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B-type natriuretic peptide

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https://www.readbyqxmd.com/read/28929118/natriuretic-peptide-system-activation-in-acute-heart-failure-patients-with-diabetes
#1
Filipe M Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt
BACKGROUND: Elevated B-type natriuretic peptide (BNP) is a hallmark in heart failure (HF). Diabetic patients with chronic HF seem to have higher BNP than nondiabetics. We studied, in acute HF, if BNP levels are different between diabetics and nondiabetics. METHODS: From a prospectively recruited population of acute HF patients, we selected a convenience sample. In pair-matched analysis, each diabetic patient was matched with a nondiabetic of the same age (±1 year), gender, and according to left ventricular systolic dysfunction...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28922407/segmental-arterial-stiffness-in-relation-to-b-type-natriuretic-peptide-with-preserved-systolic-heart-function
#2
Chih-Hsuan Yen, Chung-Lieh Hung, Ping-Ying Lee, Jui-Peng Tsai, Yau-Huei Lai, Cheng-Huang Su, Hung-I Yeh, Charles Jia-Yin Hou, Kuo-Liong Chien
BACKGROUND: Central arterial stiffness has been shown to play a key role in cardiovascular disease. However, evidence regarding such arterial stiffness from various arterial segments in relation to B-type natriuretic peptide (BNP) remains elusive. METHODS: A total of 1255 participants (47.8% men; mean age: 62.6 ± 12.3 [SD] years) with preserved left ventricular function (ejection fraction ≥50%) and ≥1 risk factors were consecutively studied. Arterial pulse wave velocity (PWV) by automatic device (VP-2000; Omron Healthcare) for heart-femoral (hf-PWV), brachial-ankle (ba-PWV), and heart-carotid (hc-PWV) segments were obtained and related to BNP concentrations (Abbott Diagnostics, Abbott Park, IL, USA)...
2017: PloS One
https://www.readbyqxmd.com/read/28917673/b-type-natriuretic-peptide-and-high-sensitivity-cardiac-troponin-for-risk-stratification-in-low-flow-low-gradient-aortic-stenosis-a-substudy-of-the-topas-study
#3
Abdellaziz Dahou, Marie-Annick Clavel, Romain Capoulade, Kim O'Connor, Henrique B Ribeiro, Nancy Côté, Florent Le Ven, Josep Rodés-Cabau, Jean G Dumesnil, Patrick Mathieu, Philippe Pibarot
OBJECTIVES: The objective of this study was to determine the prognostic value of combined measures of B-type natriuretic peptide (BNP) and high-sensitivity cardiac troponin T (hsTnT) in patients with low-flow, low-gradient aortic stenosis (LF-LG AS) who had either a preserved or reduced left ventricular ejection fraction (LVEF). BACKGROUND: An elevated BNP level is associated with increased risk of mortality in patients with LF-LG AS. The incremental prognostic value of hsTnT in these patients is unknown...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28912041/postoperative-b-type-natriuretic-peptide-monitoring-for-the-assessment-of-the-magnitude-of-shunting-through-blalock-taussig-anastomoses
#4
Cristian Mirabile, Alessandra Mazzola, Liana Valeanu, Vanessa Lopez-Lopez, Claudio Barbanti, Camilla Biselli, Carole Hennequin, Sophie Malekzadeh-Milani, Mirela Bojan
BACKGROUND: The Modified Blalock-Taussig shunt (MBTS) is the most common palliative operation performed in patients with complex cardiac defects. Postoperative morbidity and mortality rates are high, mainly due to shunt thrombosis and over-shunting. Over-shunting may be difficult to identify postoperatively based on conventional criteria. Since plasma B-type natriuretic peptide (BNP) concentrations correlate with the magnitude of shunting in various left-to-right shunt cardiac defects, we investigated its ability to identify postoperative MBTS over-shunting...
September 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28906496/urinary-nt-probnp-levels-and-echocardiographic-parameters-for-patent-ductus-arteriosus
#5
S S Khan, T Sithisarn, H S Bada, M Vranicar, P M Westgate, M Hanna
OBJECTIVE: Patent ductus arteriosus (PDA) is common in preterm infants and is associated with significant morbidities. B type natriuretic peptide (BNP) is synthesized in the ventricles secondary to volume overload and excreted as urinary N-terminal pro-brain natriuretic peptide (NT-proBNP). STUDY DESIGN: We report an observational prospective study of 64 preterm infants with birth weight ⩽1000 g. Echocardiographic parameters were obtained from clinical echocardiograms performed in the first week of life...
September 14, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28905517/the-prognostic-significance-of-tricuspid-valve-regurgitation-in-pulmonary-arterial-hypertension
#6
Libo Chen, Carolyn M Larsen, Rachel J Le, Heidi M Connolly, Sorin V Pislaru, Joseph G Murphy, Michael D McGoon, Robert P Frantz, Garvan C Kane
INTRODUCTION: Tricuspid valve regurgitation (TR) is a frequent finding in patients with pulmonary arterial hypertension (PAH). However, its prognostic significance and relation to PAH, while suspected, are poorly understood. We assessed 727 consecutive patients with newly diagnosed PAH who underwent transthoracic echocardiographic evaluation of tricuspid valve function. OBJECTIVES: The study objective was to determine the association of TR presence and severity with patient characteristics, pulmonary artery hemodynamics, and outcome...
September 14, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28905172/n-terminal-pro-b-type-natriuretic-peptide-and-the-risk-of-stroke-among-patients-hospitalized-with-acute-heart-failure-an-apex-trial-substudy
#7
Gerald Chi, James L Januzzi, Serge Korjian, Yazan Daaboul, Samuel Z Goldhaber, Adrian F Hernandez, Russell D Hull, Alex Gold, Alexander T Cohen, Robert A Harrington, C Michael Gibson
BACKGROUND: Among patients hospitalized with acute heart failure (HF), the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in short-term stroke prediction remains unclear. METHODS: In the APEX trial, 7513 patients hospitalized for an acute medical illness were randomized to receive either extended-duration betrixaban (80 mg once daily for 35-42 days) or standard-of-care enoxaparin (40 mg once daily for 10 ± 4 days) for venous thromboprophylaxis...
September 13, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28904053/cardiovascular-biomarkers-in-hypertensive-patients-with-medical-treatment-results-from-the-randomized-teamsta-protect-i-trial
#8
Annika Jagodzinski, Johannes Tobias Neumann, Francisco Ojeda, Nils Arne Sörensen, Philipp Wild, Thomas Münzel, Tanja Zeller, Dirk Westermann, Stefan Blankenberg
BACKGROUND: High blood pressure (BP) is associated with an increased rate of cardiovascular events and mortality. Cardiovascular biomarkers are able to predict long-term risk in the general population, particularly in diseased cohorts. We undertook an investigation of the effect of 2 different antihypertensive treatments on cardiovascular biomarkers in a randomized trial. METHODS: The TEAMSTA study included 481 hypertensive patients. They were randomized to either 80-mg telmisartan + 5-mg amlodipine (TA) or 40-mg olmesartan + 12...
September 13, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28899951/lowering-interleukin-12-activity-improves-myocardial-and-vascular-function-compared-with-tumor-necrosis-factor-a-antagonism-or-cyclosporine-in-psoriasis
#9
Ignatios Ikonomidis, Evangelia Papadavid, George Makavos, Ioanna Andreadou, Maria Varoudi, Kostas Gravanis, Kostas Theodoropoulos, George Pavlidis, Helen Triantafyllidi, Paraskevi Moutsatsou, Christina Panagiotou, John Parissis, Efstathios Iliodromitis, John Lekakis, Dimitrios Rigopoulos
BACKGROUND: Interleukin (IL)-12 activity is involved in the pathogenesis of psoriasis and acute coronary syndromes. We investigated the effects of IL-12 inhibition on vascular and left ventricular (LV) function in psoriasis. METHODS AND RESULTS: One hundred fifty psoriasis patients were randomized to receive an anti-IL-12/23 (ustekinumab, n=50), anti-tumor necrosis factor-a (TNF-α; etanercept, n=50), or cyclosporine treatment (n=50). At baseline and 4 months post-treatment, we measured (1) LV global longitudinal strain, twisting, and percent difference between peak twisting and untwisting at mitral valve opening (%untwMVO) using speckle-tracking echocardiography, (2) coronary flow reserve, (3) pulse wave velocity and augmentation index, (4) circulating NT-proBNP (N-terminal pro-B-type natriuretic peptide), TNF-α, IL-6, IL-12, IL-17, malondialdehyde, and fetuin-a...
September 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28899838/design-and-evaluation-of-novel-natriuretic-peptide-derivatives-with-improved-pharmacokinetic-and-pharmacodynamic-properties
#10
Naomi Morozumi, Seiji Sato, Sayaka Yoshida, Yuriko Harada, Mayumi Furuya, Yoshiharu Minamitake, Kenji Kangawa
C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor B (NPR-B), are potent positive regulators of endochondral bone growth, making the CNP pathway one of the most promising therapeutic targets for the treatment of growth failure. However, the administration of exogenous CNP is not fully effective, due to its rapid clearance in vivo. Modification of CNP to potentially druggable derivatives may result in increased resistance to proteolytic degradation, longer plasma half-life (T1/2), and better distribution to target tissues...
September 9, 2017: Peptides
https://www.readbyqxmd.com/read/28895696/b-type-natriuretic-peptide-usefulness-in-the-management-of-critically-ill-neonates
#11
Gisela L Salas, Mariela Jozefkowicz, Gustavo S Goldsmit, Gabriela Disa, Alejandra Rodiño, Susana Rodríguez, Diana Fariña
INTRODUCTION: B-type natriuretic peptide (BNP) is responsible for changes in the heart organogenesis and is associated with transition to extrauterine life. In the first week of life, BNP levels are high and return to normal with the physiological loss in weight. High BNP levels are associated with different conditions. OBJETIVE: To establish the relationship between BNP levels and criticality and the short-term clinical course among patients hospitalized in the neonatal intensive care unit...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28892359/microporous-nanocomposite-enabled-microfluidic-biochip-for-cardiac-biomarker-detection
#12
Nawab Singh, Md Azahar Ali, Prabhakar Rai, Ashutosh Sharma, Bansi Dhar Malhotra, Renu John
This paper demonstrates an ultrasensitive microfluidic biochip nanoengineered with microporous manganese-reduced graphene oxide nanocomposite for detection of cardiac biomarker, namely human cardiac troponin I. In this device, the troponin sensitive microfluidic electrode consists of a thin layer of nanocomposite material manganese-reduced graphene oxide (Mn3O4-RGO). This nanocomposite thin layer has been formed on surface of a patterned indium tin oxide (ITO) substrate after modification with 3-aminopropyletriethoxysilane (APTES) and is assembled with a polydimethylsiloxane-based microfluidic system...
September 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28890874/usefulness-of-amino-terminal-pro-b-type-natriuretic-peptide-in-evaluating-children-with-cardiac-failure
#13
Isoken A Isah, Wilson E Sadoh, Nosakhare J Iduoriyekemwen
BACKGROUND: The plasma levels of amino terminal pro-B type natriuretic peptide (NT-proBNP) have been found to be useful in evaluating children with heart failure in developed countries where the cause is mainly structural heart lesions. There is paucity of similar studies from developing countries where the causes are mostly of infectious origin. This article is aim to evaluate the relationship between plasma NT-proBNP levels and the severity, outcome and duration of admission of children with heart failure...
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28890872/cardiac-troponin-and-outcome-in-decompensated-heart-failure-with-preserved-ejection-fraction
#14
Mohammad Thawabi, Amer Hawatmeh, Sarah Studyvin, Habib Habib, Fayez Shamoon, Marc Cohen
BACKGROUND: Cardiac troponin (cTn) has been established as an effective prognostic marker in acute heart failure (HF) with predominantly reduced ejection fraction. However, it's prognostic value in heart failure with preserved ejection fraction (HFpEF) is unclear. The aim of this study is to describe the prognostic role of troponin I in patients hospitalized for HFpEF decompensation. METHODS: We included 363 consecutive patients admitted for HFpEF decompensation that was not associated with acute coronary syndrome (ACS)...
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28883854/predictive-abilities-of-baseline-measurements-of-fluid-overload-assessed-by-bioimpedance-spectroscopy-and-serum-n-terminal-pro-b-type-natriuretic-peptide-for-mortality-in-hemodialysis-patients
#15
Ianis Siriopol, Dimitrie Siriopol, Luminita Voroneanu, Adrian Covic
INTRODUCTION: Fluid overload is one of the most important, yet modifiable, risk factors associated with worse outcomes in hemodialysis (HD) patients. However, its precise assessment in clinical practice is still under investigation. MATERIAL AND METHODS: This is an observational prospective study which included 285 stable patients with end-stage renal disease on standard thrice-weekly HD therapy. Overhydration was assessed by the combination of relative fluid overload (RFO), using bioimpedance spectroscopy, and N-terminal pro-B-type natriuretic peptide (NT-proBNP)...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28883225/anemia-is-associated-with-blunted-response-to-%C3%AE-blocker-therapy-using-carvedilol%C3%A3-insights-from-japanese-chronic-heart-failure-j-chf-study
#16
Yuji Nagatomo, Tsutomu Yoshikawa, Hiroshi Okamoto, Akira Kitabatake, Masatsugu Hori
BACKGROUND: Anemia portends a poor clinical outcome in patients with chronic heart failure (CHF). However, its mechanism remains unknown. We sought to elucidate the effect of anemia on patients with HF with reduced ejection fraction (HFrEF) who receive carvedilol therapy.Methods and Results:J-CHF study was a prospective, randomized, multicenter trial that assigned 360 HFrEF patients to 2.5 mg/5 mg/20 mg carvedilol groups according to the target dose. At baseline 70 patients (19%) had anemia ([A]) defined as hemoglobin level (Hb) <13 g/dL (male) or <12 g/dL (female) and the remaining 290 did not ([N])...
September 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28882233/prognostic-significance-of-central-apneas-throughout-a-24-hour-period-in-patients%C3%A2-with-heart-failure
#17
RANDOMIZED CONTROLLED TRIAL
Michele Emdin, Gianluca Mirizzi, Alberto Giannoni, Roberta Poletti, Giovanni Iudice, Francesca Bramanti, Claudio Passino
BACKGROUND: Large trials using noninvasive mechanical ventilation to treat central apnea (CA) occurring at night ("sleep apnea") in patients with systolic heart failure (HF) have failed to improve prognosis. The prevalence and prognostic value of CA during daytime and over an entire 24-h period are not well described. OBJECTIVES: This study evaluated the occurrence and prognostic significance of nighttime, daytime, and 24-h CA episodes in a large cohort of patients with systolic HF...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28861997/profiling-b-type-natriuretic-peptide-cleavage-peptidoforms-in-human-plasma-by-capillary-electrophoresis-with-electrospray-ionization-mass-spectrometry
#18
Shenyan Zhang, Koen Raedschelders, Marcia Santos, Jennifer E Van Eyk
B-type Natriuretic Peptide (BNP) is a biologically active circulating hormone. The BNP plasma concentration is routinely used in the diagnosis of heart failure and, the intravenous infusion of recombinant BNP can be used for heart failure treat-ment. Multiple enzymes cleavage BNP in plasma. We used a capillary electrophoresis separation system (CESI 8000) with a neutral capillary coupled to electrospray ionization on a high-resolution mass spectrometry to profile the proteolysis of ex-ogenously added recombinant BNP in plasma in order to assess the potential relation in heart failure as well as a means to monitor its bioavailability after therapeutic infusion...
September 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28860791/soluble-st2-correlates-with-some-indicators-of-right-ventricular-function-in-hypertensive-heart-failure
#19
Dike B Ojji, Sandrine Lecour, Olusoji M Adeyemi, Karen Sliwa
PURPOSE: ST2 receptor, which is a member of the Toll-like/interleukin-1 (IL-1) receptor family, has been found to be increased in the serum of patients 1 day after myocardial infarction. Several other studies have shown that soluble ST2 levels correlate with severity of heart failure (HF), left ventricular ejection fraction, creatinine clearance, B-type natriuretic peptide and C-reactive protein, and are predictors of mortality in HF. Most of these studies were not only limited to ischemic heart disease but also concentrated on left-sided HF...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28859790/ivabradine-in-children-with-dilated-cardiomyopathy-and-symptomatic-chronic-heart-failure
#20
RANDOMIZED CONTROLLED TRIAL
Damien Bonnet, Felix Berger, Eero Jokinen, Paul F Kantor, Piers E F Daubeney
BACKGROUND: Heart rate reduction as a therapeutic target has been investigated in adults with heart failure (HF). Ivabradine has shown promising efficacy, but has not been evaluated in children. Currently, treatment recommendations for chronic pediatric HF are based mainly on chronic HF guidelines for adults. OBJECTIVES: The authors explored the dose-response relationship of ivabradine in children with dilated cardiomyopathy and symptomatic chronic HF. The primary endpoint was ≥20% reduction in heart rate from baseline without inducing bradycardia or symptoms...
September 5, 2017: Journal of the American College of Cardiology
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