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https://www.readbyqxmd.com/read/28733341/activity-limitations-and-subjective-well-being-after-stroke
#1
Darin B Zahuranec, Lesli E Skolarus, Chunyang Feng, Vicki A Freedman, James F Burke
OBJECTIVE: As limitations in activities of daily living are major components of many stroke outcome scales, we examined how well activity limitations predicted subjective well-being among stroke survivors in a nationally representative survey. METHODS: Individuals with a self-reported history of stroke were identified from the National Health and Aging Trends Study. Subjective well-being (primary outcome) was assessed with a validated 7-item measure (higher = greater well-being) assessing emotions (cheerful, bored, full of life, and upset) and self-realization (purpose in life, self-acceptance, and environmental mastery)...
July 21, 2017: Neurology
https://www.readbyqxmd.com/read/28723827/neurocognitive-and-symptom-trajectories-of-adhd-from-childhood-to-early-adolescence
#2
Andrea L Murray, Thomas Robinson, Gail Tripp
OBJECTIVE: This longitudinal study investigated changes in neurocognitive functioning from childhood to early adolescence in a sample of children diagnosed with DSM-IV attention-deficit hyperactivity disorder (ADHD). It also compared the neurocognitive trajectories of children who continued to meet the diagnostic criteria for ADHD at follow-up and those in partial remission. METHODS: Children diagnosed with ADHD (N = 55) were tested at baseline (M = 7.7 years, SD = 1...
July 17, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28716235/psychosis-in-parkinson-s-disease-from-the-soft-signs-to-the-hard-science
#3
REVIEW
Abhishek Lenka, Priyantha Herath, Rita Christopher, Pramod Kumar Pal
Patients with Parkinson's disease (PD) may develop a wide spectrum of non-motor symptoms during the course of illness. Psychosis is one such commonly observed non-motor symptoms of PD. Although several studies based on neuroimaging, genetics, retinal imaging, and neuropsychological evaluations have explored the pathogenesis of psychosis in PD; exact neural correlates are yet to be understood. Identification of factors related to psychosis in PD is important, as psychosis has been reported to be associated with higher rates of mortality, caregiver distress, and nursing home placements...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28715675/resting-state-brain-networks-in-patients-with-parkinson-s-disease-and-impulse-control-disorders
#4
Alessandro Tessitore, Gabriella Santangelo, Rosa De Micco, Alfonso Giordano, Simona Raimo, Marianna Amboni, Fabrizio Esposito, Paolo Barone, Gioacchino Tedeschi, Carmine Vitale
INTRODUCTION: To investigate intrinsic neural networks connectivity changes in Parkinson's disease (PD) patients with and without impulse control disorders (ICD). METHODS: Fifteen patients with PD with ICD (ICD+), 15 patients with PD without ICD (ICD-) and 24 age and sex-matched healthy controls (HC) were enrolled in the study. To identify patients with and without ICD and/or punding, we used the Minnesota Impulsive Disorders Interview (MIDI) and a clinical interview based on diagnostic criteria for each symptom...
June 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28713264/white-matter-changes-related-gait-and-executive-function-deficits-associations-with-age-and-parkinson-s-disease
#5
Jennifer Sartor, Kristina Bettecken, Felix P Bernhard, Marc Hofmann, Till Gladow, Tobias Lindig, Meltem Ciliz, Mara Ten Kate, Johanna Geritz, Sebastian Heinzel, Marije Benedictus, Philip Scheltens, Markus A Hobert, Walter Maetzler
Background: White matter changes (WMC) are a common finding among older adults and patients with Parkinson's disease (PD), and have been associated with, e.g., gait deficits and executive dysfunction. How the factors age and PD influence WMC-related deficits is, to our best knowledge, not investigated to date. We hypothesized that advanced age and presence of PD leads to WMC-related symptoms while practicing tasks with a low complexity level, and low age and absence of PD leads to WMC-related symptoms while practicing tasks with a high complexity level...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28712815/asymptomatic-carotid-stenosis-is-associated-with-cognitive%C3%A2-impairment
#6
Brajesh K Lal, Moira C Dux, Siddhartha Sikdar, Carly Goldstein, Amir A Khan, John Yokemick, Limin Zhao
BACKGROUND: Cerebrovascular risk factors (eg, hypertension, coronary artery disease) and stroke can lead to vascular cognitive impairment. The Asymptomatic Carotid Stenosis and Cognitive Function study evaluated the isolated impact of asymptomatic carotid stenosis (no prior ipsilateral or contralateral stroke or transient ischemic attack) on cognitive function. Cerebrovascular hemodynamic and carotid plaque characteristics were analyzed to elucidate potential mechanisms affecting cognition...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28709771/gesture-impairments-in-schizophrenia-are-linked-to-increased-movement-and-prolonged-motor-planning-and-execution
#7
Lars Levi Dutschke, Katharina Stegmayer, Fabian Ramseyer, Stephan Bohlhalter, Tim Vanbellingen, Werner Strik, Sebastian Walther
Schizophrenia patients present with a variety of impaired nonverbal communication skills. Performance of hand gestures is frequently impaired and associated with ratings of motor abnormalities. However, the impact of motor abnormalities to gesture performance remains unclear. To test the association between quantitative measures of motor behavior and qualitative ratings of gesture performance, we quantified movement parameters semi-automatically in videotaped recordings of gesture assessment. Thirty-one patients with schizophrenia (77...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28707277/open-label-allopregnanolone-treatment-of-men-with-fragile-x-associated-tremor-ataxia-syndrome
#8
J Y Wang, A M Trivedi, N R Carrillo, J Yang, A Schneider, C Giulivi, P Adams, F Tassone, K Kim, S M Rivera, N Lubarr, C-Y Wu, R W Irwin, R D Brinton, J M Olichney, M A Rogawski, R J Hagerman
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting approximately 45% of male and 16% of female carriers of the FMR1 premutation over the age of 50 years. Currently, no effective treatment is available. We performed an open-label intervention study to assess whether allopregnanolone, a neurosteroid promoting regeneration and repair, can improve clinical symptoms, brain activity, and magnetic resonance imaging (MRI) measurements in patients with FXTAS. Six patients underwent weekly intravenous infusions of allopregnanolone (2-6 mg over 30 min) for 12 weeks...
July 13, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28703093/cognitive-performance-norms-from-the-korean-genome-and-epidemiology-study-koges
#9
Hyun Kim, Rhoda Au, Robert J Thomas, Chang-Ho Yun, Seung Ku Lee, Changsu Han, Chol Shin
BACKGROUND: While normative data on neuropsychological performance provide baseline metrics for the assessment and diagnosis of mild cognitive impairment and dementia, a lack of comparative normative data in non-Caucasian populations makes it difficult to conduct similar evaluations and studies in individuals from diverse backgrounds. The current paper aims to provide normative data on a range of cognitive measures in a Korean general population sample and investigate various demographic and health variables associated with cognitive performance in this representative population...
July 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28701494/loss-of-phosphodiesterase-4-in-parkinson-disease-relevance-to-cognitive-deficits
#10
Flavia Niccolini, Heather Wilson, Gennaro Pagano, Christopher Coello, Mitul A Mehta, Graham E Searle, Roger N Gunn, Eugenii A Rabiner, Thomas Foltynie, Marios Politis
OBJECTIVE: To assess in vivo the expression of phosphodiesterase 4 (PDE4) and its relevance to cognitive symptoms in patients with Parkinson disease (PD) using [(11)C]rolipram PET. METHODS: We studied 12 levodopa-treated patients with PD with no concurrent diagnosis of mild cognitive impairment or dementia. Their data were compared with those from 12 healthy controls. All participants underwent neuropsychiatric and cognitive assessment using the Cambridge Neuropsychological Test Automated Battery...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28694011/the-relationship-between-salivary-c-reactive-protein-and-cognitive-function-in-children-aged-11-14years-does-psychopathology-have-a-moderating-effect
#11
Alexis E Cullen, Ben M Tappin, Patricia A Zunszain, Hannah Dickson, Ruth E Roberts, Naghmeh Nikkheslat, Mizan Khondoker, Carmine M Pariante, Helen L Fisher, Kristin R Laurens
Elevated C-reactive protein (CRP), a non-specific biomarker of systemic bodily inflammation, has been associated with more pronounced cognitive impairments in adults with psychiatric disorders, particularly in the domains of memory and executive function. Whether this association is present in early life (i.e., the time at which the cognitive impairments that characterise these disorders become evident), and is specific to those with emerging psychiatric disorders, has yet to be investigated. To this end, we examined the association between salivary CRP and cognitive function in children aged 11-14years and explored the moderating effect of psychopathology...
July 8, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28693655/longitudinal-assessment-of-self-and-informant-subjective-cognitive-complaints-in-a-sample-of-healthy-late-middle-aged-adults-enriched-with-a-family-history-of-alzheimer-s-disease
#12
Christopher R Nicholas, N Maritza Dowling, Annie M Racine, Lindsay R Clark, Sara E Berman, Rebecca L Koscik, Sanjay Asthana, Bruce Hermann, Mark A Sager, Sterling C Johnson
OBJECTIVES: The purpose of this study was to investigate the longitudinal trajectory of self- and informant-subjective cognitive complaints (SCC), and to determine if SCC predict longitudinal changes in objective measures (OM) of cognitive function. METHODS: The study included healthy and cognitively normal late middle-aged adults enriched with a family history of AD who were evaluated at up to three visits over a 4-year period. At each visit (Visit 1-3), self- and informant-SCC and OM were evaluated...
July 11, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28689261/investigation-of-cognitive-circuits-using-steady-state-cerebral-blood-volume-and-diffusion-tensor-imaging-in-patients-with-mild-cognitive-impairment-following-electrical-injury
#13
Chang-Hyun Park, Cheong Hoon Seo, Myung Hun Jung, So Young Joo, Soyeon Jang, Ho Young Lee, Suk Hoon Ohn
PURPOSE: We utilized cerebral blood volume (CBV) magnetic resonance imaging and diffusion tensor imaging (DTI) to investigate changes in cognitive networks in patients experiencing cognitive dysfunction following electrical injury. METHODS: Cognitive function was assessed across various domains, including attention, verbal memory, executive function, and language. Depressive symptoms were also evaluated. CBV maps and DTI measures were obtained from 24 patients (age, 41...
July 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28686560/-hoarding-disorder-in-dsm-5-clinical-description-and-cognitive-approach
#14
L Kalogeraki, I Michopoulos
Hoarding disorder is characterized by difficulty discarding or parting with possessions regardless their actual value as well as, in most cases, persistent acquisition of objects. Possessions are accumulated in large numbers that fill up and clutter active living space to the extent that its intended use is no longer possible resulting to significant functional impairment and/or distress. Saving and difficulty discarding appear to be associated to subjective beliefs about the instrumental, sentimental or intrinsic value of objects...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28677009/the-effects-of-physical-activity-and-fatigue-on-cognitive-performance-in-breast-cancer-survivors
#15
Diane K Ehlers, Susan Aguiñaga, Josh Cosman, Joan Severson, Arthur F Kramer, Edward McAuley
PURPOSE: Research suggests that physical activity may be a promising treatment for cancer-related cognitive impairment; however, evidence is limited by small samples and self-report measures and little is known about the underlying mechanisms. The purpose of this study was to examine the effects of physical activity on cognitive function in a national sample of breast cancer survivors (BCSs) using objective measures. We hypothesized that physical activity's effects on cognition would be indirect through survivors' self-reported fatigue...
July 4, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28667910/anxiety-and-depression-in-people-with-epilepsy-the-contribution-of-metacognitive-beliefs
#16
Peter L Fisher, Adam J Noble
PURPOSE: Anxiety and depressive disorders frequently occur in people with epilepsy (PWE). An information processing model of psychopathology, the Self-Regulatory Executive Function (S-REF) model specifies that maladaptive metacognitive beliefs and processes play a fundamental role in the development and maintenance of anxiety and depression. This study explored whether metacognitive beliefs would explain additional variance in anxiety and depression after accounting for demographics, physical and/or psychiatric illnesses, epilepsy characteristics and medication issues...
June 20, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28666826/affective-symptoms-in-schizophrenia-are-strongly-associated-with-neurocognitive-deficits-indicating-disorders-in-executive-functions-visual-memory-attention-and-social-cognition
#17
Buranee Kanchanatawan, Supaksorn Thika, George Anderson, Piotr Galecki, Michael Maes
The aim of this study was to assess the neurocognitive correlates of affective symptoms in schizophrenia. Towards this end, 40 healthy controls and 80 schizophrenia patients were investigated with six tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB), assessing spatial working memory, paired-association learning, one touch stocking, rapid visual information (RVP), emotional recognition test and intra/extradimensional set shifting. The Hamilton Depression (HDRS) and Anxiety (HAMA) Rating Scales and the Calgary Depression Scale for Schizophrenia (CDSS) as well as the Positive and Negative Syndrome Scale (PANSS) were also used...
June 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28659771/cognitive-impairment-in-patients-with-chronic-neuropathic-or-radicular-pain-an-interaction-of-pain-and-age
#18
Orla Moriarty, Nancy Ruane, David O'Gorman, Chris H Maharaj, Caroline Mitchell, Kiran M Sarma, David P Finn, Brian E McGuire
A growing body of empirical research has confirmed an association between chronic pain and cognitive dysfunction. The aim of the present study was to determine whether cognitive function is affected in patients with a diagnosis of chronic neuropathic or radicular pain relative to healthy control participants matched by age, gender, and years of education. We also examined the interaction of pain with age in terms of cognitive performance. Some limitations of previous clinical research investigating the effects of chronic pain on cognitive function include differences in the pain and cognitive scale materials used, and the heterogeneity of patient participants, both in terms of their demographics and pathological conditions...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28659161/associations-between-cerebral-amyloid-and-changes-in-cognitive-function-and-falls-risk-in-subcortical-ischemic-vascular-cognitive-impairment
#19
Elizabeth Dao, John R Best, Ging-Yuek Robin Hsiung, Vesna Sossi, Claudia Jacova, Roger Tam, Teresa Liu-Ambrose
BACKGROUND: To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adults with a primary clinical diagnosis of subcortical ischemic vascular cognitive impairment (SIVCI). METHODS: This is a secondary analysis of data acquired from a subset of participants (N = 22) who were enrolled in a randomized controlled trial of aerobic exercise (NCT01027858)...
June 28, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28657683/association-between-social-functioning-and-prefrontal-cortex-function-during-a-verbal-fluency-task-in-schizophrenia-a-near-infrared-spectroscopic-study
#20
Masashi Itakura, Shenghong Pu, Hiroaki Ohdachi, Hiroshi Matsumura, Katsutoshi Yokoyama, Izumi Nagata, Masaaki Iwata, Koichi Kaneko
AIM: Impaired social functioning is a common characteristic of patients with schizophrenia. Social functioning requires the complex operation of various executive functions. Deficits in the prefrontal cortex (PFC) have been implicated in executive dysfunction. Here we aimed to clarify the relationship between subjectively and objectively assessed social functioning, and their associations with PFC function in patients with schizophrenia. METHODS: Twenty-three patients and twenty-two age- and sex-matched healthy controls (HCs) were assessed...
June 28, 2017: Psychiatry and Clinical Neurosciences
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