Yihan Jin, Jie Song, Fang Xu, Di Zhang, Jinfang He, Jiakun Zheng, Yanan Zhang, Jintong Li, Yikun Guo, Mengjiao Xu, Xiangfeng Yu, Yanbin Liu, Qinghua Liu, Jun Yan
PURPOSE: Many studies have shown that chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is associated with asthma. The purpose of this meta-analysis was to evaluate the role of serum YKL-40 in the diagnosis and differential diagnosis of asthma, severity grading, and determination of disease state. METHODS: The PubMed, Ovid, and Cochrane databases were searched. A total of 17 articles involving 5696 subjects were included in this meta-analysis. RESULTS: The results showed that the level of YKL-40 was significantly higher in asthmatic patients than in the normal group regardless of age and residential location, and increased with severity and acute exacerbation (p < 0...
September 2022: Sleep & Breathing