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B-type natriuretic peptide

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https://www.readbyqxmd.com/read/29775443/-b-type-natriuretic-peptide-as-a-marker-of-cardiac-dysfunction-in-children-with-chronic-kidney-disease
#1
Tomasz Drożdż, Przemko Kwinta, Zbigniew Kordon, Krystyna Sztefko, Andrzej Rudziński, Katarzyna Zachwieja, Monika Miklaszewska, Danuta Czarnecka, Dorota Drożdż
Left ventricular hypertrophy is the most common organ damage in children with chronic kidney disease (CKD). AIM: The aim of the study was to assess the usefulness of B-type natriuretic peptide (BNP) as a marker of heart injury in children with CKD. MATERIALS AND METHODS: We included 66 children (41 boys and 25 girls) aged 0.7 to 18.6 (median 11.6) years with CKD stage 1-5. The concentrations of urea, creatinine, cystatin C and BNP in blood serum were assessed, and the estimated glomerular filtration rate (eGFR) was calculated from the Schwartz and Filler formulas...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29762337/real-life-indications-to-ivabradine-treatment-for-heart-rate-optimization-in-patients-with-chronic-systolic-heart-failure
#2
Lara Tondi, Gabriele Fragasso, Roberto Spoladore, Giuseppe Pinto, Marco Gemma, Massimo Slavich, Cosmo Godino, Anna Salerno, Claudia Montanaro, Alberto Margonato
: Ivabradine is a selective and specific inhibitor of If current. With its pure negative chronotropic action, it is recommended by European Society of Cardiology and American College of Cardiology/American Heart Association guidelines in symptomatic heart failure patients (NYHA ≥ 2) with ejection fraction 35% or less, sinus rhythm and heart rate (HR) at least 70 bpm, despite maximally titrated β-blocker therapy. Data supporting this indication mainly derive from the SHIFT study, in which ivabradine reduced the combined endpoint of mortality and hospitalization, despite the fact that only 26% of patients enrolled were on optimal β-blocker doses...
May 11, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29761678/ultrasound-of-jugular-veins-for-assessment-of-acute-dyspnea-in-emergency-departments-and-for-the-assessment-of-acute-heart-failure
#3
Batsheva Tzadok, Shay Shapira, Eran Tal-Or
BACKGROUND: When a patient arrives at the emergency department (ED) presenting with symptoms of acute decompensated heart failure (ADHF), it is possible to reach a definitive diagnosis through many different venues, including medical history, physical examination, echocardiography, chest X-ray, and B-type natriuretic peptide (BNP) levels. Point-of-care ultrasound (POCUS) has become a mainstream tool for diagnosis and treatment in the field of emergency medicine, as well as in various other departments in the hospital setting...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29761677/pleural-fluid-b-type-natriuretic-peptide-level-as-an-additional-indicator-for-the-fluid-s-etiology
#4
Ronen Zalts, Tomer Twizer, Ronit Leiba, Amir Karban
BACKGROUND: The identification of the etiology of a pleural effusion can be difficult. Measurement of serum B-type natriuretic peptide (BNP) levels is helpful in the diagnosis of congestive heart failure (CHF) as a cause of respiratory failure, but pleural fluid BNP measurement is still not part of the workup for pleural effusion. OBJECTIVES: To identify the correlation between pleural fluid BNP levels and clinical diagnosis. METHODS: In this cross-sectional study, data from 107 patients admitted to the department of internal medicine between November 2009 and January 2015 were obtained from medical records...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29759295/effect-of-acute-kidney-injury-after-percutaneous-mitral-valve-repair-on-outcome
#5
Maximilian Spieker, Katharina Hellhammer, Stratis Katsianos, Julian Wiora, Tobias Zeus, Patrick Horn, Malte Kelm, Ralf Westenfeld
Limited data exist on the occurrence of acute kidney injury (AKI) associated with percutaneous mitral valve repair (PMVR). The objectives of the present study were (1) to assess the prevalence of AKI after MitraClip (Abbott Vascular, Santa Clara, California) implantation, (2) to analyze the predictive factors of AKI, and (3) to evaluate the prognostic value of AKI after PMVR with a view to optimizing the management of high-risk patients. A total of 206 patients (serum creatinine [SCr] 1.3 ± 0.6 mg/dl, estimated glomerular filtration rate 55 ± 24 ml/min) who underwent PMVR were included...
April 17, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29758041/acute-effects-of-insulin-on-circulating-natriuretic-peptide-levels-in-humans
#6
Katherine N Bachmann, Serpil Muge Deger, Aseel Alsouqi, Shi Huang, Meng Xu, Jane F Ferguson, Yan Ru Su, Kevin D Niswender, T Alp Ikizler, Thomas J Wang
BACKGROUND: The natriuretic peptide hormones play an important role in salt and blood pressure regulation. In observational studies, obesity and insulin resistance have been consistently associated with lower concentrations of natriuretic peptides. It has been proposed that insulin influences natriuretic peptide production. OBJECTIVE: We sought to determine the acute effects of insulin administration on natriuretic peptide concentrations. METHODS: 31 men and women (11 lean, 10 overweight, and 10 obese), ages 30-70 years, without cardiovascular disease or overt diabetes underwent a hyperinsulinemic-euglycemic insulin clamp...
2018: PloS One
https://www.readbyqxmd.com/read/29754651/rationale-and-methods-of-the-prospective-study-of-biomarkers-symptom-improvement-and-ventricular-remodeling-during-sacubitril-valsartan-therapy-for-heart-failure-prove-hf
#7
James L Januzzi, Javed Butler, Emmanuel Fombu, Alan Maisel, Kevin McCague, Ileana L Piña, Margaret F Prescott, Jerome B Riebman, Scott Solomon
BACKGROUND: Sacubitril/valsartan is an angiotensin receptor-neprilysin inhibitor indicated for the treatment of patients with chronic heart failure (HF) with reduced ejection fraction; however, its mechanism of benefit remains unclear. Biomarkers that are linked to ventricular remodeling, myocardial injury, and fibrosis may provide mechanistic insight and important clinical guidance regarding sacubitril/valsartan use. METHODS: This 52-week, multicenter, open-label, single-arm study is designed to (1) correlate biomarker changes with cardiac remodeling parameters, cardiovascular outcomes, and patient-reported outcome data and (2) determine short- and long-term changes in concentrations of biomarkers related to potential mechanisms of action and effects of sacubitril/valsartan therapy...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29753673/prevalence-and-prognostic-significance-of-malnutrition-using-3-scoring-systems-among-outpatients-with-heart-failure-a-comparison-with-body-mass-index
#8
Shirley Sze, Pierpaolo Pellicori, Syed Kazmi, Alan Rigby, John G F Cleland, Kenneth Wong, Andrew Lawrence Clark
OBJECTIVES: The authors sought to report the prevalence, clinical associations, and prognostic consequences of malnutrition in outpatients with heart failure (HF). BACKGROUND: Malnutrition may be common in HF and associated with adverse outcomes, but few data exist. METHODS: We applied the geriatric nutritional risk index (GNRI), controlling nutritional status (CONUT) score, and prognostic nutritional index (PNI) to consecutive patients referred with suspected HF to a clinic serving a local population (n = 550,000)...
May 2, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29753374/beneficial-effects-of-pentoxifylline-plus-losartan-dual-therapy-in-type-2-diabetes-with-nephropathy
#9
Soghra Rabizadeh, Fatemeh Dehghani Firouzabadi, Sina Noshad, Sadaf Esteghamati, Mohsen Afarideh, Alireza Ghajar, Morsaleh Ganji, Mohammad Saadat, Behnam Heidari, Mohammad Taghi Najafi, Manouchehr Nakhjavani, Alireza Esteghamati
BACKGROUND: This study was designed to comparatively assess the effects of add-on pentoxifylline to losartan versus increasing the dose of losartan on serum N-terminal pro-brain natriuretic peptide (NT-proBNP), serum highly sensitive C-reactive protein (hsCRP) and the urinary albumin excretion (UAE) rate in patients with type 2 diabetes and nephropathy. METHODS: In an open-label, single-center, parallel-group, randomized clinical trial (NCT03006952), 30 patients received b...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29752392/independent-prognostic-value-of-stroke-volume-index-in-patients-with-immunoglobulin-light-chain-amyloidosis
#10
(no author information available yet)
BACKGROUND: Heart involvement is the most important prognostic determinant in AL amyloidosis patients. Echocardiography is a cornerstone for the diagnosis and provides important prognostic information. METHODS AND RESULTS: We studied 754 patients with AL amyloidosis who underwent echocardiographic assessment at the Mayo Clinic, including a Doppler-derived measurement of stroke volume (SV) within 30 days of their diagnosis to explore the prognostic role of echocardiographic variables in the context of a well-established soluble cardiac biomarker staging system...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29748349/independent-prognostic-value-of-serum-soluble-st2-measurements-in-patients-with-heart-failure-and-a-reduced-ejection-fraction-in-the-paradigm-hf-trial-prospective-comparison-of-arni-with-acei-to-determine-impact-on-global-mortality-and-morbidity-in-heart-failure
#11
Eileen O'Meara, Margaret F Prescott, Brian Claggett, Jean L Rouleau, Lu-May Chiang, Scott D Solomon, Milton Packer, John J V McMurray, Michael R Zile
BACKGROUND: Soluble ST2 (sST2) is associated with cardiac remodeling and fibrosis. In chronic heart failure, the predictive value of sST2 has not been evaluated in a model that includes both NT-proBNP (N-terminal pro-B-type natriuretic peptide) and hs-TnT (high-sensitivity cardiac troponin T), in a trial in which treatment had a major impact. Therefore, the effects of treatment on sST2 levels in PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the relationships between sST2 and outcomes, and the prognostic utility of various sST2 partition values were examined...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29747827/b-type-natriuretic-peptide-levels-and-mortality-in-patients-with-and-without-heart-failure
#12
Michelle K York, Deepak K Gupta, Cassandra F Reynolds, Eric Farber-Eger, Quinn S Wells, Katherine N Bachmann, Meng Xu, Frank E Harrell, Thomas J Wang
BACKGROUND: Circulating B-type natriuretic peptide (BNP) concentrations strongly predict mortality in patients with heart failure (HF). Both cardiac and extracardiac stimuli influence BNP levels, suggesting that BNP might have similar prognostic value in patients without HF. OBJECTIVES: The aim of this study was to compare the prognostic value of BNP between patients with and those without HF. METHODS: Using the Vanderbilt University Medical Center electronic health record, 30,487 patients (median age 63 years, 50% men, 17% black, 38% with HF) who had a first plasma BNP measurement between 2002 and 2013, with follow-up through 2015, were studied...
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29744629/cost-effectiveness-of-b-type-natriuretic-peptide-guided-care-in-patients-with-heart-failure-a-systematic-review
#13
REVIEW
Abdosaleh Jafari, Aziz Rezapour, Marjan Hajahmadi
Measuring the level of B-type natriuretic peptide (BNP), as a guide to pharmacotherapy, can increase the survival of patients with heart failure. This study is aimed at systematically reviewing the studies conducted on the cost-effectiveness of BNP-guided care in patients with heart failure. Using the systematic review method, we reviewed the published studies on the cost-effectiveness of BNP-guided care in patients with heart failure during the years 2004 to 2017. The results showed that all studies clearly stated the time horizon of the study and included direct medical costs in their analysis...
May 10, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29743380/tailored-adjunctive-cilostazol-therapy-based-on-cyp2c19-genotyping-in-patients-with-acute-myocardial-infarction-the-caldera-gene-study
#14
Koichi Kaikita, Hiromi Yoshimura, Masanobu Ishii, Takashi Kudoh, Yoshihiro Yamada, Eiichiro Yamamoto, Yasuhiro Izumiya, Sunao Kojima, Hideki Shimomura, Ryusuke Tsunoda, Kunihiko Matsui, Hisao Ogawa, Kenichi Tsujita
BACKGROUND: Patients with reduced-function CYP2C19 genotypes on dual antiplatelet therapy (DAPT) with aspirin and clopidogrel show higher clinical risk for acute myocardial infarction (AMI). We investigated the effect of CYP2C19 genotype-tailored adjunctive cilostazol therapy on treatment of AMI.Methods and Results:The study group of 138 patients with suspected AMI were screened for CYP2C19 genotype immediately after percutaneous coronary intervention (PCI) using a SPARTAN RX point-of-care device...
May 8, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29742489/renal-denervation-effects-on-myocardial-fibrosis-and-ventricular-arrhythmias-in-rats-with-ischemic-cardiomyopathy
#15
Bin Zhang, Xiaorong Li, Chu Chen, Wanying Jiang, Dasheng Lu, Qian Liu, Kai Wang, Yuhao Yan, Zhixin Jiang, Jie Geng, Hai Xu, Qijun Shan
BACKGROUND/AIMS: To investigate the impact of renal denervation (RDN) on myocardial fibrosis and ventricular arrhythmias (VAs) in rats with ischemic cardiomyopathy. METHODS: An ischemic cardiomyopathy model was reproduced with myocardial infarction (MI) in adult Sprague-Dawley male rats. The RDN/Sham-RDN procedure was performed at 2 weeks after MI. Sham-MI and sham-RDN rats served as the control group. At 4 weeks after RDN, programmed electrical stimulation (PES) was used to induce VAs, including ventricular tachycardia and ventricular fibrillation, in all 3 groups (MI+RDN, MI, and control groups)...
May 5, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29739745/left-ventricular-mechanical-unloading-by-total-support-of-impella-in-myocardial-infarction-reduces-infarct-size-preserves-left-ventricular-function-and-prevents-subsequent-heart-failure-in-dogs
#16
Keita Saku, Takamori Kakino, Takahiro Arimura, Genya Sunagawa, Takuya Nishikawa, Takafumi Sakamoto, Takuya Kishi, Hiroyuki Tsutsui, Kenji Sunagawa
BACKGROUND: Acute myocardial infarction remains a leading cause of chronic heart failure. Excessive myocardial oxygen demand relative to supply is the fundamental mechanism of myocardial infarction. We thus hypothesized that left ventricular (LV) mechanical unloading by the total support of transvascular LV assist device Impella could minimize oxygen demand, thereby reducing infarct size and preventing subsequent heart failure. METHODS AND RESULTS: In 20 dogs, we ligated the left anterior descending coronary artery for 180 minutes and then reperfused...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29735525/orthostatic-hypotension-and-risk-of-clinical-and-subclinical-cardiovascular-disease-in-middle-aged-adults
#17
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, John William McEvoy, Kunihiro Matsushita, Christie M Ballantyne, Elizabeth Selvin
BACKGROUND: Although orthostatic hypotension (OH) is a well-recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease (CVD) risk is controversial. METHODS AND RESULTS: Participants with OH, defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987-1989) within 2 minutes of standing...
May 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29733687/prognostic-and-diagnostic-significance-of-mid-regional-pro-atrial-natriuretic-peptide-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-acute-heart-failure-data-from-the-ace-2-study
#18
Mohammad Osman Pervez, Jacob A Winther, Jon Brynildsen, Heidi Strand, Geir Christensen, Arne Didrik Høiseth, Peder L Myhre, Ragnhild Røysland, Magnus Nakrem Lyngbakken, Torbjørn Omland, Helge Røsjø
PURPOSE: To compare the diagnostic and prognostic value of mid-regional pro-ANP (MR-proANP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute dyspnea. METHODS: MR-proANP and NT-proBNP were measured with commercial immunoassays at hospital admission (n = 313), on day 2 (n = 234), and before discharge (n = 91) and compared for diagnosing acute heart failure (HF; n = 143) and to predict mortality among patients with acute HF and acute exacerbation of chronic obstructive pulmonary disease (AECOPD; n = 84) separately...
May 7, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29733422/soluble-cd146-and-b-type-natriuretic-peptide-dissect-overhydration-into-functional-components-of-prognostic-relevance-in-haemodialysis-patients
#19
Mattia Arrigo, Seraina Von Moos, Kerem Gerritsen, Malha Sadoune, Kamonwan Tangvoraphonkchai, Andrew Davenport, Alexandre Mebazaa, Stephan Segerer, Pietro E Cippà
Background: Accurate volume status evaluation and differentiation of cardiac and non-cardiac components of overhydration (OH) are fundaments of optimal haemodialysis (HD) management. Methods: This study, by combining bioimpedance measurements, cardiovascular biomarkers and echocardiography, aimed at dissecting OH into its major functional components, and prospectively tested the association between cardiac and non-cardiac components of OH with mortality. In the first part, we validated soluble CD146 (sCD146) as a non-cardiac biomarker of systemic congestion in a cohort of 30 HD patients...
May 4, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29723224/effects-of-anthracycline-cyclophosphamide-and-taxane-chemotherapy-on-qtc-measurements-in-patients-with-breast-cancer
#20
Pedro Veronese, Denise Tessariol Hachul, Mauricio Ibrahim Scanavacca, Ludhmila Abrahão Hajjar, Tan Chen Wu, Luciana Sacilotto, Carolina Veronese, Francisco Carlos da Costa Darrieux
AIM: Acute and subacute cardiotoxicity are characterized by prolongation of the corrected QT interval (QTc) and other measures derived from the QTc interval, such as QTc dispersion (QTdc) and transmural dispersion of repolarization (DTpTe). Although anthracyclines prolong the QTc interval, it is unclear whether breast cancer patients who undergo the ACT chemotherapy regimen of anthracycline (doxorubicin: A), cyclophosphamide (C) and taxane (T) may present with QTc, QTdc and DTpTe prolongation...
2018: PloS One
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