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https://www.readbyqxmd.com/read/28926564/probabilistic-models-for-neural-populations-that-naturally-capture-global-coupling-and-criticality
#1
Jan Humplik, Gašper Tkačik
Advances in multi-unit recordings pave the way for statistical modeling of activity patterns in large neural populations. Recent studies have shown that the summed activity of all neurons strongly shapes the population response. A separate recent finding has been that neural populations also exhibit criticality, an anomalously large dynamic range for the probabilities of different population activity patterns. Motivated by these two observations, we introduce a class of probabilistic models which takes into account the prior knowledge that the neural population could be globally coupled and close to critical...
September 19, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28926403/pathways-from-sexual-stigma-to-incident-hiv-and-sexually-transmitted-infections-among-nigerian-men-who-have-sex-with-men
#2
Cristina Rodriguez-Hart, Rebecca G Nowak, Rashelle Musci, Danielle German, Ifeanyi Orazulike, Blessing Kayode, Hongjie Liu, Oye Gureje, Trevor A Crowell, Stefan Baral, Man Charurat
OBJECTIVES: Sexual stigma affecting men who have sex with men (MSM) in Nigeria may be an important driver of HIV and other sexually transmitted infections (STIs), but potential mechanisms through which this occurs are not well understood. This study assessed the contributions of suicidal ideation and sexual risk behaviors to causal pathways between stigma and HIV/STIs. DESIGN: Data were collected from the TRUST/RV368 Study, a prospective cohort of 1,480 MSM from Abuja and Lagos, Nigeria...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28926303/subgroups-of-adolescent-girls-with-borderline-personality-disorder-symptoms
#3
Claire Slavin-Stewart, Khrista Boylan, Jeffrey D Burke
The aim of this study was to determine whether borderline personality disorder (BPD) can be differentiated from other disorders in a clinical sample of adolescent girls. Participants (N = 75) were grouped based on the pattern of BPD symptom endorsement using a latent class analysis. Four latent classes were identified. The most impaired class endorsed seven BPD symptoms and an average of three comorbid disorders. An intermediate class endorsed three BPD symptoms and had the highest prevalence of PTSD (41.7%)...
September 19, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28923719/suicidal-ideation-and-behavior-in-institutions-of-higher-learning-a-latent-class-analysis
#4
Joel Bernanke, Hanga C Galfalvy, Maggie G Mortali, Laura A Hoffman, Christine Moutier, Charles B Nemeroff, Barbara H Stanley, Paula Clayton, Jill Harkavy-Friedman, Maria A Oquendo
Suicide is the second leading cause of death among undergraduate students, with an annual rate of 7.5 per 100,000. Suicidal behavior (SB) is complex and heterogeneous, which might be explained by there being multiple etiologies of SB. Data-driven identification of distinct at-risk subgroups among undergraduates would bolster this argument. We conducted a latent class analysis (LCA) on survey data from a large convenience sample of undergraduates to identify subgroups, and validated the resulting latent class model on a sample of graduate students...
September 9, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28921667/polysubstance-use-among-adolescents-in-a-low-income-rural-community-latent-classes-for-middle-and-high-school-students
#5
Roderick A Rose, Caroline B R Evans, Paul R Smokowski, Matthew O Howard, Katie L Stalker
PURPOSE: Rural communities are currently being impacted by a nationwide epidemic of prescription opioid misuse. Rural adolescent substance users may be at substantial risk for later addiction to these and other drugs. METHODS: This study uses Latent Class Analysis to identify subtypes of polysubstance users among a sample of 7,074 rural adolescents. Separate models were estimated for middle- and high-school youth. Predictive validity was estimated using cumulative ordinal logistic regression of the classes on a set of youth and family characteristics...
September 18, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28921526/parsing-heterogeneity-in-attention-deficit-hyperactivity-disorder-using-eeg-based-subgroups
#6
Sandra K Loo, James J McGough, James T McCracken, Susan L Smalley
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous condition for which multiple efforts to characterize brain state differences are underway. The objective of this study was to identify distinct subgroups of resting electroencephalography (EEG) profiles among children with and without ADHD and subsequently provide extensive clinical characterization of the subgroups. METHODS: Latent class analysis was used with resting state EEG recorded from a large sample of 781 children with and without ADHD (N = 620 ADHD, N = 161 Control), aged 6-18 years old...
September 18, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28919323/a-systematic-review-of-person-centered-approaches-to-investigating-patterns-of-trauma-exposure
#7
REVIEW
Meaghan L O'Donnell, Ingo Schaefer, Tracey Varker, Dzenana Kartal, David Forbes, Richard A A Bryant, Derrick Silove, Mark Creamer, Alexander McFarlane, Gin Mahli, Kim Felmingham, Miranda Van Hoof, Dusan Hadzi-Pavlovic, Angela Nickerson, Zachary Steel
Recent research has found that exposure to traumatic events may occur in certain patterns, rather than randomly. Person-centered analyses, and specifically latent class analysis, is becoming increasingly popular in examining patterns, or 'classes' of trauma exposure. This review aimed to identify whether there are consistent homogeneous subgroups of trauma-exposed individuals, and the relationship between these trauma classes and psychiatric diagnosis. A systematic review of the literature was completed using the databases EMBASE, MEDLINE (PubMed) and PsycINFO...
September 9, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/28918498/modeling-the-decision-of-mental-health-providers-to-implement-evidence-based-children-s-mental-health-services-a-discrete-choice-conjoint-experiment
#8
Charles E Cunningham, Melanie Barwick, Heather Rimas, Stephanie Mielko, Raluca Barac
Using an online, cross sectional discrete choice experiment, we modeled the influence of 14 implementation attributes on the intention of 563 providers to adopt hypothetical evidence-based children's mental health practices (EBPs). Latent class analysis identified two segments. Segment 1 (12%) would complete 100% of initial training online, devote more time to training, make greater changes to their practices, and introduce only minor modifications to EBPs. Segment 2 (88%) preferred fewer changes, more modifications, less training, but more follow-up...
September 16, 2017: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/28917950/suicide-behavior-and-associated-psychosocial-factors-among-adolescents-in-campeche-mexico
#9
Catalina González-Forteza, Carlos E Juárez-López, Alberto Jiménez, Liliana Montejo-León, Ulises R Rodríguez-Santisbón, Fernando A Wagner
Suicide is an important public health problem that requires a preventive approach. The present study aimed at assessing suicidal behaviors and their relations with other psychosocial factors in Campeche, Mexico, in order to inform the design of potential preventive interventions. A multistage probability sample of 2386 students representative of all middle schools of the state of Campeche, Mexico, took a standardized, paper-and-pencil survey covering selected psychosocial constructs including suicide behavior, depression, drug use, familial relationships, locus of control, impulsivity, and self-esteem, among others...
September 13, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28917307/evaluation-of-western-blot-elisa-and-latex-agglutination-tests-to-detect-toxoplasma-gondii-serum-antibodies-in-farmed-red-deer
#10
Kandarp Khodidas Patel, Laryssa Howe, Cord Heuer, Geoffery William Asher, Peter Raymond Wilson
Abortion due to Toxoplasma gondii has been suspected in New Zealand farmed red deer. However, knowledge around the epidemiology and prevalence of T. gondii in farmed red deer is limited. The aim of this study was to firstly, assess the sensitivity and specificity of two commercially available assays, ELISA and latex agglutination test (LAT), for use in deer and secondly, to estimate the sero-prevalence of T. gondii in red deer. A total of 252 sera from rising 2-year-old and adult hinds from 17 New Zealand red deer herds at early and late pregnancy scanning and from known aborted and/or non-aborted hinds were tested for the presence of T...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28914180/symptoms-based-phenotypes-among-women-with-dysmenorrhea-a-latent-class-analysis
#11
Chen X Chen, Susan Ofner, Giorgos Bakoyannis, Kristine L Kwekkeboom, Janet S Carpenter
Dysmenorrhea is highly prevalent and may increase women's risk for developing other chronic pain conditions. Although it is highly variable, symptom-based dysmenorrhea phenotypes have not been identified. The aims of the study were to identify symptom-based dysmenorrhea phenotypes and examine their relationships with demographic and clinical characteristics. In a cross-sectional study, 762 women with dysmenorrhea rated severity of 14 dysmenorrhea-related symptoms. Using latent class analysis, we identified three distinctive phenotypes...
September 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28913744/eight-year-latent-class-trajectories-of-academic-and-social-functioning-in-children-with-attention-deficit-hyperactivity-disorder
#12
George J DuPaul, Paul L Morgan, George Farkas, Marianne M Hillemeier, Steve Maczuga
We examined trajectories of academic and social functioning in children with attention-deficit/hyperactivity disorder (ADHD) to identify those who might be at risk for especially severe levels of academic and social impairment over time. We estimated a series of growth mixture models using data from two subsamples of children participating in the NIMH Collaborative Multisite Multimodal Treatment Study of Children with ADHD (MTA) including those with at least baseline and 96-month data for reading and mathematics achievement (n = 392; 77...
September 15, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28913676/the-cost-of-being-cool-how-adolescent-pseudomature-behavior-maps-onto-adult-adjustment
#13
Leslie Gordon Simons, Tara E Sutton, Sarah Shannon, Mark T Berg, Frederick X Gibbons
During adolescence, one's status among peers is a major concern. Such status is often largely a function of popularity and establishing oneself as "cool." While there are conventional avenues to achieving status among adolescents, engaging in adult-like, or pseudomature, behaviors such as substance use or sexual activity is a frequent occurrence. Although past research has examined the consequences of adolescent delinquency, what remains unclear is the long-term fate of adolescents who are both popular and antisocial...
September 15, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28910253/characterizing-non-monosexual-women-at-risk-for-poor-mental-health-outcomes-a-mixed-methods-study
#14
Lori E Ross, Melissa H Manley, Abbie E Goldberg, Alia Januwalla, Keisha Williams, Corey E Flanders
OBJECTIVES: Non-monosexual women - those who report attraction to or sexual relationships with individuals of more than one gender - have elevated risk for poor mental health outcomes. We aimed to examine which elements of non-monosexual experience are associated with this elevated risk. METHODS: We conducted a sequential exploratory mixed methods analysis of qualitative interview and survey data from 39 non-monosexual women recruited consecutively through prenatal care providers...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28910214/outcome-trajectories-and-prognostic-factors-for-suicide-and-self-harm-behaviors-in-patients-with-borderline-personality-disorder-following-one-year-of-outpatient-psychotherapy
#15
Shelley F McMain, Skye Fitzpatrick, Tali Boritz, Ryan Barnhart, Paul Links, David L Streiner
This study examined suicide and self-harm trajectories in 180 individuals with BPD receiving dialectical behavior therapy or general psychiatric management in a randomized controlled trial. Suicide and self-harm behaviors were assessed at baseline, every four months throughout treatment, and every 6 months over 2 years of follow-up. Latent class growth mixture modeling identified suicide and self-harm trajectories. Multinomial logistic regression analyses examined baseline patient characteristics. Three latent subgroups were identified...
September 14, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28905111/maternal-depressive-symptoms-in-childhood-and-risky-behaviours-in-early-adolescence
#16
Eirini Flouri, Sofia Ioakeimidi
Longitudinal patterns of maternal depressive symptoms have yet to be linked to risky behaviours, such as substance use or violence, in early adolescence, when such behaviours may be particularly detrimental. This study was carried out to do this. Using data from the UK's Millennium Cohort Study, it modelled the effect of trajectories of maternal depressive symptoms at child ages 3, 5, 7 and 11 years on antisocial behaviour and delinquency at age 11 years (N = 12,494). It also explored their role in predicting moral judgement and attitudes to alcohol at age 11, important predictors of delinquent or antisocial behaviour and alcohol use, respectively...
September 13, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28903866/a-bayesian-latent-class-model-to-estimate-the-accuracy-of-pregnancy-diagnosis-by-transrectal-ultrasonography-and-laboratory-detection-of-pregnancy-associated-glycoproteins-in-dairy-cows
#17
G T Fosgate, B Motimele, A Ganswindt, P C Irons
Accurate diagnosis of pregnancy is an essential component of an effective reproductive management plan for dairy cattle. Indirect methods of pregnancy detection can be performed soon after breeding and offer an advantage over traditional direct methods in not requiring an experienced veterinarian and having potential for automation. The objective of this study was to estimate the sensitivity and specificity of pregnancy-associated glycoprotein (PAG) detection ELISA and transrectal ultrasound (TRUS) in dairy cows of South Africa using a Bayesian latent class approach...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28902786/diagnosing-chronic-pancreatitis-comparison-and-evaluation-of-different-diagnostic-tools
#18
Yama Issa, Hjalmar C van Santvoort, Susan van Dieren, Marc G Besselink, Marja A Boermeester, Usama Ahmed Ali
OBJECTIVES: This study aims to compare the M-ANNHEIM, Büchler, and Lüneburg diagnostic tools for chronic pancreatitis (CP). METHODS: A cross-sectional analysis of the development of CP was performed in a prospectively collected multicenter cohort including 669 patients after a first episode of acute pancreatitis. We compared the individual components of the M-ANNHEIM, Büchler, and Lüneburg tools, the agreement between tools, and estimated diagnostic accuracy using Bayesian latent-class analysis...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28902066/latent-class-analysis-of-adhd-neurodevelopmental-and-mental-health-comorbidities
#19
Benjamin Zablotsky, Matthew D Bramlett, Susanna N Visser, Melissa L Danielson, Stephen J Blumberg
OBJECTIVE: Many children diagnosed with attention-deficit/hyperactivity disorder (ADHD) experience co-occurring neurodevelopmental and psychiatric disorders, and those who do often exhibit higher levels of impairment than children with ADHD alone. This study provides a latent class analysis (LCA) approach to categorizing children with ADHD into comorbidity groups, evaluating condition expression and treatment patterns in each group. METHODS: Parent-reported data from a large probability-based national sample of children diagnosed with ADHD (2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome) were used for an LCA to identify groups of children with similar groupings of neurodevelopmental and psychiatric comorbidities among children with current ADHD (n = 2495)...
September 8, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28900804/a-nonparametric-multidimensional-latent-class-irt-model-in-a-bayesian-framework
#20
Francesco Bartolucci, Alessio Farcomeni, Luisa Scaccia
We propose a nonparametric item response theory model for dichotomously-scored items in a Bayesian framework. The model is based on a latent class (LC) formulation, and it is multidimensional, with dimensions corresponding to a partition of the items in homogenous groups that are specified on the basis of inequality constraints among the conditional success probabilities given the latent class. Moreover, an innovative system of prior distributions is proposed following the encompassing approach, in which the largest model is the unconstrained LC model...
September 12, 2017: Psychometrika
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