keyword
MENU ▼
Read by QxMD icon Read
search

Platelets diabetes

keyword
https://www.readbyqxmd.com/read/29036612/cd40l-controls-obesity-associated-vascular-inflammation-oxidative-stress-and-endothelial-dysfunction-in-mice-translational-aspects-for-man
#1
Sebastian Steven, Mobin Dib, Michael Hausding, Fatemeh Kashani, Matthias Oelze, Swenja Kröller-Schön, Alina Hanf, Steffen Daub, Siyer Roohani, Yves Gramlich, Esther Lutgens, Eberhard Schulz, Christian Becker, Karl J Lackner, Hartmut Kleinert, Christoph Knosalla, Beate Niesler, Philipp S Wild, Thomas Münzel, Andreas Daiber
Aims: CD40 ligand (CD40L) signaling controls vascular oxidative stress and related dysfunction in angiotensin-II-induced arterial hypertension by regulating vascular immune cell recruitment and platelet activation. Here we investigated the role of CD40L in experimental hyperlipidemia. Methods and Results: Male wild type and CD40L-/- mice (C57BL/6 background) were subjected to high fat diet for sixteen weeks. Weight, cholesterol, HDL and LDL levels, endothelial function (isometric tension recording), oxidative stress (NADPH oxidase expression, dihydroethidium fluorescence) and inflammatory parameters (inducible nitric oxide synthase, interleukin-6 expression) were assessed...
September 26, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29034492/transcriptome-analyses-reveal-genes-and-pathways-associated-with-fatty-acid-composition-traits-in-pigs
#2
J Zhang, L Cui, J Ma, C Chen, B Yang, L Huang
Fatty acid composition is associated with meat quality in pigs as well as with obesity- and diabetes-related traits in humans. Liver and muscle are important tissues for fatty acid metabolism. In this study, we evaluated correlations between liver and muscle transcriptomes and fatty acid composition traits in muscle and abdominal fat tissues in 335 F2 pigs from a White Duroc × Erhualian F2 pig resource population. Transcripts significantly correlated with fatty acid composition traits were enriched for genes involved in the categories of triglyceride catabolic process, mitochondrial function, hematological and immune system, and disease such as Type II diabetes...
October 16, 2017: Animal Genetics
https://www.readbyqxmd.com/read/29032524/patterns-and-levels-of-platelet-glycosylation-in-patients-with-coronary-heart-disease-and-type-2-diabetes-mellitus
#3
Liping Li, Chenxue Qu, Xuelian Wu, Juhua Dai, Yao Lu, Yan Gong, Ran You, Yaqi Liu
Coronary heart disease (CHD) and diabetes mellitus (DM) have high reactivity of platelets and an increased risk of thrombosis. Platelet glycosylation is closely related to platelet function and survival. However, the alteration of platelet glycosylation in CHD and T2DM still remains unknown. Platelet samples were obtained from 55 healthy controls and 102 patients, including 33 CHD, 30 T2DM and 39 CHD complicated with T2DM (CHD + T2DM). Platelet glycosylation was detected using eight-lectin based assay by flow cytometry...
October 14, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29030692/changes-in-aqueous-concentrations-of-various-cytokines-after-intravitreal-bevacizumab-and-subtenon-triamcinolone-injection-for-diabetic-macular-edema
#4
Seung-Young Yu, Dong Heun Nam, Dae Yeong Lee
PURPOSE: The purpose of this study was to compare the changes in the aqueous cytokine levels after intravitreal bevacizumab with those after combined intravitreal bevacizumab and subtenon triamcinolone injection in diabetic macular edema (DME). METHODS: This study examined 24 eyes of 23 patients with DME. Each patient with DME received randomly either an intravitreal injection of bevacizumab (IVBe) or IVBe with a subtenon triamcinolone injection (IVBe + STTA)...
October 13, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29030343/carbohydrate-restriction-with-postmeal-walking-effectively-mitigates-postprandial-hyperglycemia-and-improves-endothelial-function-in-type-2-diabetes
#5
Monique Emily Francois, Etienne Myette-Cote, Tyler Daniel Bammert, Cody Durrer, Helena Neudorf, Christopher A DeSouza, Jonathan Peter Little
Postprandial hyperglycemia has deleterious effects on endothelial function. Restricting carbohydrate intake and postmeal walking have each been shown to reduce postprandial hyperglycemia but their combination and subsequent effects on endothelial function have not been investigated. Here, we sought to examine the effect of blunting postprandial hyperglycemia by following a low-carbohydrate diet, with or without postmeal walking exercise, on markers of vascular health in type 2 diabetes (T2D). In a randomized crossover design, individuals with T2D (N=11) completed three four-day controlled diet interventions consisting of i) low-carbohydrate diet alone (LC), ii) low-carbohydrate diet with 15-minute postmeal walks (LC+Ex), and iii) Low-fat control diet (CON)...
October 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29027131/selective-bet-protein-inhibition-with-apabetalone-and-cardiovascular-events-a-pooled-analysis-of-trials-in-patients-with-coronary-artery-disease
#6
Stephen J Nicholls, Kausik K Ray, Jan O Johansson, Alan Gordon, Michael Sweeney, Chris Halliday, Ewelina Kulikowski, Norman Wong, Susan W Kim, Gregory G Schwartz
BACKGROUND: Inhibition of bromodomain and extra-terminal (BET) proteins can modulate lipoprotein and inflammatory factors that mediate atherosclerosis. The impact of the BET inhibitor, apabetalone, on cardiovascular events is unknown. OBJECTIVE: Our objective was to investigate the impact of apabetalone on cardiovascular event rates in a pooled analysis of clinical studies in patients with established coronary artery disease. METHODS: We conducted a pooled analysis of patients (n = 798) with coronary artery disease who participated in clinical trials (ASSERT, ASSURE, SUSTAIN) that evaluated the impact of 3-6 months of treatment with apabetalone on lipid parameters and coronary atherosclerosis...
October 12, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29026786/the-relationship-between-type-2-diabetes-and-platelet-indicators
#7
Xiangyu Chen, Le Fang, Hongbo Lin, Peng Shen, Tao Zhang, Hui Li, Xiaoyong Li, Min Yu, Chunxiao Xu, Jie Zhang, Feng Lu, Xiaofu DU, Ruying Hu, Jieming Zhong
BACKGROUND: Currently, the studies on the relationship between type 2 diabetes and platelets indicators were carried out on a selective small sample population generally. Large sample studies in this area are rare, especially in Chinese population. In this study, we aimed to investigate the relationship between type 2 diabetes and the mean platelet volume (MPV), platelet count (PLT) and platelet distribution width (PDW). METHODS: This is a cross-sectional analysis of the routine health examination data from 20128 participants with complete baseline data in Yinzhou District 2013...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29017535/the-leucopatch%C3%A2-system-in-the-management-of-hard-to-heal-diabetic-foot-ulcers-study-protocol-for-a-randomised-controlled-trial
#8
Frances Game, William Jeffcoate, Lise Tarnow, Florence Day, Deborah Fitzsimmons, Judith Jacobsen
BACKGROUND: Diabetic foot ulcers are a common and severe complication of diabetes mellitus. Standard treatment includes debridement, offloading, management of infection and revascularisation where appropriate, although healing times may be long. The LeucoPatch® device is used to generate an autologous platelet-rich fibrin and leucocyte wound dressing produced from the patient's own venous blood by centrifugation, but without the addition of any reagents. The final product comprises a thin, circular patch composed predominantly of fibrin together with living platelets and leucocytes...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/28993732/purinergic-signalling-therapeutic-developments
#9
REVIEW
Geoffrey Burnstock
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990's when receptor subtypes for purines and pyrimidines were cloned and characterised, which includes four subtypes of the P1 (adenosine) receptor, seven subtypes of P2X ion channel receptors and 8 subtypes of the P2Y G protein-coupled receptor. Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28993156/association-between-hemoglobin-glycation-index-and-hepatic-steatosis-in-non-diabetic-individuals
#10
Teresa Vanessa Fiorentino, Maria Adelaide Marini, Elena Succurro, Francesco Andreozzi, Angela Sciacqua, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti
AIMS: Hemoglobin glycation index (HGI), which is the difference between the observed value of HbA1 and the predicted HbA1c based on plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with diabetic complications. Herein we investigated whether HGI is associated with hepatic steatosis and related biomarkers in subjects without diabetes. METHODS: 1120 White individuals without diabetes were stratified in quartiles according to HGI levels...
October 6, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28990070/metformin-accelerates-wound-healing-in-type-2-diabetic-db-db-mice
#11
Xue Han, Yulong Tao, Yaping Deng, Jiawen Yu, Yuannan Sun, Guojun Jiang
Wound healing impairment is increasingly recognized to be a consequence of hyperglycemia‑induced dysfunction of endothelial precursor cells (EPCs) in type 2 diabetes mellitus (T2DM). Metformin exhibits potential for the improvement of endothelial function and the wound healing process. However, the underlying mechanisms for the observed beneficial effects of metformin application remain to be completely understood. The present study assessed whether metformin, a widely used therapeutic drug for T2DM, may accelerate wound closure in T2DM db/db mice...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28984160/r-lipoic-acid-overdosing-affects-platelet-life-span-via-ros-mediated-autophagy
#12
Jing Liu, Qingqing Song, Yanwei Huang, Wu Sun, Dingqiang Lu, Bo Zhou
R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. The aim of this study was to investigate the effect and mechanism of ALA on platelets in vivo. Sprague-Dawley (SD) male rats were intravenously administered with low-dose ALA (20 mg/kg/d), high-dose ALA (80 mg/kg/d) and saline, respectively. Platelets count and bone marrow smear were evaluated and the expressions of markers related to apoptosis and autophagy were measured...
October 6, 2017: Platelets
https://www.readbyqxmd.com/read/28982316/platelet-oxidative-stress-and-its-relationship-with-cardiovascular-diseases-in-type-2-diabetes-mellitus-patients
#13
Mohammed El Haouari
Enhanced platelet activation and thrombosis are linked to various cardiovascular diseases. Among other mechanisms, oxidative stress seems to play a pivotal role in platelet hyperactivity. Indeed, upon stimulation by physiological agonists, human platelets generate and release several types of reactive oxygen species (ROS) such as O2-, H2O2 or OH- , further amplifying the platelet activation response via various signalling pathways, including, formation of isoprostanes, Ca2+ mobilization and NO inactivation...
October 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28980279/secondary-prevention-of-coronary-heart-disease-in-elderly-population-of-turkey-a-subgroup-analysis-of-elderturk-study
#14
Salih Kilic, Mutlu Çagan Sümerkan, Volkan Emren, Lütfü Bekar, Sinan Çersit, Elif Tunç, Gülay Gök, Emine Altuntas, Uğur Canpolat, Umit Yasar Sinan, Namık Özmen, Mehdi Zoghi
BACKGROUND: Secondary prevention plays an important role after acute coronary event due to high risk of adverse events in elderly. In present study we aimed to evaluate the lifestyle, management of risk factors and medical treatment for secondary protection in elderly patients with known coronary heart disease (CHD). METHODS: ELDERTURK is a non-interventional, multi-centered, observational study, which included total of 5694 elderly patients (> 65 years) from 50 centers in Turkey...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28976786/platelet-to-lymphocyte-ratio-predicts-contrast-induced-acute-kidney-injury-in-diabetic-patients-with-st-elevation-myocardial-infarction
#15
Bartosz Hudzik, Janusz Szkodziński, Ilona Korzonek-Szlacheta, Krzysztof Wilczek, Marek Gierlotka, Andrzej Lekston, Barbara Zubelewicz-Szkodzińska, Mariusz Gąsior
AIM: There has been a rise in contrast-induced acute kidney injury (CI-AKI). We examined the role of platelet-to-lymphocyte ratio (PLR) in predicting CI-AKI episodes in patients with myocardial infarction (MI) and diabetes. METHODS: A total of 719 patients with diabetes and MI were enrolled. Study population was divided into: group 1 (n = 615) without CI-AKI and group 2 (n = 104) with CI-AKI. RESULTS: Patients with CI-AKI had higher in-hospital mortality and a longer in-hospital stay...
October 4, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28961512/n-acetylcysteine-attenuates-systemic-platelet-activation-and-cerebral-vessel-thrombosis-in-diabetes
#16
Bin Wang, Tak Yee Aw, Karen Y Stokes
OBJECTIVE: We previously demonstrated that diabetes exacerbates stroke-induced brain injury, and that this correlates with brain methylglyoxal (MG)-to-glutathione (GSH) status. Cerebral injury was reversed by N-acetylcysteine (NAC). Here we tested if the pro-thrombotic phenotype seen in the systemic circulation and brain during diabetes was associated with increased MG-glycation of proteins, and if NAC could reverse this. METHODS: The streptozotocin (STZ)-induced mouse model of type 1 diabetes was used...
September 20, 2017: Redox Biology
https://www.readbyqxmd.com/read/28952917/accuracy-of-noninvasive-fibrosis-scores-in-predicting-the-presence-of-fibrosis-in-patients-after-liver-transplantation
#17
Mohammad Nasser Kabbany, Praveen Kumar Conjeevaram Selvakumar, John Guirguis, John Rivas, Zade Akras, Rocio Lopez, Ibrahim Hanouneh, Bijan Eghtesad, Naim Alkhouri
OBJECTIVES: Several scoring systems have been developed to noninvasively predict the presence of advanced fibrosis in patients with chronic liver disease. Hepatitis C virus and nonalcoholic fatty liver disease are the 2 most common indications for orthotopic liver transplant and are associated with disease recurrence that can lead to fibrosis progression. Here, we evaluated the performance of commonly used fibrosis scores in assessing the presence of advanced fibrosis in patients after orthotopic liver transplant...
September 26, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28951244/tyrosines-740-751-of-pdgfr%C3%AE-contribute-to-the-activation-of-akt-hif1%C3%AE-tgf%C3%AE-nexus-to-drive-high-glucose-induced-glomerular-mesangial-cell-hypertrophy
#18
Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhury
Glomerular mesangial cell hypertrophy contributes to the complications of diabetic nephropathy. The mechanism by which high glucose induces mesangial cell hypertrophy is poorly understood. Here we explored the role of the platelet-derived growth factor receptor-β (PDGFRβ) tyrosine kinase in driving the high glucose-induced mesangial cell hypertrophy. We show that high glucose stimulates the association of the PDGFRβ with PI 3 kinase leading to tyrosine phosphorylation of the latter. High glucose-induced Akt kinase activation was also dependent upon PDGFRβ and its tyrosine phosphorylation at 740/751 residues...
September 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28932736/mean-platelet-volume-and-immature-platelet-fraction-in-autoimmune-disorders
#19
REVIEW
Deonilson Schmoeller, Maria Mercedes Picarelli, Terezinha Paz Munhoz, Carlos Eduardo Poli de Figueiredo, Henrique Luiz Staub
Mean platelet volume (MPV), measured using automated blood analysers, has been appraised as a potential biomarker in cardiovascular disease, diabetes mellitus, and cancer. The test, a useful tool in differentiation of thrombocytopenic states, has now been carried out for autoimmune disorders, but data are yet scarce. Controversial results have been obtained in systemic and organ-specific autoimmune disorders. Another test, the immature platelet fraction (IPF) reflects the amount of young, reticulated platelets...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#20
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
keyword
keyword
78061
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"