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Meniscal allograft transplant

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https://www.readbyqxmd.com/read/28203596/intra-articular-implantation-of-mesenchymal-stem-cells-part-2-a-review-of-the-literature-for-meniscal-regeneration
#1
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent progression of OA. Recently, mesenchymal stem cells (MSCs) have been proposed as a possible biological therapy for meniscal regeneration...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28162881/midterm-results-of-osteochondral-allograft-transplantation-to-the-humeral-head
#2
Andrew J Riff, Adam B Yanke, Jason J Shin, Anthony A Romeo, Brian J Cole
BACKGROUND: This study evaluated clinical outcomes of osteochondral allograft (OCA) transplantation for humeral head osteochondral defects. We hypothesized that patients with isolated humeral head disease would achieve favorable results and that patients with bipolar disease would experience inferior outcomes. METHODS: We identified patients who underwent humeral head OCA transplantation. Subjective questionnaire data were obtained preoperatively and at a minimum of 2 years postoperatively...
February 2, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28161573/chondrogenically-primed-tonsil-derived-mesenchymal-stem-cells-encapsulated-in-riboflavin-induced-photocrosslinking-collagen-hyaluronic-acid-hydrogel-for-meniscus-tissue-repairs
#3
Rachel H Koh, Yinji Jin, Byung-Jae Kang, Nathaniel S Hwang
: Current meniscus tissue repairing strategies involve partial or total meniscectomy, followed by allograft transplantation or synthetic material implantation. However, allografts and synthetic implants have major drawbacks such as the limited supply of grafts and lack of integration into host tissue, respectively. In this study, we investigated the effects of conditioned medium (CM) from meniscal fibrochondrocytes and TGF-β3 on tonsil-derived mesenchymal stem cells (T-MSCs) for meniscus tissue engineering...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28125913/meniscal-extrusion-does-not-progress-during-the-midterm-follow-up-period-after-lateral-meniscal-transplantation
#4
Nam-Ki Kim, Seong-Il Bin, Jong-Min Kim, Chang-Rack Lee, Jae-Hyan Kim
BACKGROUND: Meniscal extrusion is related to degeneration of the native knee joint. However, the clinical effect of the phenomenon after meniscal allograft transplantation (MAT) has not been clearly identified. Purpose/Hypothesis: The purpose of this study was to evaluate the change in meniscal extrusion in both the coronal and sagittal planes after lateral MAT through the midterm follow-up period. We hypothesized that meniscal extrusion does not progress during the midterm follow-up period...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28075154/survivorship-after-meniscal-allograft-transplantation-according-to-articular-cartilage-status
#5
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Won-Kyeong Kim, Jun Weon Choi
BACKGROUND: Clinical outcomes after meniscal allograft transplantation (MAT) in arthritic knees are unclear, and objective estimates of graft survival according to the articular cartilage status have not been performed. HYPOTHESIS: MAT should provide clinical benefits in knees with high-grade cartilage damage, but their graft survivorship should be inferior to that in knees with low-grade chondral degeneration after MAT. STUDY DESIGN: Cohort study; Level of evidence, 3...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27916187/editorial-commentary-which-factors-influence-osteoarthritic-progression-after-meniscal-allograft-transplantation
#6
EDITORIAL
Shinichi Yoshiya
In a recent article, the authors conducted radiologic follow-up evaluation for knees that had undergone isolated meniscal allograft transplantation. Postoperative osteoarthritic progression was observed in 45% of the knees. Among the demographic and clinical characteristics, medial meniscus allograft transplantation was identified as a significant risk factor for osteoarthritic progression. However, we still do not know whether meniscal allograft transplantation can prevent or retard the subsequent progression of osteoarthritis...
December 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27909660/osteochondral-proximal-tibial-and-lateral-meniscal-allograft-transplant
#7
Guillem Gonzalez-Lomas, Andrew P Dold, Daniel J Kaplan, David J Fralinger, Laith Jazrawi
Knee pain in young, active patients with meniscus-deficient knees and articular cartilage damage can present a challenge to treatment. Meniscal allograft transplantation (MAT) has shown good clinical results as treatment for meniscus deficiency; however, worse outcomes have been observed in patients with significant chondral damage. The development of chondral restorative techniques such as osteochondral allograft transplantation (OCA) has expanded the population of patients who may benefit from MAT. We present a case of proximal tibial osteochondral and lateral meniscal allograft transplant...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27904733/intraoperative-templating-in-lateral-meniscal-allograft-transplantation
#8
Bong-Seok Yang, Nam-Hong Choi, Byeong-Yeon Kim
Recently, studies have emphasized the importance of anatomical placement of the lateral meniscal allograft to decrease postoperative extrusion. However, it is infeasible to identify the exact rotation of the allograft during transplantation. We present a patient who underwent a lateral meniscal transplantation using a wire for correct positioning of the allograft. The use of a wire intraoperatively shaped to resemble the contour of the lateral meniscal allograft will aid in more accurate and anatomical graft placement...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27803938/biological-knee-reconstruction-with-concomitant-autologous-chondrocyte-implantation-and-meniscal-allograft-transplantation-mid-to-long-term-outcomes
#9
Takahiro Ogura, Tim Bryant, Tom Minas
BACKGROUND: Treating articular cartilage defects and meniscal deficiency is challenging. Although some short- to mid-term follow-up studies report good clinical outcomes after concurrent autologous chondrocyte implantation (ACI) and meniscal allograft transplantation (MAT), longer follow-up is needed. PURPOSE: To evaluate mid- to long-term outcomes after combined ACI with MAT. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We performed a retrospective review of prospectively gathered data from patients who had undergone ACI with MAT between 1999 and 2013...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27793202/enhanced-cellular-infiltration-of-human-adipose-derived-stem-cells-in-allograft-menisci-using-a-needle-punch-method
#10
Rachel C Nordberg, Adisri Charoenpanich, Christopher E Vaughn, Emily H Griffith, Matthew B Fisher, Jacqueline H Cole, Jeffrey T Spang, Elizabeth G Loboa
BACKGROUND: The meniscus plays a crucial role in knee joint stability, load transmission, and stress distribution. Meniscal tears are the most common reported knee injuries, and the current standard treatment for meniscal deficiency is meniscal allograft transplantation. A major limitation of this approach is that meniscal allografts do not have the capacity to remodel and maintain tissue homeostasis due to a lack of cellular infiltration. The purpose of this study was to provide a new method for enhanced cellular infiltration in meniscal allografts...
October 28, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27751607/meniscal-allograft-transplantation-for-symptomatic-knee-after-meniscectomy-of-torn-discoid-medial-meniscus-report-of-three-cases
#11
Sung Il Wang
In symptomatic discoid medial meniscus, partial meniscectomy is the principal treatment method and can yield promising short-term results. However, unlike the nondiscoid meniscus, discoid medial meniscus is frequently associated with horizontal cleavage tears, attributable to the presence of myxoid degeneration in the intrameniscal substance, in that it may potentially occur deteriorating long-term results because of re-tearing of remaining meniscus or secondary degeneration of cartilage of the medial compartment after meniscectomy...
October 14, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27696125/meniscal-allograft-subluxations-are-not-associated-with-preoperative-native-meniscal-subluxations
#12
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Jae Hyan Kim, Eic Ju Lim
PURPOSE: To determine the relationship between preoperative subluxation of the original menisci and postoperative graft subluxation after lateral meniscal allograft transplantation (MAT). METHODS: Forty patients who underwent isolated lateral MATs in meniscus-deficient knees with a low-grade chondral lesion (≤ICRS grade 2) were assessed. Lateral subluxation of the native meniscus before meniscectomy and those of remaining meniscal tissue before MAT were measured on mid-coronal MRI scans taken at each time point...
September 30, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27583257/factors-predicting-meniscal-allograft-transplantation-failure
#13
Ben Parkinson, Nicholas Smith, Laura Asplin, Peter Thompson, Tim Spalding
BACKGROUND: Meniscal allograft transplantation (MAT) is performed to improve symptoms and function in patients with a meniscal-deficient compartment of the knee. Numerous studies have shown a consistent improvement in patient-reported outcomes, but high failure rates have been reported by some studies. The typical patients undergoing MAT often have multiple other pathologies that require treatment at the time of surgery. The factors that predict failure of a meniscal allograft within this complex patient group are not clearly defined...
August 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27566240/autologous-chondrocyte-implantation-improves-knee-specific-functional-outcomes-and-health-related-quality-of-life-in-adolescent-patients
#14
Gregory L Cvetanovich, Jonathan C Riboh, Annemarie K Tilton, Brian J Cole
BACKGROUND: Existing studies of autologous chondrocyte implantation (ACI) in adolescent patients have primarily reported outcomes that have not been validated for cartilage repair and have failed to include measures of general health or health-related quality of life. PURPOSE: This study assesses validated knee-specific functional outcomes and health-related quality of life after ACI in adolescent patients. STUDY DESIGN: Case series; Level of evidence, 4...
January 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27562342/international-meniscus-reconstruction-experts-forum-imref-2015-consensus-statement-on-the-practice-of-meniscal-allograft-transplantation
#15
Alan Getgood, Robert F LaPrade, Peter Verdonk, Wayne Gersoff, Brian Cole, Tim Spalding
Meniscal allograft transplantation (MAT) has become relatively commonplace in specialized sport medicine practice for the treatment of patients with a symptomatic knee after the loss of a functional meniscus. The technique has evolved since the 1980s, and long-term results continue to improve. However, there still remains significant variation in how MAT is performed, and as such, there remains opportunity for outcome and graft survivorship to be optimized. The purpose of this article was to develop a consensus statement on the practice of MAT from key opinion leaders who are members of the International Meniscus Reconstruction Experts Forum so that a more standardized approach to the indications, surgical technique, and postoperative care could be outlined with the goal of ultimately improving patient outcomes...
August 25, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27543406/return-to-play-following-meniscus-surgery
#16
REVIEW
Alaina M Brelin, John-Paul H Rue
Meniscus tears are commonly encountered in the athletic population and can result in significant loss of playing time. Current treatment methods for acute tears consist of meniscectomy and meniscal repair, whereas meniscal allograft transplant is reserved as a salvage procedure for symptomatic meniscectomized patients who desire a more functional knee. This review describes the postoperative rehabilitation protocol for each procedure and evaluates the outcomes in existing literature as it pertains to the athlete...
October 2016: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27462536/lateral-meniscal-allograft-transplantation-the-bone-trough-technique
#17
Jorge Chahla, Javier Olivetto, Chase S Dean, Raphael Serra Cruz, Robert F LaPrade
The lateral meniscus plays a critical role in the stability and health of the knee. Treating patients who have undergone a total lateral meniscectomy or functional equivalent is challenging, especially young and active patients. Current literature regarding meniscal tears supports that repair should be the first surgical option. Moreover, it is recommended to preserve as much meniscal tissue as possible. In cases in which a total or functional meniscectomy is a pre-existing condition, a lateral meniscal allograft transplantation is a possible option...
April 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27456028/revision-meniscal-allograft-transplantation-in-the-lateral-compartment-disparate-mri-and-clinical-outcomes-during-the-early-postoperative-period
#18
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Won-Kyeong Kim, Jae Hyan Kim
BACKGROUND: Little is known about clinical outcomes after revision meniscal allograft transplantation (RMAT), and there are no studies on magnetic resonance imaging (MRI) evaluations during the early remodeling period. HYPOTHESIS: The objective imaging results, as determined by MRI evaluation, would be inferior to those of published data on primary meniscal allograft transplantations (MATs), although short-term clinical improvement would be achieved after RMAT. STUDY DESIGN: Case series; Level of evidence, 4...
July 25, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27422172/which-are-the-most-reliable-methods-of-predicting-the-meniscal-size-for-transplantation
#19
Camila Cohen Kaleka, Alfredo Santos Netto, Júlio César Almeida E Silva, Mariana Key Toma, Ricardo de Paula Leite Cury, Nilson Roberto Severino, Claudio Santili
BACKGROUND: Although the size of the meniscal allograft is crucial during meniscal transplantation, the accuracy of meniscal measurement methods is still under debate. A number of methods based on radiographic and magnetic resonance imaging (MRI) data as well as on anthropometric data have been proposed, but their reproducibility and reliability are still unclear. PURPOSE: To compare meniscal length and width as measured by different techniques (anthropometric and plain radiographic) to establish which of these 2 methods is more reliable and cost-effective for determining the meniscal size in comparison to MRI...
July 15, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27410773/a-clinical-platform-for-understanding-the-relationship-between-joint-contact-mechanics-articular-cartilage-changes-after-meniscal-surgery
#20
Suzanne Maher, Hongsheng Wang, Matthew F Koff, Nicole Belkin, Hollis G Potter, Scott Rodeo
Injury to the meniscus of the knee has been implicated as a significant risk factor for the subsequent development of osteoarthritis, but the mechanisms of joint degeneration are unclear. Our objective was to develop a clinically applicable methodology to evaluate the relationship of joint contact mechanics at the time of surgery to biological changes of articular cartilage as a function of time following surgery. A series of pre-, intra- and post-operative protocols were developed which utilized electronic sensors for the direct measurement of contact mechanics, and advanced imaging to assess cartilage health...
July 13, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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