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NIDDM platelet

Ruiyu Li, Meng Li, Kaoshan Guo, Bin Li, Jinjie Hou, Liping Wu, Xianyun Liu
OBJECTIVE: Through experiment on animals and clinical trials to explore the safety and efficacy of hypoglycemic anti-deafness capsules on diabetic patients with deafness. METHODS: Total 296 patients with non-insulin dependent diabetes mellitus (NIDDM) were randomly divided into two groups. A treatment group of 164 patients (208 ears) was treated with hypoglycemic anti-deafness capsules based on TCM syndrome differentiation. A control group of 132 patients (184 ears) was treated with glibenclamide and conventional drug treatment for deafness...
October 2013: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
M Udvardy, E Posan, J Harsfalvi, K Rak
Binding studies have shown that human platelets contain binding sites for insulin with a surface density similar to that described for other cells.(1) Evidence for a reduced number and affinity of human platelet membrane insulin binding sites in non-insulin dependent diabetes mellitus (NIDDM) has been provided.(2) However, the influence of insulin and insulin receptors on platelet function has not been completely investigated and clarified. Falcon et al(3) reported phosphorylation of a subunit of the insulin receptor on platelets in response to insulin, but no alterations were detected in cAMP formation or degradation, inositol phosphate formation or phosphorylation of proteins other than the receptor itself...
1993: Platelets
F Corica, A Allegra, R Ientile, M Buemi, A Corsonello, R D'Angelo, S Bonanzinga, D Cucinotta, D Ceruso
Intraplatelet magnesium concentrations were evaluated in 50 non-insulin dependent diabetes mellitus (NIDDM) patients divided into two groups of 25 each (<60 or >65 years) and in a control group of 30 healthy subjects, divided into two age-matched subgroups of 15 each. In all patients magnesium concentrations were assayed in plasma, erythrocytes and platelets by means of direct current plasma spectrometry. Plasma, erythrocyte and platelet magnesium levels in healthy elderly subjects were found to be comparable to those in the group of younger healthy subjects, whereas plasma, erythrocyte and platelet magnesium levels in diabetics were lower than in controls...
November 1997: Archives of Gerontology and Geriatrics
M O Mekki, R V Jaykumar, A G Abdel Gader
Blood coagulation studies showed that patients with non-insulin-dependent diabetes mellitus (NIDDM) had significantly higher fibrinogen, FVIII:C, ristocetin co-factor, FV, FIX, lower ATIII, and PCV than those with insulin-dependent diabetes mellitus (IDDM). Diabetics with IDDM had a significantly higher ATIII, ristocetin co-factor, lower plasminogen and alpa-2-antiplasmin, and more enhanced platelet aggregation responses to ristocetin than age-matched controls. Patients with NIDDM as compared with controls, exhibited higher levels of fibrinogen, ristocetin co-factor, FVIII:C, FIX, and platelet count, but lower plasminogen, alpha-2-antiplasmin and PCV, reduced platelet aggragability to collage, ADP, and ristocetin...
July 1992: Annals of Saudi Medicine
Isaac Jardín, Pedro C Redondo, Ginés M Salido, José A Pariente, Juan A Rosado
Intracellular Ca2+ homeostasis in platelets of patients with non-insulin-dependent diabetes mellitus (NIDDM) has been reported to be altered, leading to an increased adhesiveness and spontaneous aggregation. Among the disturbed Ca2+ mechanism in platelets from NIDDM subjects, a reduced Ca2+ extrusion by the plasma membrane Ca2+-ATPase (PMCA) is especially relevant, maintaining an elevated cytosolic free Ca2+ concentration that results in platelet hypersensitivity. Here we show that treatment of platelets from NIDDM patients with 300 U/mL catalase or 5 mM D-mannitol, which prevent H2O2- and hydroxyl radicals-mediated oxidative stress, respectively, increases Ca2+ extrusion after treatment with thapsigargin (TG) plus ionomycin (Iono)...
August 2006: Platelets
H Wada, T Ishizuka, S Itaya, K Yamada, K Kajita, M Kimura, A Miura, T Shibata, Y Kanoh, M Ishizawa, K Yasuda
We previously reported the effects of diet, sulphonylureas or insulin on thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in non-insulin-dependent diabetes mellitus (NIDDM) patients. To clarify the mechanism of glyburide and insulin on platelet function, here we studied the in vitro effects of glyburide and insulin on thrombin-induced metabolic changes using normal human platelets. Platelet aggregation stimulated with <0.5 U/ml thrombin, 0.75-3 microM adenosine diphosphate (ADP) or 1 microg/ml collagen was significantly lower in glyburide-treated platelets, but not in insulin-treated platelets, than in untreated ones (control)...
1999: Platelets
G Leoncini, M G Signorello, A Piana, M Carrubba, U Armani
A group of 29 patients with non-insulin-dependent diabetes mellitus (NIDDM) was compared with a group of 19 patients who had good glycemic control for platelet activity and hydrogen peroxide formation. NIDDM patients showed platelet hyperactivity in response to low ADP concentrations. In addition, stimulated platelets from untreated NIDDM patients produced more hydrogen peroxide than platelets of treated and normal subjects. Hydrogen peroxide accumulation was not related to modification of the enzymatic systems involved in its synthesis and break-down...
1998: Platelets
S Yamagishi, K Nakamura, M Takeuchi
The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular diseases such as visceral obesity, hypertension, diabetes, and atherogenic dyslipidemia. Recently, insulin resistance in the absence of overt diabetes or the metabolic syndrome itself has been associated with endothelial dysfunction, one of the initial steps in the process of atherosclerosis. Postprandial hyperglycemia, one of the characteristic features of insulin resistance, induces oxidative stress generation and elicits vascular inflammation and platelet activation, thus being involved in the pathogenesis of atherosclerosis...
2005: Medical Hypotheses
Fernando R Saavedra, Pedro C Redondo, Juan M Hernández-Cruz, Gines M Salido, Jose A Pariente, Juan A Rosado
We have investigated the involvement of store-operated Ca(2+) entry (SOCE) in the abnormal platelet Ca(2+) homeostasis in patients with non insulin-dependent diabetes mellitus (NIDDM). In a medium containing 180 mg/dL glucose, platelets from NIDDM patients showed an increased SOCE compared to controls. We found that tyrosine phosphorylation was elevated in platelets from NIDDM patients. Consistent with this, the activity of the tyrosine kinase pp60(src) is enhanced in platelets from diabetic patients. When the experiments were performed in a medium containing 90 mg/dL both, SOCE and pp60(src) activity, were similar to those found in control platelets...
December 15, 2004: Archives of Biochemistry and Biophysics
C Nguyen, J Pan, M A Charles
The treatment of NIDDM is advancing on a number of fronts, ranging from the understanding of the mechanisms of action of existing agents to the development of new drugs. Glimepiride, the most recently U.S. approved sulfonylurea, is evaluated for its pancreatic and extrapancreatic activities in addition to safety, when compared with glibenclamide in preclinical studies. Glimepiride uniquely binds to the 65 kDa protein K(ATP) channel in pancreatic islet beta-cell membranes and directly stimulates insulin secretion...
May 1998: Drugs of Today
M Serban, Cristina Tanaseanu, T Kosaka, Cristina Vidulescu, Irina Stoian, Daciana S Marta, S Tanaseanu, Elena Moldoveanu
BACKGROUND: Non-insulin dependent diabetes mellitus (NIDDM) represents an independent risk factor for cardiovascular diseases (CVD), being characterized by a continuous low-grade inflammation and endothelial activation state. Plasma platelet - activating factor - acetylhydrolases (PAF-AHs) are a subgroup of Ca(2+)-independent phospholipase A(2) family (also known as lipoprotein-associated phospholipases A(2)) that hydrolyze and inactivate the lipid mediator platelet-activating factor (PAF) and/or oxidized phospholipids...
October 2002: Journal of Cellular and Molecular Medicine
Peteris Tretjakovs, Uldis Kalnins, Inese Dabina, Andrejs Erglis, Iveta Dinne, Antra Jurka, Gustavs Latkovskis, Agnis Zvaigzne, Valdis Pirags
AIM: To evaluate the levels of nitrite (NO(-)(2)) and nitrate (NO(-)(3)) ions and the incorporation of [(3)H]arachidonic acid (AA) into phospholipids of platelet membranes from coronary artery disease (CAD) patients with and without diabetes (NIDDM). SUBJECTS AND METHODS: Eighteen CAD patients (group A), 18 CAD patients with NIDDM (group B), and 20 healthy controls (group C) without dyslipidemia, peripheral vascular disease and hypertension were included in the study...
January 2003: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Hasib Salah-Uddin, Margaret J Gordon, Isobel Ford, Narendra N Tandon, Mike Greaves, Asim K Duttaroy
Increased platelet reactivity has been implicated in the vascular complications of myeloproliferative diseases and diabetes mellitus. The mechanisms of platelet hyperresponsiveness have not been fully explained. Expression of CD36 or fatty acid translocase (FAT) and its role in arachidonic acid (AA) uptake by platelets were examined in subjects with myeloproliferative disorders (MPD), those with non-insulin-dependent diabetes mellitus (NIDDM), and in normal, healthy, age-matched controls. Surface expression of CD36 on platelet membranes was increased in MPD (10...
October 2002: Molecular and Cellular Biochemistry
Michal Beránek, Katerina Kanková, Petr Kolár, Vladimír Znojil
Von Willebrand factor, a multimeric glycoprotein synthesized mainly by endothelial cells, is involved in platelet adhesion and aggregation and has an important role in the process of angiogenesis. Increased levels of von Willebrand factor, reflecting activation or damage of endothelial cells, have been described in association with proliferative diabetic retinopathy (PDR). We investigated the relationships of two polymorphisms (-1793G/C and Thr789Ala) in the von Willebrand factor gene with PDR. Genotypes were detected by polymerase chain reactions with subsequent restrictions with specific endonucleases...
September 2002: Ophthalmic Research
J Chen, C Li, P Ding, Y Ma
Twenty-one cases of acute cerebral infarction secondary to NIDDM were treated with acupuncture and conventional therapy, and compared with 16 cases treated with conventional therapy alone. The results showed that acupuncture was more effective in reducing insulin and glucagon levels (P < 0.001) and improving hypercoagulability (P < 0.05) of blood.
December 2001: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
Kalyan Srivastava, Debabrata Dash
BACKGROUND: Non-insulin-dependent diabetes mellitus (NIDDM) is characterized by the presence of abnormally active platelets in the circulation, leading to increased incidence of thrombotic complications. In this study, we have attempted to understand the pathophysiology of the platelets in NIDDM. METHODS: Platelet aggregation was induced by thrombin receptor-activating peptide or epinephrine. Membrane fluidity was derived from the steady-state fluorescence anisotropy of diphenylhexatriene incorporated in the membrane...
March 2002: Clinica Chimica Acta; International Journal of Clinical Chemistry
Z Y Wang, J M Shi, Y Han, Y C Wang, C G Ruan
Cerebrovascular disease and other vascular diseases are common complications of non-insulin-dependent diabetes mellitus (NIDDM) and are associated with its increased morbidity and mortality. Platelet activation plays an important role in the pathomechanisms of these vascular diseases. Although several indices have been used to assess platelet activation, few data are available indicating which are more sensitive or more valuable in this situation. We have measured platelet arachidonic acid metabolites [thromboxane B2 (TXB2) and 11-dehydro-thromboxane B2 (TXB2)] and plasma P-selectin, platelet fibrinogen binding and membrane glycoproteins in 47 well-characterized NIDDM patients with cerebrovascular disease, 38 NIDDM patients without vascular diseases, and 36 age-matched healthy individuals...
October 2001: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
B Wieclawska, M Rozalski, Z Trojanowski, C Watala
UNLABELLED: Thrombospondin (TSP), which is secreted from alpha-granules of activated platelets, binds to its surface receptor (CD36) in the presence of Ca2+. OBJECTIVES: We monitored how the modulation of intraplatelet Ca2+ affects TSP binding to CD36 on platelets from healthy donors and patients with type 2 diabetes mellitus. We also aimed to verify whether the impaired Ca2+ mobilisation in diabetes influences TSP binding upon the pharmacological modulation of calcium transport...
June 2001: European Journal of Haematology
T Kosaka, A Imakiire, F Mizuno, K Yamamoto
We examined the correlation between the activation of nuclear factor kappaB (NFkappaB), stimulated by environmental factors involving cytokines and growth factors in ligament cells, and the onset of ossification of the spinal ligaments (OSL) or diffuse idiopathic skeletal hyperostosis (DISH). Aseptic samples were taken carefully from non-ossified sites during surgery (75 patients). We carried out preliminary hematoxylin and eosin and toluidine blue staining, using five portions of each specimen, and excluded samples containing chondrocytic, osteoblastic, or inflammatory cells (n = 25)...
2000: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
B A Kolawole, A A Ajayi
Hypertension and diabetes mellitus are independently associated with a high rate of target organ complications, which is particularly accentuated in the Negroid race. The aims of this study were to evaluate the mortality associated with diabetes mellitus and concurrent hypertension and diabetes mellitus in indigenous Africans, and to identify and assess the factors that are predictive of intra-hospital mortality in Non-Insulin Dependent Diabetes Mellitus (NIDDM) diabetic Nigerians. The subsequent impact of the modification of these risk factors was also evaluated...
March 2000: Journal of Diabetes and its Complications
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