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Heart failure preserved ejection fraction

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https://www.readbyqxmd.com/read/28318662/mid-range-left-ventricular-ejection-fraction-clinical-profile-and-cause-of-death-in-ambulatory-patients-with-chronic-heart-failure
#1
Domingo A Pascual-Figal, Andreu Ferrero-Gregori, Ines Gomez-Otero, Rafael Vazquez, Juan Delgado-Jimenez, Jesus Alvarez-Garcia, Juan R Gimeno-Blanes, Fernando Worner-Diz, Alfredo Bardají, Luis Alonso-Pulpon, Jose Ramon Gonzalez-Juanatey, Juan Cinca
BACKGROUND: The intermediate group of patients with heart failure (HF) and mid-range left ventricular ejection fraction (HFmrEF) may constitute a specific phenotype, but a direct evidence is lacking. This study aimed to know whether this HF category is accompanied by a particular clinical phenotype and prognosis. METHODS AND RESULTS: This study includes 3446 ambulatory patients with chronic HF from two national registries. According to EF at enrollment, patients were classified as reduced (HFrEF, <40%), mid-range (HFmrEF, 40-49%) or preserved (HFpEF, ≥50%)...
March 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28318656/clinical-characteristics-and-prognosis-of-patients-admitted-for-heart-failure-a-5-year-retrospective-study-of-african-patients
#2
Kwadwo Osei Bonsu, Isaac Kofi Owusu, Kwame Ohene Buabeng, Daniel D Reidpath, Amudha Kadirvelu
BACKGROUND: Mortality associated with heart failure (HF) remains high. There are limited clinical data on mortality among HF patients from African populations. We examined the clinical characteristics, long-term outcomes, and prognostic factors of African HF patients with preserved, mid-range or reduced left ventricular ejection fraction (LVEF). METHODS AND RESULTS: We conducted a retrospective longitudinal cohort study of individuals aged ≥18years discharged from first HF admission between January 1, 2009 and December 31, 2013 from the Cardiac Clinic, Directorate of Medicine of the Komfo Anokye Teaching Hospital, Ghana...
March 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28316175/-diagnostic-value-of-combining-serum-soluble-st2-and-interleukin-33-for-heart-failure-patients-with-preserved-left-ventricular-ejection-fraction
#3
N S Luo, H F Zhang, P M Liu, Y Q Lin, T C Huang, Y Yang, J F Wang
Objective: Diagnostic efficacy of serum markers is low for heart failure patients with preserved left ventricular ejection fraction (HF-pEF) as compared to heart failure patients with reduced left ventricular ejection fraction.We sought to explore the diagnostic value of serum levels of soluble ST2 (sST2) combined with interleukin-33 (IL-33) for the diagnosis of HF-pEF in this study. Methods: A total of 376 patients with HF-pEF (HF group), 376 matched-control patients without heart failure who shared similar clinical characteristics (non-HF group) were included in the study...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28316006/management-of-heart-failure-with-preserved-ejection-fraction-current-challenges-and-future-directions
#4
REVIEW
Bharathi Upadhya, Dalane W Kitzman
Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF in patients older than 65 years. Among elderly women living in the community, HFpEF comprises nearly 90% of incident HF cases. The health and economic impact of HFpEF is at least as great as that of HF with reduced ejection fraction (HFrEF), with similar severity of acute hospitalization rates and substantial mortality. Despite the importance of HFpEF, our understanding of its pathophysiology is incomplete, and optimal treatment remains largely undefined...
March 18, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28314659/diagnostic-and-prognostic-value-of-cmr-t1-mapping-in-patients-with-heart-failure-and-preserved-ejection-fraction
#5
Karl-Philipp Rommel, Christian Lücke, Philipp Lurz
Heart failure with preserved ejection fraction (HFpEF) presents a major challenge in modern cardiology. Although this syndrome is of increasing prevalence and is associated with unfavorable outcomes, treatment trials have failed to establish effective therapies. Currently, solutions to this dilemma are being investigated, including categorizing and characterizing patients more diversely to individualize treatment. In this regard, new imaging techniques might provide important information. Diastolic dysfunction is a diagnostic and pathophysiological cornerstone in HFpEF and is believed to be caused by systemic inflammation with the development of interstitial myocardial fibrosis and myocardial stiffening...
March 14, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28314655/is-heart-failure-with-midrange-ejection-fraction-similar-to-preserved-ejection-fraction-against
#6
F Formiga
The new European guidelines (2016) for heart failure (HF) include the concept of HF with intermediate left ventricular ejection fraction (LVEF), i.e. an LVEF between 40 and 49%. Although few studies have been carried out, there are claims that HF with intermediate LVEF is not the same as HF with preserved LVEF. Perhaps the most consistent claim is the high percentage of associated ischemic heart disease, which could reflect LVEF recovery after adequate anti-ischemic treatment of HF with depressed LVEF, or even the progressive deterioration of LVEF following an ischemic event...
March 14, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28302060/heart-failure-labelled-patients-with-missing-ejection-fraction-in-primary-care-prognosis-and-determinants
#7
Miguel-Angel Muñoz, Xavier Mundet-Tuduri, Jordi Real, José-Luis Del Val, Mar Domingo, Ernest Vinyoles, Ester Calero, Caterina Checa, Nuria Soldevila-Bacardit, José-María Verdú-Rotellar
BACKGROUND: It is common to find a high variability in the accuracy of heart failure (HF) diagnosis in electronic primary care medical records (EMR). Our aims were to ascertain (i) whether the prognosis of HF labelled patients whose ejection fraction (EF) was missing in their EMR differed from those that had it registered, and (ii) the causes contributing to the differences in the availability of EF in EMR. METHODS: Retrospective cohort analyses based on clinical records of HF and attended at 52 primary healthcare centres of Barcelona (Spain)...
March 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28295985/heart-failure-with-mid-range-ejection-fraction-a-distinct-clinical-entity-insights-from-the-trial-of-intensified-versus-standard-medical-therapy-in-elderly-patients-with-congestive-heart-failure-time-chf
#8
Peter Rickenbacher, Beat A Kaufmann, Micha T Maeder, Alain Bernheim, Kaatje Goetschalckx, Otmar Pfister, Matthias Pfisterer, Hans-Peter Brunner-La Rocca
AIMS: While the conditions of heart failure (HF) with reduced (HFrEF, LVEF < 40%) and preserved (HFpEF, LVEF ≥ 50%) left ventricular ejection fraction (LVEF) are well characterized, it is unknown whether patients with HF and mid-range LVEF (HFmrEF, LVEF 40-49%) have to be regarded as a separate clinical entity. The aim of this study was to characterize these three populations and to compare outcome and response to therapy. METHODS AND RESULTS: The analysis was based on the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) comprising a population with established HF including the whole spectrum of LVEF...
March 15, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28294858/-myocardial-and-arterial-stiffness-important-determinant-of-nt-probnp-at-development-of-heart-failure-in-survivors-of-myocardial-infarction
#9
A T Teplyakov, E Yu Pyshnikova, A V Andriyanova, V V Kalyuzhin, T E Suslova, E N Nikonova, R S Karpov
AIM: To study diagnostic value of myocardial-arterial stiffness (MAS) as a determinant of N-terminal pro-brain natriuretic peptide (NT-proBNP) expression in patients with chronic heart failure (CHF) with ischemic or postinfarction left ventricular (LV) dysfunction. MATERIAL AND METHODS: We analyzed 6 months prognosis of 54 patients (mean age 61.7+/-8.6 years) with II-III NYHA class CHF divided into 2 groups: (I, n=18) with class II CHF and preserved LV ejection fraction (EF) (55+/-10...
April 2016: Kardiologiia
https://www.readbyqxmd.com/read/28292262/low-adiponectin-is-associated-with-diastolic-dysfunction-in-women-a-cross-sectional-study-from-the-troms%C3%A3-study
#10
Jon V Norvik, Henrik Schirmer, Kirsti Ytrehus, Trond G Jenssen, Svetlana N Zykova, Anne E Eggen, Bjørn O Eriksen, Marit D Solbu
BACKGROUND: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. METHODS: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomial regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest...
March 14, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28290856/-chronic-heart-failure-with-preserved-systolic-function-and-reversible-dilatation-of-cardiac-chambers
#11
O V Blagova, S V Volkov, A V Nedostup, A O Korobkov, I V Mostovoy, N G Sergushina, N V Gagarina, E A Mershina
Diagnosis of dilation (D) cardiomyopathy (CMP) requires exclusion not only of inflammatory and genetically determined forms but also of some rare diseases. This 51 year old patient with history of moderate arterial hypertension approached a cardiologist because of new onset atrial fibrillation and dyspnea. Echocardiography detected dilation of all cardiac chambers with relatively preserved ejection fraction, causing suspicion of DCMP. Among conditions excluded were coronary atherosclerosis, congenital heart defect with left to right shunt, primary pulmonary hypertension, pulmonary embolism, hypertensive heart, tachycardia induced CMP, arrhythmogenic right ventricular dysplasia, noncompaction myocardium...
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290801/-comparison-of-verapamil-and-amlodipine-for-treatment-of-chronic-heart-failure-with-preserved-left-ventricular-ejection-fraction-in-patients-with-hypertensive-disease
#12
S G Kanorskii, A F Sereda
OBJECTIVE: to compare efficacy of verapamil and amlodipine in treatment of chronic heart failure (CHF) with preserved left ventricular (LV) ejection fraction (EF) in patients with hypertensive disease (HD). MATERIAL AND METHODS: Patients with stage III HD, class II-III CHF, and LVEF more or equal 50% (n=167, age 48-70 years) underwent complex examination before and after 12 months of treatment with perindopril combined either with verapamil SR (n=85) or amlodipine (n=82)...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290786/-predictors-of-heart-failure-with-preserved-ejection-fraction-in-patients-with-metabolic-syndrome-and-preclinical-diastolic-dysfunction
#13
K G Adamyan, L G Tunyan, A L Chilingaryan, L R Tumasyan
PURPOSE: to evaluate differences in echocardiographic parameters between patients with preclinical diastolic dysfunction (PDD) and heart failure with preserved ejection fraction (HFpEF) and to identify predictors of transition from PDD to HFpEF. MATERIAL AND METHODS: Echocardiographic parameters were recorded in 325 patients with PDD and 50 healthy subjects. PDD and HFpEF were diagnosed by tissue Doppler imaging of the left ventricle (LV) during exercise stress test and detection of symptoms of heart failure...
February 2017: Kardiologiia
https://www.readbyqxmd.com/read/28289763/-gender-and-cardiovascular-diseases-why-we-need-gender-medicine
#14
V Regitz-Zagrosek
Gender medicine is concerned with the question of why diseases are expressed differently in the genders. It takes differences between men and women into account, which are often neglected by traditional medicine. Sex differences can also be found in cardiovascular diseases; therefore, risk factors for cardiovascular diseases have a different significance depending on the sex. Diabetic diseases tend to promote the occurrence of coronary heart disease (CHD) more strongly in women than in men. Myocardial infarctions affect women 10 years later than men and young women are often treated too late, possibly because myocardial infarction is consider to be a "male disease"...
March 13, 2017: Der Internist
https://www.readbyqxmd.com/read/28289007/ischemia-and-no-obstructive-coronary-artery-disease-inoca-developing-evidence-based-therapies-and-research-agenda-for-the-next-decade
#15
REVIEW
C Noel Bairey Merz, Carl J Pepine, Mary Norine Walsh, Jerome L Fleg
The Cardiovascular Disease in Women Committee of the American College of Cardiology, in conjunction with interested parties (from the National Heart, Lung, and Blood Institute, American Heart Association, and European Society of Cardiology), convened a working group to develop a consensus on the syndrome of myocardial ischemia with no obstructive coronary arteries. In general, these patients have elevated risk for a cardiovascular event (including acute coronary syndrome, heart failure hospitalization, stroke, and repeat cardiovascular procedures) compared with reference subjects and appear to be at higher risk for development of heart failure with preserved ejection fraction...
March 14, 2017: Circulation
https://www.readbyqxmd.com/read/28285121/a-novel-rehabilitation-intervention-for%C3%A2-older-patients-with-acute-decompensated%C3%A2-heart-failure-the-rehab-hf-pilot-study
#16
Gordon R Reeves, David J Whellan, Christopher M O'Connor, Pamela Duncan, Joel D Eggebeen, Timothy M Morgan, Leigh Ann Hewston, Amy Pastva, Mahesh J Patel, Dalane W Kitzman
OBJECTIVES: This study sought to assess a novel physical rehabilitation intervention in older patients hospitalized for acute decompensated heart failure (ADHF). BACKGROUND: After ADHF, older patients, who are frequently frail with multiple comorbidities, have prolonged and incomplete recovery of physical function and remain at high risk for poor outcomes. METHODS: The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) pilot study was a 3-site, randomized, attention-controlled pilot study of a tailored, progressive, multidomain physical rehabilitation intervention beginning in the hospital and continuing for 12 weeks post-discharge in patients ≥60 years hospitalized with ADHF...
March 5, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28285120/unraveling-the-relationship-between-aging-and-heart-failure-with-preserved%C3%A2-ejection-fraction-the-importance-of-exercise-and-normative-reference-standards
#17
EDITORIAL
Dalane W Kitzman, Thomas J O'Neill, Peter H Brubaker
No abstract text is available yet for this article.
March 7, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28281174/potential-expanded-indications-for-neprilysin-inhibitors
#18
REVIEW
Elizabeth Riddell, Justin M Vader
PURPOSE OF REVIEW: The goal of this article is to review potential expanded indications for neprilysin inhibitors. This article reviews the rationale and design for ongoing and future trials of sacubitril/valsartan in cardiovascular and non-cardiovascular disease. RECENT FINDINGS: Randomized trial data are lacking for use of sacubitril/valsartan in acute heart failure and advanced heart failure. Mechanistic data from animal studies suggest a role for neprilysin inhibition in the treatment of post-myocardial infarction systolic dysfunction and heart failure with preserved ejection fraction...
April 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28279521/recombinant-human-ace2-and-the-angiotensin-1-7-axis-as-potential-new-therapies-for-heart-failure
#19
Vaibhav B Patel, Judith N Lezutekong, Xueyi Chen, Gavin Y Oudit
Heart failure (HF) is a common cause of death and disability and a major economic burden in industrialized nations. Heart disease remains the leading cause of death in North America, with ischemic and hypertensive heart disease as the leading cause of HF. Various basic and clinical studies have established the role of an activated renin-angiotensin (Ang) system and Ang II generation in the progression of HF. Inhibition of an activated renin-Ang system using Ang-converting enzyme inhibitors, Ang II type 1 receptor blockers, and mineralocorticoid receptors antagonists have shown clinical benefits in patients with HF, although, largely limited to HF with reduced ejection fraction (HF-rEF)...
December 23, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28276870/renal-sympathetic-denervation-for-treatment-of-patients-with-heart-failure-summary-of-the-available-evidence
#20
Wail Nammas, Juhani Koistinen, Tuomas Paana, Pasi P Karjalainen
Heart failure syndrome results from compensatory mechanisms that operate to restore - back to normal - the systemic perfusion pressure. Sympathetic overactivity plays a pivotal role in heart failure; norepinephrine contributes to maintenance of the systemic blood pressure and increasing preload. Cardiac norepinephrine spillover increases in patients with heart failure; norepinephrine exerts direct toxicity on cardiac myocytes resulting in a decrease of synthetic activity and/or viability. Importantly, cardiac norepinephrine spillover is a powerful predictor of mortality in patients with moderate to severe HF...
February 10, 2017: Annals of Medicine
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