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tympanic membrane

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https://www.readbyqxmd.com/read/28087416/the-path-of-a-click-stimulus-from-ear-canal-to-umbo
#1
Mario Milazzo, Elika Fallah, Michael Carapezza, Nina S Kumar, Jason H Lei, Elizabeth S Olson
The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28087415/estimation-of-the-young-s-modulus-of-the-human-pars-tensa-using-in-situ-pressurization-and-inverse-finite-element-analysis
#2
S Alireza Rohani, Soroush Ghomashchi, Sumit K Agrawal, Hanif M Ladak
Finite-element models of the tympanic membrane are sensitive to the Young's modulus of the pars tensa. The aim of this work is to estimate the Young's modulus under a different experimental paradigm than currently used on the human tympanic membrane. These additional values could potentially be used by the auditory biomechanics community for building consensus. The Young's modulus of the human pars tensa was estimated through inverse finite-element modelling of an in-situ pressurization experiment. The experiments were performed on three specimens with a custom-built pressurization unit at a quasi-static pressure of 500 Pa...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28087317/acute-otitis-media-caused-by-streptococcus-pneumoniae-serotype-19a-st320-clone-epidemiological-and-clinical-characteristics
#3
Hsin Chi, Nan-Chang Chiu, Fu-Yuan Huang, Chyong-Hsin Hsu, Kuo-Sheng Lee, Li-Min Huang, Yu-Chia Hsieh
BACKGROUND: Streptococcus pneumoniae serotype 19A ST320, a highly multiresistant and virulent clone, has emerged as a common pathogen causing acute otitis media (AOM) in children. METHODS: Patients aged 0-18 years with AOM who presented at Mackay Memorial Hospital, Taipei, Taiwan were prospectively enrolled between December 1, 2009, and November 30, 2012. For each patient, a specimen of middle-ear fluid was obtained and cultured. S. pneumoniae isolates were tested by serotyping, antibiotic-resistance profiling, and multilocus sequence typing...
December 19, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28069080/role-of-circumferential-subannular-tympanoplasty-in-anterior-and-subtotal-perforations
#4
G B Singh, S Ranjan, R Arora, S Kumar
OBJECTIVE: This study aimed to evaluate the surgical success of a modified inlay tympanoplasty technique, known as circumferential subannular tympanoplasty, for anterior and subtotal perforations. METHODS: This prospective study was performed in a tertiary care teaching hospital between October 2013 and April 2016. A total of 58 adult patients of both sexes with anterior or subtotal perforations underwent circumferential subannular tympanoplasty under local anaesthesia...
January 10, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28057352/sigmoid-sinus-cortical-plate-dehiscence-induces-pulsatile-tinnitus-through-amplifying-sigmoid-sinus-venous-sound
#5
Shan Tian, Lizhen Wang, Jiemeng Yang, Rui Mao, Zhaohui Liu, Yubo Fan
Sigmoid sinus cortical plate dehiscence (SSCPD) is common in pulsatile tinnitus (PT) patients, and is treated through SSCPD resurfacing surgery in clinic, but the bio-mechanism is not clear as so far. This study aimed to clarify the bio-mechanism of PT sensation induced by SSCPD, and quantify the relationship of cortical plate (CP) thickness and PT sensation intensity. It was hypothesized that SSCPD would induce PT through significantly amplifying sigmoid sinus (SS) venous sound in this study. Finite element (FE) analysis based on radiology data of typical patient was used to verify this hypothesis, and was validated with clinical reports...
December 16, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28052725/paracrine-activity-from-adipose-derived-stem-cells-on-in-vitro-wound-healing-in-human-tympanic-membrane-keratinocytes
#6
Huan Ting Ong, Sharon Redmond, Robert Marano, Marcus Atlas, Magnus von Unge, Peder Aabel, Rodney J Dilley
Stem cell therapies for tympanic membrane repair have shown initial experimental success using mesenchymal stem cells in rat models to promote healing, however the mechanisms providing this benefit are not known. We investigated in vitro the paracrine effects of human adipose-derived stem cells (ADSC) on wound healing mechanisms for human tympanic membrane-derived keratinocytes (hTM) and immortalised human keratinocytes (HaCat). ADSC conditioned media (CMADSC) were assessed for paracrine activity on keratinocyte proliferation and migration, with hypoxic conditions for ADSC culture used to generate contrasting effects on cytokine gene expression...
January 4, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28051987/traumatic-hearing-loss-in-the-context-of-blast-related-tympanic-membrane-perforation
#7
Max D Pusz, Jon Robitschek
OBJECTIVE: Identify associated clinical factors and characterize the various forms of hearing loss in the context of blast-related traumatic tympanic membrane (TM) perforation sustained in the combat setting. METHODS: A prospective study of 41 patients who sustained a TM perforation secondary to blast injury between 2010 and 2012 while serving in combat. Clinical examinations and audiograms were obtained for all patients by a single-institution Otolaryngology service with comparative data generated from review of pre and post-trauma hearing screens...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28045835/normative-wideband-reflectance-equivalent-admittance-at-the-tympanic-membrane-and-acoustic-stapedius-reflex-threshold-in-adults
#8
M Patrick Feeney, Douglas H Keefe, Lisa L Hunter, Denis F Fitzpatrick, Angela C Garinis, Daniel B Putterman, Garnett P McMillan
OBJECTIVES: Wideband acoustic immittance (WAI) measures such as pressure reflectance, parameterized by absorbance and group delay, equivalent admittance at the tympanic membrane (TM), and acoustic stapedius reflex threshold (ASRT) describe middle ear function across a wide frequency range, compared with traditional tests employing a single frequency. The objective of this study was to obtain normative data using these tests for a group of normal-hearing adults and investigate test-retest reliability using a longitudinal design...
December 30, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/28045591/clinical-practice-guideline-update
#9
Seth R Schwartz, Anthony E Magit, Richard M Rosenfeld, Bopanna B Ballachanda, Jesse M Hackell, Helene J Krouse, Claire M Lawlor, Kenneth Lin, Kourosh Parham, David R Stutz, Sandy Walsh, Erika A Woodson, Ken Yanagisawa, Eugene R Cunningham
Objective This update of the 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation cerumen impaction clinical practice guideline provides evidence-based recommendations on managing cerumen impaction. Cerumen impaction is defined as an accumulation of cerumen that causes symptoms, prevents assessment of the ear, or both. Changes from the prior guideline include a consumer added to the development group; new evidence (3 guidelines, 5 systematic reviews, and 6 randomized controlled trials); enhanced information on patient education and counseling; a new algorithm to clarify action statement relationships; expanded action statement profiles to explicitly state quality improvement opportunities, confidence in the evidence, intentional vagueness, and differences of opinion; an enhanced external review process to include public comment and journal peer review; and 3 new key action statements on managing cerumen impaction that focus on primary prevention, contraindicated intervention, and referral and coordination of care...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28031154/single-administration-of-a-sustained-release-formulation-of-kb-r7785-inhibits-tympanic-membrane-regeneration-in-an-animal-model
#10
Peter Luke Santa Maria, Chloe Santa Maria, Sungwoo Kim, Yunzhi Peter Yang
OBJECTIVE: A pressure equalization tube placed within the tympanic membrane is the only clinically available method for inhibiting tympanic membrane regeneration. Problems associated with this include associated otorrhea, biofilm formation, medial migration of the tube, tube retention, induction of granulation tissue, and a small but significant rate of cholesteatoma. We aimed to demonstrate that a single administration of a sustained-release polymer formulation of KB-R7785 maintains tympanic membrane perforation for at least 6 months...
December 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28024609/mesenchymal-stem-cell-laden-hybrid-scaffold-for-regenerating-subacute-tympanic-membrane-perforation
#11
Chul Ho Jang, SeungHyun Ahn, Jae Whi Lee, Byeong Ha Lee, Hyeongjin Lee, GeunHyung Kim
Tympanic membrane (TM) perforation is one of the most common otology complications. To date, there has not been reported TM regeneration using bioprinted scaffold. The purpose of this study was to evaluate the efficacy and feasibility of bioprinted polycaprolactone/collagen/alginate-mesenchymal stem cell (PCAMSC) scaffolds for the regeneration of subacute TM perforation. Sprague-Dawley rats were used in an animal model of subacute TM perforation. In the experimental group (n=7), bioprinted 3D PCAMSC scaffold was placed on the perforation...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28017492/superior-canal-dehiscence-with-tegmen-defect-revealed-by-otoscopy-video-clip-demonstration-of-pulsatile-tympanic-membrane
#12
Andrea Castellucci, Cristina Brandolini, Gianluca Piras, Ignacio Javier Fernandez, Davide Giordano, Carmine Pernice, Giovanni Carlo Modugno, Antonio Pirodda, Gian Gaetano Ferri
Superior canal dehiscence is a pathologic condition of the otic capsule acting as aberrant window of the inner ear. It results in reduction of inner ear impedance and in abnormal exposure of the labyrinthine neuroepithelium to the action of the surrounding structures. The sum of these phenomena leads to the onset of typical cochleo-vestibular symptoms and signs. Among them, pulsatile tinnitus has been attributed to a direct transmission of intracranial vascular activities to labyrinthine fluids. We present the first video-otoscopic documentation of spontaneous pulse-synchronous movements of the tympanic membrane in two patients with superior canal dehiscence...
December 22, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28005809/lipoma-of-the-tympanic-membrane
#13
Nurdoğan Ata, Tahir Bülbül, Betül Berberoğlu
No abstract text is available yet for this article.
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28005796/tympanic-membrane-perforation-caused-by-thunderbolt-strike
#14
Nazim Bozan, Ahmet Faruk Kiroglu, Muzaffer Ari, Mahfuz Turan, Hakan Cankaya
Thunderbolt strike is a life-threatening entity. In the patients presenting with thunderbolt strike, the central nervous system and the cardiovascular system should be primarily evaluated, followed by tympanic membrane lesions. The most important symptom connected with ear is the loss of hearing. In this report, a 43-year-old male patient with unilateral tympanic membrane perforation, tinnitus, and bilateral sensorineural hearing loss caused by thunderbolt strike is presented through a review of the literature...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28004262/diagnostic-accuracy-of-tubomanometry-r-value-in-detecting-the-eustachian-tube-pressure-equalizing-function
#15
Cuneyt M Alper, Miriam S Teixeira, Jeehong H Kim, J Douglas Swarts
Tubomanometry is a relatively novel Eustachian tube (ET) function testing method. A number of recent studies have utilized the R value of Tubomanometry as the main objective measure in reporting their outcome in balloon dilation of ET. There is, however, a lack of evidence concerning the reliability or validity of Tubomanometry measurements. The objectives of this study are to determine the accuracy of Tubomanometry for detecting ET opening as compared to tympanometry and determine its usefulness as a measure of ET function...
December 21, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27999999/cartilage-island-on-stapes-autologous-porp-in-the-hypoventilated-middle-ear
#16
Jeanette Hess-Erga, Bart Lambertus Henricus Jozef Engelen, Flemming Slinning Vassbotn
The most common technique in sound restoration of the middle ear is prosthetic surgery. Hypoventilation of the middle ear may cause adhesive otitis or atelectasis resulting in a higher risk of prosthetic extrusion rate and recurrence of the underlying cholesteatoma. We report long-term results using an island of tragal cartilage as an autologous PORP in selected patients with poor middle ear ventilation. Retrospective chart reviews were performed for procedures involving 52 patients between year 2000 and 2009...
December 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27997514/serotypes-not-included-in-13-valent-pneumococcal-vaccine-as-causes-of-acute-otitis-media-with-spontaneous-tympanic-membrane-perforation-in-a-geographic-area-with-high-vaccination-coverage
#17
Paola Marchisio, Susanna Esposito, Marina Picca, Elena Baggi, Leonardo Terranova, Annalisa Orenti, Elia Biganzoli, Nicola Principi
In 177 children living in an area with high 13-valent pneumococcal conjugate vaccine (PCV13) coverage who had acute otitis media (AOM) complicated with spontaneous tympanic membrane perforation (STMP), Streptococcus pneumoniae was identified in the middle ear fluid of 48 (27.1%) subjects, with 37 (77.1%) cases caused by non-PCV13 serotypes.
December 15, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27995828/single-dose-intratympanic-mesna-application-inhibits-propylene-glycol-induced-cholesteatoma-formation
#18
O Ismi, Y Y Karabulut, K K Bal, Y Vayisoglu, M Unal
OBJECTIVE: Mesna (i.e. sodium 2-mercaptoethanesulfonate; C2H5NaO3S2) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears. However, this study aimed to investigate its effect on cholesteatoma formation. METHODS: A total of 20 Wistar rats were divided into two groups of 10 animals. The right and left ears of control animals were treated with saline (saline control group; n = 10 ears) and propylene glycol plus saline (propylene glycol control group; n = 10 ears), respectively...
December 20, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27994124/major-evolutionary-transitions-and-innovations-the-tympanic-middle-ear
#19
REVIEW
Abigail S Tucker
One of the most amazing transitions and innovations during the evolution of mammals was the formation of a novel jaw joint and the incorporation of the original jaw joint into the middle ear to create the unique mammalian three bone/ossicle ear. In this review, we look at the key steps that led to this change and other unusual features of the middle ear and how developmental biology has been providing an understanding of the mechanisms involved. This starts with an overview of the tympanic (air-filled) middle ear, and how the ear drum (tympanic membrane) and the cavity itself form during development in amniotes...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27992946/balloon-tuboplasty-in-patients-with-eustachian-tube-dysfunction-a-prospective-study-in-39-patients-55-ears
#20
P F Bowles, S Agrawal, M A Salam
No abstract text is available yet for this article.
December 19, 2016: Clinical Otolaryngology
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