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tympanic membrane

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https://www.readbyqxmd.com/read/29644162/clinical-study-on-middle-ear-diseases-in-children-with-orofacial-clefts
#1
Raja Kalaiarasi, Kamran A Syed, Chellappa Vijayakumar, Ajoy M Varghese, Mary John
Introduction Orofacial clefts are associated with middle ear diseases, but the magnitude of this problem is not generally well appreciated. The aim of this study was to describe the middle ear findings and audiological profile in children with orofacial clefts. Materials and methods Children with orofacial clefts attending plastic surgery and otorhinolaryngology departments of a tertiary hospital over one-year duration were included in this study. Ninety-six children with orofacial clefts were identified. They were categorized age-wise as zero to five years, more than five years to 10 years, and more than 10 years to 15 years...
February 8, 2018: Curēus
https://www.readbyqxmd.com/read/29628367/butterfly-cartilage-tympanoplasty-outcomes-a-single-institution-experience-and-literature-review
#2
Mejd Jumaily, Joel Franco, James A Gallogly, Joshua L Hentzelman, Dary J Costa, Alan P K Wild, Anthony A Mikulec
PURPOSE: In 1998, Dr. Eavey described the trans-canal inlay butterfly cartilage tympanoplasty technique, also known as cartilage button tympanoplasty. Many retrospective studies have since demonstrated its efficacy and decreased operative time when compared to underlay and overlay tympanoplasty techniques. The butterfly cartilage tympanoplasty approach uses only a cartilage graft to repair tympanic membrane perforations. The aim of this study was to review the literature for studies that examined butterfly cartilage tympanoplasty success rates and outcomes and compare them to outcomes from our cohort...
March 29, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29623476/transcription-and-microrna-profiling-of-cultured-human-tympanic-membrane-epidermal-keratinocytes
#3
Peder Aabel, Tor Paaske Utheim, Ole Kristoffer Olstad, Helge Rask-Andersen, Rodney James Dilley, Magnus von Unge
The human tympanic membrane (TM) has a thin outer epidermal layer which plays an important role in TM homeostasis and ear health. The specialised cells of the TM epidermis have a different physiology compared to normal skin epidermal keratinocytes, displaying a dynamic and constitutive migration that maintains a clear TM surface and assists in regeneration. Here, we characterise and compare molecular phenotypes in keratinocyte cultures from TM and normal skin. TM keratinocytes were isolated by enzymatic digestion and cultured in vitro...
April 5, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29619111/intratympanic-gentamicin-for-intractable-m%C3%A3-ni%C3%A3-re-s-disease-a-review-and-analysis-of-audiovestibular-impact
#4
Sertaç Yetişer
Introduction  Intratympanic gentamicin regulates the symptoms in most patients with incapacitating Ménière's disease. The treatment protocols have changed over the years from medical labyrinthectomy to preservation of vestibular function. Objectives  This study aims to review the audiovestibular response related to the effect of the drug in controlling vertigo. Data Synthesis  Articles were identified by means of a search in the PubMed database using the key words Meniere and intratympanic or transtympanic gentamicin ...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29594077/results-of-type-i-tympanoplasty-using-fascia-with-or-without-cartilage-reinforcement-10-years-experience
#5
Ali Kouhi, Mohammad Taghi Khorsandi Ashthiani, Mir Mohammad Jalali
Introduction: There remains controversy about the optimal kind of graft to repair tympanic membrane. The purpose of this study was to evaluate the anatomical and auditory outcomes of type I tympanoplasty using fascia with or without cartilage reinforcement. Materials and Methods: This retrospective cohort study was conducted from 2005 to 2015. All cases were surgically treated by a single surgeon. We excluded cases in which the etiology of chronic otitis media was cholesteatoma...
March 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29588156/-tumulus-stabilization-of-a-total-ossicular-replacement-prosthesis
#6
T Mom, C Caburet, N Saroul, L Gilain, M Gersdorff
Functional failure of total ossicular replacement prostheses (TORP) is often due to secondary displacement, ranging from simple subluxation to prosthesis extrusion following recurrence of severe tympanic membrane retraction. Several surgical techniques have been proposed to stabilize a TORP, mostly using superimposed non-organic or resorbable heterologous materials. We describe a simple so-called "tumulus" surgical technique that limits prosthesis displacement and extrusion, regardless of the type of TORP, by using a few fragments of autologous cartilage that are always available and perfectly tolerated at no cost...
March 24, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29587475/microbiological-results-from-middle-ear-effusion-in-pediatric-patients-receiving-ventilation-tube-insertion-multicenter-registry-study-on-the-effectiveness-of-ventilation-tube-insertion-in-pediatric-patients-with-chronic-otitis-media-with-effusion-part-i
#7
Myung Hoon Yoo, Yang-Sun Cho, June Choi, Yun Hoon Choung, Jae-Ho Chung, Jong Woo Chung, Gyu Cheol Han, Eun-Ju Jeon, Beom Cho Jun, Dong-Kee Kim, Kyu Sung Kim, Jun Ho Lee, Kyu-Yup Lee, Seung Hwan Lee, In Seok Moon, Hong Ju Park, Shi Nae Park, Jihye Rhee, Jae Hyun Seo, Seung Geun Yeo
Objectives: The aim of this multicenter registry study was to investigate the effectiveness of ventilation tube insertion and the microbiology of otitis media with effusion (OME) in children. This part I study was conducted to evaluate the microbiological profile of children with OME who needed ventilation tube insertion. Methods: Patients <15 years old who were diagnosed as having OME and received ventilation tube insertion were prospectively enrolled in 16 tertiary hospitals from June 2014 to December 2016...
March 28, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29587128/direct-analysis-of-pathogenic-structures-affixed-to-the-tympanic-membrane-during-chronic-otitis-media
#8
Guillermo L Monroy, Wenzhou Hong, Pawjai Khampang, Ryan G Porter, Michael A Novak, Darold R Spillman, Ronit Barkalifa, Eric J Chaney, Joseph E Kerschner, Stephen A Boppart
Objective To characterize otitis media-associated structures affixed to the mucosal surface of the tympanic membrane (TM) in vivo and in surgically recovered in vitro samples. Study Design Prospective case series without comparison. Setting Outpatient surgical care center. Subjects and Methods Forty pediatric subjects scheduled for tympanostomy tube placement surgery were imaged intraoperatively under general anesthesia. Postmyringotomy, a portable optical coherence tomography (OCT) imaging system assessed for the presence of any biofilm affixed to the mucosal surface of the TM...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29571277/tympanic-membrane-derived-stem-cell-like-cultures-for-tissue-regeneration
#9
Lawrence J Liew, Linda Q Chen, Allen Y Wang, Magnus von Unge, Marcus Atlas, Rodney J Dilley
Epidermal cells with stem cell-like characteristics have been identified in the tympanic membrane (TM) and localized specifically to the umbo and annulus regions. While they have been proposed to play a role in the regeneration of both acute and chronic tympanic membrane perforations, evidence for the mechanism and regulation of their contribution is not yet described. Indeed, the behaviour of these putative stem cells is largely unknown, in part due to a lack of refined methods for efficient cell isolation...
March 23, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29568876/fisetin-administration-improves-lps-induced-acute-otitis-media-in-mouse-in-vivo
#10
Peng Li, Dan Chen, Yang Huang
Acute otitis media is one of the most common infectious diseases worldwide in spite of the widespread vaccination. The present study was conducted to explore the effects of fisetin on mouse acute otitis media models. The animal models were established by lipopolysaccharide (LPS) injection into the middle ear of mice via the tympanic membrane. Fisetin was administered to mice for ten days through intragastric administration immediate after LPS application. Hematoxylin and eosin (H&E) staining was performed and the pro-inflammatory cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-6 and VEGF, were measured through enzyme-linked immunosorbent assay (ELISA) method and RT-qPCR analysis...
March 22, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29563067/paraquat-initially-damages-cochlear-support-cells-leading-to-anoikis-like-hair-cell-death
#11
Jianhui Zhang, Hong Sun, Richard Salvi, Dalian Ding
Paraquat (PQ), one of the most widely used herbicides, is extremely dangerous because it generates the highly toxic superoxide radical. When paraquat was applied to cochlear organotypic cultures, it not only damaged the outer hair cells (OHCs) and inner hair cells (IHCs), but also caused dislocation of the hair cell rows. We hypothesized that the dislocation arose from damage to the support cells (SCs) that anchors hair cells within the epithelium. To test this hypothesis, rat postnatal cochlear cultures were treated with PQ...
March 13, 2018: Hearing Research
https://www.readbyqxmd.com/read/29553522/a-surgical-procedure-for-the-administration-of-drugs-to-the-inner-ear-in-a-non-human-primate-common-marmoset-callithrix-jacchus
#12
Sho Kurihara, Masato Fujioka, Tomohiko Yoshida, Makoto Koizumi, Kaoru Ogawa, Hiromi Kojima, Hirotaka James Okano
Hearing research has long been facilitated by rodent models, although in some diseases, human symptoms cannot be recapitulated. The common marmoset (Callithrix jacchus) is a small, easy-to-handle New World monkey which has a similar anatomy of the temporal bone, including the middle ear ossicular chains and inner ear to humans, than in comparison with that of rodents. Here, we report a reproducible, safe, and rational surgical approach to the cochlear round window niche for the drug delivery to the inner ear of the common marmoset...
February 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29552381/pneumatic-low-coherence-interferometry-otoscope-to-quantify-tympanic-membrane-mobility-and-middle-ear-pressure
#13
Jungeun Won, Guillermo L Monroy, Pin-Chieh Huang, Roshan Dsouza, Malcolm C Hill, Michael A Novak, Ryan G Porter, Eric Chaney, Ronit Barkalifa, Stephen A Boppart
Pneumatic otoscopy to assess the mobility of the tympanic membrane (TM) is a highly recommended diagnostic method of otitis media (OM), a widespread middle ear infection characterized by the fluid accumulation in the middle ear. Nonetheless, limited depth perception and subjective interpretation of small TM displacements have challenged the appropriate and efficient examination of TM dynamics experienced during OM. In this paper, a pneumatic otoscope integrated with low coherence interferometry (LCI) was adapted with a controlled pressure-generating system to record the pneumatic response of the TM and to estimate middle ear pressure (MEP)...
February 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29551206/sound-energy-absorbance-characteristics-of-cartilage-grafts-used-in-type-1-tympanoplasty
#14
Nesibe Gül Yüksel Aslıer, Selhan Gürkan, Mustafa Aslıer, Günay Kirkim, Enis Alpin Güneri, Ahmet Ömer Ikiz
OBJECTIVE: The purpose of this prospective case-control study is to evaluate the sound energy absorbance characteristics of cartilage grafts in patients, who have undergone type 1 cartilage tympanoplasty. METHODS: Thirty-four operated ears of 32 patients and 70 ears of 35 control subjects were included. Differences of pure-tone audiometry thresholds and wideband ambient-pressure absorbance ratios with respect to the graft material, graft thickness, cartilage surface area ratio and elapsed time after surgery were analyzed...
March 15, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29550920/analyzing-eustachian-tube-function-in-patients-with-symptoms-of-chronical-eustachian-tube-dysfunction-by-pressure-chamber-measurements
#15
Moritz F Meyer, Christine Korthäuer, Stefanie Jansen, Karl-Bernd Hüttenbrink, Dirk Beutner
PURPOSE: The determination of Eustachian tube dysfunction (ETD) subtypes in daily routines is based on symptoms of the patient, otoscopy, nasopharyngoscopy, tympanometry, pure tone audiometry, and Valsalva's test, even though this clinical assessment is often not sufficient to clearly diagnose the subtype. In the study, we have evaluated the possibility of the determination of different subtypes of ETD by pressure chamber measurements. METHODS: In a single-person pressure chamber, we exposed 17 patients to pressure increases and decreases...
March 17, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29543327/systemic-corticosteroids-for-acute-otitis-media-in-children
#16
REVIEW
Respati W Ranakusuma, Yupitri Pitoyo, Eka D Safitri, Sarah Thorning, Elaine M Beller, Sudigdo Sastroasmoro, Chris B Del Mar
BACKGROUND: Acute otitis media (AOM) is a common acute infection in children. Pain is its most prominent and distressing symptom. Antibiotics are commonly prescribed for AOM, although they have only a modest effect in reducing pain at two to three days. There is insufficient evidence for benefits of other treatment options, including systemic corticosteroids. However, systemic corticosteroids are potent anti-inflammatory drugs, and so theoretically could be effective, either alone or as an addition to antibiotics...
March 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29533700/achieving-a-successful-closure-of-an-anterior-tympanic-membrane-perforation-evidence-based-systematic-review
#17
Vikranth Visvanathan, Vamsidhar Vallamkondu, Sanjiv K Bhimrao
Objectives Surgical repair of a tympanic membrane perforation is a common otologic procedure. However, achieving a successful closure can be challenging, especially if the anterior margin of the tympanic membrane is involved. The aim of this study was to systematically review the literature on evidence published in closure of anterior tympanic membrane perforations. Data Sources The following data sources were searched: Cochrane Central Register of Controlled Trials (1997 to August, 3 2017), MEDLINE (February 1948 to August 3, 2017), and Embase (1975 to August 3, 2017)...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29533334/application-of-regenerative-treatment-for-tympanic-membrane-perforation-with-cholesteatoma-tumor-or-severe-calcification
#18
Shin-Ichi Kanemaru, Rie Kanai, Misaki Yoshida, Yuji Kitada, Kaoru Omae, Shigeru Hirano
OBJECTIVE: To apply regenerative treatment for tympanic membrane (TM) perforation to patients with severe calcification of the TM, cholesteatomas, or tumors localized to the tympanic cavity. STUDY DESIGN: Controlled clinical pilot study. SETTING: General hospitals. PATIENTS: Forty-five patients (age: 8-85; M = 19, F = 26) were selected from patients with or without TM perforation for the regenerative treatment...
April 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29533328/can-fat-plug-myringoplasty-be-a-good-alternative-to-formal-myringoplasty-a-systematic-review-and-meta-analysis
#19
Doh Young Lee, Young Ho Kim
OBJECTIVE: This study reviewed available literature to evaluate the success rate of fat myringoplasty compared with methods using other graft materials and suggests proper indications for this procedure. DATA SOURCES: Studies reporting the success rate of fat myringoplasty were systematically reviewed by searching the MEDLINE, PubMed, and Embase databases for studies published from database inception to 2017. STUDY SELECTION: The following terms were used for the literature search: ("Fat" OR "Adipose") and ("Myringoplasty" OR "Tympanoplasty")...
April 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29532729/thomsen-j-et-al-the-non-specific-effect-of-endolymphatic-sac-surgery-in-treatment-of-meniere-s-disease-a-prospective-randomized-controlled-study-comparing-classic-endolymphatic-sac-surgery-with-the-insertion-of-a-ventilating-tube-in-tympanic-membrane-acta-oto
#20
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