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Aortic valvulopathy

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https://www.readbyqxmd.com/read/27888609/effects-of-lorcaserin-on-pre-existing-valvulopathy-a-pooled-analysis-of-phase-3-trials
#1
Neil J Weissman, Steven R Smith, Randi Fain, Nancy Hall, William R Shanahan
OBJECTIVE: To evaluate the effects of lorcaserin in patients with pre-existing Food and Drug Administration (FDA)-defined valvulopathy. METHODS: This is a pooled, post hoc analysis of three Phase 3 studies. BLOOM and BLOSSOM patients were 18 to 65 years of age without diabetes and with a body mass index (BMI) of 27 to 29.9 kg/m(2) and ≥1 weight-related comorbidity or a BMI of 30 to 45 kg/m(2) . BLOOM-DM patients had a BMI of 27 to 45 kg/m(2) and type 2 diabetes...
November 26, 2016: Obesity
https://www.readbyqxmd.com/read/27599727/flow-measurement-at-the-aortic-root-impact-of-location-of-through-plane-phase-contrast-velocity-mapping
#2
Litten Bertelsen, Jesper Hastrup Svendsen, Lars Køber, Ketil Haugan, Søren Højberg, Carsten Thomsen, Niels Vejlstrup
BACKGROUND: Cardiovascular magnetic resonance (CMR) is considered the gold standard of cardiac volumetric measurements. Flow in the aortic root is often measured at the sinotubular junction, even though placing the slice just above valve level may be more precise. It is unknown how much flow measurements vary at different levels in the aortic root and which level corresponds best to left ventricle volumetry. METHODS: All patients were older than 70 years presenting with at least one of the following diagnoses: diabetes, hypertension, prior stroke and/or heart failure...
September 7, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27547548/computational-fluid-dynamics-modelling-of-left-valvular-heart-diseases-during-atrial-fibrillation
#3
Stefania Scarsoglio, Andrea Saglietto, Fiorenzo Gaita, Luca Ridolfi, Matteo Anselmino
BACKGROUND: Although atrial fibrillation (AF), a common arrhythmia, frequently presents in patients with underlying valvular disease, its hemodynamic contributions are not fully understood. The present work aimed to computationally study how physical conditions imposed by pathologic valvular anatomy act on AF hemodynamics. METHODS: We simulated AF with different severity grades of left-sided valvular diseases and compared the cardiovascular effects that they exert during AF, compared to lone AF...
2016: PeerJ
https://www.readbyqxmd.com/read/27534757/-enfants-porteurs-de-valvulopathies-post-rhumatismales-en-%C3%A2-histoire-naturelle-%C3%A2-suivi-de-5-ans-au-centre-cardiaque-de-l-h%C3%A3-pital-de-shisong-cameroun
#4
J C Tantchou Tchoumi, J C Ambassa, G Butera
The aim of the study was to investigate the pattern of valvular lesions, the mortality and the challenges in five years follow-up in children with post-rheumatic valvulopathies in natural history in St. Elizabeth Catholic General hospital Shisong, cardiac centre. This retrospective analysis included 270 patients aged between 5 and 16 years old suffering from post-rheumatic valvulopathies who consulted in the cardiac centre from July 2008 through July 2013. Postrheumatic valvulopathies were diagnosed according to the World heart federation criteria...
August 17, 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27449465/a-rare-case-of-florid-antineutrophil-cytoplasmic-autoantibody-associated-vasculitis-involving-both-atrioventricular-valves
#5
Habib Khan, Sanjay Chaubey, Rynda Nitiahpapand, Jatin Desai
Cardiac involvement is rare in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis but can involve aortic and mitral valves. We present an unusual case of a 65-year-old woman who presented 16 years after an aortic valve replacement with severe mitral regurgitation with ACNA-associated vasculitis. The extensive nature of the pathologic condition, which extended to the tricuspid valve, prevented the replacement of the mitral valve during a surgical procedure. This is a rare case in which florid valvulopathy was observed in association with vasculitis...
August 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27406839/cell-matrix-mechanics-and-pattern-formation-in-inflammatory-cardiovascular-calcification
#6
REVIEW
Jeffrey J Hsu, Jina Lim, Yin Tintut, Linda L Demer
Calcific diseases of the cardiovascular system, such as atherosclerotic calcification and calcific aortic valve disease, are widespread and clinically significant, causing substantial morbidity and mortality. Vascular cells, like bone cells, interact with their matrix substrate through molecular signals, and through biomechanical signals, such as traction forces transmitted from cytoskeleton to matrix. The interaction of contractile vascular cells with their matrix may be one of the most important factors controlling pathological mineralisation of the artery wall and cardiac valves...
November 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27091952/iron-alters-valvular-interstitial-cell-function-and-is-associated-with-calcification-in-aortic-stenosis
#7
Andres Laguna-Fernandez, Miguel Carracedo, Gregoire Jeanson, Edit Nagy, Per Eriksson, Giuseppina Caligiuri, Anders Franco-Cereceda, Magnus Bäck
AIMS: Aortic valve stenosis (AS) is the most common valvulopathy and is characterized by inflammation, extracellular matrix (ECM) remodelling and calcification, causing a narrowing of the valve and the consequential obstruction of the cardiac outflow. Although intraleaflet haemorrhage is associated with AS progression, the mechanisms involved are not known. The aims of this study were to identify valvular iron in relation to pathological changes associated with AS and the effects on valvular interstitial cells (VIC) in terms of iron uptake and iron-induced responses...
April 18, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26924497/autoimmune-fibrotic-adverse-reactions-in-one-year-treatment-with-cabergoline-for-women-with-prolactinoma
#8
Berçem Ayçiçek Doğan, Ayse Arduc, Mazhar Müslüm Tuna, Dilek Berker, Nilgün Demirci, Semra Demirtaş, Hülya Çiçekcioğlu, Serdar Güler
AIM: Cabergoline is related to an elevated risk of fibrotic adverse reactions including cardiac valvular and pleuropulmonary fibrosis. We investigated pulmonary and cardiac valve fibrosis and immunological markers before and after 3 and 12 months of treatment with cabergoline in women with prolactinoma. MATERIAL-METHODS: The study included thirty-two women with newly diagnosed prolactinoma and 28 healthy women. CAB cumulative dose was 7.8±5.5 mg after 3-month therapy, and 31±22 mg after 12-month follow-up...
2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/26877396/p-092-endovascular-repair-of-aortic-coarctation-in-adult-experience-of-our-department
#9
S Benallal, M N Bouayed
OBJECTIFS: La coarctation de l'aorte représente environ 7 % des malformations cardiaques congénitales, associée dans 50 % des cas à une bicuspidie aortique ; diagnostiquée le plus souvent chez l'enfant, rarement à l'âge adulte à l'occasion d'une complication. Le but de notre étude est de montrer l'apport du traitement endovasculaire dans la prise en charge des coarctations aortiques chez l'adulte, et d'évaluer les résultats à court, moyen et long terme. MéTHODES: Étude mono-centrique prospective, non randomisée sur 28 mois, allant de mars 2013 à juillet 2015, portant sur 15 cas, traités pour coarctation de l'aorte découverte à l'âge adulte, dont l'âge moyen était de 37,3ans, avec des extrêmes allant de 15ans à 50ans, et un Sex-ratio de 1/1...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26642773/atrial-fibrillation-during-or-after-tavi-incidence-implications-and-therapeutical-considerations
#10
Manolis Vavuranakis, Angelos-Michail Kolokathis, Dimitrios A Vrachatis, Konstantinos Kalogeras, Nikolaos A Magkoutis, Sabi Fradi, Saïd Ghostine, Marianna Karamanou, Dimitrios Tousoulis
INTRODUCTION: Aortic stenosis is one of the most frequent valvulopathy of modern time necessitating interventional therapy when symptoms arise and stenosis becomes severe. First line treatment has traditionally been surgical aortic valve replacement (SAVR). However in the last decade transcatheter aortic valve implantation (TAVI) with bioprosthetic valves has proved to be a sound solution for high-risk for SAVR or inoperable patients. As expected implantation of the bioprosthetic device requires administration of antiplatelet regimen to the patients for a certain period...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26102739/1d-04-inverse-relationship-between-aortic-root-diameter-and-renal-function-in-hypertensive-subjects
#11
G Mulè, E Nardi, M Morrcale, S D'Amico, G Geraci, C Nardi, G Cerasola, S Cottone
OBJECTIVE: Recent studies suggest that enlarged aortic root diameter (ARD) may predict cardiovascular events in absence of aneurysmatic alterations. Little is known about the influence of renal function on ARD. Our study was aimed to assess the relationships between glomerular filtration rate (GFR) and ARD in hypertensive subjects. DESIGN AND METHOD: We enrolled 611 hypertensive individuals (mean age: 52 ± 15 years; men 63%) consecutively attending our outpatient unit of Nephrology and Hypertension...
June 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/26100571/heart-disease-in-patients-with-osteogenesis-imperfecta-a-systematic-review
#12
REVIEW
Hamoun Ashournia, Frank Ted Johansen, Lars Folkestad, Axel C P Diederichsen, Kim Brixen
INTRODUCTION: Osteogenesis imperfecta (OI) is a rare, inherited systemic connective tissue disease that causes decreased bioavailability of collagen type 1. Collagen type 1 is the most abundant connective tissue in the body and a key part of many organs. While the bone phenotype in OI is well described, less is known about the effects of decreased collagen on other organs. In the heart, collagen type 1 is present in the heart valves, chordae tendineae, annuli fibrosi and the interventricular septum...
October 1, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25883749/bicuspid-aortic-valve-unresolved-issues-and-role-of-imaging-specialists
#13
REVIEW
Jae-Kwan Song
Bicuspid aortic valve (BAV) is the most common congenital heart disease with marked heterogeneity in many aspects. Fusion patterns of the aortic cusp are quite variable with different type and severity of valvular dysfunction. Moreover, non-valvular cardiovascular abnormalities are associated with BAV. Among them, aortic aneurysm/dissection is the most serious clinical condition with variable patterns of segmental aortic dilatation. Potential association between BAV phenotype and valvulopathy or aortopathy has been suggested, but needs to be tested further...
March 2015: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/25692009/characterization-of-the-5-ht2c-receptor-agonist-lorcaserin-on-efficacy-and-safety-measures-in-a-rat-model-of-diet-induced-obesity
#14
Guy A Higgins, Jill Desnoyer, Annalise Van Niekerk, Leo B Silenieks, Winnie Lau, Sandy Thevarkunnel, Julia Izhakova, Ines Am DeLannoy, Paul J Fletcher, Josepha DeLay, Howard Dobson
The 5-HT2C receptor agonist lorcaserin (Belviq®) has been Food and Drug Administration (FDA) approved for the treatment of obesity. The present study is a back translational investigation into the effect of 28-day lorcaserin treatment in a diet-induced obesity (DIO) model using male, Sprague-Dawley rats. An assessment of drug effect on efficacy and multiple safety endpoints including cardiac function was undertaken. Lorcaserin (1-2 mg/kg SC b.i.d.) significantly reduced percentage body weight gain compared to vehicle-treated controls (VEH: 10...
February 2015: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/25548612/etiology-of-bicuspid-aortic-valve-disease-focus-on-hemodynamics
#15
Samantha K Atkins, Philippe Sucosky
The bicuspid aortic valve (BAV) is the most common form of inheritable cardiac defect. Although this abnormality may still achieve normal valvular function, it is often associated with secondary valvular and aortic complications such as calcific aortic valve disease and aortic dilation. The clinical significance and economic burden of BAV disease justify the need for improved clinical guidelines and more robust therapeutic modalities, which address the root-cause of those pathologies. Unfortunately, the etiology of BAV valvulopathy and aortopathy is still a debated issue...
December 26, 2014: World Journal of Cardiology
https://www.readbyqxmd.com/read/25339233/membranoproliferative-glomerulonephritis-presenting-as-arthropathy-and-cardiac-valvulopathy-in-hypocomplementemic-urticarial-vasculitis-a-case-report
#16
Chuiyoung Park, Seung Won Choi, Misung Kim, Jongha Park, Jong Soo Lee, Hyun Chul Chung
INTRODUCTION: Hypocomplementemic urticarial vasculitis syndrome is a rare disorder characterized by chronic urticarial vasculitis, arthralgia, arthritis, and hypocomplementemia. Previously, only six patients with concomitant hypocomplementemic urticarial vasculitis syndrome, Jaccoud's arthropathy, and valvular heart disease have been reported. CASE PRESENTATION: A 30-year-old Korean man presented with hypocomplementemic urticarial vasculitis syndrome. In addition to urticarial cutaneous lesions, he experienced polyarthralgia and arthritis that resulted in progressive deformity of the joints of both hands, cardiac valvulopathy with mitral, tricuspid, and aortic regurgitation, and intermittent neck swelling with laryngeal edema...
October 22, 2014: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/25325992/circulating-matrix-metalloproteinase-patterns-in-association-with-aortic-dilatation-in-bicuspid-aortic-valve-patients-with-isolated-severe-aortic-stenosis
#17
Yongshi Wang, Boting Wu, Lili Dong, Chunsheng Wang, Xiaolin Wang, Xianhong Shu
Bicuspid aortic valve (BAV) exhibits a clinical incline toward aortopathy, in which aberrant tensile and shear stress generated by BAV can induce differential expression of matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs). Whether stenotic BAV, which exhibits additional eccentric high-velocity flow jet upon ascending aorta and further worsens circumferential systolic wall shear stress than BAV with echocardiographically normal aortic valve, can lead to unique plasma MMP/TIMP patterns is still unknown...
February 2016: Heart and Vessels
https://www.readbyqxmd.com/read/25309692/multiple-cardiovascular-manifestations-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease
#18
Young Ran Kang, Jong-Hwa Ahn, Kye Hwan Kim, Young Min Choi, Jungwoo Choi, Jeong Rang Park
Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder associated with various extrarenal complications. The major cardiovascular complications of ADPKD include valvulopathies and vascular ectasia. A 64-year-old man who was diagnosed with ADPKD seven years previously was admitted to our hospital for heart failure. Pelvic computed tomography revealed multiple variable-sized cysts in both kidneys. Transthoracic echocardiography showed enlargement of the left ventricle and left atrium. Severe mitral regurgitation and moderate aortic regurgitation with annuloaortic ectasia were observed...
September 2014: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/24776359/intraoperative-monitoring-with-transesophageal-real-time-three-dimensional-echocardiography-during-transapical-prosthetic-aortic-valve-implantation
#19
Pedro Marcos-Alberca, José Luis Zamorano, Tibisay Sánchez, Luis Maroto, Leopoldo Pérez de Isla, Carlos Almería, Carlos Macaya, Enrique Rodríguez
Degenerative aortic stenosis is the most common valvulopathy in Europe. In symptomatic patients, aortic valve replacement with a prosthesis substantially improves prognosis. However, a high percentage of candidates for valve replacement surgery are rejected because of the high risk of serious complications. In recent years, percutaneous and minimally invasive surgical techniques have been developed for the transcatheter implantation of prosthetic aortic valves. These developments could lead to an increase in the number of interventions carried out in high-risk patients as the positive effect of treatment on prognosis would be retained while the complication rate would be reduced...
March 2010: Revista Española de Cardiología
https://www.readbyqxmd.com/read/24775895/short-term-results-with-the-ross-procedure-does-the-etiology-of-aortic-valvulopathy-affect-the-outcome
#20
Carmen Rus, Dolores Mesa, Manuel Concha, Jaime Casares, José Suárez de Lezo, Mónica Delgado, Manuel Franco, Elías Romo, Martín Ruiz, Federico Vallés
INTRODUCTION: The Ross procedure has become established as an appropriate method for aortic valve replacement in children and young adults. There is controversy regarding the results of this surgical technique depending on whether the aortic valve disorder is congenital or acquired. The objective of this study was to analyze the outcome of this technique in different etiologies. PATIENTS AND METHOD: We analyzed 61 patients who underwent the Ross procedure between November 1997 and November 2001...
June 2004: Revista Española de Cardiología
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