Meniscal allograft transplant

BACKGROUND: Osteochondral allograft transplantation (OCAT) is an accepted knee joint-preserving treatment strategy for focal osteochondral lesions that is often conducted in combination with meniscal allograft transplantation (MAT). Despite its frequent and simultaneous utilization, there remains a lack in the literature reporting on outcomes and failure rates after concomitant procedures. PURPOSE: To determine (1) the midterm clinical success rate after OCAT+MAT in comparison with a matched-pair cohort undergoing isolated OCAT, (2) whether patient-specific and procedural variables influence the risk of failure, and (3) patient-reported outcome measures over time...

PURPOSE: To provide an update on the incidence and extent of graft extrusion following meniscus allograft transplantation (MAT) and to systematically review the literature to identify if the type of root fixation or additional surgical techniques may reduce the risk of developing graft extrusion. METHODS: A systematic search, in accordance with the PRISMA guidelines, was conducted using the MEDLINE, EMBASE, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials (CENTRAL) databases...

BACKGROUND: Symptomatic acetabular labral insufficiency in young, active patients is often treated with labral repair or reconstruction using fresh-frozen allografts. However, fresh-frozen tendon allografts do not have tissue or material properties that closely mimic acetabular labral fibrocartilage. Recent studies suggest meniscal allografts may be a better biomechanical, geometric, and material alternative for acetabular labrum reconstruction (ALR). HYPOTHESIS: Patients undergoing open ALR using fresh meniscus allograft transplants (MAT) will have better outcomes than those using fresh-frozen tendon allografts transplants (TAT) when comparing initial treatment success, diagnostic imaging assessments, and patient-reported pain and function scores...

Treatment of meniscal tears has evolved over the last few decades, and preservation has now become the gold standard of treatment. Advancements in repair technique have extended the indication of repair. However, meniscectomy has to be performed in some situations. In these situations, meniscal allograft transplantation is considered the gold standard. But allografts are not available in every part of the world. Collagen implants and synthetic polymers are also advocated. But again, its limited research, availability, and high cost have restricted its widespread use...

BACKGROUND: Limited data are available on the outcomes and return-to-sport rates after osteochondral allograft transplant in professional athletes. PURPOSE: To evaluate the experience of a single senior surgeon in treating professional athletes with osteochondral allograft transplant, including analyzing clinical outcomes and return to sport. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: The authors performed a retrospective review of professional athletes treated with primary osteochondral allograft to the knee between January 1, 2001, and January 1, 2021, by a single surgeon...

PURPOSE: To conduct a systematic review evaluating potential correlations between preoperative articular cartilage integrity on outcomes and survivorship in patients undergoing meniscal allograft transplantation (MAT). METHODS: A literature search was performed by querying SCOPUS, PubMed, Medline, and the Cochrane Central Register for Controlled Trials from database inception through May 2023 according to the 2020 PRISMA statement. Inclusion criteria were limited to studies reporting on outcomes and survivorship following MAT based on preoperative cartilage status...

Primary meniscal allograft transplantation (PMAT) is an effective yet sometimes short-term solution to postmeniscectomy syndrome. Survivorship beyond 10 years can carry a guarded prognosis. Alternatives after failure of PMAT are typically total or unicompartmental arthroplasty, which, depending on desired activity level, can be reasonable options for older patients. However, when faced with younger, otherwise healthy patients, revision meniscal allograft transplantation (RMAT) shows outcomes in appropriately indicated patients when concomitant pathology is also addressed...

BACKGROUND: Fresh-frozen allografts are the current standard in meniscal allograft transplant (MAT) surgery, due to their availability, ease of preservation, and affordability. However, fresh-frozen grafts are associated with several clinical challenges such as graft shrinkage and extrusion, among many others. PURPOSE: To present the current knowledge on the use of fresh meniscal allografts, presenting whether benefits associated with fresh grafts provide sufficient evidence to support their use in clinical practice...

PURPOSE: The purpose of this study is to evaluate the presence of host Bone Marrow Edema (BME) surrounding osteochondral allograft plugs on routine 6-month postoperative Magnetic Resonance Imaging (MRI), and to determine whether such BME is correlated with subsequent failure. METHODS: The present study was approved under our institutional review board-approved database (#2020-2123). We included patients who underwent cartilage repair with OCA for focal chondral and osteochondral defects of the distal femur by two senior surgeons between January 2016 and May 2021 with minimum 2-year follow up...

Over the last several years, there has been a shift from arthroscopic partial meniscectomy to meniscal repair, especially in the younger patient. In case of a necessary partial meniscectomy, some patients have unremittent symptoms of pain and effusion corresponding to the postmeniscectomy syndrome. In these patients without large coronal malalignment, meniscal allograft transplantation is a valuable option to restore contact pressures, promote a chondroprotective microenvironment, and potentially delay secondary surgical interventions symptoms...

PURPOSE: The optimal treatment approach for the complex pathology of meniscal insufficiency and coexisting full-thickness cartilage defects remains unclear. The purpose of this study was to evaluate the viability, safety, and efficacy of this combined surgical approach at medium-term follow-up. METHODS: This is a single-centre longitudinal study with blinded outcome assessment. All consecutive patients treated with combined all-arthroscopic meniscal allograft transplantation (MAT) with bone bridge fixation and ACI using chondrospheres at our institution between 2001 and 2021 were eligible for inclusion...

In patients with symptomatic high loss of meniscal volume and function due to irreparable tears, meniscal allograft transplantation may result in symptom relief and ideally prevent long-term consequences of articular cartilage degeneration and osteoarthritis. However, the degree of cartilage damage at the time of meniscal allograft transplantation is associated with graft failure, and untreated high-grade cartilage lesions increase the risk. Correction of femorotibial malalignment is also essential.

The young, active patient with pain after subtotal meniscectomy represents a troubling clinical situation with limited treatment options. "Post-meniscectomy syndrome" occurs at a rate of 4-25% and is defined as the presence of knee pain and functional limitations due to increased contact stresses and overload of the articular cartilage in a knee compartment, after subtotal or total meniscectomy. Meniscal allograft transplantation (MAT) can have reasonable results for some patients, typically under the age of 50, with no degenerative change, and no, or correctable instability or malalignment...

Because of the prevalence of meniscal injuries and the difficulty treating irreparable tears and large defects, there has been increasing research and resultant engineering strategies over the past 20 years that have resulted in development of various meniscal scaffolds and meniscal implants. At this time, meniscal allograft transplant may be the "standard" consideration for the nonarthritis, meniscal deficient, stable, and properly aligned painful knee, but challenges include availability, preoperative planning and sizing, costs, and logistics...

Meniscal allograft transplantation (MAT) effectively alleviates symptoms of the meniscus deficiency. Thus, MAT is a widely accepted and recommended treatment for individuals with unicompartmental pain due to meniscus deficiency. Long-term follow-up studies have indicated that MAT yields favorable clinical outcomes, demonstrating high survivorship and low rates of serious complications. In addition, the ability of MAT to function akin to the native meniscus and shield the knee cartilage from osteoarthritis (OA) has been a subject of ongoing investigation, and recent direct MRI evidence shows long-term chondroprotection following MAT...

BACKGROUND: It is unknown whether the outcomes achieved in the early period after revision lateral meniscal allograft transplantation (RLMAT) are maintained through the midterm period. PURPOSE: To evaluate the midterm clinical and radiological results of patients who underwent RLMAT. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We reviewed the outcomes of 19 RLMATs in 18 patients with at least 5 years of follow-up data...

BACKGROUND: Graft tears are common postoperative findings in meniscal allograft transplant (MAT). Graft tear in medial MAT may be different from that of lateral MAT, considering the difference between medial meniscal tears and lateral meniscal tears. Moreover, medial MAT is frequently accompanied by ligament reconstruction, which is associated with graft tear. The effect of graft tear on the long-term survivorship of medial MAT has not been investigated. HYPOTHESIS: Graft tear would adversely affect the survivorship of medial MAT and the effect would be different according to the timing of graft tear...

BACKGROUND: Meniscal allograft transplantation (MAT) is an accepted and effective treatment option in the context of unsalvageable menisci, particularly in young and active patients. It has been shown to reduce pain and improve knee function in previously symptomatic patients. However, there is still limited knowledge about the long-term survival rates of allografts, the durability of clinical results, and the influence of patient-specific parameters, such as leg alignment, tibial slope, and preoperative International Cartilage Regeneration & Joint Preservation Society (ICRS) grade...

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Background and objective The treatment for symptomatic meniscus-deficient knees with cartilage defects remains challenging on account of insufficient meniscal substitutes. One solution for this might involve combining meniscal allograft transplantation (MAT) and cartilage repair. In this study, we aimed to analyze the effectiveness and safety of MAT concomitant with cartilage repair for symptomatic lateral meniscus-deficient knees in a setting with limited availability of meniscal transplants in Japan. Methods Nine patients who underwent MAT concomitant with osteochondral transplantation (five) and/or autologous chondrocyte implantations (seven) were followed up for at least two years (mean: 51...