Read by QxMD icon Read

Vasovagal syncope

Artur Fedorowski, Hongliang Li, Xichun Yu, Kristi A Koelsch, Valerie M Harris, Campbell Liles, Taylor A Murphy, Syed M S Quadri, Robert Hal Scofield, Richard Sutton, Olle Melander, David C Kem
AIMS: Postural tachycardia syndrome (POTS), a common and debilitating cardiovascular disorder, is characterized by an exaggerated heart rate increase during orthostasis and a wide spectrum of adrenergic-related symptoms. To determine the aetiology of POTS, we examined a possible pathophysiological role for autoantibodies against α1-adrenergic (α1AR) and β1/2-adrenergic receptors (β1/2AR). METHODS AND RESULTS: Immunoglobulin G (IgG) derived from 17 POTS patients, 7 with recurrent vasovagal syncope (VVS), and 11 normal controls was analysed for its ability to modulate activity and ligand responsiveness of α1AR and β1/2AR in transfected cells and to alter contractility of isolated rat cremaster arterioles in vitro...
October 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Panayota Flevari, Dionyssios Leftheriotis, Evangelos Repasos, Dimitrios Katsaras, Andreas Katsimardos, John Lekakis
AIMS: The optimal medical therapy of patients with vasovagal syncope (VVS) remains controversial. Fluoxetine is effective against anxiety and panic disorders, while its use has shown promising results for VVS. Anxiety sensitivity is a personality trait observed in a considerable proportion of patients with VVS, associated with predisposition to anxiety and panic disorders. Our aim was to examine whether fluoxetine exerts beneficial effects regarding VVS prevention in the subset of patients with anxiety sensitivity...
October 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Dubravka Negovetić Vranić, Josipa Jurković, Jesenka Jeličić, Antonija Balenović, Gordana Stipančić, Ivana Čuković-Bagić
Medical emergencies that are life threatening can occur in dental practice. Complications may arise because of an underlying disease or a reaction to medication. Reactions to medications may be allergic and toxic. The most common reactions are toxic reactions to local anesthetics, whereas allergies occur mainly as a consequence of the application of antibiotics, usually penicillin. In response to stress, vasovagal syncope typically occurs. Other causes may be related to an underlying disease-specific pathology (such as acute asthma attack, diabetic ketoacidosis, hypoglycemia, or seizures) or accidents (aspiration of a foreign body causing obstruction of the respiratory system)...
March 2016: Acta Stomatologica Croatica
Gianfranco Piccirillo, Federica Moscucci, Claudia Fiorucci, Claudia Di Iorio, Fabiola Mastropietri, Damiano Magrì
To seek possible differences in short-period temporal RR interval, P-wave and PR interval dispersion and spectral coherence in patients with a head-up tilt test positive for vasovagal syncope with or without prolonged asystole, severe symptoms and at high risk of trauma. We retrospectively reviewed 5 min ECG and blood pressure recordings obtained at baseline, at rest and during head-up tilt in 40 patients diagnosed as having recurrent vasovagal syncope confirmed at a head-up tilt test. We analysed autoregressive spectral power for all the ECG-derived variables, focusing on temporal P-wave and PR interval dispersion indexes as well as their spectral coherence calculated on the same 5 min recordings at rest and during tilt...
September 28, 2016: Physiological Measurement
Artur Pietrucha, Joanna Jędrzejczyk-Spaho, Ewa Konduracka, Irena Bzukała, Krzysztof Krawczyk, Olga Kruszelnicka-Kwiatkowska, Jadwiga Nessler
BACKGROUND: The purpose of this study was to evaluate the prevalence of syncope induced by head-up tilt test (HUTT) and the type of positive vasovagal response to the orthostatic stress in a relationship to the estimated phase of menstrual cycle (follicular phase, luteal phase) or menopause. METHODS: We observed a cohort of 500 women at age 13-89 years (median of age 37.5), referred to HUTT. Phase of the menstrual cycle was determined on the basis of the usual length of menstrual cycle and the day of the cycle at the time of the study...
September 26, 2016: Cardiology Journal
Rose Mary Ferreira Lisboa da Silva
The most frequent cause of syncope is vasovagal reflex. It is associated with worse quality of life, depression, fatigue and physical injury. Recurrence of vasovagal syncope is an aggravating, reaching the rate of 69%. Initial step and pharmacological treatment may not work, especially in patients with recurrent syncope without prodrome. These patients can present cardioinhibitory response with asystole. Studies were designed to analyses the effectiveness of pacemaker for prevention of syncope. In this review, nonrandomized clinical trials, open-label randomized, double-blind randomized, placebo-controlled, and studies based on tilt test or Implantable Loop Recorder findings will be discussed...
2016: Open Cardiovascular Medicine Journal
Satish Raj, Robert Sheldon
Postural tachycardia syndrome (POTS), inappropriate sinus tachycardia (IST) and vasovagal syncope (VVS) are relatively common clinical syndromes that are seen by physicians in several disciplines. They are often not well recognised and are poorly understood by physicians, are associated with significant morbidity and cause significant frustration for both patients and their physicians. The 2015 Heart Rhythm Society Expert Consensus Statement on the Diagnosis and Treatment of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia and Vasovagal Syncope provides physicians with an introduction to these disorders and initial recommendations on their investigation and treatment...
August 2016: Arrhythmia & Electrophysiology Review
Agazi G Gebreselassie, Delamo I Bekele, Yonette Paul, Julius S Ngwa, Daniel A Larbi
BACKGROUND: Current guidelines do not support the routine use of computed tomography (CT) scan of the head in the diagnostic workup of syncope. There is a lack of research to support whether these guidelines apply to the Black population. AIMS: This study aims to evaluate the yield of neuroimaging in the evaluation of Syncope in a predominantly Black patient population and to test whether current guidelines based on studies conducted in other populations hold true in this group...
July 2016: North American Journal of Medical Sciences
Susan O'Callaghan, Rose Anne Kenny
Neurocardiovascular instability (NCVI) refers to abnormal neural control of the cardiovascular system affecting blood pressure and heart rate behavior. Autonomic dysfunction and impaired cerebral autoregulation in aging contribute to this phenomenon characterized by hypotension and bradyarrhythmia. Ultimately, this increases the risk of falls and syncope in older people. NCVI is common in patients with neurodegenerative disorders including dementia. This review discusses the various syndromes that characterize NCVI icluding hypotension, carotid sinus hypersensitivity, postprandial hypotension and vasovagal syncope and how they may contribute to the aetiology of cognitive decline...
March 2016: Yale Journal of Biology and Medicine
Yoshiharu Ogawa, Takeshi Aiba, Naoya Kamei, Kenta Tominaga, Hideki Fujita, Yoshihiro Miyamoto, Toshikatsu Tanaka, Sachiko Kido
Loss of consciousness (LOC) in long QT syndrome (LQTS) patients can be caused by torsade de pointes (TdP) or vasovagal syncope (VVS). On genetic testing and head-up tilt testing (HUTT), we diagnosed three young patients with both genotyped LQTS and autonomic dysregulation. According to grade of prolongation of QT interval and LOC status, syncope episodes in two patients were classified as due to VVS, while those of the other patient were due to TdP. We also diagnosed one patient with postural orthostatic tachycardia syndrome...
July 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Andrea Nacci, Jacopo Matteucci, Salvatore Osvaldo Romeo, Stefania Santopadre, Maria Denise Cavaliere, Maria Rosaria Barillari, Stefano Berrettini, Bruno Fattori
OBJECTIVE: To perform a retrospective evaluation of the incidence of complications and adverse events during fiberoptic endoscopic evaluation of swallowing (FEES) in 2,820 examinations. PATIENTS AND METHODS: Subjects included in- and outpatients at Pisa University Hospital referred for FEES by other physicians due to dysphagia symptoms. Neurologic diseases were the most commonly diagnosed conditions in the patients tested (48.3%). Informed consent was obtained from all subjects...
2016: Folia Phoniatrica et Logopaedica
David Nilsson, Richard Sutton, Olle Melander, Artur Fedorowski
BACKGROUND: Head-up tilt test (HUT) has been used for nearly 30 years for diagnosing vasovagal syncope (VVS) and was enhanced by sublingual nitroglycerin (glyceryl trinitrate [GTN]) challenge in the 1990s. OBJECTIVE: The purpose of this study was to explore neuroendocrine differences between spontaneous and drug-induced HUT positivity. METHODS: Two hundred eighty-eight patients (41.3% male, age 49 ± 21 years) with either positive passive (n = 60 [20...
August 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Inna Kleyman, Louis H Weimer
Syncope, or the sudden loss of consciousness, is a common presenting symptom for evaluation by neurologists. It is not a unique diagnosis but rather a common manifestation of disorders with diverse mechanisms. Loss of consciousness is typically preceded by a prodrome of symptoms and sometimes there is a clear trigger. This article discusses several cases that illustrate the various causes of syncope. Reflex syncope is the most common type and includes neurally mediated, vasovagal, situational, carotid sinus hypersensitivity, and atypical forms...
August 2016: Neurologic Clinics
Julian M Stewart, Melissa Suggs, Sana Merchant, Richard Sutton, Courtney Terilli, Paul Visintainer, Marvin S Medow
BACKGROUND: Syncope is a sudden transient loss of consciousness and postural tone with spontaneous recovery; the most common form is vasovagal syncope (VVS). During VVS, gravitational pooling excessively reduces central blood volume and cardiac output. In VVS, as in hemorrhage, impaired adrenergic vasoconstriction and venoconstriction result in hypotension. We hypothesized that impaired adrenergic responsiveness because of excess nitric oxide can be reversed by reducing nitric oxide. METHODS AND RESULTS: We recorded cardiopulmonary dynamics in supine syncope patients and healthy volunteers (aged 15-27 years) challenged with a dose-response using the α1-agonist phenylephrine (PE), with and without the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine, monoacetate salt (L-NMMA)...
August 2016: Circulation. Arrhythmia and Electrophysiology
Gregory B Lim
No abstract text is available yet for this article.
September 2016: Nature Reviews. Cardiology
Wenhua Zhang, Shuo Wang, Cheng Wang, Liping Liu, Ping Lin, Fang Li, Lijia Wu, Runmei Zou
OBJECTIVE: To investigate the familial genetic characteristics of syncope in children. METHODS: A detailed medical history was taken from four twin pairs of children complaining of dizziness, headache, chest tightness, chest pain, prodromal symptoms of syncope or syncope, meanwhile, these patients were given routine physical examination, 12-lead ECG, echocardiography, Holter ECG, EEG, MRI of the head and other tests to exclude cardio-cerebrovascular and pulmonary diseases, with those with unknown origin for syncope undergoing head-up tilt test (HUTT) and inquiry of detailed family history...
October 15, 2016: International Journal of Cardiology
Muhammad Shah Miran, M Fareed K Suri, Mushtaq H Qureshi, Aamir Ahmad, Mariam K Suri, Rabia Basreen, Adnan I Qureshi
BACKGROUND: Syncope is commonly worked up for carotid stenosis, but only rarely attributed to it. Considering paucity of such cases in literature, we report a case and discuss the pathophysiology. DESIGN/METHODS: We report a patient with high-grade bilateral severe internal carotid artery (ICA) stenosis who presented with syncopal episodes in the absence of stroke, orthostatic hypotension, significant cardiovascular disease, or vasovagal etiology. We reviewed all literature pertaining to syncope secondary to carotid stenosis and other cerebrovascular disease...
June 2016: Journal of Vascular and Interventional Neurology
Wei Sun, Lihui Zheng, Yu Qiao, Rui Shi, Bingbo Hou, Lingmin Wu, Jinrui Guo, Shu Zhang, Yan Yao
BACKGROUND: Autonomic modification through catheter ablation of ganglionated plexi (GPs) in the left atrium has been reported previously as a treatment for vasovagal syncope. This study aimed to observe the long-term outcome in a larger cohort. METHODS AND RESULTS: A total of 57 consecutive patients (aged 43.2±13.4 years; 35 women) with refractory vasovagal syncope were enrolled, and high-frequency stimulation and anatomically guided GP ablation were performed in 10 and 47 cases, respectively...
July 2016: Journal of the American Heart Association
Runmei Zou, Yunli Li, Lijia Wu, Wen Li, Fang Li, Ping Lin, Zhenwu Xie, Cheng Wang
OBJECTIVES: To discuss ventricular late potentials (VLPs) in children with vasodepressor response of vasovagal syncope (VVS-V). METHODS: 184 children diagnosed as VVS-V by head-up tilt test (HUTT) were enrolled as VVS-V group, 105 age and gender matched healthy individuals without syncope were used as control group, then signal-averaged electrocardiogram was measured. RESULTS: HR was decreased [(83.98±12.27) vs (87.28±13.75)bpm, P<0.05] in VVS-V group compared with control group...
October 1, 2016: International Journal of Cardiology
Johan Skoog, Helene Zachrisson, Toste Länne, Marcus Lindenberger
BACKGROUND AND AIM: Slower lower limb blood pooling and associated blunted sympathetic activation has been detected in healthy women prone to orthostatic syncope. Whether these findings are true also for patients with vasovagal syncope (VVS) is unknown. The aim was to investigate initial blood pooling time (poolingtime, time to 50% of total blood pooling) together with hemodynamic responses and orthostatic tolerance during lower body negative pressure (LBNP) in VVS and healthy controls...
2016: Frontiers in Physiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"