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https://www.readbyqxmd.com/read/29053485/the-effects-of-electroconvulsive-therapy-augmentation-of-antipsychotic-treatment-on-cognitive-functions-in-patients-with-treatment-resistant-schizophrenia
#1
Bjanka Vuksan Ćusa, Nataša Klepac, Nenad Jakšić, Zoran Bradaš, Marija Božičević, Natalia Palac, Marina Šagud
OBJECTIVES: Treatment-resistant schizophrenia (TRS) continues to be a challenge in modern psychiatry. Most of these patients have severe neurocognitive deficits. Electroconvulsive therapy (ECT) has proved effective and safe in the treatment of TRS, but because of potential neurocognitive adverse effects, it is associated with many controversies. The aim of this prospective, open study was to evaluate the effects of ECT augmentation of antipsychotics on cognitive functions in patients with TRS...
October 19, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29052951/basic-self-disturbance-neurocognition-and-metacognition-a-pilot-study-among-help-seeking-adolescents-with-and-without-attenuated-psychosis-syndrome
#2
Dan Koren, Ravit Scheyer, Noa Reznik, Merav Adres, Alan Apter, Josef Parnas, Larry J Seidman
AIM: The goal of this pilot study was to assess the association between basic self-disturbance (SD) and deficits in neurocognitive and metacognitive functioning among help-seeking adolescents with and without attenuated psychosis syndrome (APS). METHODS: Sixty-one non-psychotic, help-seeking adolescents (age 13-18) were assessed with the examination of anomalous self-experience, the structured interview for prodromal syndromes and a new metacognitive approach to neurocognitive assessment applied to two non-social (executive functions and verbal memory) and two social (theory of mind and emotion recognition) domains...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29043468/cognitive-and-behavioral-disorders-in-parkinson-s-disease-an-update-i-cognitive-impairments
#3
Costanza Papagno, Luigi Trojano
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor symptoms such as rigidity, rest tremor, and bradykinesia. However, a growing body of evidence demonstrated that PD encompasses several non-motor disturbances as well, such as cognitive impairment. Cognitive defects can be present since early stages of the disease but tend to dominate the clinical picture as the disease progresses. Around 40% of patients with PD present with cognitive impairments in several cognitive domains including attention, working memory and executive functions, language, visuospatial skills, and episodic memory; in later stages of the disease, cognitive defects and associated behavioral disorders concur to determine clinically relevant PD-associated dementia...
October 17, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29037500/motor-behavioural-and-cognitive-correlates-of-fatigue-in-early-de-novo-parkinson-disease-patients
#4
M Siciliano, L Trojano, R De Micco, A De Mase, F Garramone, A Russo, G Tedeschi, A Tessitore
INTRODUCTION: Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS: Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES)...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29035741/association-between-psychological-distress-subjective-cognitive-complaints-and-objective-neuropsychological-functioning-in-brain-tumor-patients
#5
Aiste Pranckeviciene, Vytenis Pranas Deltuva, Arimantas Tamasauskas, Adomas Bunevicius
OBJECTIVES: Psychological distress and cognitive impairment are common complications in patients with brain tumors that are associated with poor quality of life and worse prognosis. This pilot study aimed to evaluate the associations between psychological distress, subjective cognitive complaints and baseline neuropsychological performance of brain tumor patients before neurosurgery. PATIENTS AND METHODS: Sixty-two patients with various brain tumors referred for routine neuropsychological assessment 2-3days before neurosurgery participated in the study...
October 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29035066/multiple-self-reported-sleep-measures-are-differentially-associated-with-cognitive-performance-in-community-dwelling-nondemented-elderly
#6
John P K Bernstein, Matthew Calamia, Jeffrey N Keller
OBJECTIVE: To examine associations between daytime and insomnia-related sleep problems with different domains of cognitive functioning and determine whether subclinical depressive symptoms and age moderate these associations. METHOD: A total of 903 cognitively healthy older adults enrolled in a longitudinal aging study completed the UDS neuropsychological battery (measuring attention, executive functioning, episodic memory, language and processing speed). Subclinical depressive symptoms were also assessed and self-reported measures of sleep were administered...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29032789/symptom-dimensions-of-depression-and-apathy-and-their-relationship-with-cognition-in-parkinson-s-disease
#7
Sarah M Szymkowicz, Vonetta M Dotson, Jacob D Jones, Michael S Okun, Dawn Bowers
OBJECTIVES: Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptom dimensions of depression and apathy on cognition is not well understood. The current study investigated the relationship between symptom dimensions of depression and apathy, based on factors identified in Kirsch-Darrow et al. (2011), and memory and executive function in PD. METHODS: A sample of 138 non-demented individuals with PD (mean age=64...
October 16, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29024893/plasma-ratio-of-clozapine-to-n-desmethylclozapine-can-predict-cognitive-performance-in-treatment-resistant-psychotic-patients
#8
Conrad Molins, Mar Carceller-Sindreu, Helena Navarro, Cristina Carmona, Marina Piñeiro, Estrella Martínez, Enric Álvarez, Maria J Portella
Cognitive symptoms play a central role in schizophrenia and are strongly associated with social functioning. Treatment with clozapine presents controversial results regarding its effects on cognition. The opposite effects of clozapine and n-desmethylclozapine (NDMC) on cholinergic system have been suggested to underlie these inconclusive findings. The aim of this study is to determine whether clozapine/NDMC ratio can predict cognitive performance in patients with treatment-resistant psychosis. Nineteen clinically stable patients with schizophrenia or schizoaffective disorder treated with clozapine monotherapy completed demographic and clinical interviews...
October 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28991146/effect-of-caregiver-training-on-the-neurodevelopment-of-hiv-exposed-uninfected-children-and-caregiver-mental-health-a-ugandan-cluster-randomized-controlled-trial
#9
Michael J Boivin, Noeline Nakasujja, Itziar Familiar-Lopez, Sarah M Murray, Alla Sikorskii, Jorem Awadu, Cilly Shohet, Deborah Givon, Horacio Ruiseñor-Escudero, Elizabeth E Schut, Robert O Opoka, Judith K Bass
OBJECTIVE: Early childhood development programs typically combine healthy nutrition and cognitive stimulation in an integrated model. We separately delivered these 2 components in a cluster-randomized controlled trial to evaluate their comparative effectiveness in promoting healthy child development and caregiver mental health. This is the first study to do so for HIV-affected children and their infected mothers. METHODS: Two hundred twenty-one HIV-exposed but uninfected child (2-3 years old) and caregiver dyads in 18 geographic clusters in Eastern Uganda were randomized by cluster to receive biweekly individualized sessions of either (1) Mediational Intervention for Sensitizing Caregivers (MISC) training emphasizing cognitive stimulation or (2) Uganda Community Based Association for Child Welfare (UCOBAC) program that delivered health and nutrition training...
October 4, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28990153/executive-functions-and-externalizing-symptoms-common-and-unique-associations
#10
Michael J Sulik, Jelena Obradović
In discussing the four papers in this special issue, we provide our perspective on the authors' contributions and suggest directions for future research. First, we highlight the usefulness of the bi-factor model for investigating relations among specific aspects of executive functions (EFs) and externalizing symptoms. Next, we examine the role of EFs as a protective factor that can moderate the relation between risk factors - specifically, callous-unemotional behaviors - on externalizing symptoms. And finally, we address the contributions of innovative measurement approaches to understanding the relations between EFs and externalizing symptoms, using the state-space grid methodology as an example...
October 9, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28971146/clinical-and-molecular-correlates-in-fragile-x-premutation-females
#11
Poonnada Jiraanont, Stefan R Sweha, Reem R AlOlaby, Marisol Silva, Hiu-Tung Tang, Blythe Durbin-Johnson, Andrea Schneider, Glenda M Espinal, Paul J Hagerman, Susan M Rivera, David Hessl, Randi J Hagerman, Nuanchan Chutabhakdikul, Flora Tassone
The prevalence of the fragile X premutation (55-200 CGG repeats) among the general population is relatively high, but there remains a lack of clear understanding of the links between molecular biomarkers and clinical outcomes. In this study we investigated the correlations between molecular measures (CGG repeat size, FMR1 mRNA, FMRP expression levels, and methylation status at the promoter region and in FREE2 site) and clinical phenotypes (anxiety, obsessive compulsive symptoms, depression and executive function deficits) in 36 adult premutation female carriers and compared to 24 normal control subjects...
June 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/28968564/network-basis-of-suicidal-ideation-in-depressed-adolescents
#12
Sarah J Ordaz, Meghan S Goyer, Tiffany C Ho, Manpreet K Singh, Ian H Gotlib
BACKGROUND: Suicidal ideation rates rise precipitously in adolescence, contributing to risk for attempts. Although researchers are beginning to explore the brain basis of attempts in depressed adolescents, none have focused on the basis of ideation, which has implications for prevention. This study examined the association between intrinsic neural network coherence and the severity of suicidal ideation in depressed adolescents. METHODS: Forty adolescents diagnosed with Major Depressive Disorder were administered the Columbia-Suicide Severity Rating Scale and underwent resting-state fMRI...
September 22, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28965701/environmental-exposure-to-manganese-in-air-tremor-motor-and-cognitive-symptom-profiles
#13
E S Kornblith, S L Casey, D T Lobdell, M A Colledge, R M Bowler
BACKGROUND: Excessive exposure to manganese (Mn) may cause parkinsonian-like motor and tremor symptoms and adverse cognitive effects, including problems with executive functioning (EF), resembling those found in later-stage Parkinson's disease (PD). Studies seeking to differentiate PD patients into subgroups with associated cognitive and functional outcomes using motor and tremor symptoms identified tremor-dominant (TD) and non-tremor dominant (NTD) subtypes. It is unclear whether differing patterns of pathophysiology and symptoms exist in Mn neurotoxicity, as they do in PD...
September 28, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28960841/everyday-executive-function-predicts-adaptive-and-internalizing-behavior-among-children-with-and-without-autism-spectrum-disorder
#14
Emily Gardiner, Grace Iarocci
Individuals with autism spectrum disorder (ASD) demonstrate challenges with executive function (EF), adaptive behavior, and mental health, all of which place long-term wellbeing at risk. In the current study we examined the relation between parent-rated EF and adaptive functioning and internalizing symptoms (anxiety, depression), as we expected that identifying the specific EF domains most closely related to these indices of functioning would illuminate opportunities for targeted intervention. Participants included 59 children and adolescents with ASD (M = 10...
September 27, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28951142/cognitive-deficit-in-patients-with-paranoid-schizophrenia-its-clinical-and-laboratory-correlates
#15
Mariia Dorofeikova, Nikolay Neznanov, Nataliia Petrova
The aim of this study was to search for correlates of cognitive impairment in patients with paranoid schizophrenia among clinical, demographic, anamnestic and biochemical markers (NSE, S100B protein, BDNF, hs-CRP). Patients with paranoid schizophrenia (n=125) were examined using the Brief Assessment of Cognitive Function in Schizophrenia, the Rey-Osterrieth Complex Figure task, and a number of clinical scales including the Positive and Negative Syndrome Scale. The majority of patients demonstrated cognitive impairment...
September 20, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28947182/pain-aging-and-dementia-towards-a-biopsychosocial-model
#16
REVIEW
Lucia Gagliese, Lynn R Gauthier, Nadine Narain, Tamlyn Freedman
Dementia is a progressive disease associated with irreversible impairment and loss of cognitive abilities. About half of older people with dementia experience pain. In this paper, we propose that pain in older people with dementia can be conceptualized as the final result of the interaction of three heterogeneous phenomena, pain, aging, and dementia, which are created and influenced by the interactions of predisposing, lifelong, and current biopsychosocial factors. We review pain assessment in people with dementia using both self-report and observational/behavioral measures...
September 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28945319/the-association-between-theory-of-mind-executive-function-and-the-symptoms-of-autism-spectrum-disorder
#17
Catherine R G Jones, Emily Simonoff, Gillian Baird, Andrew Pickles, Anita J S Marsden, Jenifer Tregay, Francesca Happé, Tony Charman
It has been strongly argued that atypical cognitive processes in autism spectrum disorder (ASD) contribute to the expression of behavioural symptoms. Comprehensive investigation of these claims has been limited by small and unrepresentative sample sizes and the absence of wide-ranging task batteries. The current study investigated the cognitive abilities of 100 adolescents with ASD (mean age = 15 years 6 months), using 10 tasks to measure the domains of theory of mind (ToM) and executive function (EF). We used structural equation modelling as a statistically robust way of exploring the associations between cognition and parent-reported measures of social communication and restricted and repetitive behaviours (RRBs)...
September 25, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28933882/maternal-depressive-symptoms-mother-child-interactions-and-children-s-executive-function
#18
Noa Gueron-Sela, Marie Camerota, Michael T Willoughby, Lynne Vernon-Feagans, Martha J Cox
This study examined the independent and mediated associations between maternal depression symptoms (MDS), mother-child interaction, and child executive function (EF) in a prospective longitudinal sample of 1,037 children (50% boys) from predominantly low-income and rural communities. When children were 6, 15 and 24 months of age, mothers reported their level of depressive symptomatology. At 24 and 36 months of age, mother-child interactions during play were rated for warmth-sensitivity and harsh-intrusiveness, and dyadic joint attention and maternal language complexity were assessed from a book sharing activity...
September 21, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28922588/persistent-negative-symptoms-in-first-episode-psychosis-early-cognitive-and-social-functioning-correlates-and-differences-between-early-and-adult-onset
#19
Olga Puig, Immaculada Baeza, Elena de la Serna, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Mara Parellada, Iluminada Corripio, Eduard Vieta, Julio Bobes, Judith Usall, Fernando Contreras, Manuel J Cuesta, Miquel Bernardo, Josefina Castro-Fornieles, The PEPs Group
OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011)...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28919130/the-nuts-and-bolts-of-cognitive-remediation-exploring-how-different-training-components-relate-to-cognitive-and-functional-gains
#20
Matteo Cella, Til Wykes
BACKGROUND: Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the relationship between CR ingredients, including alliance with a therapist, and therapy outcomes. METHOD: This is a secondary analysis based on data from a published randomised controlled trial comparing CR+treatment-as-usual (TAU) to TAU alone...
September 14, 2017: Schizophrenia Research
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