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Orthostatic hypotension

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https://www.readbyqxmd.com/read/27911340/dementia-predictors-in-parkinson-disease-a-validation-study
#1
Julius Bm Anang, Takashi Nomura, Silvia Rios Romenets, Kenji Nakashima, Jean-Francois Gagnon, Ronald B Postuma
In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson's disease. Here, we validate these dementia predictors using two additional prospective cohorts (n = 134). After a 3.6-year follow-up, 35/134 developed dementia (7.2% per year). When confirming individual variables, 5/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls/freezing did not significantly predict dementia; however, point estimates of OR were all >1...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27906941/epidural-blood-patch-for-the-treatment-of-spontaneous-and-iatrogenic-orthostatic-headache
#2
Yun So, Jung Min Park, Pil-Moo Lee, Cho Long Kim, Cheolhan Lee, Jae Hun Kim
BACKGROUND: The cerebrospinal fluid (CSF) leakage could be happened spontaneously or related to the procedures such as spinal anesthesia, epidural anesthesia, CSF tapping, intrathecal chemotherapy or other spinal procedures. The leakage of CSF leads to intracranial hypotension of which distinguishing clinical feature is orthostatic headache. The epidural blood patch is a gold-standard treatment for intracranial hypotension-related orthostatic headaches. OBJECTIVE: We conducted this study to compare the efficacy and number of epidural blood patches for spontaneous and iatrogenic orthostatic headaches...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27905360/-orthostatic-hypotension-in-dementia-with-lewy-bodies
#3
A Sh Chimagomedova, O S Levin
The features of orthostatic hypotension in patients with dementia with Lewy bodies are considered. The early diagnosis of these disorders could prevent adverse conditions (falls and syncopes), improve activities of daily living and quality-of-life. Current approaches to treatment of orthostatic hypotension are analyzed.
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27903817/effects-of-orthostatic-hypotension-on-cognition-in-parkinson-disease
#4
Justin Centi, Roy Freeman, Christopher H Gibbons, Sandy Neargarder, Alexander O Canova, Alice Cronin-Golomb
OBJECTIVE: To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and within-group design. METHODS: Individuals without dementia with idiopathic PD included 18 with OH (PDOH) and 19 without OH; 18 control participants were also included. Neuropsychological tests were conducted in supine and upright-tilted positions. Blood pressure was assessed in each posture. RESULTS: The PD groups performed similarly while supine, demonstrating executive dysfunction in sustained attention and response inhibition, and reduced semantic fluency and verbal memory (encoding and retention)...
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27903812/orthostatic-hypotension-cognition-and-parkinson-disease-dumbing-down-by-standing-up
#5
Laura S Boylan, Lambros Messinis
No abstract text is available yet for this article.
November 30, 2016: Neurology
https://www.readbyqxmd.com/read/27894887/ultrasound-tissue-pulsatility-imaging-suggests-impairment-in-global-brain-pulsatility-and-small-vessels-in-elderly-patients-with-orthostatic-hypotension
#6
Julie Biogeau, Thomas Desmidt, Paul-Armand Dujardin, Redouane Ternifi, Charlotte Eudo, Emilie Vierron, Jean-Pierre Remenieras, Frédéric Patat, Vincent Camus, Thierry Constans
BACKGROUND: Orthostatic hypotension (OH) is highly prevalent in the elderly, and this population can be exposed to serious complications, including falls and cognitive disorders, as well as overall mortality. However, the pathophysiology of OH is still poorly understood, and innovative methods of cerebral blood flow (CBF) assessment have been required to accurately investigate cerebrovascular reactivity in OH. OBJECTIVES: We want to compare brain tissue pulsatility (BTP) changes during an orthostatic challenge in elderly patients over 80 with and without OH...
November 25, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27888574/normal-heart-in-parkinson-s-disease-is-this-a-distinct-clinical-phenotype
#7
J-S Kim, H-E Park, I-S Park, Y-S Oh, D-W Ryu, I-U Song, Y-A Jung, I R Yoo, H-S Choi, P H Lee, K-S Lee
BACKGROUND AND PURPOSE: Reduction of metaiodobenzylguanidine (MIBG) uptake has been observed in almost all patients with Parkinson's disease (PD), associated with hyposmia, orthostatic hypotension and rapid eye movement sleep behavioral disorder (RBD). In contrast, a subgroup of patients with PD with normal MIBG uptake have been reported to have milder disease and preserved cognition compared with those with lower MIBG. The aim of this study was to investigate whether non-motor manifestations of PD differ between patients with normal and abnormal myocardial MIBG uptake...
November 26, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27885251/postprandial-and-orthostatic-hypotension-treated-by-sitagliptin-in-a-patient-with-dementia-with-lewy-bodies
#8
Yoshihiro Saito, Joji Ishikawa, Kazumasa Harada
BACKGROUND Postprandial hypotension, induced by an absorption of glucose from intestine, could be treated by acarbose; however, it was unclear whether dipeptidyl peptidase-4 inhibitor reduced postprandial hypotension. CASE REPORT A 78-year-old woman who had experienced episodes of dizziness and hypotension after eating was admitted to our hospital. During 24-hour ambulatory blood pressure monitoring, there were repeated episodes of marked postprandial hypotension; i.e., a significant systolic blood pressure reduction within two hours after eating (from -58 to -64 mm Hg after meals)...
November 25, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27884577/low-pressure-pericardial-tamponade-case-report-and-review-of-the-literature
#9
Brooks M Walsh, Lauren A Tobias
BACKGROUND: Focused cardiac ultrasound (FoCUS) is accurate for determining the presence of a pericardial effusion. Using FoCUS to evaluate for pericardial tamponade, however, is more involved. Many experts teach that tamponade is unlikely if the inferior vena cava (IVC) shows respiratory variation and is not distended. CASE REPORT: A 53-year-old woman presented to the emergency department (ED) with severe orthostatic hypotension, exertional dyspnea, and hypoxia...
November 21, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27865581/-orthostatic-hypotension-that-great-unknown
#10
S M Velilla-Zancada, M A Prieto-Díaz, C Escobar-Cervantes, L Manzano-Espinosa
Orthostatic hypotension is an anomaly of growing interest in scientific research. Although certain neurogenic diseases are associated with this phenomenon, it can also be associated with non-neurological causes. Although orthostatic hypotension is defined by consensus as a decrease in the systolic blood pressure of at least 20mmHg, or a decrease in diastolic blood pressure of at least 10mmHg, within 3min of standing, the studies differ on how to diagnose it. Orthostatic hypotension is associated with certain cardiovascular risk factors and with drug treatment, but the results are contradictory...
November 16, 2016: Semergen
https://www.readbyqxmd.com/read/27864838/preoperative-alpha-blockade-in-phaeochromocytoma-and-paraganglioma-is-it-always-necessary
#11
Michelle Isaacs, Paul Lee
Resection of phaeochromocytoma and paraganglioma (PPGL) is traditionally preceded by alpha-blockade to prevent complications of haemodynamic instability intraoperatively. While there is general agreement on preoperative alpha-blockade for classic PPGLs presenting with hypertension, it is less clear whether alpha-blockade is necessary in predominantly dopamine-secreting tumours, normotensive PPGLs, as well as tumours that appear to be biochemically "silent". Preoperative management of these "atypical" PPGLs is challenging and the treatment approach must be individualised, carefully weighing the risk of intraoperative hypertension against the possibility of orthostatic and prolonged postoperative hypotension...
November 19, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27864240/new-horizons-in-orthostatic-hypotension
#12
REVIEW
James Frith, Steve W Parry
BACKGROUND: orthostatic hypotension (OH) is a common disabling condition associated with increased morbidity and mortality. Much of the evidence available is derived from younger populations with chronic neurological disease leading to uncertainty for the diagnosis and management of older people. OBJECTIVE: to provide an overview of recent and emerging evidence for the diagnosis, management and prognosis of OH in older persons. METHODS: a narrative review of recent studies, emerging therapies and relevant regulatory updates...
November 17, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27861346/unusual-phenotype-of-pathologically-confirmed-progressive-supranuclear-palsy-with-autonomic-dysfunction-and-cerebellar-ataxia-case-report
#13
Katerina Mensikova, Lucie Tuckova, Jiri Ehrmann, Petr Kanovsky
BACKGROUND: Based on the results of recent multicenter clinical-pathological studies, it seems that the clinical heterogeneity of progressive supranuclear palsy (PSP) is much broader than previously thought. We will report 2 cases of patients with unusual manifestation of pathologically confirmed PSP. METHODS: Two female patients were diagnosed with the parkinsonian phenotype of multiple system atrophy (MSAP) according to current clinical diagnostic criteria at the ages of 55 and 60 years, respectively...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27861223/gastrointestinal-and-urologic-sphincter-dysfunction-in-stiff-person-syndrome
#14
Oana M Dumitrascu, Evgeny I Tsimerinov, Richard A Lewis
OBJECTIVES: Stiff person syndrome is a neurologic disorder characterized by axial rigidity leading to progressive disability, with broad clinical spectrum. METHODS: We report 2 cases with unique clinical presentation. RESULTS: Two young men suffered progressive urinary retention requiring bladder catheterization, anorectal spasms and constipation, complicated subsequently with lower extremity trigger-induced spasms, and gait instability. Associated symptoms revealed brainstem involvement (vertigo, diplopia, and cranial neuropathies) and dysautonomia (abnormal sweating and orthostatic hypotension)...
December 2016: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/27858196/congenital-eyelid-ptosis-decreased-glomerular-filtration-and-orthostatic-hypotension-answers
#15
Tessa Wassenberg, Michèl Willemsen, Henry Dijkman, Jaap Deinum, Leo Monnens
No abstract text is available yet for this article.
November 17, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27858193/congenital-eyelid-ptosis-decreased-glomerular-filtration-and-orthostatic-hypotension-questions
#16
Tessa Wassenberg, Michèl Willemsen, Henry Dijkman, Jaap Deinum, Leo Monnens
No abstract text is available yet for this article.
November 17, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27854087/spontaneous-intracranial-hypotension-complicated-by-malignancyinduced-disseminated-intravascular-coagulation-a-case-report
#17
Hung-Yi Wu, Shu-Shya Hseu, Shih-Pin Chen, Jiing-Feng Lirng, Yen-Feng Wang, Shuu-Jiun Wang, Jong-Ling Fuh
PURPOSE: Spontaneous intracranial hypotension (SIH) is a rare type of headache. The association of SIH with malignancy and disseminated intravascular coagulation (DIC) has not previously been reported. CASE REPORT: A 60-year-old woman had orthostatic headache for more than one month before admission. MRI of brain showed diffuse pachymeningeal enhancement with bilateral subdural hematoma. MR myelography revealed epidural fluid collection and possible CSF leakage at the level of C5 to C6...
September 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27832615/-changes-in-spinal-mri-findings-for-epidural-fluid-collection-in-the-treatment-of-intracranial-hypotension
#18
Norimitsu Nakagawa
We have experienced 30 cases of intracranial hypotension in the last three years. Spinal MRI was performed in all cases, and 27 patients demonstrated epidural fluid collection(EFC). Of these 30 patients, 6 were treated conservatively with bed rest and hydration, and 24 were treated with epidural blood patch(EBP). Twenty-two patients were cured, 4 were improved significantly, and 4 were improved partially. We examined spinal MR images of 22 patients after 3 months of treatment. The EFC wasn't visible in 11 cases;however, residual EFC was found in the 11 remaining cases...
November 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27831488/falls-risk-orthostatic-hypotension-and-optimum-blood-pressure-management-is-it-all-in-our-heads
#19
Ciarán Finucane, Rose Anne Kenny
No abstract text is available yet for this article.
November 9, 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/27826809/vasomotor-regulation-in-patients-with-multiple-system-atrophy
#20
Kazumasa Shindo, Mai Tsuchiya, Yuta Ichinose, Kishin Koh, Takanori Hata, Nobuo Yamashiro, Fumikazu Kobayashi, Takamura Nagasaka, Yoshihisa Takiyama
To investigate the vasomotor regulation in multiple system atrophy (MSA), we simultaneously recorded muscle sympathetic nerve activity (MSNA), heart rate, and blood pressure in 14 MSA patients without syncope and 18 healthy subjects. Resting MSNA bursts were significantly less frequent in MSA patients than healthy subjects (p < 0.001), while the increase of MSNA bursts with head-up tilt was significantly greater in MSA patients (p < 0.01). In patients with MSA, orthostatic hypotension may be prevented by an augmented MSNA response...
November 8, 2016: Journal of Neural Transmission
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