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https://www.readbyqxmd.com/read/29664549/evaluation-of-soluble-concentration-fas-and-fas-ligand-in-maternal-and-cord-blood-3rd-trimester-of-pregnancy
#1
Agata Karowicz-Bilińska, Urszula Kowalska-Koprek, Dorota Estemberg, Anita Sikora-Szubert
OBJECTIVES: The the study was to estimate the concentrations of antiapoptotic sFas and pro-apoptotic FasL in the serum of pregnant women in the third trimester of pregnancy and in the cord blood serum of neonates from vein and arteries separately. The correlation could be crucial for evaluation of apoptosis process intensity in placenta and the role of fetal blood circulation system on distribution of sFas and FasL. MATERIAL AND METHODS: The study group consisted of 28 pregnant women in physiological pregnancy, between 38- 41 weeks...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29649792/comparison-of-different-compression-to-ventilation-ratios-2-1-3-1-and-4-1-during-cardiopulmonary-resuscitation-in-a-porcine-model-of-neonatal-asphyxia
#2
Matteo P Pasquin, Po-Yin Cheung, Sparsh Patel, Min Lu, Tze-Fun Lee, Michael Wagner, Megan O'Reilly, Georg M Schmölzer
BACKGROUND: High-quality chest compression is essential during neonatal cardiopulmonary resuscitation (CPR). However, the optimal compression to ventilation ratio (C:V) that should be used during neonatal CPR to optimize coronary and cerebral perfusion while providing adequate ventilation remains unknown. OBJECTIVE: We hypothesized that different C:V ratios (e.g., 2: 1 or 4: 1) will reduce the time to return of spontaneous circulation (ROSC) in severely asphyxiated piglets...
April 12, 2018: Neonatology
https://www.readbyqxmd.com/read/29643616/labor-analgesia-in-parturients-of-fetal-growth-restriction-having-raised-umbilical-doppler-vascular-indices
#3
Sukhen Samanta, Kajal Jain, Neerja Bhardwaj, Vanita Jain, Preet Mohinder Singh, Sujay Samanta, Veenu Singla, Rini Saha
Background and Aims: Fetuses with abnormal umbilical blood flow are at a higher risk of adverse perinatal outcome than those with normal flow. Epidural analgesia (EA) has shown to decrease villous vascular resistance in preeclamptic women during labor. The present study evaluates the effects of epidural ropivacaine and intramuscular (IM) tramadol on Doppler blood flow in parturients with fetal growth restriction and raised umbilical artery (UmA) blood flow. Material and Methods: In this prospective nonrandomized comparative study, 36 term parturients with sonographic evidence of UmA systolic-diastolic (S-D) ratio ≥3 were enrolled...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29615691/effects-of-intestinal-microbiota-on-brain-development-in-humanized-gnotobiotic-mice
#4
Jing Lu, Lei Lu, Yueyue Yu, Joanne Cluette-Brown, Camilia R Martin, Erika C Claud
Poor growth in the Neonatal Intensive Care Unit is associated with an increased risk for poor neurodevelopmental outcomes for preterm infants, however the mechanism is unclear. The microbiome has increasingly been recognized as a modifiable environmental factor to influence host development. Here we explore the hypothesis that the microbiome influences both growth phenotype and brain development. A germ free mouse transfaunation model was used to examine the effects of preterm infant microbiotas known to induce either high growth or low growth phenotypes on postnatal brain development...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615676/silent-infection-of-human-dendritic-cells-by-african-and-asian-strains-of-zika-virus
#5
Nathalie J Vielle, Beatrice Zumkehr, Obdulio García-Nicolás, Fabian Blank, Miloš Stojanov, Didier Musso, David Baud, Artur Summerfield, Marco P Alves
While Zika virus (ZIKV) circulated for decades (African lineage strains) without report of outbreaks and severe complications, its emergence in French Polynesia and subsequently in the Americas (Asian lineage strains) was associated with description of severe neurological defects in newborns/neonates and adults. With the aim to identify virus lineage-dependent factors, we compared cell susceptibility, virus replication, cell death and innate immune responses following infection with two African and three contemporary Asian lineage strains of ZIKV...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29599125/establishment-of-human-pluripotent-stem-cell-derived-pancreatic-%C3%AE-like-cells-in-the-mouse-pancreas
#6
Haiting Ma, Katherine J Wert, Dmitry Shvartsman, Douglas A Melton, Rudolf Jaenisch
Type 1 diabetes is characterized by autoimmune destruction of β cells located in pancreatic islets. However, tractable in vivo models of human pancreatic β cells have been limited. Here, we generated xenogeneic human pancreatic β-like cells in the mouse pancreas by orthotopic transplantation of stem cell-derived β (SC-β) cells into the pancreas of neonatal mice. The engrafted β-like cells expressed β cell transcription factors and markers associated with functional maturity. Engrafted human cells recruited mouse endothelial cells, suggesting functional integration...
March 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29590206/worldwide-increased-prevalence-of-human-adenovirus-type-3-hadv-3-respiratory-infections-is-well-correlated-with-heterogeneous-hypervariable-regions-hvrs-of-hexon
#7
Ezazul Haque, Urmila Banik, Tahmina Monwar, Leela Anthony, Arun Kumar Adhikary
Human adenovirus type 3 (HAdV-3) respiratory infections occurs worldwide in both children and adults, leading to severe morbidity and mortality, particularly in the paediatric age group and especially in neonates. During HAdV infection, neutralizing antibodies are formed against the epitopes located in the hyper variable regions (HVRs) of the hexon protein. These neutralizing antibodies provide protection against reinfection by viruses of the same type. Therefore it is reasonable to speculate that variations of HAdV-3 in the HVRs could impair the immunity acquired by previous infection with a different strain with variation in its HVRs...
2018: PloS One
https://www.readbyqxmd.com/read/29582727/maternal-low-quality-protein-diet-exerts-sex-specific-effects-on-plasma-amino-acid-profile-and-alters-hepatic-expression-of-methyltransferases-in-adult-rat-offspring
#8
A Akyol, A Kabasakal Cetin, A Gulec, H Dasgin, A Ayaz, I Onbasilar
Nutrition during pregnancy and lactation is a critical factor in the development of the offspring. Both protein content and source in maternal diet affect neonatal health, but the long-term effects of maternal low-quality protein diet on the offspring are less clear. This study aimed to examine the effects of maternal low-quality protein diet on offspring's growth, development, circulating metabolites and hepatic expression of methyltransferases. Virgin Wistar rats were mated at 11 weeks of age. Dams were then maintained on either a chow diet with 20% casein as the control group (C), or a low-quality protein diet with 20% wheat gluten as the experimental group (WG) throughout gestation and lactation...
March 27, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29578985/acog-committee-opinion-no-732-influenza-vaccination-during-pregnancy
#9
(no author information available yet)
Influenza vaccination is an essential element of prepregnancy, prenatal, and postpartum care because influenza can result in serious illness, including a higher chance of progressing to pneumonia, when it occurs during the antepartum or postpartum period. In addition to hospitalization, pregnant women with influenza are at increased risk of intensive care unit admission and adverse perinatal and neonatal outcomes. The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices and the American College of Obstetricians and Gynecologists recommend that all adults receive an annual influenza vaccine and that women who are or will be pregnant during influenza season receive an inactivated influenza vaccine as soon as it is available...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29578983/acog-committee-opinion-no-732-summary-influenza-vaccination-during-pregnancy
#10
(no author information available yet)
Influenza vaccination is an essential element of prepregnancy, prenatal, and postpartum care because influenza can result in serious illness, including a higher chance of progressing to pneumonia, when it occurs during the antepartum or postpartum period. In addition to hospitalization, pregnant women with influenza are at increased risk of intensive care unit admission and adverse perinatal and neonatal outcomes. The Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices and the American College of Obstetricians and Gynecologists recommend that all adults receive an annual influenza vaccine and that women who are or will be pregnant during influenza season receive an inactivated influenza vaccine as soon as it is available...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29572879/patient-specific-atrial-hemodynamics-of-a-double-lumen-neonatal-cannula-in-correct-caval-position
#11
Jamil Muhammad, Mohammad Rezaeimoghaddam, Bilgesu Cakmak, Reza Rasooli, Ece Salihoglu, Yahya Yıldız, Kerem Pekkan
Clinical success of pediatric veno-venous (VV) extracorporeal membrane oxygenation (ECMO) is associated with the double lumen cannula cardiovascular device design as well as its anatomic orientation in the atrium. The positions of cannula ports with respect to the vena cavae and the tricuspid valve are believed to play a significant role on device hemodynamics. Despite various improvements in ECMO catheters, especially for the neonatal and congenital heart patients, it is still challenging to select a catalogue size that would fit to most patients optimally...
March 23, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29572538/in-vivo-depletion-of-serum-igg-by-an-affibody-molecule-binding-the-neonatal-fc-receptor
#12
Johan Seijsing, Shengze Yu, Fredrik Y Frejd, Ingmarie Höiden-Guthenberg, Torbjörn Gräslund
Lowering the total level of Immunoglobulin G (IgG) in circulation is a promising general treatment option for many autoimmune diseases driven by pathogenic autoantibodies. The half-life of IgG in circulation is unusually long as a consequence of its interaction with the neonatal Fc receptor (FcRn), which protects it from lysosomal degradation by cells in contact with blood. Blocking the IgG/FcRn interaction prevents FcRn-mediated rescue, which may lead to increased catabolism and a lowering of the total IgG level...
March 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29571293/biomarkers-of-endothelial-dysfunction-predict-sepsis-mortality-in-young-infants-a-matched-case-control-study
#13
Julie Korol Wright, Kyla Hayford, Vanessa Tran, Gulam Muhammed Al Kibria, Abdullah Baqui, Ali Manajjir, Arif Mahmud, Nazma Begum, Mashuk Siddiquee, Kevin C Kain, Azadeh Farzin
BACKGROUND: Reducing death due to neonatal sepsis is a global health priority, however there are limited tools to facilitate early recognition and treatment. We hypothesized that measuring circulating biomarkers of endothelial function and integrity (i.e. Angiopoietin-Tie2 axis) would identify young infants with sepsis and predict their clinical outcome. METHODS: We conducted a matched case-control (1:3) study of 98 young infants aged 0-59 days of life presenting to a referral hospital in Bangladesh with suspected sepsis...
March 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29563294/divergent-pathogenic-properties-of-circulating-coxsackievirus-a6-associated-with-emerging-hfmd
#14
Shao-Hua Wang, Ao Wang, Pan-Pan Liu, Wen-Yan Zhang, Juan Du, Shuang Xu, Guan-Chen Liu, Bai-Song Zheng, Chen Huan, Ke Zhao, Xiao-Fang Yu
Coxsackievirus A6 (CV-A6) is an emerging pathogen associated with hand, foot, and mouth disease (HFMD). Its genetic characterization and pathogenic properties are largely unknown. Here, we report 39 circulating CV-A6 strains isolated in 2013 from HFMD patients in Northeast China. Three major clusters of CV-A6 were identified and related to CV-A6 mostly from Shanghai, indicating that domestic CV-A6 strains were responsible for HFMD emerging in Northeast China. Four full-length CV-A6 genomes representing each cluster were sequenced and analyzed further...
March 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29552241/interrupted-aortic-arch-diagnosis-by-computed-tomography-angiography-and-3-d-reconstruction-a-case-report
#15
Tatiana Marcela Pérez, Sandra Milena García, Martha Lucía Velasco, Angela Paola Sánchez
Interrupted aortic arch is an extremely rare congenital malformation representing about 1% of congenital heart disease. Early symptoms usually occur early in the neonatal period and clinical deterioration is often rapid and long-term prognosis is limited. Nonetheless, this condition has been identified later in adult life in rare cases. We report a case in an adult male with absence of hypertension history and no further cardiac compromise, with a severe posterior chest pain alongside dyspnea and sweating. Computed tomography angiography revealed interrupted aortic arch type A, bivalve aorta, hemopericardium, aortic dissection Stanford A, and important collateral circulation...
February 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29546600/focus-on-neonatal-and-infantile-onset-of-nephrogenic-syndrome-of-inappropriate-antidiuresis-12-years-later
#16
REVIEW
Flaminia Bardanzellu, Maria Cristina Pintus, Valentina Masile, Vassilios Fanos, Maria Antonietta Marcialis
Nephrogenic syndrome of inappropriate antidiuresis (NSIAD), first described in 2005, is a rare genetic X-linked disease, presenting with hyponatremia, hyposmolarity, euvolemia, inappropriately concentrated urine, increased natriuresis, and undetectable or very low arginine-vasopressine (AVP) circulating levels. It can occur in neonates, infants, or later in life. NSIAD must be early recognized and treated to prevent severe hyponatremia, which can show a dangerous impact on neonatal outcome. In fact, it potentially leads to death or, in case of survival, neurologic sequelae...
March 15, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29543148/prevalence-antimicrobial-resistance-and-serotype-distribution-of-group-b-streptococcus-isolated-among-pregnant-women-and-newborns-in-rabat-morocco
#17
Cinta Moraleda, Rachid Benmessaoud, Jessica Esteban, Yuly López, Hassan Alami, Amina Barkat, Tligui Houssain, Meryem Kabiri, Rachid Bezad, Saad Chaacho, Lola Madrid, Jordi Vila, Carmen Muñoz-Almagro, Jordi Bosch, Sara M Soto, Quique Bassat
PURPOSE: Group B streptococcus (GBS) is an important cause of neonatal sepsis worldwide. Data on the prevalence of maternal GBS colonization, risk factors for carriage, antibiotic susceptibility and circulating serotypes are necessary to tailor adequate locally relevant public health policies. METHODOLOGY: A prospective study including pregnant women and their newborns was conducted between March and July 2013 in Morocco. We collected clinical data and vagino-rectal and urine samples from the recruited pregnant women, together with the clinical characteristics of, and body surface samples from, their newborns...
March 15, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29532452/hepcidin-an-iron-regulatory-hormone-of-innate-immunity-is-differentially-expressed-in-premature-fetuses-with-early-onset-neonatal-sepsis
#18
Sammy M Tabbah, Catalin S Buhimschi, Katherine Rodewald-Millen, Christopher R Pierson, Vineet Bhandari, Philip Samuels, Irina A Buhimschi
OBJECTIVE:  Hepcidin, a mediator of innate immunity, binds the iron exporter ferroportin, leading to functional hypoferremia through intracellular iron sequestration. We explored hepcidin-ferroportin interactions in neonates clinically diagnosed with early-onset neonatal sepsis (EONS). STUDY DESIGN:  Hepcidin and interleukin (IL)-6 were quantified by enzyme-linked immunosorbent assay (ELISA) in 92 paired cord blood-maternal blood samples in the following groups: "Yes" EONS ( n  = 41, gestational age [GA] 29 ± 1 weeks) and "No" EONS ( n  = 51, GA 26 ± 1 weeks)...
February 2, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29530740/ductus-arteriosus-and-fetal-echocardiography-implications-for-practice
#19
REVIEW
Silvia G V Alvarez, Angela McBrien
The ductus arteriosus (DA) is a crucial part of the fetal circulation, both in the normal fetus and in critical congenital heart disease (CHD). It allows shunting between the pulmonary and systemic circulations. In physiological prenatal conditions, the DA lets the majority of right ventricular output bypass the fluid-filled, high-resistance lungs. The DA can cause hemodynamic compromise in the fetus and neonate when constricted or absent (in isolation or in patients with CHD) and may lead to pre- or postnatal sequelae within other systems when forming part of a vascular ring...
March 7, 2018: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29526349/necrotizing-enterocolitis-in-patients-with-congenital-heart-disease-a-single-center-experience
#20
Patricio E Lau, Stephanie M Cruz, Elena C Ocampo, Sushma Nuthakki, Candace C Style, Timothy C Lee, David E Wesson, Oluyinka O Olutoye
PURPOSE: The purpose of this study was to evaluate the characteristics of patients with congenital heart disease (CHD) who developed necrotizing enterocolitis (NEC). METHODS: A retrospective review of neonates with CHD at a tertiary care center between January 2006 and January 2016 was performed. Diagnosis of NEC was based on modified Bell's criteria. Patients were grouped by Risk Adjustment for Congenital Heart Surgery (RACHS-1) or by ductal-dependent (DD) lesions that require a patent ductus arteriosus to supply pulmonary or systemic circulation...
February 7, 2018: Journal of Pediatric Surgery
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