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melanoma and diet

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https://www.readbyqxmd.com/read/27671038/melanoma-and-obesity-should-antioxidant-vitamins-be-addressed
#1
Sofia Oliveira, Pedro Coelho, Cristina Prudêncio, Mónica Vieira, Raquel Soares, Susana G Guerreiro, Rúben Fernandes
Melanoma is an aggressive form of skin cancer refractory to conventional therapies. Obesity has reached epidemic dimensions acting as a risk factor for several cancer types, such as melanoma. Several reactive species of oxygen are also involved in melanoma initiation and progression. Low levels of antioxidant content and/or activity in lightly pigmented cells could expose them to an extremely oxidative environment and rise the susceptibility to oxidative damage and consequently loss of cell homeostasis. Despite the knowledge about melanoma biology, pathogenesis and developed therapies, is extremely important to understand the antioxidant modulation of melanoma under an environment of obesity, especially the effect of some natural compounds of the diet, such as antioxidant vitamins A, C and E and selenium in order to establish alternatives to conventional therapies, which are known to be ineffective against melanoma...
September 23, 2016: Life Sciences
https://www.readbyqxmd.com/read/27589085/the-cancer-drug-dasatinib-increases-pgc-1%C3%AE-in-adipose-tissue-but-has-adverse-effects-on-glucose-tolerance-in-obese-mice
#2
Lykke Sylow, Jonathan Z Long, Isha A Lokurkar, Xing Zeng, Erik A Richter, Bruce M Spiegelman
Dasatinib (Sprycel) is a tyrosine kinase inhibitor approved for treatment of chronic myeloid leukemia. In this study, we identify dasatinib as a potent inducer of Peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α mRNA. Dasatinib increased PGC-1α mRNA expression up to 6-fold in 3T3-F442A adipocytes, primary adipocytes, and epididymal white adipose tissue from lean and diet-induced obese mice. Importantly, gene expression translated into increased PGC-1α protein content analyzed in melanoma cells and isolated mitochondria from adipocytes...
November 2016: Endocrinology
https://www.readbyqxmd.com/read/27525031/modified-atkins-diet-in-advanced-malignancies-final-results-of-a-safety-and-feasibility-trial-within-the-veterans-affairs-pittsburgh-healthcare-system
#3
Jocelyn L Tan-Shalaby, Jennifer Carrick, Krystal Edinger, Dana Genovese, Andrew D Liman, Vida A Passero, Rashmikant B Shah
BACKGROUND: Dysfunctional mitochondrial processes limit malignant cells ability to use energy from fatty acids and ketones. Animal studies using ketogenic diets for cancer show encouraging results. We tested the diet's safety and feasibility in cancer patients across a broad variety of solid tumors. METHODS: We recruited 17 advanced cancer patients who were not on chemotherapy. They consumed 20 to 40 g of carbohydrates daily with evaluations performed weekly until week 4, then every 4 weeks until 16 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27416086/could-a-specific-dietary-intake-be-a-risk-factor-for-cutaneous-melanoma
#4
Clarissa B Hohmann, Renan R Bonamigo, Majoriê M Segatto, Manuela M Costa, Simona Mastroeni, Cristina Fortes
The incidence of cutaneous melanoma (CM) has increased in the last decade. Some risk factors are well known, but there are other possible risk factors being studied, such as those involving nutrition. The objective of this case-control study was to assess the association between diet and CM. Classical risk factors, dietary intake, and body mass index were assessed. Binary logistic regression was used to study the association between dietary intake and the risk for CM. Classical risk factors associated with CM were confirmed...
June 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27411588/fasting-mimicking-diet-reduces-ho-1-to-promote-t%C3%A2-cell-mediated-tumor-cytotoxicity
#5
Stefano Di Biase, Changhan Lee, Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Rafael de Cabo, Min Wei, Todd E Morgan, Valter D Longo
Immune-based interventions are promising strategies to achieve long-term cancer-free survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy while protecting normal cells, including hematopoietic stem and immune cells, from its toxic side effects. Here, we show that the combination of chemotherapy and a fasting-mimicking diet (FMD) increases the levels of bone marrow common lymphoid progenitor cells and cytotoxic CD8(+) tumor-infiltrating lymphocytes (TILs), leading to a major delay in breast cancer and melanoma progression...
July 11, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27338620/dna-aptamers-raised-against-ages-as-a-blocker-of-various-aging-related-disorders
#6
Sho-Ichi Yamagishi, Kensei Taguchi, Kei Fukami
A non-enzymatic reaction between sugars or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules, which could impair their structural integrity and function. This process begins with the conversion of reversible Schiff base adducts, and then to more stable, covalently-bound Amadori rearrangement products. Over a course of days to weeks, these early glycation products undergo further reactions, such as rearrangements and dehydration to become irreversibly crossed-linked, fluorescent protein derivatives termed advanced glycation end products (AGEs)...
August 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27128581/a-prospective-cohort-study-on-dietary-acrylamide-intake-and-the-risk-for-cutaneous-malignant-melanoma
#7
Nadezda Lipunova, Leo J Schouten, Piet A van den Brandt, Janneke G F Hogervorst
Epidemiological studies have shown inconsistent associations between dietary acrylamide exposure and the risk for various malignancies. This is the first epidemiological study on the association between acrylamide intake and the risk for cutaneous malignant melanoma (CMM). A case-cohort analysis was carried out within the prospective Netherlands Cohort Study on diet and cancer. Acrylamide intake was estimated from a food frequency questionnaire combined with acrylamide data for Dutch foods. After 17.3 years of follow-up, 501 microscopically confirmed cases of CMM were identified...
April 28, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27049717/high-fat-diet-increases-melanoma-cell-growth-in-the-bone-marrow-by-inducing-osteopontin-and-interleukin-6
#8
Guang-Liang Chen, Yubin Luo, Daniel Eriksson, Xianyi Meng, Cheng Qian, Tobias Bäuerle, Xiao-Xiang Chen, Georg Schett, Aline Bozec
The impact of metabolic stress induced by obesity on the bone marrow melanoma niche is largely unknown. Here we employed diet induced obese mice model, where mice received high-fat (HFD) or normal diet (ND) for 6 weeks before challenge with B16F10 melanoma cells. Tumor size, bone loss and osteoclasts numbers were assessed histologically in the tibial bones. For defining the molecular pathway, osteopontin knock-out mice, interleukin 6 neutralizing antibody or Janus kinase 2 inhibition were carried out in the same model...
May 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/26826928/chyle-leak-following-right-axillary-lymph-node-dissection-a-case-report-and-review-of-current-literature
#9
J D Daggett, A W Watt, P D Smith
This report discusses the case of a chyle leak following a right axillary lymph node dissection for breast cancer. This presented as a sudden change in drainage character from a right axillary surgical drain from serous to milky white shortly after restarting a diet. The diagnosis of chyle leak was confirmed by laboratory testing of the fluid and managed with closed suction drainage. Chyle leak is a rare, but increasingly recognized complication following axillary clearance for breast cancer and melanoma.
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26599547/glycoprotein-nonmetastatic-melanoma-b-gpnmb-positive-macrophages-contribute-to-the-balance-between-fibrosis-and-fibrolysis-during-the-repair-of-acute-liver-injury-in-mice
#10
Kotaro Kumagai, Kazuaki Tabu, Fumisato Sasaki, Yoichiro Takami, Yuko Morinaga, Seiichi Mawatari, Shinichi Hashimoto, Shiroh Tanoue, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirofumi Uto, Hirohito Tsubouchi, Akio Ido
BACKGROUND AND AIMS: Glycoprotein nonmetastatic melanoma B (Gpnmb), a transmembrane glycoprotein that is expressed in macrophages, negatively regulates inflammation. We have reported that Gpnmb is strongly expressed in the livers of rats fed a choline-deficient, L-amino acid-defined (CDAA) diet. However, the role of macrophage-expressed Gpnmb in liver injury is still unknown. This study aimed to clarify the characteristics of infiltrating macrophages that express Gpnmb, and the involvement of Gpnmb in the repair process in response to liver injury...
2015: PloS One
https://www.readbyqxmd.com/read/26446958/antioxidants-can-increase-melanoma-metastasis-in-mice
#11
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, Volkan I Sayin, Murali K Akula, Christin Karlsson, Martin G Dalin, Levent M Akyürek, Per Lindahl, Jonas Nilsson, Martin O Bergo
Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some trials show that antioxidants actually increase cancer risk and a study in mice showed that antioxidants accelerate the progression of primary lung tumors. However, little is known about the impact of antioxidant supplementation on the progression of other types of cancer, including malignant melanoma. We show that administration of N-acetylcysteine (NAC) increases lymph node metastases in an endogenous mouse model of malignant melanoma but has no impact on the number and size of primary tumors...
October 7, 2015: Science Translational Medicine
https://www.readbyqxmd.com/read/26437735/cancers-in-australia-in-2010-attributable-to-modifiable-factors-summary-and-conclusions
#12
David C Whiteman, Penelope M Webb, Adele C Green, Rachel E Neale, Lin Fritschi, Christopher J Bain, D Max Parkin, Louise F Wilson, Catherine M Olsen, Christina M Nagle, Nirmala Pandeya, Susan J Jordan, Annika Antonsson, Bradley J Kendall, Maria Celia B Hughes, Torukiri I Ibiebele, Kyoko Miura, Susan Peters, Renee N Carey
OBJECTIVE: To estimate the numbers and proportions of cancers occurring in Australia in 2010 attributable to modifiable causal factors. METHODS: We estimated the population attributable fraction (PAF) of cancers associated with exposure to 13 causal factors using standard formulae incorporating exposure prevalence and relative risk data. We also calculated the potential impact of changing exposure to some factors. RESULTS: A total of 32% of all cancers diagnosed in Australia in 2010 (excluding keratinocyte cancers) were attributable to the 13 factors assessed (men 33%; women 31%)...
October 2015: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/26212104/systematic-review-of-studies-investigating-the-association-between-dietary-habits-and-cutaneous-malignant-melanoma
#13
REVIEW
C de Waure, G Quaranta, M R Gualano, C Cadeddu, A Jovic-Vranes, B Djikanovic, G La Torre, W Ricciardi
OBJECTIVE: Several papers have dealt with diet as a risk factor for cutaneous malignant melanoma (CMM). This study aimed to synthesize available data on the topic. STUDY DESIGN: A systematic review of observational studies assessing the association between dietary habits and CMM was performed. METHODS: Electronic databases were used to identify eligible articles. Quality was assessed through the Newcastle-Ottawa scale. Case-control and cohort studies evaluating the intake of food/nutrients through the assessment of dietary habits and the occurrence of CMM were considered eligible...
August 2015: Public Health
https://www.readbyqxmd.com/read/26153206/effect-of-blocking-of-neuropeptide-y-y2-receptor-on-tumor-angiogenesis-and-progression-in-normal-and-diet-induced-obese-c57bl-6-mice
#14
Masoud Alasvand, Bahman Rashidi, S H Javanmard, Maziar Mohammad Akhavan, Majid Khazaei
BACKGROUND: Obesity is a risk factor for some types of cancers. Angiogenesis is a necessary step in the multistage progression of tumors such as melanoma. Previous studies reported that neuropeptide Y (NPY) regulates angiogenesis by activating the Y2 receptor on endothelial cells. The present study examined the effects of the NPY Y2 receptor antagonist on tumor weight, angiogenesis and serum levels of vascular endothelial growth factor (VEGF), VEGF receptor-1 (VEGF-R1), and nitric oxide (NO)...
2015: Global Journal of Health Science
https://www.readbyqxmd.com/read/26147450/dietary-antioxidants-and-melanoma-evidence-from-cohort-and-intervention-studies
#15
Kyoko Miura, Adèle C Green
Melanoma is the most serious form of skin cancer affecting mostly people of Caucasian origin and is associated with high exposure to solar ultraviolet (UV) radiation. Antioxidants in the diet are thought to prevent UV-induced DNA damage and oxidative stress and laboratory-based studies have shown that high antioxidant intakes inhibit melanoma development. Corresponding epidemiological evidence is inconsistent, however. We therefore reviewed results from prospective observational studies and randomized controlled trials (RCTs) to clarify whether consumption of antioxidant vitamin C, E (tocopherol), and A (retinol), carotenoids and selenium, as food, supplements, or both, or high fruit and vegetable intake, reduce the incidence of cutaneous melanoma...
2015: Nutrition and Cancer
https://www.readbyqxmd.com/read/26109516/reconstruction-of-maxillary-defect-with-musculo-adipose-rectus-free-flap
#16
Tsu-Hui Hubert Low, Andrew Lindsay, Jonathan Clark, Francis Chai, Richard Lewis
BACKGROUND: The rectus myocutaneous free flap (RMFF) is used for medium to large maxillectomy defects. However, in patients with central obesity the inset could be difficult due to the bulk from excessive layer of adipose tissue. We describe a modification of the RMFF for patients with excessive central obesity with a flap consisting of adipose tissue with minimal rectus muscle; the musculo-adipose rectus free flap (MARF). METHODS: Five cases of MARF reconstruction were performed between 2003 and 2013, with patients' body mass indexes ranging from 29...
June 24, 2015: Microsurgery
https://www.readbyqxmd.com/read/26108541/diet-quality-and-risk-of-melanoma-in-an-italian-population
#17
Carlotta Malagoli, Marcella Malavolti, Claudia Agnoli, Catherine M Crespi, Chiara Fiorentini, Francesca Farnetani, Caterina Longo, Cinzia Ricci, Giuseppe Albertini, Anna Lanzoni, Leonardo Veneziano, Annarosa Virgili, Calogero Pagliarello, Marcello Santini, Pier Alessandro Fanti, Emi Dika, Sabina Sieri, Vittorio Krogh, Giovanni Pellacani, Marco Vinceti
BACKGROUND: Some results from laboratory and epidemiologic studies suggest that diet may influence the risk of melanoma, but convincing evidence for a role of single nutrients or food items is lacking. Diet quality, which considers the combined effect of multiple food items, may be superior for examining this relation. OBJECTIVE: We sought to assess whether diet quality, evaluated with the use of 4 different dietary indexes, is associated with melanoma risk. METHODS: In this population-based case-control study, we analyzed the relation between 4 diet quality indexes, the Healthy Eating Index 2010 (HEI-2010), Dietary Approaches to Stop Hypertension (DASH) index, Greek Mediterranean Index (GMI), and Italian Mediterranean Index (IMI), and melanoma risk in a northern Italian community, with the use of data from 380 cases and 719 matched controls who completed a semiquantitative food frequency questionnaire...
August 2015: Journal of Nutrition
https://www.readbyqxmd.com/read/26025912/%C3%AE-caryophyllene-potently-inhibits-solid-tumor-growth-and-lymph-node-metastasis-of-b16f10-melanoma-cells-in-high-fat-diet-induced-obese-c57bl-6n-mice
#18
Jae In Jung, Eun Ji Kim, Gyoo Taik Kwon, Yoo Jin Jung, Taesung Park, Yongkang Kim, Rina Yu, Myung-Sook Choi, Hyang Sook Chun, Seung-Hae Kwon, Song Her, Ki Won Lee, Jung Han Yoon Park
We reported previously that high-fat diet (HFD) feeding stimulated solid tumor growth and lymph node (LN) metastasis in C57BL/6N mice injected with B16F10 melanoma cells. β-caryophyllene (BCP) is a natural bicyclic sesquiterpene found in many essential oils and has been shown to exert anti-inflammatory activities. To examine whether BCP inhibits HFD-induced melanoma progression, 4-weeks old, male C57BL/6N mice were fed a control diet (CD, 10 kcal% fat) or HFD (60 kcal% fat + 0, 0.15 or 0.3% BCP) for the entire experimental period...
September 2015: Carcinogenesis
https://www.readbyqxmd.com/read/26000630/cancer-incidence-among-patients-with-anorexia-nervosa-from-sweden-denmark-and-finland
#19
Lene Mellemkjaer, Fotios C Papadopoulos, Eero Pukkala, Anders Ekbom, Mika Gissler, Jane Christensen, Jørgen H Olsen
A diet with restricted energy content reduces the occurrence of cancer in animal experiments. It is not known if the underlying mechanism also exists in human beings. To determine whether cancer incidence is reduced among patients with anorexia nervosa who tend to have a low intake of energy, we carried out a retrospective cohort study of 22 654 women and 1678 men diagnosed with anorexia nervosa at ages 10-50 years during 1968-2010 according to National Hospital Registers in Sweden, Denmark and Finland. The comparison group consisted of randomly selected persons from population registers who were similar to the anorexia nervosa patients in respect to sex, year of birth and place of residence...
2015: PloS One
https://www.readbyqxmd.com/read/25802234/scd5-induced-oleic-acid-production-reduces-melanoma-malignancy-by-intracellular-retention-of-sparc-and-cathepsin-b
#20
Maria Bellenghi, Rossella Puglisi, Francesca Pedini, Alessandra De Feo, Federica Felicetti, Lisabianca Bottero, Sabina Sangaletti, Maria Cristina Errico, Marina Petrini, Cinzia Gesumundo, Massimo Denaro, Nadia Felli, Luca Pasquini, Claudio Tripodo, Mario Paolo Colombo, Alessandra Carè, Gianfranco Mattia
A proper balance between saturated and unsaturated fatty acids (FAs) is required for maintaining cell homeostasis. The increased demand of FAs to assemble the plasma membranes of continuously dividing cancer cells might unbalance this ratio and critically affect tumour outgrowth. We unveiled the role of the stearoyl-CoA desaturase SCD5 in converting saturated FAs into mono-unsaturated FAs during melanoma progression. SCD5 is down-regulated in advanced melanoma and its restored expression significantly reduced melanoma malignancy, both in vitro and in vivo, through a mechanism governing the secretion of extracellular matrix proteins, such as secreted protein acidic and rich in cysteine (SPARC) and collagen IV and of their proteases, such as cathepsin B...
July 2015: Journal of Pathology
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