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Heart failure preserved ejection fraction

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https://www.readbyqxmd.com/read/28927192/alcohol-hypertension-and-heart-failure-with-preserved-or-normal-ejection-fraction
#1
John E Sanderson
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28925663/top-poems-of-2016-consistent-with-the-principles-of-the-choosing-wisely-campaign
#2
Roland Grad, Mark H Ebell
A challenge in the Choosing Wisely campaign is to identify low-value clinical actions supported by high-quality evidence. We applied a method based on crowdsourcing the Daily POEM (patient-oriented evidence that matters) to identify low-value clinical actions from research studies consistent with the principles of Choosing Wisely. In 2016, we analyzed an average of 1,382 questionnaires on 265 unique POEMs delivered to physician members of the Canadian Medical Association. From these questionnaires, we identified the POEMs ranking highest on one questionnaire item directly linked to reducing overdiagnosis or overtreatment...
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925073/role-of-cardiopulmonary-exercise-testing-in-clinical-stratification-in-heart-failure-a-position-paper-from-the-committee-on-exercise-physiology-and-training-of-the-heart-failure-association-of-the-european-society-of-cardiology
#3
REVIEW
Ugo Corrà, Pier Giuseppe Agostoni, Stefan D Anker, Andrew J S Coats, Maria G Crespo Leiro, Rudolph A de Boer, Veli-Pekka Hairola, Loreena Hill, Mitja Lainscak, Lars H Lund, Marco Metra, Piotr Ponikowski, Jillian Riley, Petar M Seferović, Massimo F Piepoli
Traditionally, the main indication for cardiopulmonary exercise testing (CPET) in heart failure (HF) was for the selection of candidates to heart transplantation: CPET was mainly performed in middle-aged male patients with HF and reduced left ventricular ejection fraction. Today, CPET is used in broader patients' populations, including women, elderly, patients with co-morbidities, those with preserved ejection fraction, or left ventricular assistance device recipients, i.e. individuals with different responses to incremental exercise and markedly different prognosis...
September 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28925061/biomarkers-and-prognostication-in-heart-failure-with-reduced-and-preserved-ejection-fraction-similar-but-different
#4
EDITORIAL
Iain B Squire
No abstract text is available yet for this article.
September 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28919241/cardiopulmonary-exercise-testing-in-patients-with-heart-failure-and-a-preserved-ejection-fraction-filling-the-prognostic-knowledge-gap
#5
Cemal Ozemek, Ross Arena
No abstract text is available yet for this article.
September 14, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28917679/epidemiology-of-left-ventricular-systolic%C3%A2-dysfunction-and-heart-failure-in%C3%A2-the-framingham-study-an-echocardiographic-study-over-3-decades
#6
Ramachandran S Vasan, Vanessa Xanthakis, Asya Lyass, Charlotte Andersson, Connie Tsao, Susan Cheng, Jayashri Aragam, Emelia J Benjamin, Martin G Larson
OBJECTIVES: The purpose of this study was to describe the temporal trends in prevalence of left ventricular systolic dysfunction (LVSD) in individuals without and with heart failure (HF) in the community over a 3-decade period of observation. BACKGROUND: Temporal trends in the prevalence and management of major risk factors may affect the epidemiology of HF. METHODS: We compared the frequency, correlates, and prognosis of LVSD (left ventricular ejection fraction [LVEF] <50%) among Framingham Study participants without and with clinical HF in 3 decades (1985 to 1994, 1995 to 2004, and 2005 to 2014)...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28912121/cortical-bone-stem-cell-therapy-preserves-cardiac-structure-and-function-after-myocardial-infarction
#7
Thomas E Sharp, Giana J Schena, Alexander R Hoachlandr-Hobby, Timothy Starosta, Remus M Berretta, Markus Wallner, Giulia Borghetti, Polina Gross, Daohai Yu, Jaslyn Johnson, Eric A Feldsott, Danielle M Trappanese, Amir Toib, Joseph E Rabinowitz, Jon C George, Hajime Kubo, Sadia Mohsin, Steven R Houser
Rationale: Cortical bone stem cells (CBSCs) have been shown to reduce ventricular remodeling and improve cardiac function in a murine myocardial infarction (MI) model. These effects were superior to other stem cell types that have been used in recent early stage clinical trials. However, CBSC efficacy has not been tested in a preclinical large animal model using approaches that could be applied to patients. Objective: To determine if post-MI transendocardial injection of allogeneic CBSCs reduces pathological structural and functional remodeling and prevents the development of heart failure in a swine MI model...
September 14, 2017: Circulation Research
https://www.readbyqxmd.com/read/28901848/pulmonary-hypertension-secondary-to-left-heart-disease
#8
Ghazal Kabbach, Debabrata Mukherjee
Pulmonary hypertension (PH) related to left heart disease (LHD) is the most common form of PH, accounting for more than two third of all PH cases. The hemodynamic abnormalities seen in PH-LHD are complex, and there are currently minimal evidence-based recommendations for the management of PH-LHD. While it is accepted that PH in the context of left heart disease is a marker of worse prognosis, it remains unclear whether its primary treatment is beneficial or harmful. In this article, we discuss the prevalence and significance of PH in patients with heart failure (HF) with reduced ejection fraction (HFrEF) as well as HF with preserved ejection fraction (HFpEF), and those with valvular heart disease and provide insights into the complex pathophysiology of cardiopulmonary interrelationship in individuals with PH due to left heart disease...
September 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28899987/heart-failure-related-hyperphosphorylation-in-the-cardiac-troponin-i-c-terminus-has-divergent-effects-on-cardiac-function-in-vivo
#9
Yuejin Li, Guangshuo Zhu, Nazareno Paolocci, Pingbo Zhang, Cyrus Takahashi, Nazli Okumus, Amir Heravi, Gizem Keceli, Genaro Ramirez-Correa, David A Kass, Anne M Murphy
BACKGROUND: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances myofilament calcium sensitivity and alters calpain-mediated cTnI proteolysis. However, how its hyperphosphorylation affects cardiac function in vivo remains unknown. METHODS AND RESULTS: To address the question, 2 transgenic mouse models were generated: a phospho-mimetic cTnIS200D and a phospho-silenced cTnIS200A, each driven by the cardiomyocyte-specific α-myosin heavy chain promoter...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28893960/physical-activity-in-heart-failure-with-preserved-ejection-fraction-moving-toward-a-newer-treatment-paradigm
#10
EDITORIAL
Ambarish Pandey, Jarett D Berry
No abstract text is available yet for this article.
September 12, 2017: Circulation
https://www.readbyqxmd.com/read/28892213/evaluation-of-longitudinal-and-radial-left-ventricular-functions-using-two-and-three-dimensional-echocardiography-before-and-after-intravenous-immunoglobulin-administration-in-patients-with-acute-kawasaki-disease
#11
Ikuo Hashimoto, Yu Saitou, Nao Sakata, Ko Shibata
BACKGROUND: The relationship between left ventricular (LV) function and longitudinal or radial contraction has not yet been elucidated in patients with acute Kawasaki disease (KD), especially before and after intravenous immunoglobulin (IVIG) administration. METHODS: We studied 28 KD patients without coronary aneurysms (average 3.2 years). The LV end-diastolic volume (LVEDV), end-systolic volume (LVESV), stroke volume (LVSV), and ejection fraction (LVEF) were assessed using three-dimensional echocardiography before IVIG, after IVIG administration, and in the convalescent phase...
September 11, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28891242/inorganic-vs-organic-nitrates-for-heart-failure-with-preserved-ejection-fraction-it-s-not-all-in-your-head
#12
EDITORIAL
Jay N Patel, Sanjiv J Shah
No abstract text is available yet for this article.
September 11, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28891228/investigating-a-biomarker-driven-approach-to-target-collagen-turnover-in-diabetic-heart-failure-with-preserved-ejection-fraction-patients-effect-of-torasemide-vs-furosemide-on-serum-c-terminal-propeptide-of-procollagen-type-i-drop-pip-trial
#13
Tobias Daniel Trippel, Sophie Van Linthout, Dirk Westermann, Ruhdja Lindhorst, Anja Sandek, Stefanie Ernst, Anna Bobenko, Mario Kasner, Frank Spillmann, Arantxa González, Begoña López, Susana Ravassa, Burkert Pieske, Walter J Paulus, Javier Díez, Frank Edelmann, Carsten Tschöpe
AIM: Heart failure with preserved ejection fraction (HFpEF) is associated with myocardial remodelling including severe pro-fibrotic changes contributing to an increase in left ventricular stiffness and diastolic dysfunction. Serum C-terminal propeptide of procollagen type I (PIP) strongly correlates with the turnover of extracellular cardiac matrix proteins and fibrosis. Torasemide, but not furosemide, was described to reduce collagen type I synthesis in clinically unstable patients with heart failure with reduced ejection fraction...
September 11, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28891212/heart-rate-in-heart-failure-with-preserved-ejection-fraction-target-or-marker
#14
EDITORIAL
Andreas P Kalogeropoulos, Javed Butler
No abstract text is available yet for this article.
September 11, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28890872/cardiac-troponin-and-outcome-in-decompensated-heart-failure-with-preserved-ejection-fraction
#15
Mohammad Thawabi, Amer Hawatmeh, Sarah Studyvin, Habib Habib, Fayez Shamoon, Marc Cohen
BACKGROUND: Cardiac troponin (cTn) has been established as an effective prognostic marker in acute heart failure (HF) with predominantly reduced ejection fraction. However, it's prognostic value in heart failure with preserved ejection fraction (HFpEF) is unclear. The aim of this study is to describe the prognostic role of troponin I in patients hospitalized for HFpEF decompensation. METHODS: We included 363 consecutive patients admitted for HFpEF decompensation that was not associated with acute coronary syndrome (ACS)...
August 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28888522/sleep-disordered-breathing-and-heart-failure-what-does-the-future-hold
#16
REVIEW
Martin R Cowie, Angela M Gallagher
Most patients with heart failure (HF) have sleep-disordered breathing (SDB), with central (rather than obstructive) sleep apnea becoming the predominant form in patients with more severe disease. Cyclical apnea and hypopneas are associated with sleep disturbance, hypoxemia, hemodynamic changes, and sympathetic activation. These patients have a worse prognosis than those without SDB. Mask-based therapies of positive airway pressure targeted at SDB can improve measures of sleep quality and can partially normalize the sleep and respiratory physiology...
August 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28882290/the-potential-of-clinical-phenotyping-of-heart%C3%A2-failure-with-imaging-biomarkers-for%C3%A2-guiding%C3%A2-therapies-a-focused-update
#17
REVIEW
Partho P Sengupta, Christopher M Kramer, Jagat Narula, Vasken Dilsizian
The need for noninvasive assessment of cardiac volumes and ejection fraction (EF) ushered in the use of cardiac imaging techniques in heart failure (HF) trials that investigated the roles of pharmacological and device-based therapies. However, in contrast to HF with reduced EF (HFrEF), modern HF pharmacotherapy has not improved outcomes in HF with preserved EF (HFpEF), largely attributed to patient heterogeneity and incomplete understanding of pathophysiological insights underlying the clinical presentations of HFpEF...
September 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28879773/association-of-admission-and-discharge-anemia-status-with-outcomes-in-patients-hospitalized-for-acute-decompensated-heart-failure-differences-between-patients-with-preserved-and-reduced-ejection-fraction
#18
Katsuya Kajimoto, Yuichiro Minami, Shigeru Otsubo, Naoki Sato
BACKGROUND: In acute decompensated heart failure patients with a preserved or reduced ejection fraction, the association of admission and discharge anemia status with outcomes remains unclear. METHODS AND RESULTS: Of the 4842 patients enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, 4433 patients (2017 with a preserved and 2416 with a reduced ejection fraction) were examined to investigate associations among the anemia status at admission and discharge (no anemia, developed anemia, resolved anemia, or persistent anemia), a preserved or reduced ejection fraction and the primary endpoint (all-cause death and readmission for heart failure)...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28873219/treatment-effectiveness-in-heart-failure-with-comorbidity-lung-disease-and-kidney-disease
#19
Jerry H Gurwitz, David J Magid, David H Smith, Grace H Tabada, Sue Hee Sung, Larry A Allen, David D McManus, Robert J Goldberg, Mayra Tisminetzky, Alan S Go
OBJECTIVES: To assess the clinical effectiveness of beta-blocker therapy in individuals with heart failure (HF) and chronic lung disease and of angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) in individuals with HF and chronic kidney disease. DESIGN: Retrospective cohort study. SETTING: Community. PARTICIPANTS: Individuals with HF with reduced ejection fraction (HFrEF) or HF with preserved ejection fraction (HFpEF)...
September 5, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28872259/prevalence-and-prognostic-importance-of-precipitating-factors-leading-to-heart-failure-hospitalization-recurrent-hospitalizations-and-mortality
#20
Elke Platz, Pardeep S Jhund, Brian L Claggett, Marc A Pfeffer, Karl Swedberg, Christopher B Granger, Salim Yusuf, Scott D Solomon, John J McMurray
AIMS: Hospitalizations for heart failure (HF) are common and are associated with significant morbidity, mortality and cost. However, precipitating factors leading to HF hospitalization and their importance with respect to subsequent outcomes are not well understood. METHODS AND RESULTS: The symptoms and signs present at admission and investigator-identified factors thought to have contributed to the first adjudicated HF hospitalization in the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) programme were prospectively collected and stratified by ejection fraction (EF)...
September 4, 2017: European Journal of Heart Failure
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