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https://www.readbyqxmd.com/read/28634733/dynamic-properties-of-human-tympanic-membrane-after-exposure-to-blast-waves
#1
Warren G Engles, Xuelin Wang, Rong Z Gan
Blast overpressure causes dynamic damage to middle ear components, and tympanic membrane (TM) rupture is the most frequent middle ear injury. However, it is unclear how the blast waves change mechanical properties of the TM and affect sound transmission through the ear. This paper reports the current study on dynamic properties of the TM after exposure to blast waves by using acoustic loading and laser Doppler vibrometry (LDV). The TM specimens were prepared from human temporal bones following exposures to blast overpressure...
June 20, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28608748/tympanic-membrane-and-ossicular-sparing-modified-lateral-temporal-bone-resection
#2
Yaser Ghavami, Yarah M Haidar, Marlon Maducdoc, Tjoson Tjoa, Omid Moshtaghi, Harrison W Lin, Hamid R Djalilian
A modified lateral temporal bone resection (mLTBR) is a unique technique that spares the tympanic membrane (TM) and ossicles in select patients with squamous cell carcinoma (SCCa). The records of 5 patients with SCCa of the temporal bone with negative frozen-section biopsy at the tympanic annulus were reviewed. The mean follow-up time for the patients was 29.2 months. One patient received postoperative radiation due to cervical nodal extracapsular spread. All patients were recurrence free as of the most recent follow-up (range, 8-50 months)...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28608739/safety-of-repeated-dose-intratympanic-injections-with-am-101-in-acute-inner-ear-tinnitus
#3
Hinrich Staecker, Michael Morelock, Timothy Kramer, Pavel Chrbolka, Joong Ho Ahn, Thomas Meyer
Objective To evaluate the safety and tolerability of repeated intratympanic administration of the gel-formulated NMDA receptor antagonist AM-101 in acute patients with inner ear tinnitus. Study Design Prospective, double-blind, randomized, placebo-controlled study. Setting Sixty-nine secondary and tertiary sites in North America, Europe, and Asia. Subjects and Methods In total, 343 subjects with persistent acute tinnitus after traumatic cochlear injury or otitis media were randomized to receive 3 intratympanic doses of either AM-101 0...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28608552/a-perspective-on-stem-cell-therapy-for-ear-disorders
#4
Rahul Mittal, Hyunseo D Jung, Jeenu Mittal, Adrien A Eshraghi
The use of stem cells in cell-based therapy is an emerging concept for the treatment of ear disorders. Tympanic membrane perforation (TMP) and inner ear disorders are some of the most commonly presented otologic disorders that can benefit from advances in cell-based therapy. Studies have already demonstrated that stem cell-based therapy can potentially be an effective treatment modality for acute and chronic TMP. Recent studies have also shown promise in application of cell-based approach to treat inner ear dysfunction...
June 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28607890/endoscopic-tympanoplasty-using-nasal-septal-cartilage-allograft
#5
N Ahilasamy, Badra Shanti, Sivaprakasam Rajasekaran
The purpose of the study was to analyze the morphological and functional outcomes in a series of 60 patients for whom Type I tympanoplasty was done using alcohol preserved nasal septal cartilage allograft through endoscopic permeatal route. The study was a prospective, interventional (surgical) study of 60 patients between October 2012 and September 2014. Patients were operated using 0°, 4 mm, 18 cm long Hopkin's rod endoscope through permeatal route. 70% ethyl alcohol preserved allogeneic nasal septal cartilage with thickness of around 0...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28606657/the-effects-of-fibroblast-growth-factor-2-delivered-via-a-gelfoam-patch-on-the-regeneration-of-myringosclerotic-traumatic-eardrum-perforations-lying-close-to-the-malleus
#6
Zhong-Hai Jin, Yi-Han Dong, Zi-Han Lou
OBJECTIVE: We evaluated the effects of fibroblast growth factor-2 (FGF-2) delivered via a Gelfoam patch on the regeneration of myringosclerotic traumatic tympanic membrane perforations (TMPs) lying close to the malleus. STUDY DESIGN: A prospective, randomized, controlled clinical study. SETTING: A university-affiliated teaching hospital. SUBJECTS AND METHODS: We prospectively analyzed, in a randomized manner, the outcomes of treatment for traumatic TMPs constituting >25% of the tympanic membrane...
June 9, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28588421/evaluation-of-the-safety-and-efficacy-of-a-novel-product-for-the-removal-of-impacted-human-cerumen
#7
Douglas Fullington, Jenny Song, Antionette Gilles, Xiaowen Guo, Waley Hua, C Eric Anderson, Joseph Griffin
BACKGROUND: This open-label study evaluated the safety and efficacy of a novel product for the removal of impacted cerumen in adult patients. METHODS: This was a prospective, single-center, single-arm, self-controlled clinical trial conducted in a community general practice setting. The novel product contains glycolic acid in an otologically-acceptable buffer containing sodium bicarbonate and glycerin and other buffering agents. The product was instilled into the ear canal prior to irrigation with warm water...
2017: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/28586587/laser-myringotomy-versus-ventilation-tubes-in-otitis-media-with-effusion
#8
Mohammad Yousaf, Suhail Ahmad Malik, Tahir Haroon
OBJECTIVE: Otitis media with effusion (OME) is a leading cause of difficulty in hearing in paediatric population. Otitis media with effusion must be detected and managed early to prevent conductive hearing loss in children. It was aimed to compare results of laser myringotomy and ventilation tube insertion, in terms of hearing improvement and recurrence of Middle ear effusion (MEE). METHODS: This randomized controlled trial was conducted from February 2012 to January 2015...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28585463/endoscopic-lateral-cartilage-graft-tympanoplasty
#9
Cameron C Wick, Demetri Arnaoutakis, Vivian F Kaul, Brandon Isaacson
Objective To describe a novel technique for lateral graft tympanoplasty. Study Design Case series with chart review. Setting Tertiary care university hospital. Subjects and Methods Pediatric and adult patients with tympanic membrane perforations deemed unfavorable for a medial graft technique due to the perforation characteristics or myringitis. Results Between 2014 and 2016, 34 ears from 31 patients underwent a transcanal endoscopic lateral cartilage graft tympanoplasty. The mean age was 24.4 years (range, 6-71 years), and 22 patients (65%) were younger than 18 years...
May 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28583486/ototoxicity-associated-with-topical-administration-of-diclofenac-sodium-as-an-otic-drop-an-experimental-animal-study
#10
Engin Acioglu, Ozgur Yigit, Firat Onur, Ahmet Atas, Ela Araz Server, Eyup Kara
OBJECTIVES: The aim of the study is to evaluate the ototoxicity of topical diclofenac sodium in comparison to positive and negative controls prior to the investigation of analgesic and anti-inflammatory efficacy of the agent in otic administration. METHODS: Twenty four ears of 12 guinea pigs were included in the study. Wide myringotomy was performed on all tympanic membranes under general anesthesia and auditory brainstem responses (ABR) were evaluated. The subjects were separated into four groups, two groups received diclofenac sodium at low and high doses, positive controls received gentamicin and negative controls received isotonic sodium chloride topically for 14 days and ABRs were reevaluated...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28576521/the-effect-of-caffeic-acid-phenethyl-ester-cape-on-tympanosclerosis
#11
İbrahim Ağrı, Arzu Erdal Ağrı, Mehmet Eser Sancaktar, Asude Ünal, Erkan Can, Mustafa Bakırtaş, Fatih Yılmaz, Mehmet Derya Demirağ, Recep Ünal
OBJECTIVE: To investigate the effects of caffeic acid phenethyl ester (CAPE) on tympanosclerosis. MATERIALS AND METHODS: Thirty-two male Sprague Dawley rats were separated into 4 groups as CAPE (n = 10), alcohol (n = 10), control (n = 8) and normal (n = 4) groups. All tympanic membranes except normal group were myringotomised and type 3 Streptococcus pneumoniae strains was injected into their middle ears. Myringotomies were repeated for 5 weeks. Intraperitoneal (i...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28555595/endoscopic-vs-microscopic-approach-in-stapes-surgery-advantages-in-the-middle-ear-structures-visualization-and-trainee-s-point-of-view
#12
Giannicola Iannella, Dario Marcotullio, Massimo Re, Alessandra Manno, Benedetta Pasquariello, Diletta Angeletti, Vincenzo Falasca, Giuseppe Magliulo
OBJECTIVE: Comparing the endoscopic and microscopic approaches in stapes surgery, and establishing the surgical approach that allows better results in terms of visualization of the middle ear structures and aids assistant's training. MATERIALS AND METHODS: Twenty-one residents from the first to the fifth year of training in Otolaryngology were enrolled in this prospective study. A questionnaire specifically designed to investigate the understanding of middle ear anatomy, the surgical steps, and a personal opinion about endoscopic stapes surgery was submitted to each resident...
April 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28553861/endothelial-progenitor-cells-populate-the-stromal-stem-niche-of-tympanum
#13
Mugurel Constantin Rusu, Vasile Sorin Mănoiu, Viorela Maria Popescu, Radu Constantin Ciuluvică
The tympanic membrane (TM) integrity is of utmost integrity for the sense of hearing. Therefore, the intrinsic potential of the TM to regenerate and repair deserves complete characterization. Existing studies brought evidence on the epithelial stem niche of the TM. However, the stromal compartment was not evaluated for harbouring a distinctive stem, or progenitor, niche. We aimed doing this in transmission electron microscopy. We used TMs dissected out from 3 male Oryctolagus cuniculus rabbits. Evidence of stromal quiescent stem cells with was gathered...
May 29, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28538639/development-of-the-emergency-preservation-and-resuscitation-for-cardiac-arrest-from-trauma-epr-cat-clinical-trial
#14
Samuel A Tisherman, Hasan B Alam, Peter M Rhee, Thomas M Scalea, Tomas Drabek, Raquel M Forsythe, Patrick M Kochanek McCm
BACKGROUND: Patients who suffer a cardiac arrest from trauma rarely survive, even with aggressive resuscitation attempts, including an Emergency Department (ED) thoracotomy. Emergency Preservation and Resuscitation (EPR) was developed to utilize hypothermia to buy time to obtain hemostasis before irreversible organ damage occurs. Large animal studies have demonstrated that cooling to tympanic membrane temperature 10°C during exsanguination cardiac arrest can allow up to 2 hours of circulatory arrest and repair of simulated injuries with normal neurologic recovery...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28537107/clinical-and-audiological-short-term-and-long-term-outcomes-of-fat-graft-myringoplasty
#15
Johan Knutsson, Annika Kahlin, Magnus von Unge
INTRODUCTION: Results of fat graft myringoplasty are often reported with only short-term follow-up. Audiological results are less commonly reported, as well as long-term follow-up results. MATERIALS AND METHODS: One hundred consecutive patients scheduled for fat graft myringoplasty were included in a prospective cohort study. Clinical and audiological outcomes were assessed at six weeks and one year postoperatively. RESULTS: Perforation sizes ranged from 0...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28530447/middle-ear-function-and-pathophysiology-in-andean-children-living-at-high-altitudes
#16
S Allen Counter, Leo H Buchanan, Fernando Ortega, Anthony B Jacobs, Göran Laurell
Counter, S. Allen, Leo H. Buchanan, Fernando Ortega, Anthony B. Jacobs, and Göran Laurell. Middle ear function and pathophysiology in Andean children living at high altitudes. High Alt Med Biol. 18:163-170, 2017.-The extent of altitude-related middle ear disorders in children native to high altitudes is unclear. This study examined middle ear pathophysiology in two groups of children living in high-altitude Ecuadorian Andean communities by investigating middle ear pressure (MEP), tympanic membrane compliance (TMC), and ear canal volume (ECV) using tympanometry, and by otological examination...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28502255/a-moist-edge-environment-aids-the-regeneration-of-traumatic-tympanic-membrane-perforations
#17
Z C Lou, Z H Lou
OBJECTIVE: To review the history of moist therapy used to regenerate traumatic tympanic membrane perforations. STUDY DESIGN: Literature review. METHODS: The literature on topical agents used to treat traumatic tympanic membrane perforations was reviewed, and the advantages and disadvantages of moist therapy were analysed. RESULTS: A total of 76 studies were included in the analysis. Topical applications of certain agents (e...
July 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28500879/role-of-forensic-medicine-in-evaluating-non-fatal-physical-violence-against-women-by-their-husbands-in-jordan
#18
Hasan Abedr-Rahman, Hafsah Omar Salameh, Rakiz J Salameh, Laith I Alabdallat, Imad M Al-Abdallat
OBJECTIVE: Intimate partner violence against women is a major health problem in most nations, but to date, there has been little awareness of the extent or seriousness of this issue in Jordan. Forensic medical practitioners play a significant role in diagnosing, evaluating and reporting these cases. The Jordanian judicial system is dependent on forensic reports. This study aims to assess the role of forensic medicine in evaluating the physical injuries sustained by women who are abused by their husbands...
July 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28499303/-long-term-follow-up-and-patient-satisfaction-after-tympanoplasty-with-titanium-clip-prothesis
#19
Guido Wolferts, Daniel Schicke, K-Wolfgang Delank
Aim of the present study is to evaluate the long term results of ossiculoplasty using titanium clip prosthesis. A retrospective analysis with prospective follow-up has been done including for all patients who had a Clip-PORP implanted between the years 2002-2013. Following this, audiometric hearing results were measured with clinical examination including otoscopy and quality of life evaluation using Glasgow benefit inventory. 48 patients (51 ears, 29 men, 19 women, average age 44.1 years) received followed up after an average duration of 6...
May 12, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28498081/finite-element-analysis-of-auditory-characteristics-in-patients-with-middle-ear-diseases
#20
Bo Tu, Xiaoping Li, Zhenhua Nie, Changzheng Shi, Hengguo Li
CONCLUSION: This study validates that a finite element model of the human ossicular chain and tympanic membrane can be used as an effective surgical assessment tool in clinics. OBJECTIVE: The present study was performed to investigate the application of a finite element model of ossicular chain and tympanic membrane for fabrication of individualized artificial ossicles. METHODS: Twenty patients (20 ears) who underwent surgery for middle ear disease (n = 20) and 10 healthy controls (10 ears) were enrolled in the hospital...
July 2017: Acta Oto-laryngologica
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