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Meniscus transplant

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https://www.readbyqxmd.com/read/29908335/platelet-derived-growth-factor-coated-decellularized-meniscus-scaffold-for-integrative-healing-of-meniscus-tears
#1
Kwang Il Lee, Merissa Olmer, Jihye Baek, Darryl D D'Lima, Martin K Lotz
The aim of this study was to examine the potential of platelet-derived growth factor (PDGF)-coated decellularized meniscus scaffold in mediating integrative healing of meniscus tears by inducing endogenous cell migration. Fresh bovine meniscus was chemically decellularized and covalently conjugated with heparin and PDGF-BB. In vitro PDGF release kinetics was measured. The scaffold was transplanted into experimental tears in avascular bovine meniscus explants and cultured for 2 and 4 weeks. The number migrating and proliferating cells at the borderline between the scaffold and injured explant and PDGF receptor-β (PDGFR β) expressing cells were counted...
June 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29899552/the-radiated-deep-frozen-xenogenic-meniscal-tissue-regenerated-the-total-meniscus-with-chondroprotection
#2
Dong Jiang, Zheng-Zheng Zhang, Feng Zhao, Shao-Jie Wang, Yan-Song Qi, Li-Heng Zhao, Ji-Ying Zhang, Jia-Kuo Yu
Meniscal allograft transplantation yields good and excellent results but is limited by donor availability. The purpose of the study was to evaluate the effectiveness of radiated deep-frozen xenogenic meniscal tissue (RDF-X) as an alternative graft choice in meniscal transplantation. The xenogenic meniscal tissues were harvested from the inner 1/3 part of the porcine meniscus and then irradiated and deeply frozen. The medial menisci of rabbits were replaced by the RDF-X. Meniscal allograft transplantation, meniscectomy and sham operation served as controls...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29881226/the-use-of-platelet-rich-fibrin-with-platelet-rich-plasma-support-meniscal-repair-surgery
#3
Masahiko Kemmochi, Shigeru Sasaki, Masako Takahashi, Tomitaka Nishimura, Chisa Aizawa, Jun Kikuchi
Introduction: Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. Materials and Methods: Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29804613/editorial-commentary-meniscus-transplantation-with-or-without-bone-blocks-if-you-don-t-have-to-break-it-don-t
#4
EDITORIAL
Kevin R Stone
The C-shaped meniscus cartilages normally insert into bone around the tibial spines of the knee. As the knee joint rotates and flexes, circumferential hoop stresses are generated within the tissue, resisted by the collagen fibers that define both the insertion points and the ultrastructure of the meniscus tissue itself. For a transplanted meniscus to work normally, the biomechanical interface of the collagen fibers to the bone must be recreated.
June 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29804609/editorial-commentary-is-the-capsulodesis-the-solution-to-reduce-graft-extrusion-in-meniscal-allograft-transplantation
#5
EDITORIAL
Sang Hak Lee
The causes of graft extrusion after lateral meniscus allograft transplantation seem to be a multifactorial problem. A recent study shows that the lateral capsulodesis technique could result in better results relative to the degree of meniscal extrusion compared with the bone-bridge fixation technique. Long-term comparative clinical studies are needed to confirm the efficacy of this procedure.
June 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29804608/editorial-commentary-meniscal-allograft-transplantation-still-effective-with-poor-cartilage-but-much-better-with-good-cartilage-better-done-earlier
#6
EDITORIAL
Jong-Min Kim, Bum-Sik Lee, Seong-Il Bin
Meniscal allograft transplantation (MAT) is an established treatment for a symptomatic, meniscus-deficient knee. It is well known that MAT is effective in patients with good cartilage even in the early era of this procedure. The role of MAT in arthritic knees is getting more and more clear with increasing evidence over the last decade. Now we are able to expand our surgical indication to arthritic patients and provide them with individualized explanation for outcome and survival.
June 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29770332/incidence-and-extent-of-graft-extrusion-following-meniscus-allograft-transplantation
#7
REVIEW
Dae-Hee Lee
Background: The incidence and extent of graft extrusion after meniscus allograft transplantation (MAT) may differ in patients undergoing medial and lateral meniscus transplantation due to the use of different surgical techniques. This meta-analysis was therefore designed to quantify the extent and incidence of graft extrusion after meniscus allograft transplantation. Methods: Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, all studies reporting absolute extrusion, relative percentage of extrusion (RPE), or frequency of major extrusions (>3 mm) on magnetic resonance imaging in patients undergoing medial or lateral MAT were included...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29741957/effects-of-proud-large-osteochondral-plugs-on-contact-forces-and-knee-kinematics-a-robotic-study
#8
Peter Z Du, Keith L Markolf, Daniel V Boguszewski, Kent T Yamaguchi, Christopher J Lama, David R McAllister, Kristofer J Jones
BACKGROUND: Osteochondral allograft (OCA) transplantation is used to treat large focal femoral condylar articular cartilage defects. A proud plug could affect graft survival by altering contact forces (CFs) and knee kinematics. HYPOTHESIS: A proud OCA plug will significantly increase CF and significantly alter knee kinematics throughout controlled knee flexion. STUDY DESIGN: Controlled laboratory study. METHODS: Human cadaver knees had miniature load cells, each with a 20-mm-diameter cylinder of native bone/cartilage attached at its exact anatomic position, installed in both femoral condyles at standardized locations representative of clinical defects...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29699841/lateral-meniscus-allograft-transplantation-with-platelet-rich-plasma-injections-a-minimum-two-year-follow-up-study
#9
Hua Zhang, Shiyang Chen, Man Qiu, Aiguo Zhou, Wenlong Yan, Jian Zhang
BACKGROUND: The aim of this study was to report the short-term clinical and imaging outcomes of lateral meniscus allograft transplantations (LMAT) combined with intra-articular platelet-rich plasma (PRP) injection. METHODS: Thirty-three patients who had undergone LMAT combined with intra-articular PRP injection were evaluated. The Lysholm, International Knee Documentation Committee (IKDC), Western Ontario and McMaster Universities Osteoarthritis Index, Tegner activity level scale and visual analog scale for pain scores were used to evaluate the outcomes...
April 24, 2018: Knee
https://www.readbyqxmd.com/read/29665604/-foreign-material-free-anterior-cruciate-ligament-repair-with-hamstring-graft-felmet-technique
#10
Marc Chmielnicki, Wolfram Siebert, Axel Prokop
Rupture of the anterior cruciate ligament (ACL) is a common sports injury. Shear forces can damage the articular cartilage and lead to early osteoarthritis. Ligamentary stabilisation of the knee is necessary. Today, arthroscopic ACL repair is a standard knee procedure. Transplant fixation is often performed using implants, e.g. interference screws. The foreign material-free procedure using the Felmet technique enables biological, mechanically stable fixation of the hamstring tendon graft. We demonstrate the surgical technique, including meniscus suture and a video case study...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29594507/graft-extrusion-after-medial-and-lateral-mat-differs-according-to-surgical-technique-a-meta-analysis
#11
Seong-Il Bin, Hyun-Jung Kim, Dae-Hee Lee
INTRODUCTION: It is unclear whether the incidence and amount of graft extrusion differ between knees undergoing medial and lateral meniscus allograft transplantation (MAT). This meta-analysis, therefore, compared the incidence and amount of transplanted meniscus allograft extrusion following medial and lateral MAT. MATERIALS AND METHODS: All studies comparing absolute or relative extrusions, or proportion of major extrusions (> 3 mm), on magnetic resonance imaging between medial and lateral MATs were included...
June 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29573933/capsulodesis-versus-bone-trough-technique-in-lateral-meniscal-allograft-transplantation-graft-extrusion-and-functional-results
#12
Angel Masferrer-Pino, Joan C Monllau, Maximiliano Ibáñez, Juan I Erquicia, Xavier Pelfort, Pablo E Gelber
PURPOSE: To compare the radiographic results (in terms of graft extrusion) and the functional results of lateral meniscus allograft transplantations (MAT) performed with a bony fixation technique or with a soft tissue fixation technique after capsulodesis. METHODS: A prospective series of 29 consecutive lateral MAT was analyzed. The inclusion criterion for MAT was lateral joint line pain due to a previous meniscectomy. Malalignment, patients who had an Ahlback grade greater than II, and patients with a body mass index over 30 were considered as the exclusion criterion to prevent confounding results...
June 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29552463/bone-trough-lateral-meniscal-allograft-transplantation-the-tapered-teardrop-technique
#13
Michael A Zacchilli, Amos Z Dai, Eric J Strauss, Laith M Jazrawi, Robert J Meislin
The meniscus plays a vital role in knee biomechanics, and its physical absence or functional incompetence (e.g., irreparable root or radial tear) leads to unacceptably high rates of joint degeneration in affected populations. Meniscal allograft transplantation has been used successfully to treat patients with postmeniscectomy syndrome, and there is early laboratory and radiographic evidence hinting at a potential prophylactic role in preventing joint degeneration. We present a technique for lateral meniscal allograft transplantation using the CONMED Meniscal Allograft Transplantation system...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29514370/contemporary-surgical-trends-in-the-management-of-symptomatic-meniscal-tears-among-united-states-military-servicemembers-from-2010-to-2015
#14
Timothy B Pekari, Kevin C Wang, Eric J Cotter, Nicholas Kusnezov, Brian R Waterman
The purpose of this investigation is to report on trends over time in the treatment of meniscal pathology among military orthopaedic surgeons, as well as to evaluate the impact of patient demographics and concomitant procedure on the type of meniscal procedure performed. We performed a retrospective analysis of all active-duty United States military servicemembers who underwent a meniscal procedure from 2010 to 2015 within the Military Health System. Patient demographics and surgical variables were extracted from the electronic medical record...
March 7, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29512522/-homeostasis-and-disorder-of-musculoskeletal-system-transplantation-of-synovial-mesenchymal-stem-cells-for-cartilage-and-meniscus-regeneration
#15
Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya
Cartilage injury remains one of the common clinical problems due to its limited regeneration capacities. Meniscectomy commonly performed for meniscus injury leads to osteoarthritis, but the indication of meniscus repair is limited. We have identified that synovial mesenchymal stem cells(MSCs)are superior to MSCs derived from other tissues in proliferation capacity and in vitro/in vivo chondrogenic potentials. When suspension of synovial MSCs was placed on the cartilage defect for 10 minutes, 60% of the cells attached to the defect site...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29482862/meniscal-allograft-transplantation-the-effect-of-cartilage-status-on-survivorship-and-clinical-outcome
#16
Ahmed Mahmoud, James Young, Joanne Bullock-Saxton, Peter Myers
PURPOSE: To evaluate the survivorship of meniscal allograft transplantations (MATs), their clinical outcomes, and to compare the effect of perioperative cartilage status on survivorship. METHOD: A consecutive series of MATs with a minimum postsurgical time of 4 years were included from a prospectively collected database from 2001 to 2015. Mechanical failure was defined as transplant removal or knee arthroplasty. The effect of peri-operative cartilage status on survivorship was analyzed using a Kaplan-Meier analysis...
February 23, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29456708/meniscal-allograft-transplantation-using-a-novel-all-arthroscopic-technique-with-specifically-designed-instrumentation
#17
Ya-Dong Zhang, Shu-Xun Hou, Hong-Bin Zhong, Yi-Chao Zhang, Dian-Zhong Luo
The present study describes a novel all-arthroscopic technique for medial and lateral meniscal allograft transplantation (MAT). Surgical instruments were specifically designed to assist in the all-arthroscopic approach for MAT. The bone plug attachment technique, either the arthroscopic-assisted or all-arthroscopic approach, attaches bone plugs to the anterior and posterior horns. In the present study, two sets of surgical implements were designed: One to produce bone plugs of predefined sizes in the anterior and posterior horns of the allograft meniscus (bone plug implements) and a second to create bone tunnels in the receptor tibial plateau to hold the bone plugs (bone tunnel implements)...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29430389/arthroscopic-lateral-meniscal-allograft-transplantation-with-the-key-hole-technique
#18
Dhong Won Lee, Jung Ho Park, Kyu Sung Chung, Jeong Ku Ha, Jin Goo Kim
The efficacy of meniscus allograft transplantation (MAT) for the meniscus-deficient knee has been widely recognized as being excellent in terms of pain relief and functional improvement. Lateral MAT is usually performed with the bone bridge technique that uses a bone bridge connecting the anterior and posterior horns of an allograft. The slot position for the meniscal graft insertion is of great importance with the bone bridge technique, especially in the key-hole method. The purpose of this Technical Note is to describe lateral MAT using the key-hole technique in which an allograft with a bone bridge carved to accommodate the key-hole-shaped slot is properly secured to the slot...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29397425/native-tissue-based-strategies-for-meniscus-repair-and-regeneration
#19
REVIEW
Zengzeng Zhang, Weimin Guo, Shuang Gao, Mingxue Chen, Xu Li, Xueliang Zhang, Xiaoguang Jing, Mingjie Wang, Yu Zhang, Shi Shen, Zehao Wang, Baichuan Sun, Ying Chai, Chengfu Zhou, Shuyun Liu, Quanyi Guo
Meniscus injuries appear to be becoming increasingly common and pose a challenge for orthopedic surgeons. However, there is no curative approach for dealing with defects in the inner meniscus region due to its avascular nature. Numerous strategies have been applied to regenerate and repair meniscus defects and native tissue-based strategies have received much attention. Native tissue usually has good biocompatibility, excellent mechanical properties and a suitable microenvironment for cellular growth, adhesion, redifferentiation, extracellular matrix deposition and remodeling...
February 3, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29382216/preoperative-tibial-subchondral-bone-marrow-lesion-patterns-and-associations-with-outcomes-after-isolated-meniscus-allograft-transplantation
#20
Bryan M Saltzman, Eric J Cotter, Jeffrey P Stephens, Gregory L Cvetanovich, Brett Madden, Kevin Wang, Adam B Yanke, Brian J Cole
BACKGROUND: The association between preoperative tibial subchondral bone marrow lesion (BML) patterns and outcomes after isolated meniscus allograft transplantation (MAT) are unknown. PURPOSE: To determine (1) if a superior classification means exists (ie, high interrater reliability [IRR]) for grading tibial subchondral BML before isolated MAT and (2) whether quality and/or severity of preoperative tibial subchondral BML patterns was associated with clinical outcomes and/or failure rates after isolated MAT...
April 2018: American Journal of Sports Medicine
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