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Aortic valvulopathy

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https://www.readbyqxmd.com/read/28648391/role-of-global-longitudinal-strain-in-the-prediction-of-outcome-in-patients-with-severe-aortic-valve-stenosis
#1
Bastian Fries, Dan Liu, Philipp Gaudron, Kai Hu, Peter Nordbeck, Georg Ertl, Frank Weidemann, Sebastian Herrmann
In the present study, we assessed the role of Global Longitudinal Strain (GLS) as a predictor of all-cause mortality in patients with severe aortic valve stenosis (AS), irrespective of their type of treatment. Data of 807 patients with AS receiving complete echocardiographic and clinical examination were retrospectively analyzed. Valve area <1 cm(2) and sufficient image quality were inclusion criteria; patients with severe concomitant valvulopathy were excluded. Patients were grouped into treatment (aortic valve replacement [AVR]) and conservative (non-AVR) groups...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28599977/fate-of-remnant-sinuses-of-valsalva-in-patients-with-bicuspid-and-trileaflet-valves-undergoing-aortic-valve-ascending-aorta-and-aortic-arch-replacement
#2
Rita Karianna Milewski, Andreas Habertheuer, Joseph E Bavaria, Mary Siki, Wilson Y Szeto, Eric Krause, Varun Korutla, Nimesh D Desai, Prashanth Vallabhajosyula
OBJECTIVE: In patients presenting with aortic valvulopathy with concomitant ascending aortic aneurysm, surgical management of the sinus of Valsalva segment remains undefined, especially for moderately dilated aortic roots. In patients with this pathology undergoing aortic valve replacement with supracoronary ascending aorta replacement, we assessed the fate of the remnant preserved sinus of Valsalva segment stratified by aortic valve morphology and pathology. METHODS: From 2002 to 2015, 428 patients underwent elective aortic valve replacement with supracoronary ascending aorta replacement...
August 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28541271/protein-altering-and-regulatory-genetic-variants-near-gata4-implicated-in-bicuspid-aortic-valve
#3
Bo Yang, Wei Zhou, Jiao Jiao, Jonas B Nielsen, Michael R Mathis, Mahyar Heydarpour, Guillaume Lettre, Lasse Folkersen, Siddharth Prakash, Claudia Schurmann, Lars Fritsche, Gregory A Farnum, Maoxuan Lin, Mohammad Othman, Whitney Hornsby, Anisa Driscoll, Alexandra Levasseur, Marc Thomas, Linda Farhat, Marie-Pierre Dubé, Eric M Isselbacher, Anders Franco-Cereceda, Dong-Chuan Guo, Erwin P Bottinger, G Michael Deeb, Anna Booher, Sachin Kheterpal, Y Eugene Chen, Hyun Min Kang, Jacob Kitzman, Heather J Cordell, Bernard D Keavney, Judith A Goodship, Santhi K Ganesh, Gonçalo Abecasis, Kim A Eagle, Alan P Boyle, Ruth J F Loos, Per Eriksson, Jean-Claude Tardif, Chad M Brummett, Dianna M Milewicz, Simon C Body, Cristen J Willer
Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 BAV cases and 4,660 age, sex and ethnicity-matched controls with replication in up to 1,326 cases and 8,103 controls. We identify association with a noncoding variant 151 kb from the gene encoding the cardiac-specific transcription factor, GATA4, and near-significance for p.Ser377Gly in GATA4. GATA4 was interrupted by CRISPR-Cas9 in induced pluripotent stem cells from healthy donors...
May 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28415104/p697new-indices-for-a-best-quantification-of-left-ventricular-function-in-heart-valve-diseases
#4
A Hubert, E Galli, G Bouzille, E Samset, E Donal
Aims. The Assessment of left ventricular (LV) function remains a clinical challenge especially in patients with preserved LV ejection fraction (EF) and valvular heart diseases (VHD). Mechanical dispersion is supposed to be a strong predictor of events and, to be related to the extent of fibrosis. Regional cardiac work is a new validated and very promising approach to quantify LV-function. We investigated the differences in mechanical dispersions and global LV work (totW) and wasted work fraction (WWF) in normal subjects and in patients with severe primary mitral regurgitation (MR) and severe aortic stenosis (AS)...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28351655/arterial-hypertension-and-aortic-valve-stenosis-shedding-light-on-a-common-liaison
#5
REVIEW
Charalampos I Liakos, Charalampos A Grassos, Dimitrios P Papadopoulos, Kyriakos S Dimitriadis, Constantinos P Tsioufis, Dimitrios Tousoulis
Arterial hypertension and aortic valve stenosis are common disorders and frequently present as concomitant diseases, especially in elderly patients. The impact of hypertension on heart haemodynamics is substantial, thus affecting the clinical presentation of any coexisting valvulopathy, especially of aortic stenosis. However, the interaction between these 2 entities is not thoroughly discussed in the European or/and American guidelines on the management of hypertension or/and valvular heart disease. The present review summarizes all available evidence on the potential interplay between hypertension and aortic valve stenosis, aiming to help physicians understand the pathophysiology and select the best diagnostic and therapeutic strategies (medical or/and interventional) for better management of these high-risk patients, taking into account the impact on outcome as well as the risk-benefit-ratio...
March 27, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28281241/decellularized-cryopreserved-allografts-as-off-the-shelf-allogeneic-alternative-for-heart-valve-replacement-in-vitro-assessment-before-clinical-translation
#6
Laura Iop, Adolfo Paolin, Paola Aguiari, Diletta Trojan, Elisa Cogliati, Gino Gerosa
Cryopreserved allogeneic conduits are the elective biocompatible choice among currently available substitutes for surgical replacement in end-stage valvulopathy. However, degeneration occurs in 15 years in adults or faster in children, due to recipient's immunological reactions to donor's antigens. Here, human aortic valves were decellularized by TRICOL, based on Triton X-100 and sodium cholate, and submitted to standard cryopreservation (TRICOL-human aortic valves (hAVs)). Tissue samples were analyzed to study the effects of the combined procedure on original valve architecture and donor's cell removal...
March 9, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28217516/long-term-cardiac-valvulopathy-safety-of-cabergoline-in-prolactinoma
#7
Shruti Khare, Anurag R Lila, Rishikesh Patil, Milind Phadke, Prafulla Kerkar, Tushar Bandgar, Nalini S Shah
BACKGROUND: Clinical relevance of association of cabergoline use for hyperprolactinemia and cardiac valvulopathy remains unclear. OBJECTIVE: The aim of the study was to determine the prevalence of valvular heart abnormalities in patients taking cabergoline for the treatment of prolactinoma and to explore any associations with the cumulative dose of drug used. DESIGN: A cross-sectional echocardiographic study was performed in patients who were receiving cabergoline therapy for prolactinoma...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27888609/effects-of-lorcaserin-on-pre-existing-valvulopathy-a-pooled-analysis-of-phase-3-trials
#8
Neil J Weissman, Steven R Smith, Randi Fain, Nancy Hall, William R Shanahan
OBJECTIVE: To evaluate the effects of lorcaserin in patients with pre-existing Food and Drug Administration (FDA)-defined valvulopathy. METHODS: This is a pooled, post hoc analysis of three Phase 3 studies. BLOOM and BLOSSOM patients were 18 to 65 years of age without diabetes and with a body mass index (BMI) of 27 to 29.9 kg/m(2) and ≥1 weight-related comorbidity or a BMI of 30 to 45 kg/m(2) . BLOOM-DM patients had a BMI of 27 to 45 kg/m(2) and type 2 diabetes...
January 2017: Obesity
https://www.readbyqxmd.com/read/27599727/flow-measurement-at-the-aortic-root-impact-of-location-of-through-plane-phase-contrast-velocity-mapping
#9
Litten Bertelsen, Jesper Hastrup Svendsen, Lars Køber, Ketil Haugan, Søren Højberg, Carsten Thomsen, Niels Vejlstrup
BACKGROUND: Cardiovascular magnetic resonance (CMR) is considered the gold standard of cardiac volumetric measurements. Flow in the aortic root is often measured at the sinotubular junction, even though placing the slice just above valve level may be more precise. It is unknown how much flow measurements vary at different levels in the aortic root and which level corresponds best to left ventricle volumetry. METHODS: All patients were older than 70 years presenting with at least one of the following diagnoses: diabetes, hypertension, prior stroke and/or heart failure...
September 7, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27547548/computational-fluid-dynamics-modelling-of-left-valvular-heart-diseases-during-atrial-fibrillation
#10
Stefania Scarsoglio, Andrea Saglietto, Fiorenzo Gaita, Luca Ridolfi, Matteo Anselmino
BACKGROUND: Although atrial fibrillation (AF), a common arrhythmia, frequently presents in patients with underlying valvular disease, its hemodynamic contributions are not fully understood. The present work aimed to computationally study how physical conditions imposed by pathologic valvular anatomy act on AF hemodynamics. METHODS: We simulated AF with different severity grades of left-sided valvular diseases and compared the cardiovascular effects that they exert during AF, compared to lone AF...
2016: PeerJ
https://www.readbyqxmd.com/read/27534757/children-with-post-rheumatic-valvulopathies-in-natural-history-five-years-follow-up-in-the-cardiac-centre-st-elizabeth-catholic-general-hospital-shisong-cameroon
#11
J C Tantchou Tchoumi, J C Ambassa, G Butera
The aim of the study was to investigate the pattern of valvular lesions, the mortality and the challenges in five years follow-up in children with post-rheumatic valvulopathies in natural history in St. Elizabeth Catholic General hospital Shisong, cardiac centre. This retrospective analysis included 270 patients aged between 5 and 16 years old suffering from post-rheumatic valvulopathies who consulted in the cardiac centre from July 2008 through July 2013. Postrheumatic valvulopathies were diagnosed according to the World heart federation criteria...
December 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27449465/a-rare-case-of-florid-antineutrophil-cytoplasmic-autoantibody-associated-vasculitis-involving-both-atrioventricular-valves
#12
Habib Khan, Sanjay Chaubey, Rynda Nitiahpapand, Jatin Desai
Cardiac involvement is rare in antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis but can involve aortic and mitral valves. We present an unusual case of a 65-year-old woman who presented 16 years after an aortic valve replacement with severe mitral regurgitation with ACNA-associated vasculitis. The extensive nature of the pathologic condition, which extended to the tricuspid valve, prevented the replacement of the mitral valve during a surgical procedure. This is a rare case in which florid valvulopathy was observed in association with vasculitis...
August 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27406839/cell-matrix-mechanics-and-pattern-formation-in-inflammatory-cardiovascular-calcification
#13
REVIEW
Jeffrey J Hsu, Jina Lim, Yin Tintut, Linda L Demer
Calcific diseases of the cardiovascular system, such as atherosclerotic calcification and calcific aortic valve disease, are widespread and clinically significant, causing substantial morbidity and mortality. Vascular cells, like bone cells, interact with their matrix substrate through molecular signals, and through biomechanical signals, such as traction forces transmitted from cytoskeleton to matrix. The interaction of contractile vascular cells with their matrix may be one of the most important factors controlling pathological mineralisation of the artery wall and cardiac valves...
November 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27091952/iron-alters-valvular-interstitial-cell-function-and-is-associated-with-calcification-in-aortic-stenosis
#14
Andres Laguna-Fernandez, Miguel Carracedo, Gregoire Jeanson, Edit Nagy, Per Eriksson, Giuseppina Caligiuri, Anders Franco-Cereceda, Magnus Bäck
AIMS: Aortic valve stenosis (AS) is the most common valvulopathy and is characterized by inflammation, extracellular matrix (ECM) remodelling and calcification, causing a narrowing of the valve and the consequential obstruction of the cardiac outflow. Although intraleaflet haemorrhage is associated with AS progression, the mechanisms involved are not known. The aims of this study were to identify valvular iron in relation to pathological changes associated with AS and the effects on valvular interstitial cells (VIC) in terms of iron uptake and iron-induced responses...
December 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26924497/autoimmune-fibrotic-adverse-reactions-in-one-year-treatment-with-cabergoline-for-women-with-prolactinoma
#15
Berçem Ayçiçek Doğan, Ayse Arduc, Mazhar Müslüm Tuna, Dilek Berker, Nilgün Demirci, Semra Demirtaş, Hülya Çiçekcioğlu, Serdar Güler
AIM: Cabergoline is related to an elevated risk of fibrotic adverse reactions including cardiac valvular and pleuropulmonary fibrosis. We investigated pulmonary and cardiac valve fibrosis and immunological markers before and after 3 and 12 months of treatment with cabergoline in women with prolactinoma. MATERIAL-METHODS: The study included thirty-two women with newly diagnosed prolactinoma and 28 healthy women. CAB cumulative dose was 7.8±5.5 mg after 3-month therapy, and 31±22 mg after 12-month follow-up...
2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/26877396/p-092-endovascular-repair-of-aortic-coarctation-in-adult-experience-of-our-department
#16
S Benallal, M N Bouayed
OBJECTIFS: La coarctation de l'aorte représente environ 7 % des malformations cardiaques congénitales, associée dans 50 % des cas à une bicuspidie aortique ; diagnostiquée le plus souvent chez l'enfant, rarement à l'âge adulte à l'occasion d'une complication. Le but de notre étude est de montrer l'apport du traitement endovasculaire dans la prise en charge des coarctations aortiques chez l'adulte, et d'évaluer les résultats à court, moyen et long terme. MéTHODES: Étude mono-centrique prospective, non randomisée sur 28 mois, allant de mars 2013 à juillet 2015, portant sur 15 cas, traités pour coarctation de l'aorte découverte à l'âge adulte, dont l'âge moyen était de 37,3ans, avec des extrêmes allant de 15ans à 50ans, et un Sex-ratio de 1/1...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26642773/atrial-fibrillation-during-or-after-tavi-incidence-implications-and-therapeutical-considerations
#17
REVIEW
Manolis Vavuranakis, Angelos-Michail Kolokathis, Dimitrios A Vrachatis, Konstantinos Kalogeras, Nikolaos A Magkoutis, Sabi Fradi, Saïd Ghostine, Marianna Karamanou, Dimitrios Tousoulis
INTRODUCTION: Aortic stenosis is one of the most frequent valvulopathy of modern time necessitating interventional therapy when symptoms arise and stenosis becomes severe. First line treatment has traditionally been surgical aortic valve replacement (SAVR). However in the last decade transcatheter aortic valve implantation (TAVI) with bioprosthetic valves has proved to be a sound solution for high-risk for SAVR or inoperable patients. As expected implantation of the bioprosthetic device requires administration of antiplatelet regimen to the patients for a certain period...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26102739/1d-04-inverse-relationship-between-aortic-root-diameter-and-renal-function-in-hypertensive-subjects
#18
G Mulè, E Nardi, M Morrcale, S D'Amico, G Geraci, C Nardi, G Cerasola, S Cottone
OBJECTIVE: Recent studies suggest that enlarged aortic root diameter (ARD) may predict cardiovascular events in absence of aneurysmatic alterations. Little is known about the influence of renal function on ARD. Our study was aimed to assess the relationships between glomerular filtration rate (GFR) and ARD in hypertensive subjects. DESIGN AND METHOD: We enrolled 611 hypertensive individuals (mean age: 52 ± 15 years; men 63%) consecutively attending our outpatient unit of Nephrology and Hypertension...
June 2015: Journal of Hypertension
https://www.readbyqxmd.com/read/26100571/heart-disease-in-patients-with-osteogenesis-imperfecta-a-systematic-review
#19
REVIEW
Hamoun Ashournia, Frank Ted Johansen, Lars Folkestad, Axel C P Diederichsen, Kim Brixen
INTRODUCTION: Osteogenesis imperfecta (OI) is a rare, inherited systemic connective tissue disease that causes decreased bioavailability of collagen type 1. Collagen type 1 is the most abundant connective tissue in the body and a key part of many organs. While the bone phenotype in OI is well described, less is known about the effects of decreased collagen on other organs. In the heart, collagen type 1 is present in the heart valves, chordae tendineae, annuli fibrosi and the interventricular septum...
October 1, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25883749/bicuspid-aortic-valve-unresolved-issues-and-role-of-imaging-specialists
#20
REVIEW
Jae-Kwan Song
Bicuspid aortic valve (BAV) is the most common congenital heart disease with marked heterogeneity in many aspects. Fusion patterns of the aortic cusp are quite variable with different type and severity of valvular dysfunction. Moreover, non-valvular cardiovascular abnormalities are associated with BAV. Among them, aortic aneurysm/dissection is the most serious clinical condition with variable patterns of segmental aortic dilatation. Potential association between BAV phenotype and valvulopathy or aortopathy has been suggested, but needs to be tested further...
March 2015: Journal of Cardiovascular Ultrasound
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