keyword
MENU ▼
Read by QxMD icon Read
search

Platelets diabetes

keyword
https://www.readbyqxmd.com/read/29453473/prehospital-events-in-st-elevation-myocardial-infarction-undergoing-primary-angioplasty
#1
Sachin Dhungel, Rabi Malla, Chandramani Adhikari, Arun Maskey, Rajeeb Rajbhandari, Ranjit Sharma, Deewakar Sharma, Man Bhadhur Kc, Ajay Adhikari, Binaya Rauniyar, Dipak Limbu, Milan Gautam
INTRODUCTION: Pre-hospital delay includes time from onset of symptoms of myocardial infarction till arrival to emergency room of the hospital. This defines time from symptom onset to first medical contact and first medical contact to emergency room. This study aims to study the prehospital events and determining factors in patients undergoing primary angioplasty. METHODS: This was a cross sectional study in Shahid Gangalal National Heart Centre for three months...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29446615/leveraging-engineering-of-cells-for-drug-delivery
#2
Zhaowei Chen, Quanyin Hu, Zhen Gu
Cell therapy has become a momentum-gathering treatment strategy for a variety of diseases, including cancer, diabetes, hemophilia, and cardiomyopathy. However, clinical applications of conventional cell therapies have often been compromised by rapid decline in viability and function of the transplanted cells due to host recognition and subsequent foreign body rejection. Along this line, cell engineering technologies such as cell encapsulation within microcapsules and immobilization in porous scaffolds have been implemented to address the immunosuppression concerns...
February 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29434166/diabetes-mellitus-induces-hyperreactivity-of-5-hydroxytryptamine-5-ht-induced-constriction-in-human-internal-thoracic-artery-and-is-associated-with-increase-in-the-membrane-protein-level-of-5-ht2a-receptor
#3
Tatsuo Shiba, Atsuko Yokota, Shuji Gamoh, Naoko Tanaka-Totoribe, Masachika Kuwabara, Eisaku Nakamura, Takahiro Hayase, Kunihide Nakamura, Ryuichi Yamamoto
Studies indicate that 5-hydroxytryptamine (5-HT) released from activated platelets in coronary artery bypass grafting (CABG) induces 5-HT2A receptor-mediated graft spasm. We previously reported that 5-HT-induced constriction of human endothelium-denuded saphenous vein (SV) was significantly augmented in patients with diabetes mellitus (DM) than in patients without DM (non-DM), without changes in the levels of the membrane-bound 5-HT2A receptor of their smooth muscle cells. Although the internal thoracic artery (ITA) is the key graft conduit for CABG, the effect of DM on the ITA graft spasm is still unclear...
February 10, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29425798/the-antioxidant-status-of-coenzyme-q10-and-vitamin-e-in-children-with-type-1-diabetes
#4
Usama M Alkholy, Nermin Abdalmonem, Ahmed Zaki, Mohamed A Elkoumi, Mustafa I Abu Hashim, Maha A A Basset, Hossam E Salah
OBJECTIVE: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes. METHOD: This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups...
February 6, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29424303/antiplatelet-for-coronary-artery-disease-in-specific-condition-no-size-fits-all
#5
Benny M Setiadi, Muhammad Munawar, Beny Hartono, Adhitia B Prakoso, Anggia C Lubis, Reza M Munandar
Antiplatelet is the cornerstone therapy for patient with coronary artery disease. Several comorbidities can influence the efficacy and safety of antiplatelet agent. Diabetes mellitus is characterized by increased platelet reactivity and reduced response to antiplatelet. Elderly patients have both reduced response to antiplatelet and increased risk of bleeding. Patients with renal dysfunction also had decreased efficacy of antiplatelet accompanied with increased risk of bleeding. In patients with atrial fibrillation, the concomitant use of anticoagulant with antiplatelet poses an increased risk of bleeding...
February 8, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29422826/role-of-plasma-growth-factor-in-the-healing-of-chronic-ulcers-of-the-lower-legs-and-foot-due-to-ischaemia-in-diabetic-patients
#6
Tomasz Miłek, Krzysztof Baranowski, Piotr Zydlewski, Piotr Ciostek, Krzysztof Mlosek, Wojciech Olszewski
Introduction: It has been demonstrated that plasma growth factor (PGF) responsible for proliferation of smooth muscle cells and fibroblasts significantly shortens treatment duration. Aim: To determine the role of human growth factor in the healing of ulcers due to ischaemic diabetic foot syndrome (DFS) following previous angioplasty of the blood vessels of the lower leg and foot. Material and methods: The study group included 50 patients with ischaemic diabetic foot complicated by lower leg ulcers in which angioplasty of the stenotic arteries in the distal lower leg and foot was performed...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29421448/a-potential-new-risk-factor-for-stroke-streptococcus-mutans-with-collagen-binding-protein
#7
Chikanori Inenaga, Kazuya Hokamura, Kazuhiko Nakano, Ryota Nomura, Shuhei Naka, Toshihiko Ohashi, Takashi Ooshima, Nagato Kuriyama, Toshimitsu Hamasaki, Koichiro Wada, Kazuo Umemura, Tokutaro Tanaka
OBJECTIVE: Among human oral bacteria, particular kinds of Streptococcus mutans (SM) known as dental caries pathogen have a collagen-binding protein called Cnm and show platelet aggregation inhibition and matrix metalloproteinase-9 activation. We have previously reported that these strains may be a risk factor for intracerebral hemorrhage. As a major sample providing hospital, we report here the clinical details including intracranial aneurysms and ischemic stroke. METHODS: Under permission of our ethical committee, 429 samples of whole saliva were taken from patients who were admitted or visited our hospital from February 16, 2010 to February 28, 2011...
February 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29420092/an-assessment-of-platelet-parameters-in-different-ethnic-groups-with-hypertension-subtypes-and-associated-risk-factors-in-xinjiang-china
#8
Asiya Abudesimu, Fen Liu, Dilixiati Siti, Dilare Adi, Zhenyan Fu, Xiang Ma, Xiang Xie, Yining Yang, Xiaomei Li, Yitong Ma
The goal of this study was to investigate platelet parameters in populations with hypertension subtypes among the Han, Uygur, and Kazakh ethnic groups and their associated risk factors in Xinjiang, northwestern China. In total, 9816 adult participants were recruited from a multiethnic, cross-sectional cardiovascular risk survey. Our results indicated that the platelet counts in Han, Uygur, and Kazakh participants with isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic diastolic hypertension (SDH) varied significantly (P < 0...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29417230/identification-of-megakaryocytes-as-a-target-of-advanced-glycation-end-products-in-diabetic-complications-in-bone-marrow
#9
Benfang Wang, Jianjiang Yu, Ting Wang, Ying Shen, Dandan Lin, Xin Xu, Yiqiang Wang
AIMS: To define the possible effect of diabetic conditions on megakaryocytes, the long-know precursors of platelets and lately characterized modulator of hematopoietic stem quiescence-activation transition. METHODS: Megakaryoblastic MEG-01 cell culture and TPO/SCF/IL-3-induced differentiation of human umbilical blood mononuclear cells toward megakaryocytes were used to test effects of glycated bovine serum albumin (BSA-AGEs). The ob/ob mice and streptozotocin-treated mice were used as models of hyperglycemia...
February 8, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29408797/effect-of-cilostazol-on-platelet-reactivity-among-patients-with-peripheral-artery-disease-on-clopidogrel-therapy
#10
Dagmar F Hernandez-Suarez, Hector Núñez-Medina, Stuart A Scott, Angel Lopez-Candales, Jose M Wiley, Mario J Garcia, Kyle Melin, Karid Nieves-Borrero, Christina Rodriguez-Ruiz, Lorraine Marshall, Jorge Duconge
BACKGROUND: Antiplatelet therapy with clopidogrel is recommended to reduce cardiovascular events in patients with peripheral artery disease (PAD); however, clopidogrel efficacy has not been adequately studied in this patient population. Therefore, we aimed to determine the effects of cilostazol therapy on platelet reactivity among PAD patients on clopidogrel. METHODS: We performed a cross-sectional pilot study of 46 Puerto Rican patients diagnosed with PAD. The cohort was divided based on use of clopidogrel and cilostazol (n=24) or clopidogrel alone (n=22)...
February 6, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29407053/antiplatelet-therapy-in-diabetes
#11
REVIEW
Arjun Majithia, Deepak L Bhatt
Cardiovascular disease (CVD) is a significant cause of morbidity and mortality among patients with diabetes mellitus (DM). Increased platelet reactivity among patients with DM contributes to disproportionately high levels of atherothrombotic CVD. Consequently, there has been tremendous interest in exploring the role of antiplatelet therapies in DM to reduce the development of and frequency of future cardiovascular events.
March 2018: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29404341/thrombosis-and-vascular-inflammation-in-diabetes-mechanisms-and-potential-therapeutic-targets
#12
REVIEW
Nikoletta Pechlivani, Ramzi A Ajjan
Cardiovascular disease remains the main cause of morbidity and mortality in patients with diabetes. The risk of vascular ischemia is increased in this population and outcome following an event is inferior compared to individuals with normal glucose metabolism. The reasons for the adverse vascular profile in diabetes are related to a combination of more extensive atherosclerotic disease coupled with an enhanced thrombotic environment. Long-term measures to halt the accelerated atherosclerotic process in diabetes have only partially addressed vascular pathology, while long-term antithrombotic management remains largely similar to individuals without diabetes...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29403592/management-of-retinal-diseases-in-pregnant-patients
#13
REVIEW
Julie M Rosenthal, Mark W Johnson
Pregnancy leads to significant changes in the body, which potentially affect the retina. Pregnancy can induce disease, such as that seen in hypertensive retinopathy and choroidopathy. It can cause exudative retinal detachments in the HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), disseminated intravascular coagulation (DIC), and thrombotic thrombocytopenic purpura (TTP), and provoke arterial and venous retinal occlusive disease. Pregnancy may also exacerbate pre-existing retinal disease, such as idiopathic central serous chorioretinopathy (ICSC) and diabetic retinopathy...
January 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29401607/mscs-promote-the-development-and-improve-the-function-of-neonatal-porcine-islet-grafts
#14
Sirong He, Chengshi Wang, Xiaojiong Du, Younan Chen, Jiuming Zhao, Bole Tian, Huimin Lu, Yi Zhang, Jingping Liu, Guang Yang, Lan Li, Hongxia Li, Jingqiu Cheng, Yanrong Lu
Deficient insulin secretion caused by immaturity is the predominant disadvantage of neonatal porcine islets (NPIs) when they serve as a source for islet xenotransplantation. We hypothesize that the transplantation of NPIs with a combination of mesenchymal stem cells (MSCs) can accelerate NPI maturation and improve the engraftment and function of NPIs. After indirect coculturing with monkey MSCs over 21 d, insulin secretion and the expression of regulatory genes relevant to development were assessed in NPIs...
January 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29398809/a-study-of-platelet-indices-in-type-2-diabetes-mellitus-patients
#15
Kumari Shilpi, R M Potekar
Altered platelets have been reported in patients with diabetes mellitus and has been considered as a 'prothrombotic state' with enhanced platelet reactivity. They have been associated with increased risk of vascular complications in these patients. Platelet indices correlate with functional status of platelets and is an emerging risk factor of vascular complications in diabetes. The study was undertaken to know the efficacy of platelet analysis in assessing the prognosis of diabetes mellitus. A prospective hospital based study of platelet parameters MPV, PDW and P-LCR was carried out on 280 cases diagnosed with Type 2 diabetes Mellitus and 280 controls with normal blood glucose levels...
January 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29396861/opposite-impact-of-methylene-tetrahydrofolate-reductase-c677t-and-methylene-tetrahydrofolate-reductase-a1298c-gene-polymorphisms-on-systemic-inflammation
#16
Koroush Khalighi, Gang Cheng, Seyedabbas Mirabbasi, Bahar Khalighi, Yin Wu, Wuqiang Fan
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been found to be related with many diseases. Systemic inflammation is now considered as a major predisposition factor for diseases including diabetes mellitus (DM), coronary arterial disease (CAD), stroke, and cancer. This study aimed to investigate whether systemic inflammation is a possible underlying pathogenesis for MTHFR gene polymorphism-related disease. METHODS: A total of 292 patients were enrolled, and single nucleotide polymorphisms for MTHFR C667T and A1298C were genotyped...
February 3, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29390253/factors-associated-with-acute-oral-mucosal-reaction-induced-by-radiotherapy-in-head-and-neck-squamous-cell-carcinoma-a-retrospective-single-center-experience
#17
Zhenchao Tao, Jin Gao, Liting Qian, Yifan Huang, Yan Zhou, Liping Yang, Jian He, Jing Yang, Ru Wang, Yangyang Zhang
To investigate risk factors for acute oral mucosal reaction during head and neck squamous cell carcinoma radiotherapy.A retrospective study of patients with head and neck squamous cell carcinoma who underwent radiotherapy from November 2013 to May 2016 in Anhui Provincial Cancer Hospital was conducted. Data on the occurrence and severity of acute oral mucositis were extracted from clinical records. Based on the Radiation Therapy Oncology Group (RTOG) grading of acute radiation mucosal injury, the patients were assigned into acute reaction (grades 2-4) and minimum reaction (grades 0-1) groups...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386225/pdgf-bb-carried-by-endothelial-cell-derived-extracellular-vesicles-reduces-vascular-smooth-muscle-cell-apoptosis-in-diabetes
#18
Gabriele Togliatto, Patrizia Dentelli, Arturo Rosso, Giusy Lombardo, Maddalena Gili, Sara Gallo, Chiara Gai, Anna Solini, Giovanni Camussi, Maria Felice Brizzi
Endothelial cell-derived extracellular vesicles (CD31EVs) are a new entity for therapeutic/prognostic purposes. The roles of CD31EVs as mediators of smooth muscle cell (VSMC) dysfunction in type 2 diabetes (T2D) is investigated herein.We demonstrated that, unlike non-diabetic, diabetic serum-derived-EVs (D-CD31EVs) boosted apoptosis resistance of VSMCs cultured in hyperglycaemic condition. Biochemical analysis revealed that this effect relies on changes in the balance between anti-apoptotic/pro-apoptotic signals: increase of bcl-2 and decrease of bak/bax...
January 31, 2018: Diabetes
https://www.readbyqxmd.com/read/29384050/polyphenols-potential-use-in-the-prevention-and-treatment-of-cardiovascular-diseases
#19
Rosaria Vincenza Giglio, Angelo Maria Patti, Arrigo Fg Cicero, Giuseppe Lippi, Manfredi Rizzo, Peter P Toth, Maciej Banach
BACKGROUND: Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses. Their effects on human health depend on the amount consumed and on their bioavailability. Many studies have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure, improving endothelial function, increasing antioxidant defences, inhibiting platelet aggregation and low-density lipoprotein oxidation, and reducing inflammatory responses...
January 29, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29368387/the-impact-of-acquired-thrombocytopenia-on-long-term-outcomes-of-patients-undergoing-elective-percutaneous-coronary-intervention-an-analysis-of-8-271-consecutive-patients
#20
Shuai Liu, Chenxi Song, Yanyan Zhao, Chenggang Zhu, Lei Feng, Kefei Dou, Bo Xu
BACKGROUND: Acquired thrombocytopenia is associated with an increased risk of adverse events of patients with acute coronary syndrome. However, data on its long-term prognostic significance are limited. The aim of our study was to investigate the association between acquired thrombocytopenia and long-term clinical outcomes. METHODS: We examined 8,271 consecutive patients who underwent elective percutaneous coronary intervention (PCI) at Fuwai Hospital from January 2013 to December 2013...
January 25, 2018: Catheterization and Cardiovascular Interventions
keyword
keyword
78061
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"