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https://www.readbyqxmd.com/read/27920350/symptom-cluster-research-with-biomarkers-and-genetics-using-latent-class-analysis
#1
Samantha Conley
The purpose of this article is to provide an overview of latent class analysis (LCA) and examples from symptom cluster research that includes biomarkers and genetics. A review of LCA with genetics and biomarkers was conducted using Medline, Embase, PubMed, and Google Scholar. LCA is a robust latent variable model used to cluster categorical data and allows for the determination of empirically determined symptom clusters. Researchers should consider using LCA to link empirically determined symptom clusters to biomarkers and genetics to better understand the underlying etiology of symptom clusters...
December 5, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27918703/patterns-and-predictors-of-change-in-moderate-to-vigorous-physical-activity-over-time-in-multiple-sclerosis
#2
Rachel E Klaren, Jeffer E Sasaki, Edward McAuley, Robert W Motl
BACKGROUND: Physical inactivity is common in persons with multiple sclerosis (MS), but there is very little known about the pattern and predictors of changes in physical activity over time. PURPOSE: This study examined changes in moderate-to-vigorous physical activity (MVPA) over a 30-month time period and the demographic and clinical predictors of such changes in relapsing-remitting MS (RRMS). METHODS: 269 persons with MS wore an accelerometer for a 7-day period and completed a demographic/clinical scale every 6 months over a 30-month period...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27915076/men-presenting-with-sexual-thoughts-of-children-or-coercion-flights-of-fancy-or-plans-for-crime
#3
Tamara Turner-Moore, Mitch Waterman
INTRODUCTION: There is limited evaluation of clinical and theoretical claims that sexual thoughts of children and coercing others facilitate sexual offending. The nature of these thoughts (what they contain) also is unknown. AIM: To examine the relation between child or coercive sexual thoughts and sexual offending and to determine the nature of these thoughts and any differences among sexual offending (SO), non-sexual offending (NSO), and non-offending (NO) men...
November 30, 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27914733/latent-class-analysis-in-health-research
#4
Alice Kongsted, Anne Molgaard Nielsen
No abstract text is available yet for this article.
August 12, 2016: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27914470/symptom-profiles-and-inflammatory-markers-in-moderate-to-severe-copd
#5
Huong Q Nguyen, Jerald R Herting, Kenneth C Pike, Sina A Gharib, Gustavo Matute-Bello, Soo Borson, Ruth Kohen, Sandra G Adams, Vincent S Fan
BACKGROUND: Physical and psychological symptoms are the hallmark of patients' subjective perception of their illness. The purpose of this analysis was to determine if patients with COPD have distinctive symptom profiles and to examine the association of symptom profiles with systemic biomarkers of inflammation. METHODS: We conducted latent class analyses of three physical (dyspnea, fatigue, and pain) and two psychological symptoms (depression and anxiety) in 302 patients with moderate to severe COPD using baseline data from a longitudinal observational study of depression in COPD...
December 3, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27911960/application-of-latent-growth-modeling-to-identify-different-working-life-trajectories-the-case-of-the-spanish-workss-cohort
#6
Laura Serra, María Andrée López Gómez, Albert Sanchez-Niubo, George L Delclos, Fernando G Benavides
Objective The aim of this study was to describe the application of latent class growth analysis (LCGA) to identify different working life trajectories (WLT) using employed working time by year as a repeated measure. Methods Trajectories are estimated using LCGA, which considers all individuals within a trajectory to be homogeneous. The methodology was applied to a subsample of the Spanish WORKing life Social Security (WORKss) cohort, limited to persons born 1956-1965 (N=247 475). The number of days worked per year is used as a repeated measure across 32 time points (1981-2013)...
December 2, 2016: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/27907454/menopause-is-associated-with-accelerated-lung-function-decline
#7
Kai Triebner, Bobette Matulonga, Ane Johannessen, Sandra Suske, Bryndís Benediktsdóttir, Pascal Demoly, Shyamali C Dharmage, Karl A Franklin, Judith Garcia Aymerich, José Antonio Gullón Blanco, Joachim Heinrich, Mathias Holm, Debbie Jarvis, Rain Jõgi, Eva Lindberg, Jesús Martínez Moratalla Rovira, Nerea Muniozguren Agirre, Isabelle Pin, Nicole Probst-Hensch, Luca Puggini, Chantal Raherison, José Luis Sánchez-Ramos, Vivi Schlünssen, Jordi Sunyer, Cecilie Svanes, Steinar Hustad, Bénédicte Leynaert, Francisco Gómez Real
RATIONALE: Menopause is associated with changes in sex hormones, which affect immunity, inflammation, and osteoporosis and may impair lung function. Lung function decline has not previously been investigated in relation to menopause. OBJECTIVES: To study whether lung function decline, assessed by forced vital capacity and forced expiratory volume in one second, is accelerated in women who undergo menopause. METHODS: The population-based longitudinal European Community Respiratory Health Survey provided serum samples, spirometry and questionnaire data about respiratory and reproductive health from three study waves (N=1438)...
December 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27907223/-mental-retirement-trajectories-of-work-engagement-preceding-retirement-among-older-workers
#8
Astrid de Wind, Fenna Rm Leijten, Trynke Hoekstra, Goedele A Geuskens, Alex Burdorf, Allard J van der Beek
Objectives Before actual retirement, employees may already distance themselves from work, which could be referred to as "mental retirement". However, trajectories of work motivation, ie, work engagement, have not been studied yet. The present study aimed to (i) identify different trajectories of work engagement among older workers approaching the retirement age, and (ii) examine their associations with actual retirement. Methods In total 3171 employees aged 55-62 years, who participated in the Dutch Study on Transitions in Employment, Ability and Motivation were included in this study...
December 1, 2016: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/27906669/hemoglobin-level-trajectories-in-the-early-treatment-period-are-related-with-survival-outcomes-in-patients-with-breast-cancer
#9
Chia-Lin Lee, Chun-Hao Tsai, Dah-Cherng Yeh, Chi-Shy Lin, Yu-Fen Li, Huey-En Tzeng
Hemoglobin (Hb) levels are reportedly related with treatment outcomes and survival in patients of breast cancer. However, the long-term change in Hb levels after treatment and the effects of Hb on survival remain unknown. This retrospective cohort study enrolled 1931 breast cancer patients with pathological stage I-IV between 1/1/2003 and 12/31/2013. Latent class modeling was used to identify trajectories in monthly Hb levels over time. The primary endpoint was 10-year cancer-related death. We identified 5 distinct Hb trajectories: persistent anemia (5...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27905058/regularized-latent-class-analysis-with-application-in-cognitive-diagnosis
#10
Yunxiao Chen, Xiaoou Li, Jingchen Liu, Zhiliang Ying
Diagnostic classification models are confirmatory in the sense that the relationship between the latent attributes and responses to items is specified or parameterized. Such models are readily interpretable with each component of the model usually having a practical meaning. However, parameterized diagnostic classification models are sometimes too simple to capture all the data patterns, resulting in significant model lack of fit. In this paper, we attempt to obtain a compromise between interpretability and goodness of fit by regularizing a latent class model...
November 30, 2016: Psychometrika
https://www.readbyqxmd.com/read/27903334/applying-an-evidence-based-assessment-model-to-identify-students-at-risk-for-perceived-academic-problems-following-concussion
#11
Danielle M Ransom, Alison R Burns, Eric A Youngstrom, Christopher G Vaughan, Maegan D Sady, Gerard A Gioia
OBJECTIVES: The aim of this study was to demonstrate the utility of an evidence-based assessment (EBA) model to establish a multimodal set of tools for identifying students at risk for perceived post-injury academic problems. METHODS: Participants included 142 students diagnosed with concussion (age: M=14.95; SD=1.80; 59% male), evaluated within 4 weeks of injury (median=16 days). Demographics, pre-injury history, self- and parent-report measures assessing symptom severity and executive functions, and cognitive test performance were examined as predictors of self-reported post-injury academic problems...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27899364/identification-of-shared-and-unique-serum-lipid-profiles-in-diabetes-mellitus-and-myocardial-infarction
#12
Sanela Kjellqvist, Christian Klose, Michal A Surma, George Hindy, Inês G Mollet, Anna Johansson, Patrick Chavaux, Johan Gottfries, Kai Simons, Olle Melander, Céline Fernandez
BACKGROUND: Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. METHODS AND RESULTS: We used shotgun mass spectrometry to determine serum levels of 255 molecular lipids in 316 controls, 171 DM, and 99 myocardial infarction (MI) events from a cohort derived from the Malmö Diet and Cancer study. Orthogonal projections to latent structures analyses were conducted between the lipids and clinical parameters describing DM or MI...
November 29, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27896298/applying-latent-class-assignments-for-accelerometry-data-to-external-populations-data-from-the-national-health-and-nutrition-examination-survey-2003-2006
#13
Kelly R Evenson, Fang Wen, Annie Green Howard, Amy H Herring
Latent class analysis can identify unmeasured mutually exclusive categories (class membership) among participants for either observed categorical or continuous variables. More recently, latent class analysis has been applied to accelerometry to better understand the day-to-day patterns of physical activity and sedentary behavior. Typically, the class assignments are only relevant to the study for which they were derived and not made available for others to use. Using one-week accelerometry (ActiGraph #AM7164) data collected from the National Health and Nutrition Examination Survey during 2003-2006, latent classes of physical activity and sedentary behavior were derived separately for youths 6-17 years and adults >=18 years...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27895025/medical-treatment-of-aortic-stenosis
#14
Guillaume Marquis-Gravel, Björn Redfors, Martin B Leon, Philippe Généreux
Untreated, severe, symptomatic aortic stenosis is associated with a dismal prognosis. The only treatment shown to improve survival is aortic valve replacement; however, before symptoms occur, aortic stenosis is preceded by a silent, latent phase characterized by a slow progression at the molecular, cellular, and tissue levels. In theory, specific medical therapy should halt aortic stenosis progression, reduce its hemodynamic repercussions on left ventricular function and remodeling, and improve clinical outcomes...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27894119/trajectories-and-predictors-of-allograft-dysfunction-after-renal-transplantation-in-children
#15
Vandréa Carla de Souza, Muriel Rabilloud, Pierre Cochat, Mario Bernardes Wagner, Clotilde Druck Garcia, Bruno Ranchin, Jean Iwaz, Luciano Selistre, Laurence Dubourg
BACKGROUND: The survival rates of renal transplant children are indeed on the rise, but it is still important to ensure that there is optimal renal function in these children in all their future growing years. The number of functioning nephrons and the graft ability to adapt to an increasing demand during body growth seem to be the most important factors for long-term allograft function. This study examined the long-term change in the glomerular filtration rate in a pediatric kidney transplant cohort and the importance of the recipient and donor ages in predicting transplant outcome...
November 29, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27893813/azidothymidine-sensitizes-primary-effusion-lymphoma-cells-to-kaposi-sarcoma-associated-herpesvirus-specific-cd4-t-cell-control-and-inhibits-virf3-function
#16
Samantha J Williamson, Samantha M Nicol, Michael Stürzl, Shereen Sabbah, Andrew D Hislop
Kaposi sarcoma-associated herpesvirus (KSHV) is linked with the development of Kaposi sarcoma and the B lymphocyte disorders primary effusion lymphoma (PEL) and multi-centric Castleman disease. T cell immunity limits KSHV infection and disease, however the virus employs multiple mechanisms to inhibit efficient control by these effectors. Thus KSHV-specific CD4+ T cells poorly recognize most PEL cells and even where they can, they are unable to kill them. To make KSHV-infected cells more sensitive to T cell control we treated PEL cells with the thymidine analogue azidothymidine (AZT), which sensitizes PEL lines to Fas-ligand and TRAIL challenge; effector mechanisms which T cells use...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27893245/the-quest-for-identity-in-adolescence-heterogeneity-in-daily-identity-formation-and-psychosocial-adjustment-across-5-years
#17
Andrik I Becht, Stefanie A Nelemans, Susan J T Branje, Wilma A M Vollebergh, Hans M Koot, Jaap J A Denissen, Wim H J Meeus
Identity formation is one of the key developmental tasks in adolescence. According to Erikson (1968) experiencing identity uncertainty is normative in adolescence. However, empirical studies investigating identity uncertainty on a daily basis are lacking. Hence, studying individual differences in daily certainty (i.e., identity commitment levels) and uncertainty (i.e., identity commitment fluctuations and identity reconsideration) in the identity formation process may advance our knowledge about the extent to which adolescents' identity uncertainty is part of normative identity development...
December 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27892960/new-genome-wide-algorithm-identifies-novel-in-vivo-expressed-mycobacterium-tuberculosis-antigens-inducing-human-t-cell-responses-with-classical-and-unconventional-cytokine-profiles
#18
Mariateresa Coppola, Krista E van Meijgaarden, Kees L M C Franken, Susanna Commandeur, Gregory Dolganov, Igor Kramnik, Gary K Schoolnik, Inaki Comas, Ole Lund, Corine Prins, Susan J F van den Eeden, Gro E Korsvold, Fredrik Oftung, Annemieke Geluk, Tom H M Ottenhoff
New strategies are needed to develop better tools to control TB, including identification of novel antigens for vaccination. Such Mtb antigens must be expressed during Mtb infection in the major target organ, the lung, and must be capable of eliciting human immune responses. Using genome-wide transcriptomics of Mtb infected lungs we developed data sets and methods to identify IVE-TB (in-vivo expressed Mtb) antigens expressed in the lung. Quantitative expression analysis of 2,068 Mtb genes from the predicted first operons identified the most upregulated IVE-TB genes during in-vivo pulmonary infection...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27889856/gender-differences-in-anxiety-trajectories-from-middle-to-late-adolescence
#19
Christine McCauley Ohannessian, Stephanie Milan, Anna Vannucci
Although developmental trajectories of anxiety symptomatology have begun to be explored, most research has focused on total anxiety symptom scores during childhood and early adolescence, using racially/ethnically homogenous samples. Understanding the heterogeneous courses of anxiety disorder symptoms during middle to late adolescence has the potential to clarify developmental risk models of anxiety and to inform prevention programs. Therefore, this study specifically examined gender differences in developmental trajectories of anxiety disorder symptoms (generalized anxiety disorder, panic disorder, and social anxiety disorder) from middle to late adolescence in a diverse community sample (N = 1000; 57 % female; 65 % White), assessed annually over 2 years...
November 26, 2016: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/27888736/activity-engagement-and-physical-function-in-old-age-sample
#20
Krupa N Shah, Feng V Lin, Fang Yu, James M McMahon
OBJECTIVES: To describe the patterns of engagement in mental, physical, and social activity (MA, PA, and SA) and to examine the relationship between combined activity engagement and physical function among community-dwelling older adults. DESIGN: Cross-sectional correlational study. SETTING: Multiple communities. PARTICIPANTS: A total of 466 individuals aged 55 years or older. MEASUREMENTS: Physical function was assessed using grip strength and gait speed...
November 17, 2016: Archives of Gerontology and Geriatrics
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