad Roufarshbaf, Sina Soheili, Farzaneh Payghambarzadeh, Mohsen Masjedi
The growing prevalence of childhood obesity has become a serious health problem over the past decades. As the immune system is greatly affected by excess weight, in this review of reviews, we discuss the findings of review articles about the relationship between childhood/maternal obesity and children's immune system. We searched English-language articles in PubMed, Scopus, ISI Thomson Reuters, and Google Scholar databases. All relevant reviews, either systematic or narrative, were retrieved. Then their quality was assessed by using the Assessment of Multiple Systematic Reviews and International Narrative Systematic Assessment tools, respectively...
June 12, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28596096/hearing-loss-and-associated-medical-conditions-among-individuals-65-years-and-older
#12
Michael M McKee, Michelle L Stransky, Amanda Reichard
BACKGROUND: Hearing loss is prevalent, but few studies have investigated its associations with common medical conditions. OBJECTIVE: The objective was to assess the prevalence of medical conditions among individuals with hearing loss, compared to those without hearing loss, in people aged 65 years and older. METHODS: The National Health Interview Survey (NHIS) collects data on a variety of health-related topics, including disability. Three years of NHIS data (2011-2013; unweighted n = 53,111) were pooled to examine subpopulations of individuals with hearing loss...
June 1, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28586602/frequency-of-metabolic-syndrome-in-asthmatic-patients-of-hazara-division
#13
Nasir Ahmed, Syed Moosa Kazim, Syed Yasir Gillani
OBJECTIVE: Bronchial asthma is a common disease and most asthmatics are obese. Both asthma and obesity are showing parallel trends in their increasing prevalence. Obesity is also the main component of metabolic syndrome and several studies have shown metabolic syndrome to be associated with bronchial asthma. The present study was, therefore, designed to determine the frequency of metabolic syndrome among patients with chronic asthma in our setup. METHODS: This cross-sectional study was conducted in Department of Medicine, Ayub Teaching Hospital, Abbottabad from May to November, 2014...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28581533/gastrointestinal-complications-and-refeeding-guidelines-in-patients-with-anorexia-nervosa
#14
REVIEW
Żaneta Malczyk, Joanna Małgorzata Oświęcimska
Anorexia nervosa (AN) is the third most common disorder, after obesity and asthma, in the population of adolescents between 13-18 years of age. Food intake reduction is associated with whole body dysfunction, affecting its physical, psychological and social spheres. As a result of starvation, dysfunction develops in virtually all systems and organs. However, most frequently patients with AN complain of digestive symptoms, such as a feeling of fullness after meals, pain in the upper abdomen, dysphagia, nausea, bloating and constipation...
April 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28570148/an-official-american-thoracic-society-workshop-report-obesity-and-metabolism-an-emerging-frontier-in-lung-health-and-disease
#15
Benjamin T Suratt, Niki D J Ubags, Deepa Rastogi, Kelan G Tantisira, Benjamin J Marsland, Irina Petrache, Janice B Allen, Jason H T Bates, Fernando Holguin, Meredith C McCormack, Evangelos D Michelakis, Stephen M Black, Manu Jain, Ana L Mora, Viswanathan Natarajan, Yury I Miller, Michael B Fessler, Konstantin G Birukov, Ross S Summer, Stephanie A Shore, Anne E Dixon
The world is in the midst of an unprecedented epidemic of obesity. This epidemic has changed the presentation and etiology of common diseases. For example, steatohepatitis, directly attributable to obesity, is now the most common cause of cirrhosis in the United States. Type 2 diabetes is increasingly being diagnosed in children. Pulmonary researchers and clinicians are just beginning to appreciate the impact of obesity and altered metabolism on common pulmonary diseases. Obesity has recently been identified as a major risk factor for the development of asthma and for acute respiratory distress syndrome...
June 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28561247/asthma-during-pregnancy-exacerbations-management-and-health-outcomes-for-mother-and-infant
#16
Vanessa E Murphy, Megan E Jensen, Peter G Gibson
One in 10 pregnant women worldwide has asthma and of these, 10% will have a severe exacerbation requiring oral corticosteroids (OCSs) in pregnancy. This review of recent publications in the field will describe the effects of exacerbation on maternal and neonatal health, the use of asthma medications during pregnancy, and will suggest novel management approaches for asthma in pregnancy. Pregnancy results in unpredictable changes in the disease; therefore, regular monitoring of symptoms is recommended. Uncontrolled asthma is frequently described in cohorts of pregnant women with asthma, and some recent studies show associations with adverse perinatal outcomes, as previously demonstrated with exacerbations...
April 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28552381/influence-of-maternal-body-mass-index-and-macrophage-activation-on-asthma-exacerbations-in-pregnancy
#17
Vanessa E Murphy, Megan E Jensen, Heather Powell, Peter G Gibson
BACKGROUND: Obesity is a risk factor for exacerbations of asthma, but the mechanisms of this effect in pregnancy are unknown. OBJECTIVE: This study determined the influence of maternal body mass index, gestational weight gain, eosinophilic inflammation, and systemic macrophage activation on the risk of exacerbations during pregnancy. METHODS: Women with asthma (n = 164) participated in the study. Body mass index recorded at baseline (17 weeks gestation) was categorized as healthy weight (18...
May 25, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28543872/pai-1-gain-of-function-genotype-factors-increasing-pai-1-levels-and-airway-obstruction-the-gala-ii-cohort
#18
Michael G Sherenian, Seong H Cho, Albert Levin, Jin-Young Min, Sam S Oh, Donglei Hu, Joshua Galanter, Saunak Sen, Scott Huntsman, Celeste Eng, Jose R Rodriguez-Santana, Denise Serebrisky, Pedro C Avila, Ravi Kalhan, Lewis J Smith, Luisa N Borrell, Max A Seibold, L Keoki Williams, Esteban G Burchard, Rajesh Kumar
BACKGROUND: PAI-1 gain of function variants promote airway fibrosis, and are associated with asthma and with worse lung function in subjects with asthma. OBJECTIVE: We sought to determine if the association of a gain-of-function polymorphism in Plasminogen Activator Inhibitor -1 (PAI-1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common exposures that increase PAI-1 level. METHODS: We studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II cohort...
May 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28534818/a-review-of-the-impact-of-maternal-obesity-on-the-cognitive-function-and-mental-health-of-the-offspring
#19
REVIEW
Laura Contu, Cheryl A Hawkes
Globally, more than 20% of women of reproductive age are currently estimated to be obese. Children born to obese mothers are at higher risk of developing obesity, coronary heart disease, diabetes, stroke, and asthma in adulthood. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and function of the offspring brain across the lifespan. This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring...
May 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28527867/association-of-neck-circumference-and-pulmonary-function-in-children
#20
Onur Akın, Mutluay Arslan, Cem Haymana, Erdem Karabulut, Bulent Hacihamdioglu, Suleyman Tolga Yavuz
BACKGROUND: Childhood obesity leads to many complications including impaired respiratory function. There are various anthropometric parameters related to obesity. OBJECTIVE: To investigate the correlation between anthropometric indices and pulmonary function test results in children without asthma. METHODS: Children without any respiratory disorders were enrolled in this study. Anthropometric measurements, such as height, weight, neck circumference (NC), and waist circumference, were obtained from the enrollees and body mass index was calculated...
May 17, 2017: Annals of Allergy, Asthma & Immunology
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