Dominic Habgood-Coote, Clare Wilson, Chisato Shimizu, Anouk M Barendregt, Ria Philipsen, Rachel Galassini, Irene Rivero Calle, Lesley Workman, Philipp K A Agyeman, Gerben Ferwerda, Suzanne T Anderson, J Merlijn van den Berg, Marieke Emonts, Enitan D Carrol, Colin G Fink, Ronald de Groot, Martin L Hibberd, John Kanegaye, Mark P Nicol, Stéphane Paulus, Andrew J Pollard, Antonio Salas, Fatou Secka, Luregn J Schlapbach, Adriana H Tremoulet, Michael Walther, Werner Zenz, Michiel Van der Flier, Heather J Zar, Taco Kuijpers, Jane C Burns, Federico Martinón-Torres, Victoria J Wright, Lachlan J M Coin, Aubrey J Cunnington, Jethro A Herberg, Michael Levin, Myrsini Kaforou
BACKGROUND: Appropriate treatment and management of children presenting with fever depend on accurate and timely diagnosis, but current diagnostic tests lack sensitivity and specificity and are frequently too slow to inform initial treatment. As an alternative to pathogen detection, host gene expression signatures in blood have shown promise in discriminating several infectious and inflammatory diseases in a dichotomous manner. However, differential diagnosis requires simultaneous consideration of multiple diseases...
August 11, 2023: Med