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https://www.readbyqxmd.com/read/29035222/an-advanced-mri-multi-modalities-segmentation-methodology-dedicated-to-multiple-sclerosis-lesions-exploration-and-differentiation
#1
Olfa Ghribi, Lamia Sellami, Mohamed Ben Slima, Ahmed Ben Hamida, Chokri Mhiri, Keireddine Ben Mahfoudh
Multiple sclerosis is one of the most common neurological diseases in young people. This paper dealt with an automatic biomedical aided tool involving volumetric segmentation of Multiple Sclerosis lesions. To meet this challenge, our proposed methodology requires one preliminary cerebral zones segmentation performed using a new Gaussian Mixture Model based on various databases atlases. Afterwards, lesion segmentation begins with the estimation of a lesion map which is then subjected to threshold constraints and refined by a new lesion expansion algorithm...
October 16, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/29034969/experience-with-mad-on-children-with-epilepsy-in-egypt-after-classic-kd-failure
#2
O F El Rashidy, M F Nassar, Y G El Gendy, S M Deifalla, S Gaballa
BACKGROUND AND AIM: Modified Atkins diet (MAD) is a less restrictive type of ketogenic diet (KD) as compared to the classic one. The aim of this study was to evaluate the impact of 9 months MAD treatment on the growth and seizure control in patients with intractable epilepsy as well as the quality of life (QoL) of their mothers. SUBJECTS AND METHODS: The study included 15 patients with intractable epilepsy who could not tolerate their classic KD management plan...
October 16, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29032616/a-survey-on-hematology-oncology-pediatric-aieop-centres-the-challenge-of-posterior-reversible-encephalopathy-syndrome
#3
Daniele Zama, Pietro Gasperini, Massimo Berger, Mariagrazia Petris, Maria D De Pasquale, Simone Cesaro, Maria E Guerzoni, Elena Mastrodicasa, Francesca Savina, Ottavio Ziino, Valentina Kiren, Paola Muggeo, Rosa M Mura, Fraia Melchionda, Giulio A Zanazzo
Posterior reversible encephalopathy syndrome (PRES) is one of the most common neurological complications in hematology-oncology pediatric patients. Despite an increasingly recognized occurrence, no clear consensus exists regarding how best to manage the syndrome, because most cases of PRES have reported in single case reports or small series. Aim of this paper is to identify incidence, clinical features, management and outcome of PRES in a large series of hematology-oncology pediatric patients METHODS: The cases of PRES occurred in twelve centres of the Italian Association of Pediatric Haematology and Oncology were reported RESULTS: 124 cases of PRES in 112 pediatric patients were recorded with an incidence of 2...
October 15, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29026989/the-pattern-peculiarities-and-management-challenges-of-spina-bifida-in-a-teaching-hospital-in-southwest-nigeria
#4
Edward O Komolafe, Chiazor Udochukwu Onyia, Ibironke O Ogunbameru, Oluwamuyiwa A Dada, Oluwafemi F Owagbemi, Fred S Ige-Orhionkpaibima, Oluseun A Olarewaju, Efosa O Obamwonyi, Muhammad I Abdullahi
PURPOSE: Spina bifida is a common congenital anomaly of the nervous system. It is frequently associated with significant morbidity and sometimes mortality in affected children. In this paper, we review the clinico-epidemiological pattern, peculiarities, and therapeutic challenges of this condition in our practice setting. METHODS: This is a retrospective study of all cases of spina bifida managed from July 2000 to March 2016 at a tertiary health facility located in the southwest region of Nigeria...
October 12, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29021878/displaced-supracondylar-humerus-fractures-in-children-are-they-all-identical
#5
S K Gera, McH Tan, Y G Lim, Kbl Lim
Introduction: This study aims to ascertain if there are any differences in supracondylar fractures between children under seven years of age and those above 7 years of age. Materials and Methods: All cases of displaced humerus supracondylar fractures that required surgical stabilization were identified and retrospectively reviewed. Demographic data, mode of injury, associated neurovascular injuries and details of surgery performed were obtained from clinical records. The Gartland classification and the extent of comminution of fractures were also documented from review of radiographs...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28991673/mortality-and-morbidity-among-hospitalized-adult-patients-with-neurological-diseases-in-cameroon
#6
Katie Kompoliti, Jacques Doumbe, Yacoumba Njankouo Mapoure, Theophile Nyinyikua, Bichun Ouyang, Hiral Shah, Sara Calvo, Abel Fernandez-Sierra, Maria Esther Cubo Delgado
BACKGROUND: There is inadequate information on the morbidity and mortality (M&M) from neurological diseases in sub-Saharan Africa. OBJECTIVE: To record the M&M from neurological diseases in adults in Cameroon from 2013 to 2015 using a registry and surveillance from two urban health care centers. METHODS: Records from all adult admissions from two urban hospitals over a two year period were reviewed. Adult cases with neurological diagnosis as the main cause for admission were identified...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28988934/bis-choline-tetrathiomolybdate-in-patients-with-wilson-s-disease-an-open-label-multicentre-phase-2-study
#7
Karl Heinz Weiss, Frederick K Askari, Anna Czlonkowska, Peter Ferenci, Jeff M Bronstein, Danny Bega, Aftab Ala, David Nicholl, Susan Flint, Lars Olsson, Thomas Plitz, Carl Bjartmar, Michael L Schilsky
BACKGROUND: Wilson's disease is a genetic disorder in which copper accumulates in the liver, brain, and other tissues. Therapies are limited by efficacy, safety concerns, and multiple daily dosing. Bis-choline tetrathiomolybdate (WTX101) is an oral first-in-class copper-protein-binding molecule that targets hepatic intracellular copper and reduces plasma non-ceruloplasmin-bound copper (NCC) by forming tripartite complexes with albumin and increasing biliary copper excretion. We aimed to assess the efficacy and safety of WTX101 in the initial or early treatment of patients with Wilson's disease...
October 5, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28984605/the-pitfall-of-behavioral-variant-frontotemporal-dementia-mimics-despite%C3%A2-multidisciplinary-application-of%C3%A2-the%C3%A2-ftdc-criteria
#8
Welmoed A Krudop, Annemieke Dols, Cora J Kerssens, Piet Eikelenboom, Niels D Prins, Christiane Möller, Sigfried Schouws, Didi Rhebergen, Eric van Exel, Wiesje M van der Flier, Sietske Sikkes, Philip Scheltens, Max L Stek, Yolande A L Pijnenburg
BACKGROUND: The behavioral variant of frontotemporal dementia (bvFTD) has a broad differential diagnosis including other neurological and psychiatric disorders. Psychiatric misdiagnoses occur in up to 50% of bvFTD patients. Numbers on misdiagnosis of bvFTD in psychiatric disorders are lacking. OBJECTIVE: The aim of our study was to investigate the frequency and characteristics of bvFTD misdiagnoses in psychiatric disorders and other neurologic disorders. METHODS: Thirty-five patients with a (possible or probable) bvFTD diagnosis made by specialized memory clinic neurologists were included...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28984538/lessons-learned-from-administration-of-high-dose-methylprednisolone-sodium-succinate-for-acute-pediatric-spinal-cord-injuries
#9
Michelle C Caruso, Margot C Daugherty, Suzanne M Moody, Richard A Falcone, Karin S Bierbrauer, Gary L Geis
OBJECTIVE Methylprednisolone sodium succinate (MPSS) has been studied as a pharmacological adjunct that may be given to patients with acute spinal cord injury (ASCI) to improve neurological recovery. MPSS treatment became the standard of care in adults despite a lack of evidence supporting clinical benefit. More recently, new guidelines from neurological surgeon groups recommended no longer using MPSS for ASCI, due to questionable clinical benefit and known complications. However, little information exists in the pediatric population regarding MPSS use in the setting of ASCI...
October 6, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28971571/clinicopathological-features-of-neuroblastic-tumors-with-opsoclonus-myoclonus-ataxia-syndrome-follicular-structure-predicts-a-better-neurological-outcome
#10
Hiroko Fukushima, Takeshi Inoue, Yuichi Takama, Naomi Ishii, Takahiro Okuno, Yasutsugu Kobayashi, Akihiro Yoneda, Tetsuro Nakamura, Ichiro Kuki, Junichi Hara
Neuroblastic tumors (NT) with opsoclonus-myoclonus syndrome (OMS) display characteristic histological features, such as lymphocytic infiltration with lymphoid follicles, indicating an underlying immune response. We retrospectively assessed NT patients from 2001 to 2016. Five cases of NT with OMS and 76 cases of NT without OMS were histopathologically reviewed in this study. The grade of lymphocytic infiltration was evaluated. The number of follicles was counted and the presence or absence of lymphoid follicles was recorded for each case...
October 2017: Pathology International
https://www.readbyqxmd.com/read/28969878/epilepsy-in-22q11-2-deletion-syndrome-a-case-series-and-literature-review
#11
Basanagoud Mudigoudar, Sunitha Nune, Stephen Fulton, Ehab Dayyat, James W Wheless
BACKGROUND: The 22q11.2 deletion syndrome affects multiple organ systems, and the neurological manifestations are an important aspect of this disorder. Many are aware of cardiac anomalies associated with this uncommon genetic disorder. However, the different types of seizures, electroencephalography (EEG), and brain magnetic resonance imaging (MRI) findings seen in this condition are not appreciated. METHODS: Medical records of four patients with epilepsy due to 22q11...
August 26, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28966813/assessing-the-accuracy-of-neurological-surgery-resident-case-logs-at-a-single-institution
#12
Matthew J McPheeters, Rachel D Talcott, Molly E Hubbard, Stephen J Haines, Matthew A Hunt
BACKGROUND: Despite the importance of case logs in evaluating residents, no studies assess their accuracy in neurological surgery. Studies from other specialties reveal variations in reporting. This study assesses the accuracy of neurological surgery resident case logs at a single institution. METHODS: Data was collected from three databases: billing data and two separate resident-managed case logs [department log and Accreditation Council for Graduate Medical Education (ACGME) case logs], containing records of procedures performed by 14 neurological surgery residents at a single institution over a 1-year period...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28966357/feline-meningoencephalomyelitis-of-unknown-origin-a-retrospective-analysis-of-16-cases
#13
Arianna Negrin, Sarah Spencer, Giunio Bruto Cherubini
This study aimed to describe the signalment, clinical signs, magnetic resonance imaging (MRI) findings, cerebrospinal fluid (CSF) analysis, treatment, and outcome of feline meningoencephalomyelitis of unknown origin (FMUO). Medical records from 16 cats meeting the inclusion criteria of CSF pleocytosis, negative CSF polymerase chain reaction (PCR)-infectious disease results, and characteristic MRI findings were retrospectively reviewed. Median age was 9.4 years. Clinical signs included ataxia, proprioceptive deficits, seizures, and spinal hyperesthesia...
October 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28965448/neuromuscular-scoliosis-complication-rates-from-2004-to-2015-a-report-from-the-scoliosis-research-society-morbidity-and-mortality-database
#14
Daniel Cognetti, Heather M Keeny, Amer F Samdani, Joshua M Pahys, Darrell S Hanson, Kathy Blanke, Steven W Hwang
OBJECTIVE Postoperative complications are one of the most significant concerns in surgeries of the spine, especially in higher-risk cases such as neuromuscular scoliosis. Neuromuscular scoliosis is a classification of multiple diseases affecting the neuromotor system or musculature of patients leading to severe degrees of spinal deformation, disability, and comorbidity, all likely contributing to higher rates of postoperative complications. The objective of this study was to evaluate deformity correction of patients with neuromuscular scoliosis over a 12-year period (2004-2015) by looking at changes in postsurgical complications and management...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28962953/arachnoid-cyst-associated-chronic-subdural-hematoma-report-of-14-cases-and-a-systematic-literature-review
#15
Xuanxuan Wu, Guichen Li, Jinchuan Zhao, Xiaobo Zhu, Yang Zhang, Kun Hou
BACKGROUND: Arachnoid cyst (AC) associated chronic subdural hematoma (CSDH) differs a lot from its counterparts without AC in epidemiological, demographic, and clinical characteristics, management, and prognosis. To further illustrate the epidemiological, demographic, and clinical characteristics, diagnosis, treatment, and prognosis of AC associated CSDH. METHODS: A retrospective study of the medical records at the neurosurgical departments of two institutions was performed combined with a systematic PubMed search of the published studies written in English and Chinese...
September 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28959791/clinical-features-diagnosis-and-outcomes-of-rhino-orbito-cerebral-mucormycosis-a-retrospective-analysis
#16
A Abdollahi, T Shokohi, N Amirrajab, R Poormosa, A M Kasiri, S J Motahari, S M Ghoreyshi, S A Madani, M Nikkhah, M Ghasemi, L Vahedi Larijani, M Didehdar, Z Seifi, N Gholinejad, M Ilkit
BACKGROUND AND PURPOSE: Rhino-orbito-cerebral mucormycosis (ROCM) is a rare disease with acute and fulminant manifestation. This infection is associated with high morbidity and mortality rates. Herein, we reviewed the manifestations, underlying conditions, medical treatments, and surgical interventions in ROCM patients admitted to a tertiary referral center in northern Iran over a seven-year period. MATERIALS AND METHODS: In a retrospective analysis, 15 cases of ROCM were identified from 2007 to 2013 in Bu Ali Sina Hospital, Sari, Iran...
December 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28958927/microscopic-minimally-invasive-keyhole-technique-for-surgical-resection-of-spinal-dumbbell-tumors
#17
Jie Xu, Chun-Hua Liu, Yuan Lin, Fen-Qi Luo
OBJECTIVE: Multiple surgical modalities have been developed and applied for surgical excision of spinal dumbbell tumors. However, the microscopic minimally invasive keyhole technique has not yet been well characterized for this purpose. Here we report our experience with one-stage surgical resection of both intra- and extra-foraminal /paraspinal components of spinal dumbbell tumors using the microsurgical keyhole technique. METHODS: We retrospectively reviewed 12 cases of spinal dumbbell tumors treated via one-stage surgical resection by the same senior spinal surgeon from January 2013 and April 2017...
September 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28956469/alpha-beta-double-negative-t-cells-in-children-with-systemic-lupus-erythematosus-the-relation-to-disease-activity-and-characteristics
#18
Zeinab A El-Sayed, Rasha H El-Owaidy, Neama L Mohamed, Beshoy A Shehata
OBJECTIVES: We aimed to investigate alpha beta double negative (αβ DN) T-cell percentages in juvenile systemic lupus erythematosus (JSLE) and their relation to disease activity and organ involvement. METHODS: This prospective study was carried out over a period of 12 months and included 21 JSLE patients and 20 healthy matched controls. SLE disease activity index 2000 (SLEDAI-2K) scores were recorded in addition to αβ DN T-cell percentages measurement at enrollment and after remission...
September 28, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28948805/neuroborreliosis-in-patients-hospitalised-for-lyme-borreliosis-in-the-czech-republic-in-2003-2013
#19
B Kříž, M Malý, M Daniel
STUDY OBJECTIVE: The objective was to analyse and evaluate a cohort of Lyme borreliosis (LB) patients with neuroborreliosis (LNB) hospitalised in the Czech Republic in 2003-2013. MATERIAL AND METHODS: Data analysed in this study were obtained from the National Register of Hospitalised Patients, which is a nationwide population register maintained at the Institute of Health Information and Statistics of the Czech Republic. Data collection from all departments of bed care establishments are regularly processed every year...
2017: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/28946178/the-impact-of-temporary-clipping-during-aneurysm-surgery-on-the-incidence-of-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#20
Vesna Malinova, Bawarjan Schatlo, Martin Voit, Patricia Suntheim, Veit Rohde, Dorothee Mielke
OBJECTIVE Clipping of a ruptured intracranial aneurysm requires some degree of vessel manipulation, which in turn is believed to contribute to vasoconstriction. One of the techniques used during surgery is temporary clipping of the parent vessel. Temporary clipping may either be mandatory in cases of premature rupture (rescue) or represent a precautionary or facilitating surgical step (elective). The aim of this study was to study the association between temporary clipping during aneurysm surgery and the incidence of vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (aSAH) in a large clinical series...
September 15, 2017: Journal of Neurosurgery
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