keyword
https://read.qxmd.com/read/38537025/effects-of-an-early-intensive-blood-pressure-lowering-strategy-using-remifentanil-and-dexmedetomidine-in-patients-with-spontaneous-intracerebral-hemorrhage-a-multicenter-prospective-superiority-randomized-controlled-trial
#1
JOURNAL ARTICLE
Rui Dong, Fen Li, Bin Li, Qiming Chen, Xianjian Huang, Jiehua Zhang, Qibing Huang, Zeli Zhang, Yunxing Cao, Mingbiao Yang, Jianwei Li, Zhanfu Li, Cuiyu Li, Guohua Liu, Shu Zhong, Guang Feng, Ming Zhang, Yumei Xiao, Kangyue Lin, Yunlong Shen, Huanzhang Shao, Yuan Shi, Xiangyou Yu, Xiaopeng Li, Lan Yao, Xinyu Du, Ying Xu, Pei Kang, Guoyi Gao, Bin Ouyang, Wenjin Chen, Zhenhua Zeng, Pingyan Chen, Chunbo Chen, Hong Yang
BACKGROUND: Although it has been established that elevated blood pressure and its variability worsen outcomes in spontaneous intracerebral hemorrhage, antihypertensives use during the acute phase still lacks robust evidence. A blood pressure-lowering regimen using remifentanil and dexmedetomidine might be a reasonable therapeutic option given their analgesic and anti-sympathetic effects. The objective of this superiority trial was to validate the efficacy and safety of this blood pressure-lowering strategy that uses remifentanil and dexmedetomidine in patients with acute intracerebral hemorrhage...
March 27, 2024: Anesthesiology
https://read.qxmd.com/read/38530411/impact-of-early-follow-up-ct-in-the-conservative-management-of-traumatic-brain-injury-on-surgical-decision-making-a-retrospective-single-center-analysis-with-special-respect-to-coagulopathy
#2
JOURNAL ARTICLE
Mats L Moskopp, Dag Moskopp, Lennart W Sannwald
INTRODUCTION: Initial management of traumatic brain injury (TBI) without immediate need for surgical therapy varies across centers. The additional value of routine repeat cranial computerized tomography (CT) to neurological monitoring is controversial. This retrospective study investigates the impact of routine follow-up CT after 6 h (CT6h) in initially conservatively managed TBI on surgical decision making. Furthermore, the impact of coagulopathy on lesion size and progression was examined...
March 26, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://read.qxmd.com/read/38526462/high-efficacy-therapy-discontinuation-vs-continuation-in-patients-50-years-and-older-with-nonactive-ms
#3
JOURNAL ARTICLE
Guillaume Jouvenot, Guilhem Courbon, Mathilde Lefort, Fabien Rollot, Romain Casey, Emmanuelle Le Page, Laure Michel, Gilles Edan, Jérome de Seze, Laurent Kremer, Kevin Bigaut, Sandra Vukusic, Guillaume Mathey, Jonathan Ciron, Aurélie Ruet, Elisabeth Maillart, Pierre Labauge, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun-Frenay, Thibault Moreau, David Axel Laplaud, Eric Berger, Bruno Stankoff, Pierre Clavelou, Eric Thouvenot, Olivier Heinzlef, Jean Pelletier, Abdullatif Al-Khedr, Olivier Casez, Bertrand Bourre, Philippe Cabre, Abir Wahab, Laurent Magy, Jean-Philippe Camdessanché, Ines Doghri, Solène Moulin, Haifa Ben-Nasr, Céline Labeyrie, Karolina Hankiewicz, Jean-Philippe Neau, Corinne Pottier, Chantal Nifle, Nicolas Collongues, Anne Kerbrat
IMPORTANCE: A recent randomized clinical trial concluded that discontinuing medium-efficacy therapy might be a reasonable option for older patients with nonactive multiple sclerosis (MS), but there is a lack of data on discontinuing high-efficacy therapy (HET). In younger patients, the discontinuation of natalizumab and fingolimod is associated with a risk of rebound of disease activity. OBJECTIVE: To determine whether discontinuing HET in patients 50 years and older with nonactive MS is associated with an increased risk of relapse compared with continuing HET...
March 25, 2024: JAMA Neurology
https://read.qxmd.com/read/38525734/a-large-language-model-based-generative-natural-language-processing-framework-fine-tuned-on-clinical-notes-accurately-extracts-headache-frequency-from-electronic-health-records
#4
JOURNAL ARTICLE
Chia-Chun Chiang, Man Luo, Gina Dumkrieger, Shubham Trivedi, Yi-Chieh Chen, Chieh-Ju Chao, Todd J Schwedt, Abeed Sarker, Imon Banerjee
OBJECTIVE: To develop a natural language processing (NLP) algorithm that can accurately extract headache frequency from free-text clinical notes. BACKGROUND: Headache frequency, defined as the number of days with any headache in a month (or 4 weeks), remains a key parameter in the evaluation of treatment response to migraine preventive medications. However, due to the variations and inconsistencies in documentation by clinicians, significant challenges exist to accurately extract headache frequency from the electronic health record (EHR) by traditional NLP algorithms...
March 25, 2024: Headache
https://read.qxmd.com/read/38522424/artificial-intelligence-performance-in-clinical-neurology-queries-the-chatgpt-model
#5
JOURNAL ARTICLE
Erman Altunisik, Yasemin Ekmekyapar Firat, Emine Kilicparlar Cengiz, Gulsum Bayana Comruk
INTRODUCTION: The use of artificial intelligence technology is progressively expanding and advancing in the health and biomedical literature. Since its launch, ChatGPT has rapidly gained popularity and become one of the fastest-growing artificial intelligence applications in history. This study evaluated the accuracy and comprehensiveness of ChatGPT-generated responses to medical queries in clinical neurology. METHODS: We directed 216 questions from different subspecialties to ChatGPT...
March 24, 2024: Neurological Research
https://read.qxmd.com/read/38520886/a-phase-ii-randomised-controlled-trial-of-intranasal-oxytocin-in-anorexia-nervosa
#6
JOURNAL ARTICLE
Sarah Maguire, Alice Kesby, Rachel Brownlow, Glenn E Hunt, Marcellius Kim, Claire McAulay, Jessica R Grisham, Iain S McGregor, Anastasia Suraev, Richard C Kevin, Janice Russell
BACKGROUND: Anorexia nervosa (AN) is an eating disorder (ED) with high mortality rates and limited response to existing treatments, prompting the need to identify effective agents and adjuncts. There is evidence for an emerging role for the neuropeptide oxytocin (OT) in the pathophysiology of AN, with studies showing a perturbed oxytocinergic system in patients with AN. Preliminary evidence has demonstrated that intranasal OT (IN-OT) can produce anxiolytic effects in AN, as well as reducing concern about eating, and dysfunctional attentional biases related to the disorder...
March 19, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38520876/use-of-cupping-therapy-in-musculoskeletal-disorders-a-cross-sectional-study-on-the-profile-training-and-practice-of-brazilian-physical-therapists
#7
JOURNAL ARTICLE
Wesley Rodrigo Costa Rios, Hugo Jario Almeida Silva, Nayara Silva Pontes, André Pontes-Silva, Mariana Arias Avila, Bruno Tirotti Saragiotto, José Jailson de Almeida Júnior, Germanna Medeiros Barbosa, Marcelo Cardoso de Souza
INTRODUCTION: Cupping therapy is a widely used technique in Brazilian physical therapy for the treatment of musculoskeletal disorders. However, there is limited scientific evidence to support its effectiveness. OBJECTIVE: To investigate the profile, training, clinical practice, and scientific updates of Brazilian Physical Therapists who use cupping therapy as a therapeutic resource for musculoskeletal disorders. METHODS: A cross-sectional study was conducted through an online questionnaire, including 646 Physical Therapists who use cupping therapy in their practice...
March 18, 2024: Musculoskeletal Science & Practice
https://read.qxmd.com/read/38520799/corticospinal-inhibition-investigated-in-relation-to-upper-extremity-motor-function-in-cervical-spinal-cord-injury
#8
JOURNAL ARTICLE
Tarun Arora, Jia Liu, Akhil Mohan, Xin Li, Kyle O'laughlin, Teale Bennett, Gregory Nemunaitis, Francois Bethoux, Svetlana Pundik, Gail Forrest, Steven Kirshblum, Kevin Kilgore, Anne Bryden, M Kristi Henzel, Xiaofeng Wang, Kelsey Baker, Nabila Brihmat, Mehmed Bayram, Ela B Plow
OBJECTIVE: Corticospinal inhibitory mechanisms are relevant to functional recovery but remain poorly understood after spinal cord injury (SCI). Post-injury characteristics of contralateral silent period (CSP), a measure of corticospinal inhibition evaluated using transcranial magnetic stimulation (TMS), is inconsistent in literature. We envisioned that investigating CSP across muscles with varying degrees of weakness may be a reasonable approach to resolve inconsistencies and elucidate the relevance of corticospinal inhibition for upper extremity function following SCI...
February 28, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/38516471/the-efficacy-of-trigger-site-surgery-in-the-elimination-of-chronic-migraine-headache-an-update-in-the-rate-of-success-and-failure
#9
REVIEW
Eyad Faizo, Ahmad Fallata, Iman Mirza, Ahmed K Koshak, Yasmeen T Bucklain, Reema Alharbi, Abdulrahman Tasji, Taha Tasji, Ahmed Kabbarah
Migraine headache (MH) is a prevalent neurovascular disorder that affects approximately 15% of the global population. They are more common in women and typically affect young and middle-aged individuals. Chronic MH is characterized by headaches occurring on ≥15 days per month for over three months. While only 5% of MHs are refractory, about 20%-50% do not respond to pharmacologic treatments. As a result, surgical interventions have emerged as an alternative method to eliminate MH since 2000 AD. These surgical treatments primarily target the peripheral mechanisms of MH, focusing on common trigger sites...
February 2024: Curēus
https://read.qxmd.com/read/38515953/endoscopic-ultrasonography-related-diagnostic-accuracy-and-clinical-significance-on-small-rectal-neuroendocrine-neoplasms
#10
JOURNAL ARTICLE
Jun Weng, Yu-Fan Chen, Shu-Han Li, Yan-Hua Lv, Ruo-Bing Chen, Guo-Liang Xu, Shi-Yong Lin, Kun-Hao Bai
This research aimed to examine the diagnostic accuracy and clinical significance of endoscopic ultrasonography (EUS) in the context of small rectal neuroendocrine neoplasms (NENs). A total of 108 patients with rectal subepithelial lesions (SELs) with a diameter of < 20 mm were included in the analysis. The diagnosis and depth assessment of EUS was compared to the histology findings. The prevalence of NENs in rectal SELs was 78.7% (85/108). The sensitivity of EUS in detecting rectal NENs was 98.9% (84/85), while the specificity was 52...
February 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38515548/twenty-years-of-blast-induced-neurotrauma-current-state-of-knowledge
#11
JOURNAL ARTICLE
Tarun Sachdeva, Shailesh G Ganpule
Blast-induced neurotrauma (BINT) is an important injury paradigm of neurotrauma research. This short communication summarizes the current knowledge of BINT. We divide the BINT research into several broad categories-blast wave generation in laboratory, biomechanics, pathology, behavioral outcomes, repetitive blast in animal models, and clinical and neuroimaging investigations in humans. Publications from 2000 to 2023 in each subdomain were considered. The analysis of the literature has brought out salient aspects...
2024: Neurotrauma reports
https://read.qxmd.com/read/38515438/exploring-cognitive-progression-subtypes-in-the-framingham-heart-study
#12
JOURNAL ARTICLE
Huitong Ding, Biqi Wang, Alexander P Hamel, Cody Karjadi, Ting F A Ang, Rhoda Au, Honghuang Lin
INTRODUCTION: Alzheimer's disease (AD) is a heterogeneous disorder characterized by complex underlying neuropathology that is not fully understood. This study aimed to identify cognitive progression subtypes and examine their correlation with clinical outcomes. METHODS: Participants of this study were recruited from the Framingham Heart Study. The Subtype and Stage Inference (SuStaIn) method was used to identify cognitive progression subtypes based on eight cognitive domains...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38513108/surgical-hip-dislocation-in-the-era-of-hip-arthroscopy-demonstrates-high-survivorship-and-improvements-in-patient-reported-outcomes-for-complex-femoroacetabular-impingement
#13
JOURNAL ARTICLE
Zachary Trotzky, Brian Muffly, Nora Cao, Ernest Sink
BACKGROUND: Over the past decade, hip arthroscopy has become more commonly used in the treatment of patients with femoroacetabular impingement (FAI) as well as those with many other intra-articular hip pathologies. As such, the indications for open surgical hip dislocation have narrowed to include complex intra-articular and extra-articular bony morphologies and revision hip preservation. Although surgical hip dislocation has been established as an effective approach, previous research using contemporary indications has been limited primarily to smaller cohorts with short-term follow-up...
March 21, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38512735/performance-of-the-action-observation-based-brain-computer-interface-in-stroke-patients-and-gaze-metrics-analysis
#14
JOURNAL ARTICLE
Xin Zhang, Lin He, Qiang Gao, Ning Jiang
Brain-computer interfaces (BCIs) are anticipated to improve the efficacy of rehabilitation for people with motor disabilities. However, applying BCI in clinical practice is still a challenge due to the great diversity of patients. In the current study, a novel action observation (AO) based BCI was proposed and tested on stroke patients. Ten non-hemineglect patients and ten hemineglect patients were recruited. Four AO stimuli were designed, each presenting a decomposed action to complete the reach-and-grasp task...
March 21, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/38510622/single-and-multilevel-corpectomy-and-vertebral-body-replacement-for-treatment-of-spinal-infections-a-retrospective-single-center-study-of-100-cases
#15
JOURNAL ARTICLE
J Neuhoff, O Berkulian, A Kramer, S Thavarajasingam, A Wengert, P Schleicher, A Pingel, F Kandziora
BACKGROUND: The optimal operative approach for treating spinal infections remains a subject of debate. Corpectomy and Vertebral Body Replacement (VBR) have emerged as common modalities, yet data on their feasibility and complication profiles are limited. METHODS: This retrospective single-center study examined 100 consecutive cases (2015-2022) that underwent VBR for spinal infection treatment. A comparison between Single-level-VBR and Multi-level-VBR was performed, evaluating patient profiles, revision rates, and outcomes...
2024: Brain Spine
https://read.qxmd.com/read/38510336/emerging-artificial-intelligence-aided-diagnosis-and-management-methods-for-ischemic-strokes-and-vascular-occlusions-a-comprehensive-review
#16
REVIEW
G A U R I Parvathy, B A L A K R I S H N A N Kamaraj, B I K I K U M A R Sah, A A K A N S H R A H U L Maheshwari, A I S W A R I Y A A N N A Alexander, V I N D H E S H Dixit, H A S S A N Mumtaz, M U H A M M A D Saqib
Large-vessel occlusion (LVO) stroke is a promising field for the use of AI, especially machine learning (ML) because optimal results are highly dependent on timely diagnosis, communication, and treatment. In order to better understand the current state of artificial intelligence (AI) in relation to LVO strokes, its efficacy, and potential future applications, we searched relevant literature to perform a comprehensive evaluation of the topic. The databases PubMed, Embase, and Scopus were extensively searched for this review...
April 2024: World neurosurgery: X
https://read.qxmd.com/read/38508903/anti-alpha-synuclein-and-anti-tau-immunotherapies-can-a-cocktail-approach-work
#17
REVIEW
Kirsys Patricia Del Giudice, Marina Cosgaya, Idoia Zaro, Valeria Ravasi, Pilar Santacruz, Celia Painous, Manel Fernández, Ana Cámara, Yaroslau Compta
The hypothesis that neurodegenerative diseases are proteinopathies due to toxic effect of different underlying proteins, such as amyloid-beta and 3+4R-tau in Alzheimer's disease (AD) and alpha-synuclein in Parkinson's disease (PD), while still controversial is supported by several studies in the literature. This has led to conduct clinical trials attempting to reduce the load of these allegedly toxic proteins by immunotherapy, mostly but not solely based on antibodies against these proteins. Already completed clinical trials have ranged from initially negative results to recently partial positive outcomes, specifically for anti-amyloid antibodies in AD but also albeit to lesser degree for anti-synuclein antibodies in PD...
March 8, 2024: Parkinsonism & related Disorders
https://read.qxmd.com/read/38508207/-functional-outcome-of-peripheral-nerve-injury-after-pediatric-supracondylar-humerus-fracture-comparison-of-surgical-and-conservative-treatment
#18
JOURNAL ARTICLE
Stefanie Deininger, Gregor Antoniadis, Maria Teresa Pedro
Supracondylar humerus fractures are the most common elbow fractures in children up to 10 years of age. The incidence of associated nerve injuries varies up to 15% depending on the data. Traumatic and iatrogenic lesions mainly affect the ulnar nerve. The regeneration of peripheral nerves is comparatively better in childhood. In the present study, the functional results after surgical and conservative treatment of nerve injuries in children after supracondylar fractures were compared and analyzed for influencing factors...
February 2024: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://read.qxmd.com/read/38506887/salvage-of-brachiocephalic-aneurysmatic-fistulas-using-eptfe-graft-with-a-minimally-invasive-approach
#19
JOURNAL ARTICLE
Burak Tamtekin, Güler Gülsen Ersoy
BACKGROUND: In this study, we evaluated our surgical approach in requiring surgical treatment of brachiocephalic arteriovenous fistula (AVF) aneurysms for salvage of AVF. METHODS: Between 2012 and 2022, 20 patients (16 men, 4 women; mean age 54.5 years) who were surgically treated for a brachiocephalic AVF aneurysm in our Cardiovascular Surgery Clinic were evaluated retrospectively. These 20 patients were operated on for aneurysm thrombosis and fistula failure in 16 patients, sudden rupture and severe bleeding in 3 patients, cosmetic reasons, and anxiety in 1 patient...
March 20, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38503539/gluing-together-a-fragmented-healthcare-system-for-geriatrics-will-be-hard-it-s-time-for-united-action
#20
JOURNAL ARTICLE
Christopher C Colenda, William B Applegate
"Gluing" together integrated Geriatric Clinical Service lines (GCSL) within the US healthcare system is a significant challenge. Reasons encompass health professional workforce shortages, inconsistent requirements for geriatric educational competencies among the health professional disciplines, preconceived ageist attitudes about older adults with complex illnesses, and a US healthcare system infrastructure that is not aligned with longitudinal and interdisciplinary care needs for older adults. This review focuses on three major characteristics of the US healthcare system that have impeded widespread dissemination of GCSLs: 1) the US's historical fee for service (FFS) reimbursement system; 2) increasing reliance upon disease specific specialty care services for older patients that have resulted from advances in medicine; and 3) rising consolidation of US healthcare systems over the last 30 years...
April 2024: American Journal of Geriatric Psychiatry
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