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https://www.readbyqxmd.com/read/28432794/posttraumatic-stress-and-anxiety-in-patients-with-an-implantable-cardioverter-defibrillator-trajectories-and-vulnerability-factors
#1
M Habibović, J Denollet, S S Pedersen
BACKGROUND: Implantable cardioverter defibrillator (ICD) therapy is first-line treatment for the primary and secondary prevention of sudden cardiac death. Despite the unequivocal medical benefits, living with an ICD may affect patients' psychological functioning and general well-being. We examined the trajectories of symptoms of posttraumatic stress disorder (PTSD) and anxiety in patients with an ICD and the vulnerability factors associated with an increased risk of symptoms of PTSD and anxiety...
April 22, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28431973/understanding-the-relationship-of-cigarette-smoking-trajectories-through-adolescence-and-weight-status-in-young-adulthood-in-the-united-states
#2
Minal Patel, Annette Kaufman, Yvonne Hunt, Linda Nebeling
PURPOSE: Adolescent cigarette smoking has steadily declined since 1999, whereas adolescent obesity rates have quadrupled since the 1980s. Few studies address the longitudinal relationship of smoking and weight in youth and young adulthood. This study examines the relationship of smoking trajectories beginning in adolescence on weight status in young adulthood in a nationally representative longitudinal sample. METHODS: The study sample was drawn from the National Longitudinal Study of Adolescent to Adult Health Waves I-IV (N = 13,361)...
April 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28431193/evaluation-of-cholesterol-as-a-biomarker-for-suicidality-in-a-veteran-sample
#3
Chuck Reuter, Barbara Caldwell, Heather Basehore
A reduction in total cholesterol may alter the microviscosity of the brain-cell-membrane, reducing serotonin receptor exposure. The resulting imbalance between serotonin and dopamine may lead to an increased risk for suicidality. The objective of this research was to evaluate total cholesterol as a biological marker for suicidality in a sample of US military veterans. The study population consisted of veterans who received care at the Coatesville Veterans Affairs Medical Center (VAMC) and were included in the Suicide Prevention Coordinator's database for having suicidal ideation with evidence of escalating intent, a documented suicide attempt, or committed suicide between 2009 and 2015...
April 21, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28430817/kaposi-sarcoma-herpesvirus-kshv-latency-associated-nuclear-antigen-lana-recruits-components-of-the-mrn-mre11-rad50-nbs1-repair-complex-to-modulate-an-innate-immune-signaling-pathway-and-viral-latency
#4
Giuseppe Mariggiò, Sandra Koch, Guigen Zhang, Magdalena Weidner-Glunde, Jessica Rückert, Semra Kati, Susann Santag, Thomas F Schulz
Kaposi Sarcoma Herpesvirus (KSHV), a γ2-herpesvirus and class 1 carcinogen, is responsible for at least three human malignancies: Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman's Disease (MCD). Its major nuclear latency protein, LANA, is indispensable for the maintenance and replication of latent viral DNA in infected cells. Although LANA is mainly a nuclear protein, cytoplasmic isoforms of LANA exist and can act as antagonists of the cytoplasmic DNA sensor, cGAS. Here, we show that cytosolic LANA also recruits members of the MRN (Mre11-Rad50-NBS1) repair complex in the cytosol and thereby inhibits their recently reported role in the sensing of cytoplasmic DNA and activation of the NF-κB pathway...
April 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28430793/identifying-a-combined-construct-of-grief-and-explosive-anger-as-a-response-to-injustice-amongst-survivors-of-mass-conflict-a-latent-class-analysis-of-data-from-timor-leste
#5
Susan J Rees, Alvin Kuowei Tay, Elisa Savio, Zelia Maria Da Costa, Derrick Silove
Previous studies have identified high rates of explosive anger amongst post-conflict populations including Timor-Leste. We sought to test whether explosive anger was integrally associated with symptoms of grief amongst the Timorese, a society that has experienced extensive conflict-related losses. In 2010 and 2011 we recruited adults (n = 2964), 18-years and older, living in an urban and a rural village in Timor-Leste. We applied latent class analysis to identify subpopulations based on symptoms of explosive anger and grief...
2017: PloS One
https://www.readbyqxmd.com/read/28429601/later-life-preparation-patterns-on-depression-among-korean-baby-boom-generations
#6
Seok In Nam, Junpyo Kim, Jimin Shin, Arram Yim
The aim of this study was to examine the later-life preparation pattern of Korean baby boomers and its effect on depression. Using the fourth wave of Korean Retirement and Income Study, later-life preparation was measured by economic, physical, and psychological preparation, and leisure, and family relationship satisfaction. The data analysis included latent class analysis, correlations, multiple logistic regression, and analysis of variance. Later-life patterns of Korean baby boomers were classified as high-level (35...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/28429157/scenes-as-micro-cultures-examining-heterogeneity-of-hiv-risk-behavior-among-gay-bisexual-and-other-men-who-have-sex-with-men-in-toronto-canada
#7
Syed W Noor, Barry D Adam, David J Brennan, David A Moskowitz, Sandra Gardner, Trevor A Hart
Using latent class analysis (LCA), we examined patterns of participation in multiple scenes, how sexual risk practices vary by scene, and psychosocial factors associated with these patterns among 470 gay, bisexual, and other men who have sex with men (GBM) recruited from Toronto. We calculated posterior probability of being in a class from participation in nine separate scenes. We used Entropy, the Bayesian information criterion and the Lo-Mendel-Rubin likelihood ratio test to identify the best fit model. Fit indices suggested a four-class solution...
April 20, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28426364/patterns-of-mood-and-personality-factors-and-associations-with-sti-hiv-related-drug-and-sex-risk-among-african-american-male-inmates
#8
Joy D Scheidell, Carl W Lejuez, Carol E Golin, Adaora A Adimora, David A Wohl, Larry D Keen, Michael Hammond, Selena Judon-Monk, Maria R Khan
BACKGROUND: Research on the association between antisocial personality disorder (ASPD) with comorbid mental disorders and sexually transmitted infection (STI)/HIV risk among inmates is scant despite the high prevalence of psychopathology and of STI/HIV in this population. METHODS: We used baseline data from Project DISRUPT, a cohort study conducted among incarcerated African American men (n = 207), to measure associations between ASPD and STI/HIV risk. We also conducted latent class analyses (LCAs) to identify subgroups defined by ASPD with comorbid stress, depression, and borderline personality disorder symptoms and measured associations between latent class membership and STI/HIV risk...
June 7, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28423058/accurate-phenotyping-reconciling-approaches-through-bayesian-model-averaging
#9
Carla Chia-Ming Chen, Jonathan Macgregor Keith, Kerrie Lee Mengersen
Genetic research into complex diseases is frequently hindered by a lack of clear biomarkers for phenotype ascertainment. Phenotypes for such diseases are often identified on the basis of clinically defined criteria; however such criteria may not be suitable for understanding the genetic composition of the diseases. Various statistical approaches have been proposed for phenotype definition; however our previous studies have shown that differences in phenotypes estimated using different approaches have substantial impact on subsequent analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28422690/doubly-nonparametric-sparse-nonnegative-matrix-factorization-based-on-dependent-indian-buffet-processes
#10
Junyu Xuan, Jie Lu, Guangquan Zhang, Richard Yi Da Xu, Xiangfeng Luo
Sparse nonnegative matrix factorization (SNMF) aims to factorize a data matrix into two optimized nonnegative sparse factor matrices, which could benefit many tasks, such as document-word co-clustering. However, the traditional SNMF typically assumes the number of latent factors (i.e., dimensionality of the factor matrices) to be fixed. This assumption makes it inflexible in practice. In this paper, we propose a doubly sparse nonparametric NMF framework to mitigate this issue by using dependent Indian buffet processes (dIBP)...
April 12, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28420335/trajectories-of-life-satisfaction-and-their-predictors-among-korean-older-adults
#11
Hyun Ja Lim, Dae Kee Min, Lilian Thorpe, Chel Hee Lee
BACKGROUND: Among older adults, life satisfaction (LS) correlates with health, mortality, and successful ageing. As various potential threats to LS tend to increase with advancing years, patterns of age-related changes in LS among older adults remain inconsistent. This study aimed to identify LS trajectories in older adults and the characteristics of individuals who experience them. METHODS: Large-scale, nationally representative, longitudinal data collected from 2005 to 2013 were analyzed for this study...
April 19, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28419430/the-role-of-family-characteristics-for-students-academic-outcomes-a%C3%A2-person-centered-approach
#12
Isabelle Häfner, Barbara Flunger, Anna-Lena Dicke, Hanna Gaspard, Brigitte M Brisson, Benjamin Nagengast, Ulrich Trautwein
Using data from 1,571 ninth-grade students (Mage  = 14.62) from 82 academic track schools in Germany and their predominantly Caucasian middle-class parents, configurations of different family characteristics reported by parents were investigated. Latent profile analyses considering academic involvement, family interest, parents' self-concept, child's need for support, and parents' time and energy identified average, indifferent, motivated and engaged, motivated and disengaged, and involved families. Cross-sectional and longitudinal associations with students' motivational (self-concept, effort, and interest) and achievement outcomes (achievement test and grades) in math were analyzed...
April 17, 2017: Child Development
https://www.readbyqxmd.com/read/28411388/adiposity-across-the-adult-life-course-and-incidence-of-primary-liver-cancer-the-nih-aarp-cohort
#13
Baiyu Yang, Jessica L Petrick, Scott P Kelly, Barry I Graubard, Neal D Freedman, Katherine A McGlynn
Obesity relatively late in adulthood has been consistently associated with increased risk of primary liver cancer. However, little is known about the role of early adult adiposity and evolution of adiposity across adulthood in hepatocarcinogenesis. We examined adult body mass index (BMI; kg/m(2) ) in relation to hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) in a large prospective cohort. Weight at ages 18, 35, 50 and at study baseline was retrospectively reported by 303,620 participants...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28410860/comprehensive-screening-for-suicide-risk-in-primary-care
#14
Guy S Diamond, Joanna L Herres, E Stephanie Krauthamer Ewing, Tita O Atte, Syreeta W Scott, Matt B Wintersteen, Robert J Gallop
INTRODUCTION: Suicide is a major public health problem and a complex clinical challenge. Assessment and early identification could be enhanced with screening tools that look beyond depression. The purpose of this study was to identify profiles of risk behaviors and social stress associated with suicidal ideation and behavior using the Behavioral Health Screen. METHODS: The study used screening data from 2,513 primary care patients (aged 14-24 years). Data were collected between 2008 and 2012, and were analyzed in 2016...
April 11, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28410365/effects-of-physical-education-extracurricular-sports-activities-and-leisure-satisfaction-on-adolescent-aggressive-behavior-a-latent-growth-modeling-approach
#15
Sanghyun Park, Weisheng Chiu, Doyeon Won
The present study aimed to investigate the longitudinal influence of physical education classes, extracurricular sports activities, and leisure satisfaction on aggressive behavior among South Korean adolescents. Data were drawn from the Korea Youth Panel Survey. We used latent growth curve modeling to explain the growth trajectory of adolescent aggressive behaviors and a multi-group analysis to investigate gender differences in aggressive behavior. The results indicated that adolescents' aggressive behavior significantly changed with age...
2017: PloS One
https://www.readbyqxmd.com/read/28408894/the-relationships-between-mental-health-symptoms-and-gambling-behavior-in-the-transition-from-adolescence-to-emerging-adulthood
#16
Dominic Sagoe, Ståle Pallesen, Daniel Hanss, Tony Leino, Helge Molde, Rune A Mentzoni, Torbjørn Torsheim
There is a paucity of longitudinal investigations of gambling behavior in the transition from adolescence to emerging adulthood. We conducted a longitudinal investigation of the associations and patterns of change between mental health symptoms and gambling behavior. A representative sample of Norwegians completed questionnaires containing demographic, mental health, and gambling measures at age 17 (N = 2055), and at ages 18 (N = 1334) and 19 (N = 1277). Using latent class analysis, three classes of gambling behavior were identified: consistent non-gambling (71...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28406657/using-latent-variable-and-person-centered-approaches-to-examine-the-role-of-psychopathic-traits-in-sex-offenders
#17
Sonja Krstic, Craig S Neumann, Sandeep Roy, Carrie A Robertson, Raymond A Knight, Robert D Hare
The current study employed both latent variable- and person-centered approaches to examine psychopathic traits in a large sample of sex offenders (N = 958). The offenders, who had committed a range of sexual crimes, had been assessed with the Psychopathy Checklist-Revised (PCL-R; Hare, 2003). Structural equation modeling results indicated that the four-factor model of psychopathy (Hare, 2003; Neumann, Hare, & Newman, 2007) provided good representation of the dimensional nature of psychopathic traits across the sample of offenders, and that the PCL-R factors significantly predicted sexual crimes...
April 13, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28401837/new-insight-on-intergenerational-attachment-from-a-relationship-based-analysis
#18
Heidi N Bailey, George M Tarabulsy, Greg Moran, David R Pederson, Sandi Bento
Research on attachment transmission has focused on variable-centered analyses, where hypotheses are tested by examining linear associations between variables. The purpose of this study was to apply a relationship-centered approach to data analysis, where adult states of mind, maternal sensitivity, and infant attachment were conceived as being three components of a single, intergenerational relationship. These variables were assessed in 90 adolescent and 99 adult mother-infant dyads when infants were 12 months old...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28400527/targeting-energy-metabolism-in-mycobacterium-tuberculosis-a-new-paradigm-in-antimycobacterial-drug-discovery
#19
REVIEW
Dirk Bald, Cristina Villellas, Ping Lu, Anil Koul
Drug-resistant mycobacterial infections are a serious global health challenge, leading to high mortality and socioeconomic burdens in developing countries worldwide. New innovative approaches, from identification of new targets to discovery of novel chemical scaffolds, are urgently needed. Recently, energy metabolism in mycobacteria, in particular the oxidative phosphorylation pathway, has emerged as an object of intense microbiological investigation and as a novel target pathway in drug discovery. New classes of antibacterials interfering with elements of the oxidative phosphorylation pathway are highly active in combating dormant or latent mycobacterial infections, with a promise of shortening tuberculosis chemotherapy...
April 11, 2017: MBio
https://www.readbyqxmd.com/read/28398138/examining-human-behavior-in-video-games-the-development-of-a-computational-model-to-measure-aggression
#20
Richard Lamb, Leonard Annetta, Douglas Hoston, Marina Shapiro, Benjamin Matthews
Video games with violent content have raised considerable concern in popular media and within academia. Recently, there has been considerable attention regarding the claim of the relationship between aggression and video game play. The authors of this study propose the use of a new class of tools developed via computational models to allow examination of the question; is there is a relationship between violent video games and aggression. The purpose of this study is to computationally model and compare the General Aggression Model with the Diathesis Mode of Aggression related to the play of violent content in video games...
April 11, 2017: Social Neuroscience
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