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https://www.readbyqxmd.com/read/29924429/number-location-and-time-since-prior-fracture-as-predictors-of-future-fracture-in-elderly-from-the-general-population
#1
Claudia Beaudoin, Sonia Jean, Lynne Moore, Philippe Gamache, Louis Bessette, Louis-Georges Ste-Marie, Jacques P Brown
Prognostic tools are available to identify individuals at high risk of osteoporotic fracture and assist physicians in management decisions. Some authors have suggested improving the predictive ability of current tools by integrating characteristics of prior fractures (number, location and time since prior fracture). The objectives of this study were i) to evaluate the sex-age-specific association between characteristics of prior fractures and the occurrence of a future osteoporotic fracture and ii) to assess whether the characteristics of prior fractures could increase the discriminative ability of fracture risk prediction tools...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29924411/acceptance-psychiatric-symptoms-and-migraine-disability-an-observational-study-in-a-headache-center
#2
Elizabeth K Seng, Alexander J Kuka, Sarah Jo Mayson, Todd A Smitherman, Dawn C Buse
OBJECTIVE: To evaluate relationships between psychiatric symptoms, acceptance, and migraine-related disability in a sample of people with migraine presenting at a tertiary care headache center. BACKGROUND: Migraine is a chronic disease that can be severely disabling. Despite a strong theoretical basis and evidence in other pain conditions, little is known about relationships between acceptance, psychiatric symptoms, and migraine-related disability. METHODS: Ninety patients with physician-diagnosed migraine completed surveys assessing demographics, headache symptoms, severe migraine-related disability (Migraine Disability Assessment Scale total score dichotomized at ≥ 21), depression (Patient Health Questionnaire-9) and anxiety symptoms (Generalized Anxiety Disorder-7), and acceptance (Chronic Pain Acceptance Questionnaire; subscales: Pain Willingness and Activity Engagement)...
June 2018: Headache
https://www.readbyqxmd.com/read/29923966/efficacy-and-safety-of-immunosuppressive-agents-for-thyroid-eye-disease
#3
Diego Strianese
PURPOSE: To present an update on the efficacy and safety of immunosuppressive therapy for thyroid eye disease (TED) and to offer a general recommendation for management of TED, in light of these reports. METHODS: Data were retrieved from a literature search on PubMed, using the following words: thyroid eye disease, immunosuppressant, corticosteroid, methotrexate, azathioprine, cyclosporine, cyclophosphamide, rituximab, etanercept, adalimumab, tocilizumab, teprotumumab, adverse effects, side effects, and complications...
June 18, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29923025/cannabinoids-for-treatment-of-ms-symptoms-state-of-the-evidence
#4
REVIEW
Jessica Rice, Michelle Cameron
PURPOSE OF REVIEW: Cannabis and cannabinoids have been used medically and recreationally for thousands of years and recently there has been a growing body of research in this area. With increased access now that medical marijuana is available in many jurisdictions, patients and providers want to know more about the evidence for benefits and risks of cannabinoid use. This paper provides an overview of the available cannabinoid-based formulations, a summary of the highest quality evidence for the use of cannabinoids for treating spasticity and pain associated with multiple sclerosis (MS), and a discussion of possible dosing regimens based on information from these studies...
June 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29922962/gaps-in-transgender-medical-education-among-healthcare-providers-a-major-barrier-to-care-for-transgender-persons
#5
REVIEW
Sira Korpaisarn, Joshua D Safer
A lack of access to knowledgeable providers is the greatest reported barrier to care for transgender individuals. The purpose of this manuscript is to review the recent literature characterizing transgender medicine education for medical providers and to summarize effective interventions for improving education in transgender care. The PubMed database was searched for all literature that assessed transgender medical education among physicians or trainees and all papers that reported results of transgender-specific educational interventions...
June 19, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29922910/-prescribing-valproate-to-girls-and-women-of-childbearing-age-in-germany-analysis-of-trends-based-on-claims-data
#6
Nadine Wentzell, Ulrike Haug, Tania Schink, Susanne Engel, Judith Liebentraut, Roland Linder, Marlies Onken, Christof Schaefer, Katarina Dathe
BACKGROUND: Measures to raise awareness of the teratogenic potential of valproate and restrict its use in girls/women of childbearing age have been intensified. For Germany, the impact of these measures on valproate prescription rates remains unknown. OBJECTIVES: Trends in prescribing valproate, the underlying treatment indication, and the specialty of the prescribing physician are analyzed. MATERIALS AND METHODS: With claims data from several statutory health insurance providers from 2004 to 2016 (approximately 3...
June 19, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29922346/a-lemon-a-day-keeps-fatigue-away-the-abcde-of-fatigue
#7
EDITORIAL
Sanjay Kalra, Rakesh Sahay
Fatigue is a common symptom in clinical medicine. The complex and multifaceted etiopathogenesis of fatigue is a challenge for the differential diagnosis and management of fatigue. This brief communication shares two simple mnemonics - LEMON and ABCDE - which help in the evaluation of fatigue. These frameworks are as relevant to endocrinology and diabetes as to general practice. The mnemonic LEMON stands for lifestyle, endocrine, medical/metabolic, observer (physician) and nutrition-related factors which may cause fatigue; ABCDE lists the aetiology of fatigue in three columns related to physiological/nutritional, psychosocial and biomedical causes (each column includes one cause and how this relates to the ABCDE rubric)...
April 2018: European endocrinology
https://www.readbyqxmd.com/read/29922217/alcohol-use-and-alcohol-related-seizures-in-patients-with-epilepsy
#8
Michael Hamerle, Leyli Ghaeni, Alexander Kowski, Florian Weissinger, Martin Holtkamp
Purpose: This study aimed to assess alcohol consumption and the occurrence of alcohol-related seizures in patients with epilepsy within the last 12 months. Methods: In an epilepsy outpatient clinic, a standardized questionnaire was used to collect data retrospectively from consecutive adult epilepsy patients who had been suffering from the disease for at least 1 year. Logistic regression analyses were performed to identify independent predictors. Results: A total of 310 patients with epilepsy were included...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29921471/rethinking-the-concept-of-sepsis-and-septic-shock
#9
REVIEW
Joana A Cabrita, Isabel Pinheiro, L Menezes Falcão
Sepsis is a major global health problem and represents a challenge for physicians all over the world. The knowledge of sepsis and septic shock is a topic of interest among the scientific community and society in general. New guidelines for management of sepsis and septic shock were developed in 2016, providing an update on this area. In Sepsis-3 new definitions for sepsis and septic shock were published. The purpose of this narrative review is to discuss and compare the new criteria of 2016 with the old criteria, purposing at the same time an alternative approach for this topic...
June 16, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29921179/-promising-future-in-general-internal-medicine-for-the-next-generation-of-physicians
#10
Victoria Perpinias Allenbach, Zsofia Rozsnyai, Sven Streit
Promising Future in General Internal Medicine for the Next Generation of Physicians Abstract. We are facing a lack of specialists in general internal medicine in general practitioners' practices as well as in hospitals, while at the same time the population ages and usually displays several chronic diseases (multimorbidity). Thanks to more university places, an improved job description for general internal medicine and new further education offers (curricula), interest in general internal medicine increased again, as surveys of students indicate...
June 2018: Praxis
https://www.readbyqxmd.com/read/29920515/knowledge-attitudes-and-practice-regarding-medication-use-in-pregnant-women-in-southern-italy
#11
Monica Navaro, Luigi Vezzosi, Gabriella Santagati, Italo Francesco Angelillo
The study assessed knowledge, attitudes, and medication use of a random sample of pregnant women attending outpatient Gynecology and Obstetrics clinics at randomly selected public General and Teaching hospitals in Naples, Italy. A total of 503 women participated. Those more likely to know that a pregnant woman with chronic condition must discuss whether or not to take a medication with the physician were Italian, aged 31-40 years, employed, with no history of abortion, having had a medical problem within the previous year, with a better self-perceived health status, who knew how to use medications during pregnancy, and who needed information on medications...
2018: PloS One
https://www.readbyqxmd.com/read/29916615/-the-complaint-of-suspected-occupational-disease-news-critical-issues-and-applicative-suggestions
#12
Giuseppe Taino, Nicoletta Cornaggia, Barbara Fioramonti, Marcello Imbriani
OBJECTIVES: The Legislative Decree n. 151 of 14 September 2015 lays down new provisions concerning the DPR 1124/65. The major developments occur with Article 53 of Presidential Decree 1124/65, which transfer the obligation to send the medical certificate, attached to the report of accident and occupational disease, from the employer to the physician - "every physician lends immediate assistance to an injured worker or to a worker that suffers from an occupational disease" - using telematic systems, either directly or through the health facilities...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916266/quality-of-life-and-its-association-with-treatment-satisfaction-adherence-to-medication-and-trust-in-physician-among-patients-with-hypertension-a-cross-sectional-designed-study
#13
Siba Jneid, Hicham Jabbour, Aline Hajj, Antoine Sarkis, Hady Licha, Souheil Hallit, Lydia Rabbaa Khabbaz
OBJECTIVE: Patients with hypertension tend to have a lower health-related quality of life (HRQOL) compared to normotensive patients. This study's main objectives are to assess (1) HRQOL and factors that might impact it and (2) association between HRQOL and adherence to treatment, trust in physician, and treatment satisfaction among patients with hypertension. METHODS: A cross-sectional study enrolled 196 patients from medical-care offices in Beirut, North and South Lebanon...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29915870/a-systematic-review-of-clinical-pharmacist-interventions-in-paediatric-hospital-patients
#14
REVIEW
Aaron Drovandi, Kelvin Robertson, Matthew Tucker, Niechole Robinson, Stephen Perks, Therése Kairuz
Clinical pharmacists provide beneficial services to adult patients, though their benefits for paediatric hospital patients are less defined. Five databases were searched using the MeSH terms 'clinical pharmacist', 'paediatric/paediatric', 'hospital', and 'intervention' for studies with paediatric patients conducted in hospital settings, and described pharmacist-initiated interventions, published between January 2000 and October 2017. The search strategy after full-text review identified 12 articles matching the eligibility criteria...
June 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29915758/adult-onset-seizures-clinical-etiological-and-radiological-profile
#15
Sarabjot Kaur, Ravinder Garg, Simmi Aggarwal, Sumit Pal Singh Chawla, Ranabir Pal
Introduction: Adult onset seizure disorder is a major public health concern in terms of burden of disease, nature of illness, and its impact on individual, family, and community. This study was done to assess the clinical profile and etiology of adult onset seizures and correlates of clinical and radiological pattern. Materials and Methods: This was a prospective cross-sectional hospital-based study conducted on 100 cases presenting with adult onset seizures. Results: Adult onset seizures were most prevalent in the young and middle-aged adults than elderly; generalized seizures were more common than focal seizures...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915755/knowledge-attitudes-and-practice-behaviors-of-medical-specialists-for-the-relationship-between-diabetes-and-periodontal-disease-a-questionnaire-survey
#16
Vishnu Teja Obulareddy, Sreenivas Nagarakanti, Vijay Kumar Chava
Introduction: Increased risk of periodontal disease has been associated with diabetes mellitus (DM) and also periodontitis is considered as the sixth complication of DM. Medical physicians may have an advantageous position compared to the dentists to provide early patient counseling about oral health because patients attend medical offices more often than to dental offices and are more likely to be affiliated to medical than to dental insurance. Hence, the medical practitioners should have sufficient knowledge in this regard...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915644/right-ventricular-dysplasia-management-and-treatment-in-light-of-current-evidence
#17
REVIEW
Amr Idris, Syed Raza Shah, Ki Park
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare cardiovascular disease that predisposes to ventricular arrhythmias potentially leading to sudden cardiac death (SCD). ARVC varies considerably with multiple clinical presentations, ranging from no symptoms to cardiac arrhythmias to SCD. ARVC prevalence is not well known, but the estimated prevalence in the general population is 1:5000. Diagnosis of ARVC can be made by using the Revised European Society of Cardiology criteria for ARVC that includes ventricular structural and functional changes, ECG abnormalities, arrhythmias, family and genetic factors...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915446/refractory-hypotension-due-to-nivolumab-induced-adrenal-insufficiency
#18
Yoshiaki Tsukizawa, Keisuke Kondo, Toshihisa Ichiba, Hiroshi Naito, Kazuhito Mizuki, Ken Masuda
Nivolumab, a new immune checkpoint inhibitor that has been found to improve outcomes for patients with some advanced cancers, is being increasingly used. Immune checkpoint inhibitors can cause immune-related adverse events, including dermatitis, enterocolitis, hepatitis and hypophysitis, but adrenal insufficiency rarely occurs. We present a case of Nivolumab-induced adrenal insufficiency in a man who complained of refractory hypotension. A 52-year-old man with non-small cell lung cancer visited our emergency department complaining of fatigue and diarrhea...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29915439/%C3%AF-editors-choice%C3%AF-practice-management-for-elderly-patients-with-breast-cancer-findings-from-a-survey-by-the-japan-breast-cancer-study-group
#19
Masataka Sawaki, Kenji Tamura, Akihiko Shimomura, Yumiko Taki, Fumio Nagashima, Hiroji Iwata
Information on patterns of clinical care for elderly breast cancer patients is lacking. The aims of this study are two-fold, firstly, to clarify daily practice treatments for elderly breast cancer patients in Japan, and secondly, to plan a prospective clinical trial to address unresolved clinical questions. We investigated practice care of elderly breast cancer patients in 38 institutions of the Japan Clinical Oncology Group (JCOG). Questionnaires asked: (1) definition of "elderly" for each treatment, (2) clinical standard anti-HER2 therapy in each age-group, (3) recommended docetaxel dose in each age-group, (4) considerations for future clinical trials, and (5) other information about geriatric oncology concerning breast cancer...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29914436/treatment-in-the-stampede-era-for-castrate-resistant-prostate-cancer-in-the-uk-ongoing-challenges-and-underappreciated-clinical-problems
#20
Rosa U Greasley, Rebecca Turner, Karen Collins, Janet Brown, Liam Bourke, Derek J Rosario
BACKGROUND: This study aimed to explore the opinions of healthcare professionals regarding the management of men with advanced prostate cancer with particular emphasis on treatment timing and sequencing; treatment adverse-effects and exercise a supportive therapy. METHODS: Semi-structured interviews with a purposively selected group of healthcare professionals involved in prostate cancer care within the NHS, conducted over the phone or face to face. A total of 37 healthcare professionals participated in the interviews including urologists, clinical oncologists, medical oncologists, clinical nurse specialists, general practitioners, physiotherapists, exercise specialists, service managers, clinical commissioners and primary care physicians...
June 19, 2018: BMC Cancer
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