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https://www.readbyqxmd.com/read/28531273/phenotypes-of-atopic-dermatitis-depending-on-the-timing-of-onset-and-progression-in-childhood
#1
Caroline Roduit, Remo Frei, Martin Depner, Anne M Karvonen, Harald Renz, Charlotte Braun-Fahrländer, Elisabeth Schmausser-Hechfellner, Juha Pekkanen, Josef Riedler, Jean-Charles Dalphin, Erika von Mutius, Roger Pascal Lauener, Anne Hyvärinen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Marie-Laure Dalphin, Vincent Kaulek, Markus Ege, Jon Genuneit, Sabina Illi, Micahel Kabesch, Bianca Schaub, Petra Ina Pfefferle, Gert Doekes
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking. Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28527921/drug-induced-fatal-arrhythmias-acquired-long-qt-and-brugada-syndromes
#2
REVIEW
Isik Turker, Tomohiko Ai, Hideki Itoh, Minoru Horie
Since the early 1990s, the concept of primary "inherited" arrhythmia syndromes or ion channelopathies has evolved rapidly as a result of revolutionary progresses made in molecular genetics. Alterations in genes coding for membrane proteins such as ion channels or their associated proteins responsible for the generation of cardiac action potentials (AP) have been shown to cause specific malfunctions which eventually lead to cardiac arrhythmias. These arrhythmic disorders include congenital long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, short QT syndrome, progressive cardiac conduction disease, etc...
May 17, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28524714/consumption-patterns-of-nightlife-attendees-in-munich-a-latent-class-analysis
#3
Tessa-Virginia Hannemann, Ludwig Kraus, Daniela Piontek
BACKGROUND: The affinity for substance use among patrons of nightclubs has been well established. With novel psychoactive substances (NPS) quickly emerging on the European drug market, trends, and patterns of use are potentially changing. OBJECTIVES: (1) The detection of subgroups of consumers in the electronic dance music scene of a major German metropolitan city, (2) describing the consumption patterns of these subgroups, (3) exploring the prevalence and type of NPS consumption in this population at nightlife events in Munich...
May 19, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28524713/usual-alcohol-consumption-and-risks-for-nonfatal-fall-injuries-in-the-united-states-results-from-the-2004-2013-national-health-interview-survey
#4
Chiung M Chen, Young-Hee Yoon
BACKGROUND: Acute alcohol consumption is known to be a risk factor for fall injuries. OBJECTIVE: The study sought to determine whether usual alcohol consumption increases the risk for nonfatal fall injuries. METHOD: Data from 289,187 sample adults in the 2004-2013 U.S. National Health Interview Surveys were analyzed. Of these, 3,368 (∼1%) reported a total of 3,579 fall-injury episodes requiring medical consultation in the past 3 months...
May 19, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28521242/a-structured-latent-model-for-ovarian-carcinoma-subtyping-from-histopathology-slides
#5
Aïcha BenTaieb, Hector Li-Chang, David Huntsman, Ghassan Hamarneh
Accurate subtyping of ovarian carcinomas is an increasingly critical and often challenging diagnostic process. This work focuses on the development of an automatic classification model for ovarian carcinoma subtyping. Specifically, we present a novel clinically inspired contextual model for histopathology image subtyping of ovarian carcinomas. A whole slide image is modelled using a collection of tissue patches extracted at multiple magnifications. An efficient and effective feature learning strategy is used for feature representation of a tissue patch...
May 9, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28516847/who-is-at-risk-for-intimate-partner-violence-victimization-using-latent-class-analysis-to-explore-interpersonal-polyvictimization-and-polyperpetration-among-pregnant-young-couples
#6
Tiara C Willie, Adeya Powell, Jessica Lewis, Tamora Callands, Trace Kershaw
The purpose of our study was (a) to use latent class analyses to identify subgroups of interpersonal polyvictimizationand polyperpetration among young pregnant couples and (b) examine actor-partner effects of latent classes on current intimate partner violence (IPV) victimization. Data were collected from 296 pregnant young couples recruited at obstetrics and gynecology clinics. A 3-latent class model emerged for women: Polyvictim-Polyperpetrator, Nonvictim-Nonperpetrator, and Community and Prior IPV Victim...
May 17, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28515185/the-job-content-questionnaire-in-various-occupational-contexts-applying-a-latent-class-model
#7
Kionna Oliveira Bernardes Santos, Tânia Maria de Araújo, Fernando Martins Carvalho, Robert Karasek
OBJECTIVE: To evaluate Job Content Questionnaire(JCQ) performance using the latent class model. METHODS: We analysed cross-sectional studies conducted in Brazil and examined three occupational categories: petroleum industry workers (n=489), teachers (n=4392) and primary healthcare workers (3078)and 1552 urban workers from a representative sample of the city of Feira de Santana in Bahia, Brazil. An appropriate number of latent classes was extracted and described each occupational category using latent class analysis, a multivariate method that evaluates constructs and takes into accountthe latent characteristics underlying the structure of measurement scales...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28513971/predictors-and-the-distal-outcome-of-general-internet-use-the-identification-of-children-s-developmental-trajectories
#8
Jeong Jin Yu, Su Jung Park
This study examined the predictors and distal outcome in relation to the frequency of online activities and investigated the presence of prototypical trajectories following different patterns of general Internet use over 5 years. The data set consisted of a nationally representative sample of 2,840 fourth graders (Mage  = 9.86 years) in South Korea at baseline. Analyses revealed rank-order stability in general Internet use with four latent classes: high stable (5.8%), high quadratic (20.3%), moderate stable (32...
May 17, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28511291/fatigue-older-age-higher-body-mass-index-and-female-gender-predict-worse-disability-in-early-rheumatoid-arthritis-despite-treatment-to-target-a-comparison-of-two-observational-cohort-studies-from-the-united-kingdom
#9
Sarah Twigg, Elizabeth M A Hensor, Jane Freeston, Ai Lyn Tan, Paul Emery, Alan Tennant, Ann W Morgan
OBJECTIVES: Compare disease activity and disability over 2 years in early rheumatoid arthritis (RA) before and after implementation of treat to target (T2T) and identify predictors of adverse outcome. METHODS: Yorkshire Early Arthritis Register (YEAR) recruited 725 patients with early RA between 2002-2009, treated with a step-up approach. The IACON study (Inflammatory Arthritis CONtinuum) recruited cases between 2010-2014 and treated to target. 384 IACON cases met 2010 ACR/EULAR criteria...
May 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28511286/who-achieves-low-risk-drinking-during-alcohol-treatment-an-analysis-of-patients-in-three-alcohol-clinical-trials
#10
Katie Witkiewitz, Matthew R Pearson, Kevin A Hallgren, Stephen A Maisto, Corey R Roos, Megan Kirouac, Adam D Wilson, Kevin A Montes, Nick Heather
BACKGROUND AND AIMS: There is evidence that low risk drinking is possible during the course of alcohol treatment and can be maintained following treatment. Our aim was to identify characteristics associated with low risk drinking during treatment in a large sample of individuals as they received treatment for alcohol dependence. DESIGN: Integrated analysis of data from the COMBINE study, Project MATCH, and the United Kingdom Alcohol Treatment Trial using repeated measures latent class analysis to identify patterns of drinking and predictors of low risk drinking patterns during treatment...
May 16, 2017: Addiction
https://www.readbyqxmd.com/read/28510994/improved-detection-of-burkholderia-pseudomallei-from-non-blood-clinical-specimens-using-enrichment-culture-and-pcr-narrowing-diagnostic-gap-in-resource-constrained-settings
#11
Chaitanya Tellapragada, Tushar Shaw, Annet D'Souza, Vandana Kalwaje Eshwara, Chiranjay Mukhopadhyay
OBJECTIVES: To evaluate the diagnostic utility of enrichment culture and PCR for improved case detection rates of non-bacteremic form of melioidosis in limited resource settings. METHODS: Clinical specimens (n=525) obtained from patients presenting at a tertiary care hospital of south India with clinical symptoms suggestive of community-acquired pneumonia, lower respiratory tract infections, superficial or internal abscesses, chronic skin ulcers and bone or joint infections were tested for the presence of Burkholderia pseudomallei using conventional culture (CC), enrichment culture (EC) and PCR...
May 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28509391/common-mental-disorder-including-psychotic-experiences-trailblazing-a-new-recovery-pathway-within-the-improving-access-to-psychological-therapies-programme-in-england
#12
Jesus Perez, Debra A Russo, Jan Stochl, James Clarke, Zoe Martin, Christina Jassi, Paul French, David Fowler, Peter B Jones
Psychotic experiences, depressive and anxiety symptoms may be manifestations of a latent continuum of common mental distress. The Improving Access to Psychological Therapies (IAPT) programme has increased the reach of psychological treatments to people with common mental disorders in England. However, psychotic experiences are neither measured nor considered in therapy. We aimed to confirm the presence of psychotic experiences among IAPT service-users and determine whether these experiences are associated with higher depression/anxiety levels and poorer recovery...
May 16, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28508249/self-and-peer-identified-victims-in-late-childhood-differences-in-perceptions-of-the-school-ecology
#13
Molly Dawes, Chin-Chih Chen, Thomas W Farmer, Jill V Hamm
Patterns of adjustment for youth victimized by peers vary depending on whether youth are identified as victims through self-reports, peer-reports, or both. In order to provide more targeted strategies that may help mitigate negative consequences associated with specific victimization groups, more information is needed about how these youth perceive their school ecology (bullying and academic ecology), their feelings of school belonging, and their valuing of school. Based on the convergence of self- and peer-reports of victimization, we identified four victim groups from a sample of students in 5th grade classrooms (N = 1360; 52...
May 15, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28506313/latent-variable-mixture-models-to-test-for-differential-item-functioning-a-population-based-analysis
#14
Xiuyun Wu, Richard Sawatzky, Wilma Hopman, Nancy Mayo, Tolulope T Sajobi, Juxin Liu, Jerilynn Prior, Alexandra Papaioannou, Robert G Josse, Tanveer Towheed, K Shawn Davison, Lisa M Lix
BACKGROUND: Comparisons of population health status using self-report measures such as the SF-36 rest on the assumption that the measured items have a common interpretation across sub-groups. However, self-report measures may be sensitive to differential item functioning (DIF), which occurs when sub-groups with the same underlying health status have a different probability of item response. This study tested for DIF on the SF-36 physical functioning (PF) and mental health (MH) sub-scales in population-based data using latent variable mixture models (LVMMs)...
May 15, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28502760/patterns-of-gestational-weight-gain-and-birthweight-outcomes-in-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development-fetal-growth-studies-singletons-a-prospective-study
#15
Sarah J Pugh, Paul S Albert, Sungduk Kim, William Grobman, Stefanie N Hinkle, Roger B Newman, Deborah A Wing, Katherine L Grantz
BACKGROUND: Inadequate or excessive total gestational weight gain is associated with increased risks of small- and large-for-gestational-age births, respectively, but evidence is sparse regarding overall and trimester-specific patterns of gestational weight gain in relation to these risks. Characterizing the interrelationship between patterns of gestational weight gain across trimesters can reveal whether the trajectory of gestational weight gain in the first trimester sets the path for gestational weight gain in subsequent trimesters, thereby serving as an early marker for at-risk pregnancies...
May 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28500010/robust-latent-subspace-learning-for-image-classification
#16
Xiaozhao Fang, Shaohua Teng, Zhihui Lai, Zhaoshui He, Shengli Xie, Wai Keung Wong
This paper proposes a novel method, called robust latent subspace learning (RLSL), for image classification. We formulate an RLSL problem as a joint optimization problem over both the latent SL and classification model parameter predication, which simultaneously minimizes: 1) the regression loss between the learned data representation and objective outputs and 2) the reconstruction error between the learned data representation and original inputs. The latent subspace can be used as a bridge that is expected to seamlessly connect the origin visual features and their class labels and hence improve the overall prediction performance...
May 10, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28500009/end-to-end-feature-aware-label-space-encoding-for-multilabel-classification-with-many-classes
#17
Zijia Lin, Guiguang Ding, Jungong Han, Ling Shao
To make the problem of multilabel classification with many classes more tractable, in recent years, academia has seen efforts devoted to performing label space dimension reduction (LSDR). Specifically, LSDR encodes high-dimensional label vectors into low-dimensional code vectors lying in a latent space, so as to train predictive models at much lower costs. With respect to the prediction, it performs classification for any unseen instance by recovering a label vector from its predicted code vector via a decoding process...
May 9, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28499106/alcohol-and-cigarette-use-from-ages-23-to-55-links-with-health-and-well-being-in-the-long-term-national-child-development-study
#18
Jeremy Staff, Jennifer Maggs
OBJECTIVE: Using longitudinal data from the National Child Development Study, an ongoing study of a nationally representative British cohort born in 1958 (n = 9,137; 51% female), we examined how patterns of alcohol and cigarette use from young adulthood (age 23) to midlife (age 55) are associated with health and well-being. METHOD: We first used a nonparametric multilevel latent class specification to identify eight unique paths of alcohol and cigarette use from ages 23 to 55, and then assessed how these long-term latent paths related to overall health, heart problems, chronic illness, and quality of life at midlife...
May 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28498531/developmental-latent-patterns-of-identification-as-mostly-heterosexual-versus-lesbian-gay-or-bisexual
#19
Jerel P Calzo, Katherine E Masyn, S Bryn Austin, Hee-Jin Jun, Heather L Corliss
Scant research exists on the development of mostly heterosexual identity, the largest sexual orientation minority subgroup. We used longitudinal latent class analysis to characterize the patterns of identification with lesbian, gay, bisexual (LGB), or mostly heterosexual identities from ages 12 to 23 in 13,859 youth (57% female) in a U.S. national cohort. Three classes emerged: completely heterosexual (88.2%), mostly heterosexual (9.5%), and LGB (2.4%). LGB class youth generally identified with sexual minority identities by ages 12-17...
March 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28490902/patient-and-physician-preferences-for-anticancer-drugs-for-the-treatment-of-metastatic-colorectal-cancer-a-discrete-choice-experiment
#20
Juan Marcos González, Sarika Ogale, Robert Morlock, Joshua Posner, Brett Hauber, Nicolas Sommer, Axel Grothey
OBJECTIVE: Many publications describe preferences for colorectal cancer (CRC) screening; however, few studies elicited preferences for anticancer-drug treatment for metastatic CRC (mCRC). This study was designed to elicit preferences and risk tolerance among patients and oncologists in the USA for anticancer drugs to treat mCRC. MATERIALS AND METHODS: Patients aged 18 years or older with a self-reported diagnosis of mCRC and board-certified (or equivalent) oncologists who had treated patients with mCRC were recruited by two survey research companies from existing online patient panels in the USA...
2017: Cancer Management and Research
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