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https://www.readbyqxmd.com/read/28224110/comparison-of-inhaled-milrinone-nitric-oxide-and-prostacyclin-in-acute-respiratory-distress-syndrome
#1
Martin Albert, Daniel Corsilli, David R Williamson, Marc Brosseau, Patrick Bellemare, Stéphane Delisle, Anne Qn Nguyen, France Varin
AIM: To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome (ARDS). METHODS: Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of iNO (20 ppm) or nebulized epoprostenol (10 μg/mL) was done in all patients...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28217583/profile-of-trauma-patients-in-the-emergency-department-of-a-tertiary-care-hospital-in-south-india
#2
Kundavaram Paul Prabhakar Abhilash, Nilanchal Chakraborthy, Gautham Raja Pandian, Vineet Subodh Dhanawade, Thomas Kurien Bhanu, Krishna Priya
BACKGROUND: Trauma is an increasing cause of morbidity and mortality in India. This study was done to improve the understanding of the mode of trauma, severity of injuries, and outcome of trauma victims in our hospital. MATERIALS AND METHODS: This was a retrospective observational study of all adult trauma patients more than 18-year-old presenting to our emergency department (ED). Details of the incident, injuries, and outcome were noted. RESULTS: The ED attended to 16,169 patients during the 3-month study period with 10% (1624/16,169) being adult trauma incidents...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28195897/base-of-skull-blocks-for-open-reduction-and-internal-fixation-of-faciomaxillary-fractures
#3
Sandeep Mehrotra, Sunil Anand
INTRODUCTION: Faciomaxillary fractures (FMF) occur in a significant proportion of trauma patients. Nearly all polytrauma patients and even those with isolated FMF are managed under general anesthesia for definitive management. We propose the use of regional nerve blocks as a safe and effective means for open reduction and fixation of isolated FMF. AIM AND OBJECTIVES: The aim is to evaluate the feasibility, effectiveness and safety of base of skull maxillomandibular and distal trigeminal nerve blocks in the management of FMF...
February 14, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28190439/neurologic-complications-of-polytrauma
#4
R M Jha, L Shutter
Neurologic complications in polytrauma can be classified by etiology and clinical manifestations: neurovascular, delirium, and spinal or neuromuscular problems. Neurovascular complications include ischemic strokes, intracranial hemorrhage, or the development of traumatic arteriovenous fistulae. Delirium and encephalopathy have a reported incidence of 67-92% in mechanically ventilated polytrauma patients. Causes include sedation, analgesia/pain, medications, sleep deprivation, postoperative state, toxic ingestions, withdrawal syndromes, organ system dysfunction, electrolyte/metabolic abnormalities, and infections...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28187475/concomitant-sternal-fracture-in-flail-chest-an-analysis-of-21-741-polytrauma-patients-from-the-traumaregister-dgu%C3%A2
#5
Stefan Schulz-Drost, Sebastian Krinner, Andreas Langenbach, Pascal Oppel, Rolf Lefering, Dominic Taylor, Friedrich F Hennig, Andreas Mauerer
Background Isolated sternal fractures (SFs) rarely show complications, but their influence in a thorax trauma of the seriously injured still remains unclear. Methods A retrospective analysis of the TraumaRegister DGU(®) was performed involving the years 2009 to 2013 (Injury Severity Score [ISS] ≥ 16, primary admission to a trauma center). Cohort formation: Unilateral and bilateral flail chest (FC) injuries with and without a concomitant SF, respectively. Results In total, 21,741 patients (25% female) met the inclusion criteria, with 3,492 (16...
February 10, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28164622/using-the-expression-of-mirnas-as-biomarkers-for-the-evaluation-acute-respiratory-distress-syndrome-in-the-critically-ill-polytrauma-patient
#6
REVIEW
Marius Papurica, Alexandru F Rogobete, Carmen A Cradigati, Mirela Sarandan, Raluca Dumache, Lavinia M Bratu, Sonia E Popovici, Dorel Sandesc, Corina Vernic, Ovidiu H Bedreag
BACKGROUND: A high percentage of critically ill polytrauma patients develop acute respiratory distress syndrome (ARDS), both because of the primary traumatic injuries and because of the secondary post-traumatic injuries. For adequate management of these patients, new complex evaluation and monitoring methods are needed, methods that could answer as many questions as possible regarding the pathophysiological changes associated with ARDS. Currently, a series of clinical and biochemical markers are being used which unfortunately do not respond to the needs of an intensive care clinician...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164614/using-circulating-mirnas-as-biomarkers-for-the-evaluation-and-monitoring-of-the-mitochondrial-damage-in-the-critically-ill-polytrauma-patients
#7
REVIEW
Ovidiu H Bedreag, Marius Papurica, Alexandru F Rogobete, Dorel Sandesc, Raluca Dumache, Carmen A Cradigati, Mirela Sarandan, Lavinia M Bratu, Sonia E Popovici, Laurentiu V Sima
BACKGROUND: The multiple-traumatic critical patient presents a variety of pathophysiological, cellular, and molecular dysfunctions. One of the most important is represented by mitochondrial damage which afterwards is responsible for the augmentation and worsening of a series of pathologies that lead to the worsening of the clinical status of the patient. The severe inflammatory response, sepsis, and the redox imbalance are other pathologies that together with the multiple traumas are responsible for the mitochondrial dysfunctions...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164593/modulation-of-the-redox-expression-and-inflammation-response-in-the-critically-ill-polytrauma-patient-with-thoracic-injury-statistical-correlations-between-antioxidant-therapy
#8
Ovidiu H Bedreag, Alexandru F Rogobete, Dorel Sandesc, Carmen A Cradigati, Mirela Sarandan, Sonia E Popovici, Raluca Dumache, Florin G Horhat, Corina Vernic, Laurentiu V Sima, Loredana Luca, Marius Papurica
BACKGROUND: One of the major causes of mortality in the world is represented by multiple traumas. Thoracic trauma is commonly associated with polytraumas. A series of physiopathological complications follow polytraumas, leading to a significant decrease in the survival rate. As a result of injuries, significant quantities of free radicals (FR) are produced, responsible for oxidative stress (OS). To minimize the effects of OS, we recommend the administration of antioxidant substances. In this study we want to highlight statistically significant correlations between antioxidant therapy and a series of clinical variables...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164582/the-use-of-lipid-peroxidation-expression-as-a-biomarker-for-the-molecular-damage-in-the-critically-ill-polytrauma-patient
#9
REVIEW
Florin G Horhat, Alexandru F Rogobete, Marius Papurica, Dorel Sandesc, Sonia Tanasescu, Victor Dumitrascu, Monica Licker, Razvan Nitu, Carmen A Cradigati, Mirela Sarandan, Ovidiu Boruga, Ciprian D Crisan, Emil Ungureanu, Daniela M Popa, Sonia E Popovici, Ovidiu H Bedreag
BACKGROUND: The critically ill polytrauma patient, apart from the primary, traumatic injuries and the secondary, port-traumatic injuries, presents with a series of molecular disasters. Dysfunctions of the biochemical pathways and molecular damage add to the worsening of the clinical status of these patients, one of the most well-known molecular phenomena being oxidative stress (OS), responsible for an escalation of the inflammatory status, multiple infections, and multiple organ dysfunction syndrome (MODS)...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164531/literature-research-regarding-mirnas-expression-in-the-assessment-and-evaluation-of-the-critically-ill-polytrauma-patient-with-traumatic-brain-and-spinal-cord-injury
#10
Lavinia M Bratu, Alexandru F Rogobete, Marius Papurica, Dorel Sandesc, Carmen A Cradigati, Mirela Sarandan, Raluca Dumache, Sonia E Popovici, Dan C Crisan, Horia Stanca, Sonia Tanasescu, Ovidiu H Bedreag
BACKGROUND: One of the most severe conditions specific to the critically ill polytrauma patient is traumatic brain injury and traumatic spinal cord injury. The mortality rate is high in the case of these patients, both because of the direct traumatic lesions, and because of the pathophysiological imbalances associated with trauma. Amongst the most common pathologies associated with the critically ill polytrauma patients responsible for a lower survival rate, are redox imbalance, systemic inflammatory response, infections, and multiple organ dysfunction syndrome...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164521/using-the-expression-of-damage-associated-molecular-pattern-damp-for-the-evaluation-and-monitoring-of-the-critically-ill-polytrauma-patient
#11
REVIEW
Marius Papurica, Alexandru F Rogobete, Dorel Sandesc, Carmen A Cradigati, Mirela Sarandan, Raluca Dumache, Florin G Horhat, Lavinia M Bratu, Razvan Nitu, Dan C Crisan, Delia I Horhat, Elena S Popovici, Sonia Tanasescu, Vlad Daliborca, Ovidiu Boruga, Ovidiu H Bedreag
BACKGROUND: The critically ill polytrauma patient continues to be one of the most complex cases in the intensive care unit (ICU). The molecular damage is closely connected with the severe, specific pathophysiological imbalances, such as severe inflammation, infections, hypermetabolism, oxidative stress, and ultimately multiple organ dysfunction syndrome (MODS). METHODS: The literature available on PubMed and Scopus was analysed for this study. The key words used in the search were "biomarkers in critically ill patients", "molecular damage", "sepsis biomarkers", "miRNAs biomarkers", and "oxidative stress"...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28155826/comprehensive-treatment-of-the-multiply-injured-patient-a-case-study
#12
Piotr Piekarczyk, Krzysztof Kwiatkowski, Konrad Borcz, Krzysztof Piątkowski, Robert Skowronek
BACKGROUND: We describe the case of a 35-year-old man who suffered multiple organ injuries following a traffic accident. CASE REPORT: A total of 47 fractures were diagnosed in that patient. He was treated in stages according to the principles of Damage Control Orthopedics. He underwent 6 sessions of surgery with 23 surgical approaches. A follow-up examination at 12 months post injury found bone union of all fractures. The clinical and functional outcome of treatment was good as joint mobility was similar to the pre-accident status and the patient returned to work...
March 23, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28149854/from-static-to-dynamic-a-sepsis-specific-dynamic-model-from-clinical-criteria-in-polytrauma-patients
#13
EDITORIAL
Rami A Namas, Yoram Vodovotz
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28149247/blast-pulmonaire-primaire-chez-le-br%C3%A3-l%C3%A3-a-propos-d%C3%A2-un-cas-et-revue-de-la-litt%C3%A3-rature
#14
S Siah, A Emane, M Bertin-Maghit
Blasts can cause specific lesions requiring specialized care. After an explosion, primary blast injury (due to the shock wave), secondary blast injury (due to shrapnel) or tertiary blast injury (due to the victim being displaced by the blast) can occur. Secondary and tertiary blasts are much more frequent than primary blasts and can lead to polytrauma. Burns occur in 5% of cases and are termed quaternary blast lesions, which include lesions not due to the above-mentioned mechanisms. Care of secondary and tertiary blasts does not differ to that for any polytrauma...
September 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28148670/injuries-to-the-upper-extremities-in-polytrauma-limited-effect-on-outcome-more-than-ten-years-after-injury-a-cohort-study-in-629-patients
#15
C Macke, M Winkelmann, P Mommsen, C Probst, B Zelle, C Krettek, C Zeckey
AIMS: To analyse the influence of upper extremity trauma on the long-term outcome of polytraumatised patients. PATIENTS AND METHODS: A total of 629 multiply injured patients were included in a follow-up study at least ten years after injury (mean age 26.5 years, standard deviation 12.4). The extent of the patients' injury was classified using the Injury Severity Score. Outcome was measured using the Hannover Score for Polytrauma Outcome (HASPOC), Short Form (SF)-12, rehabilitation duration, and employment status...
February 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28138737/-care-for-severely-injured-persons-update-of-the-2016-s3-guideline-for-the-treatment-of-polytrauma-and-the-severely-injured
#16
P Hilbert-Carius, T Wurmb, H Lier, M Fischer, M Helm, C Lott, B W Böttiger, M Bernhard
In 2011 the first interdisciplinary S3 guideline for the management of patients with serious injuries/trauma was published. After intensive revision and in consensus with 20 different medical societies, the updated version of the guideline was published online in September 2016. It is divided into three sections: prehospital care, emergency room management and the first operative phase. Many recommendations and explanations were updated, mostly in the prehospital care and emergency room management sections...
January 30, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28135424/traumatic-brain-injury-incidence-clinical-overview-and-policies-in-the-us-military-health-system-since-2000
#17
Thomas M Swanson, Brad M Isaacson, Cherina M Cyborski, Louis M French, Jack W Tsao, Paul F Pasquina
Exposure to explosive armaments during Operation Iraqi Freedom and Operation Enduring Freedom contributed to approximately 14% of the 352 612 traumatic brain injury (TBI) diagnoses in the US military between 2000 and 2016. The US Department of Defense issued guidelines in 2009 to (1) standardize TBI diagnostic criteria; (2) classify TBI according to mechanism and severity; (3) categorize TBI symptoms as somatic, psychological, or cognitive; and (4) systematize types of care given during the acute and rehabilitation stages of TBI treatment...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28130347/non-traumatic-incidental-findings-in-patients-undergoing-whole-body-computed-tomography-at-initial-emergency-admission
#18
Eduard K Kroczek, Gero Wieners, Ingo Steffen, Tobias Lindner, Florian Streitparth, Bernd Hamm, Martin H Maurer
OBJECTIVE: To evaluate the number, localisation and importance of non-traumatic incidental findings (IFs) in patients with suspected or obvious multiple trauma undergoing whole-body CT (WBCT) in a level-1 trauma centre. METHODS: Between January 2009 and December 2013, a total of 2440 patients with trauma undergoing WBCT at admission to a level-1 trauma centre of a university hospital were retrospectively analysed, through imaging IFs unrelated to trauma with the radiological reports...
January 27, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28122406/similar-change-in-platelets-and-leucocytes-24%C3%A2-h-after-injury-is-associated-with-septic-shock-a-week-later
#19
Saskia Jol, Falco Hietbrink, Luke P H Leenen, Leo Koenderman, Karlijn J P van Wessem
BACKGROUND: Septic shock is a severe complication in polytrauma patients. Early identification of patients at risk can guide future prevention strategies. Platelets (PLTs) and leucocytes presumably play an important role in the post-injury inflammatory response. The role of early changes in PLT and leucocyte counts was investigated in search for the aetiology of the development of septic complications. METHODS: Polytrauma patients (aged 16-80 years) admitted to the intensive care unit with an expected stay of at least 3 days were included...
January 25, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28120256/osteoporosis-among-hospitalized-patients-with-proximal-femoral-fractures-in-assiut-university-trauma-unit-egypt
#20
Osama Farouk, Dalia G Mahran, Hatem G Said, Mohamed M Alaa, Amr Eisa, Hisham Imam, G Z Said
: The study was done to investigate osteoporosis prevalence in 275 hip fracture admissions at the Trauma Unit of Assiut University Hospitals and associated factors, which are understudied in our locality. Prevalence was 74.9%. Female sex, older age, low body mass index, and fall on the ground were associated with osteoporosis. PURPOSE: This study aims to identify osteoporosis prevalence in hip fracture admissions at the Trauma Unit of Assiut University Hospitals and to study the independent correlates of osteoporosis-related fracture...
December 2017: Archives of Osteoporosis
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