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https://www.readbyqxmd.com/read/29666899/altered-mitochondrial-bioenergetics-and-ultrastructure-in-the-skeletal-muscle-of-young-adults-with-type-1-diabetes
#1
Cynthia M F Monaco, Meghan C Hughes, Sofhia V Ramos, Nina E Varah, Christian Lamberz, Fasih A Rahman, Chris McGlory, Mark A Tarnopolsky, Matthew P Krause, Robert Laham, Thomas J Hawke, Christopher G R Perry
AIMS/HYPOTHESIS: A comprehensive assessment of skeletal muscle ultrastructure and mitochondrial bioenergetics has not been undertaken in individuals with type 1 diabetes. This study aimed to systematically assess skeletal muscle mitochondrial phenotype in young adults with type 1 diabetes. METHODS: Physically active, young adults (men and women) with type 1 diabetes (HbA1c 63.0 ± 16.0 mmol/mol [7.9% ± 1.5%]) and without type 1 diabetes (control), matched for sex, age, BMI and level of physical activity, were recruited (n = 12/group) to undergo vastus lateralis muscle microbiopsies...
April 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29666474/the-cisd-gene-family-regulates-physiological-germline-apoptosis-through-ced-13-and-the-canonical-cell-death-pathway-in-caenorhabditis-elegans
#2
Skylar D King, Chipo F Gray, Luhua Song, Rachel Nechushtai, Tina L Gumienny, Ron Mittler, Pamela A Padilla
Programmed cell death, which occurs through a conserved core molecular pathway, is important for fundamental developmental and homeostatic processes. The human iron-sulfur binding protein NAF-1/CISD2 binds to Bcl-2 and its disruption in cells leads to an increase in apoptosis. Other members of the CDGSH iron sulfur domain (CISD) family include mitoNEET/CISD1 and Miner2/CISD3. In humans, mutations in CISD2 result in Wolfram syndrome 2, a disease in which the patients display juvenile diabetes, neuropsychiatric disorders and defective platelet aggregation...
April 17, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29652635/far2-is-associated-with-kidney-disease-in-mice-and-humans
#3
Grant Backer, Sean Eddy, Susan M Sheehan, Yuka Takemon, Anna Reznichenko, Holly S Savage, Matthias Kretzler, Ron Korstanje
Mesangial matrix expansion is an important process in the initiation of chronic kidney disease, yet the genetic factors driving its development are unknown. Our previous studies have implicated Far2 as a candidate gene associated with differences in mesangial matrix expansion between mouse inbred strains. Consistent with the hypothesis that increased expression of Far2 leads to mesangial matrix expansion through increased production of platelet-activating factor precursors, we show that FAR2 is capable of mediating de novo platelet-activating factor synthesis in vitro and driven by the transcription factor NKX3...
April 13, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29651306/association-of-mean-platelet-volume-with-incident-type-2-diabetes-mellitus-risk-the-dongfeng-tongji-cohort-study
#4
Zhaoyang Li, Jing Wang, Xu Han, Jing Yuan, Huan Guo, Xiaomin Zhang, Dan Zheng, Yuhan Tang, Handong Yang, Meian He
Background: Most of prior studies to demonstrate the association between mean platelet volume (MPV) and type 2 diabetes mellitus (T2DM) risk were cross-sectional design with inconsistent results. In the present prospective cohort study, we aimed to explore the relationship between MPV and incident T2DM risk among a middle-aged and older Chinese population. Methods: This prospective study included 14,009 individuals derived from the Dongfeng-Tongji cohort which was launched in 2008...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29644884/prospective-analysis-of-surgical-bone-margins-after-partial-foot-amputation-in-diabetic-patients-admitted-with-moderate-to-severe-foot-infections
#5
Brian M Schmidt, Jonathan B McHugh, Rajiv M Patel, James S Wrobel
BACKGROUND: Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Secondary aims included evaluating interobserver reliability of histopathologic data at both the distal-to and proximal-to surgical bone margin...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29626150/rac1-modulates-endothelial-function-and-platelet-aggregation-in-diabetes-mellitus
#6
Gabriele Giacomo Schiattarella, Albino Carrizzo, Federica Ilardi, Antonio Damato, Mariateresa Ambrosio, Michele Madonna, Valentina Trimarco, Marina Marino, Elena De Angelis, Silvio Settembrini, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito, Carmine Vecchione
BACKGROUND: Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. METHODS AND RESULTS: We used both in vitro and ex vivo approaches to test the effects of pharmacological inhibition of Rac1 during hyperglycemic condition...
April 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29625513/trends-characteristics-and-clinical-outcomes-of-patients-undergoing-percutaneous-coronary-intervention-in-korea-between-2011-and-2015
#7
Seungbong Han, Gyung Min Park, Yong Giun Kim, Mahn Won Park, Sung Ho Her, Seung Whan Lee, Young Hak Kim
BACKGROUND AND OBJECTIVES: We sought to evaluate nationwide trends, characteristics, and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in Korea. METHODS: From National Health Insurance claims data in Korea, 81,115 patients, who underwent PCI for the first episode of coronary artery disease between 2011 and 2015, were enrolled. Patients were categorized into angina (n=49,288) or acute myocardial infarction (AMI, n=31,887) groups and analyzed...
April 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29624604/acute-myocardial-infarction-occurring-while-on-chronic-clopidogrel-therapy-clopidogrel-failure-is-associated-with-high-incidence-of-clopidogrel-poor-responsiveness-and-stent-thrombosis
#8
Ehud Regev, Elad Asher, Paul Fefer, Roy Beigel, Israel Mazin, Shlomi Matetzky
OBJECTIVES: The clinical significance of the laboratory-based phenomenon of clopidogrel hypo-responsiveness and platelet reactivity associated with acute myocardial infarction, despite chronic clopidogrel therapy, is largely unknown. We aimed to determine platelet reactivity and clinical and angiographic features in 29 consecutive patients sustaining an acute myocardial infarction despite chronic (≥1 month) clopidogrel therapy. METHODS: Platelet reactivity was determined on admission using conventional aggregometry...
2018: PloS One
https://www.readbyqxmd.com/read/29623504/coarse-grained-molecular-dynamics-simulations-of-fibrin-polymerization-effects-of-thrombin-concentration-on-fibrin-clot-structure
#9
Sumith Yesudasan, Xianqiao Wang, Rodney D Averett
Studies suggest that patients with deep vein thrombosis and diabetes often have hypercoagulable blood plasma, leading to a higher risk of thromboembolism formation through the rupture of blood clots, which may lead to stroke and death. Despite many advances in the field of blood clot formation and thrombosis, the influence of mechanical properties of fibrin in the formation of thromboembolisms in platelet-poor plasma is poorly understood. In this paper, we combine the concepts of reactive molecular dynamics and coarse-grained molecular modeling to predict the complex network formation of fibrin clots and the branching of fibrin monomers...
April 5, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29622820/high-risk-of-coagulopathy-among-type-2-diabetes-mellitus-clients-at-a-municipal-hospital-in-ghana
#10
Richard Kd Ephraim, Yaw A Awuku, Patrick Adu, Lord Tw Ampomah, Prince Adoba, Solomon Panford, Jerry Pk Ninnoni, Hope Agbodzakey
Background: Persistent hyperglycaemia in diabetes mellitus causes coagulopathies due to glycation of haemoglobin, prothrombin, fibrinogen and other proteins involved in the clotting mechanism. Shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) reflect hypercoagulable state, which is associated with an increased thrombotic risk and adverse cardiovascular effects. This study assessed the coagulation profile of type 2 diabetes mellitus (T2DM) clients at a municipal hospital in Ghana...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29621477/stromal-vascular-fraction-promotes-fibroblast-migration-and-cellular-viability-in-a-hyperglycemic-microenvironment-through-up-regulation-of-wound-healing-cytokines
#11
Shaun S Tan, Xin Yi Yeo, Zhen Chang Liang, Sunil K Sethi, Samuel S W Tay
Diabetic wounds have impaired healing and a propensity for further morbidity, which may result in amputations. Stromal vascular fraction (SVF) is an autologous source of heterogeneous cell population obtained from adipose tissue, which is rich in stem cells and presents little immunogenicity to the host. In this study, we hypothesized that murine fibroblasts subjected to hyperglycemic conditions co-treated with SVF exhibit greater functional activity through the colorimetric MTT assay and a cell-monolayer in-vitro scratch assay...
April 2, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29617185/long-non-coding-rna-metallothionein-1-pseudogene-3-promotes-p2y12-expression-by-sponging-mir-126-to-activate-platelet-in-diabetic-animal-model
#12
Ming Zhou, Meng Gao, Yanwei Luo, Rong Gui, Hongwen Ji
Platelet hyperaggregation and hypercoagulation are associated with increase of thrombogenic risk, especially in patients with type 2 diabetes (T2D). High activity of P2Y12 receptor is found in T2D patients, exposing such patients to a prothrombotic condition. P2Y12 is a promising target for antiplatelet, but due to P2Y12 receptor constitutive activation, the clinical practical phenomena such as "clopidogrel resistance" are commonly occurring. In this study, we investigate the role of lncRNA on platelet activation...
April 4, 2018: Platelets
https://www.readbyqxmd.com/read/29616850/the-relationship-between-erectile-dysfunction-severity-mean-platelet-volume-and-vitamin-d-levels
#13
Mehmet Gokhan Culha, Hasan Anil Atalay, Halil Lutfi Canat, Ilter Alkan, Sait Ozbir, Osman Can, Alper Otunctemur
BACKGROUND: The aim of this study was to evaluate the relationship between mean platelet volume (MPV) and vitamin D levels according to ED severity. METHODS: Between October 2015 and September 2017, patients who applied to the andrology outpatient clinic with an ED complaint were retrospectively reviewed. Patients with diabetes, hypertension, hyperlipidemia, malignancy, late-onset hypogonadism and smokers were not included in the study. The International Erectile Function Index-Erectile Function (IIEF-EF) questionnaire was used to assess the levels of erectile function...
April 4, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29615970/the-potential-role-of-platelet-related-micrornas-in-the-development-of-cardiovascular-events-in-high-risk-populations-including-diabetic-patients-a-review
#14
REVIEW
Justyna Pordzik, Katarzyna Pisarz, Salvatore De Rosa, Axel Dyve Jones, Ceren Eyileten, Ciro Indolfi, Lukasz Malek, Marek Postula
Platelet activation plays a pivotal role in the development and progression of atherosclerosis, which often leads to potentially fatal ischemic events at later stages of the disease. Platelets and platelet microvesicles (PMVs) contain large amounts of microRNA (miRNA), which contributes largely to the pool of circulating miRNAs. Hence, they represent a promising option for the development of innovative diagnostic biomarkers, that can be specific for the underlying etiology. Circulating miRNAs can be responsible for intracellular communication and may have a biological effect on target cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29613817/acute-kidney-injury-after-non-cardiovascular-surgery-risk-factors-and-impact-on-development-of-chronic-kidney-disease-and-long-term-mortality
#15
Leili Pourafkari, Pradeep Arora, Jahan Porhomayon, Hasan H Dosluoglu, Preksha Arora, Nader D Nader
OBJECTIVE: To identify factors associated with acute kidney injury (AKI) and its progression to chronic kidney disease (CKD) in a non-cardiac/non-vascular surgery setting. METHODS: We examined Veterans Affairs Surgical Quality database for surgical entries between 2000-2014. Demographics, comorbidities, laboratory findings and hospital outcomes were assessed. Primary endpoint was occurrence of AKI defined as increase of ≥0.3 mg/dL, 48 hours postoperatively...
April 3, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29605541/activation-of-the-12-15-lipoxygenase-pathway-accompanies-metabolic-decline-in-db-db-pre-diabetic-mice
#16
Anca D Dobrian, Ryan W Huyck, Lindsey Glenn, Vijay Gottipati, Bronson A Haynes, Göran I Hansson, Anna Marley, William L McPheat, Jerry L Nadler
The 12-lipoxygenase (12LO) pathway is a promising target to reduce islet dysfunction, adipose tissue (AT) inflammation and insulin resistance. Optimal pre-clinical models for the investigation of selective12LO inhibitors in this context have not yet been identified. The objective of this study was to characterize the time course of 12LO isoform expression and metabolite production in pancreatic islets and AT of C57BLKS/J-db/db obese diabetic mouse in a pre-diabetic state in order to establish a suitable therapeutic window for intervention with selective lipoxygenase inhibitors...
March 29, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29595116/ameliorative-potentials-of-methanol-fractions-of-cnidoscolus-aconitifolius-on-some-hematological-and-biochemical-parameters-in-streptozotocin-diabetic-rats
#17
Ngozi Achi, Christopher Ohaeri, Ifeoma Ijeh, Chinedum Eleazu, Kalu Igwe, Chima Onyeabo
There is paucity of information in literature on the effect of Cnidoscolus aconitifolius on the hematological, coagulation activities, electrolyte balance and antioxidant activities of humans or animals. </p><p> Objectives: To determine the ameliorative potentials of methanol fractions of Cnidoscolus aconitifolius on hematological, coagulation, electrolyte, hepatic and renal antioxidant activities of streptozotocin- induced diabetic rats using standard techniques. </p><p> Method: Thirty rats, distributed into five groups of six rats each were used for this study...
March 27, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29588839/non-invasive-markers-of-liver-fibrosis-in-fatty-liver-disease-are-unreliable-in-people-of-south-asian-descent
#18
Sampath De Silva, Wenhao Li, Polychronis Kemos, James H Brindley, Jibran Mecci, Salma Samsuddin, Joanne Chin-Aleong, Roger M Feakins, Graham R Foster, Wing-Kin Syn, William Alazawi
Objective: Liver biopsy is the most accurate method for determining stage and grade of injury in non-alcoholic fatty liver disease (NAFLD). Given risks and limitations of biopsy, non-invasive tests such as NAFLD fibrosis score, aspartate transaminase (AST) to platelet ratio index, Fib-4, AST/alanine transaminase ratio and BARD are used. Prevalence and severity of NAFLD and metabolic syndrome vary by ethnicity, yet tests have been developed in largely white populations. We tested our hypothesis that non-invasive tests that include metabolic parameters are less accurate in South Asian compared with white patients...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29581826/increased-visceral-fat-volume-raises-the-risk-for-recurrence-of-hepatocellular-carcinoma-after-curative-treatment
#19
Kenji Imai, Koji Takai, Toshihide Maeda, Satoshi Watanabe, Tatsunori Hanai, Atsushi Suetsugu, Makoto Shiraki, Masahito Shimizu
Obesity is a risk factor for the development of hepatocellular carcinoma (HCC). This study aimed to assess the influence of visceral fat on the recurrence of HCC after curative treatment. In 207 curative cases of HCC, the cross-sectional areas of visceral and subcutaneous fat mass on the computed tomographic image at the fourth lumbar vertebra were normalized by the square of the height to obtain the visceral fat mass index (VFMI) and the subcutaneous fat mass index (SFMI), respectively. Whether VFMI and SFMI contributed to recurrence of HCC and overall survival was analyzed using a Cox proportional hazards model...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29581246/the-association-of-neutrophil-to-lymphocyte-ratio-mean-platelet-volume-and-platelet-distribution-width-with-diabetic-retinopathy-and-nephropathy-a-meta-analysis
#20
Juxiang Liu, Xingguang Liu, Youpeng Li, Jinxing Quan, Suhong Wei, Siqin An, Ruifei Yang, Jing Liu
The aim of this study was to investigate the correlation of neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet distribution width (PDW) with diabetic nephropathy (DN) and diabetic retinopathy (DR). We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to 01 December 2017. Standardized mean difference (SMD) was calculated with confidence interval (CI) of 95%. A total of 48 studies were included in our meta-analysis. Compared to patients with type Ⅱ diabetes mellitus (T2DM) and without DR, NLR, MPV and PDW was higher in patients with DR (SMD = 0...
March 26, 2018: Bioscience Reports
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