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peptide self-assembly

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https://www.readbyqxmd.com/read/29147558/discovery-and-design-of-self-assembling-peptides
#1
REVIEW
Shuguang Zhang
Peptides are ubiquitous in nature and useful in many fields, from agriculture as pesticides, in medicine as antibacterial and antifungal drugs founded in the innate immune systems, to medicinal chemistry as hormones. However, the concept of peptides as materials was not recognized until 1990 when a self-assembling peptide as a repeating segment in a yeast protein was serendipitously discovered. Peptide materials are so called because they have bona fide materials property and are made from simple amino acids with well-ordered nanostructures under physiological conditions...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29147557/the-diversity-and-utility-of-amyloid-fibrils-formed-by-short-amyloidogenic-peptides
#2
REVIEW
Zahraa S Al-Garawi, Kyle L Morris, Karen E Marshall, Jutta Eichler, Louise C Serpell
Amyloidogenic peptides are well known for their involvement in diseases such as type 2 diabetes and Alzheimer's disease. However, more recently, amyloid fibrils have been shown to provide scaffolding and protection as functional materials in a range of organisms from bacteria to humans. These roles highlight the incredible tensile strength of the cross-β amyloid architecture. Many amino acid sequences are able to self-assemble to form amyloid with a cross-β core. Here we describe our recent advances in understanding how sequence contributes to amyloidogenicity and structure...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29147554/geometrical-frustration-as-a-potential-design-principle-for-peptide-based-assemblies
#3
REVIEW
Tao Jiang, Elizabeth L Magnotti, Vincent P Conticello
Two-dimensional peptide and protein assemblies have been the focus of increased scientific research as they display significant potential for the creation of functional nanomaterials. Soluble subunits derived from a variety of protein motifs have been demonstrated to self-assemble into structurally defined nanosheets under environmentally benign conditions in which the components often retain their native structure and function. These types of two-dimensional assemblies may have an advantage for nanofabrication in that their extended planar shapes can be more straightforwardly incorporated into the current formats of nanoscale devices...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29147553/crafting-of-functional-biomaterials-by-directed-molecular-self-assembly-of-triple-helical-peptide-building-blocks
#4
REVIEW
Jayati Banerjee, Helena S Azevedo
Collagen is the most abundant extracellular matrix protein in the body and has widespread use in biomedical research, as well as in clinics. In addition to difficulties in the production of recombinant collagen due to its high non-natural imino acid content, animal-derived collagen imposes several major drawbacks-variability in composition, immunogenicity, pathogenicity and difficulty in sequence modification-that may limit its use in the practical scenario. However, in recent years, scientists have shifted their attention towards developing synthetic collagen-like materials from simple collagen model triple helical peptides to eliminate the potential drawbacks...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29147550/self-assembly-of-nucleopeptides-to-interact-with-dnas
#5
Xuewen Du, Jie Zhou, Xinming Li, Bing Xu
As a novel class of biomaterials, nucleopeptides, via the conjugation of nucleobases and peptides, usually self-assemble to form nanofibres driven mainly by hydrogen bonds. Containing nucleobase(s), nucleopeptides have a unique property-interacting with nucleic acids. Here we report the design and characterization of nucleopeptides that self-assemble in water and are able to interact with single-stranded DNAs (ssDNAs). Containing nucleobases on their side chains, these nucleopeptides bind with the ssDNAs, and the ssDNAs reciprocally affect the self-assembly of nucleopeptides...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29147549/redox-sensitive-reversible-self-assembly-of-amino-acid-naphthalene-diimide-conjugates
#6
Wathsala Liyanage, Paul W Rubeo, Bradley L Nilsson
Peptide and low molecular weight amino acid-based materials that self-assemble in response to environmental triggers are highly desirable candidates in forming functional materials with tunable biophysical properties. In this paper, we explore redox-sensitive self-assembly of cationic phenylalanine derivatives conjugated to naphthalene diimide (NDI). Self-assembly of the cationic Phe-NDI conjugates into nanofibrils was induced in aqueous solvent at high ionic strength. Under reducing conditions, these self-assembled Phe-NDI conjugate fibrils underwent a morphological change to non-fibril aggregates...
December 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/29146781/self-assembling-peptide-semiconductors
#7
REVIEW
Kai Tao, Pandeeswar Makam, Ruth Aizen, Ehud Gazit
Semiconductors are central to the modern electronics and optics industries. Conventional semiconductive materials bear inherent limitations, especially in emerging fields such as interfacing with biological systems and bottom-up fabrication. A promising candidate for bioinspired and durable nanoscale semiconductors is the family of self-assembled nanostructures comprising short peptides. The highly ordered and directional intermolecular π-π interactions and hydrogen-bonding network allow the formation of quantum confined structures within the peptide self-assemblies, thus decreasing the band gaps of the superstructures into semiconductor regions...
November 17, 2017: Science
https://www.readbyqxmd.com/read/29140068/arginine-rich-peptide-induced-supramolecular-self-assembly-of-water-soluble-anionic-alkynylplatinum-ii-complexes-a-continuous-and-label-free-luminescence-assay-for-trypsin-and-inhibitor-screening
#8
Angela Sin-Yee Law, Margaret Ching-Lam Yeung, Vivian Wing-Wah Yam
A water-soluble anionic alkynylplatinum(II) 2,6-bis(benzimidazol-2'-yl)pyridine (bzimpy) complex has been strategically designed and synthesized to show supramolecular self-assembly with cationic arginine-rich peptides through unique noncovalent Pt(II)···Pt(II) and π-π stacking interactions. Upon introduction of trypsin, the arginine-rich peptides can be hydrolyzed into small fragments and deaggregation of the platinum(II) complex molecules is observed. The aggregation-deaggregation process has been probed by UV-vis absorption, emission, and resonance light scattering (RLS) studies...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29135944/design-synthesis-and-use-of-peptides-derived-from-human-papillomavirus-l1-protein-for-the-modification-of-gold-electrode-surfaces-by-self-assembled-monolayers
#9
John Alejandro Lara Carrillo, Ricardo Fierro Medina, Juan Manríquez Rocha, Erika Bustos Bustos, Diego Sebastián Insuasty Cepeda, Javier Eduardo García Castañeda, Zuly Jenny Rivera Monroy
In order to obtain gold electrode surfaces modified with Human Papillomavirus L1 protein (HPV L1)-derived peptides, two sequences, SPINNTKPHEAR and YIK, were chosen. Both have been recognized by means of sera from patients infected with HPV. The molecules, Fc-Ahx-SPINNTKPHEAR, Ac-C-Ahx-(Fc)KSPINNTKPHEAR, Ac-C-Ahx-SPINNTKPHEAR(Fc)K, C-Ahx-SPINNTKPHEAR, and (YIK)₂-Ahx-C, were designed, synthesized, and characterized. Our results suggest that peptides derived from the SPINNTKPHEAR sequence, containing ferrocene and cysteine residues, are not stable and not adequate for electrode surface modification...
November 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29133981/electrostatic-interactions-between-polyglutamic-acid-and-polylysine-yields-stable-polyion-complex-micelles-for-deoxypodophyllotoxin-delivery
#10
Yutong Wang, Liping Huang, Yan Shen, Lidan Tang, Runing Sun, Di Shi, Thomas J Webster, Jiasheng Tu, Chunmeng Sun
To achieve enhanced physical stability of poly(ethylene glycol)-poly(d,l-lactide) polymeric micelles (PEG-PDLLA PMs), a mixture of methoxy PEG-PDLLA-polyglutamate (mPEG-PDLLA-PLG) and mPEG-PDLLA-poly(l-lysine) (mPEG-PDLLA-PLL) copolymers was applied to self-assembled stable micelles with polyion-stabilized cores. Prior to micelle preparation, the synthetic copolymers were characterized by (1)H-nuclear magnetic resonance (NMR) and infrared spectroscopy (IR), and their molecular weights were calculated by (1)H-NMR and gel permeation chromatography (GPC)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29133898/intertwining-dna-rna-nanocapsules-loaded-with-tumor-neoantigens-as-synergistic-nanovaccines-for-cancer-immunotherapy
#11
Guizhi Zhu, Lei Mei, Harshad D Vishwasrao, Orit Jacobson, Zhantong Wang, Yijing Liu, Bryant C Yung, Xiao Fu, Albert Jin, Gang Niu, Qin Wang, Fuwu Zhang, Hari Shroff, Xiaoyuan Chen
Nanomedicines that co-deliver DNA, RNA, and peptide therapeutics are highly desirable yet remain underdeveloped for cancer theranostics. Herein, we report self-assembled intertwining DNA-RNA nanocapsules (iDR-NCs) that efficiently delivered synergistic DNA CpG and short hairpin RNA (shRNA) adjuvants, as well as tumor-specific peptide neoantigens into antigen presenting cells (APCs) in lymph nodes for cancer immunotherapy. These nanovaccines were prepared by (1) producing tandem CpG and shRNA via concurrent rolling circle replication and rolling circle transcription, (2) self-assembling CpG and shRNA into DNA-RNA microflowers, (3) shrinking microflowers into iDR-NCs using PEG-grafted cationic polypeptides, and (4) physically loading neoantigen into iDR-NCs...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29131232/homogenous-graphene-oxide-peptide-nanofiber-hybrid-hydrogel-as-biomimetic-polysaccharide-hydrolase
#12
Xingxing He, Fuyuan Zhang, Jifeng Liu, Guozhen Fang, Shuo Wang
Cellulose, an impressive potential sustainable fuel, is difficult to hydrolyze because of the protection of β-1,4-glycosidic bonds through the tight hydrogen bonding network. In this study, homogenous graphene oxide (GO)-peptide nanofiber hybrid hydrogels (GO-PNFs) were designed as a β-glycosyl hydrolase mimetic to achieve efficient degradation of cellobiose and cellopentaose. For comparison, free peptides, graphene oxide mixed with free peptides (GO-peptdies) and self-assembled peptide nanofibers (PNFs) were also studied for their activity as a hydrolase mimetics for degradation of cellobiose...
November 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29128535/branched-peptides-integrate-into-self-assembled-nanostructures-and-enhance-biomechanics-of-peptidic-hydrogels
#13
Raffaele Pugliese, Federico Fontana, Amanda Marchini, Fabrizio Gelain
Self-assembling peptides (SAP) have drawn an increasing interest in the tissue engineering community. They display unquestionable biomimetic properties, tailorability and promising biocompatibility. However their use has been hampered by poor mechanical properties making them fragile soft scaffolds. To increase SAP hydrogel stiffness we introduced a novel strategy based on multiple ramifications of (LDLK)3, a well-known linear SAP, connected with one or multiple "lysine knots". Differently branched SAPs were tested by increasing the number of (LDLK)3-like branches and by adding the neuro-regenerative functional motif BMHP1 as a single branch...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29127706/peptide-strand-length-controls-the-energetics-of-self-assembly-and-morphology-of-%C3%AE-sheet-fibrils
#14
Robert P W Davies, Binbin Liu, Steven Maude, Lisa M Carrick, Irina Nyrkova, Tom C McLeish, Sarah A Harris
Self-assembling peptides can be used as versatile, natural, and multifunctional building blocks to produce a variety of well-defined nanostructures, materials and devices for applications in medicine and nanotechnology. Here, we concentrate on the 1D self-assembly of de novo designed Px-2 peptide β-strands into anti-parallel β-sheet tapes and higher order aggregates. We study six members of the Px-2 family, ranging from 3 amino acids (aa) to 13 aa in length, using a range of complementary experimental techniques, computer simulation and theoretical statistical mechanics...
November 11, 2017: Biopolymers
https://www.readbyqxmd.com/read/29126321/reciprocal-nucleopeptides-as-the-ancestral-darwinian-self-replicator
#15
Eleanor F Banwell, Bernard M A G Piette, Anne Taormina, Jonathan G Heddle
Even the simplest organisms are too complex to have spontaneously arisen fully-formed, yet precursors to first life must have emerged ab initio from their environment. A watershed event was the appearance of the first entity capable of evolution: the Initial Darwinian Ancestor. Here we suggest that nucleopeptide reciprocal replicators could have carried out this important role and contend that this is the simplest way to explain extant replication systems in a mathematically consistent way. We propose short nucleic- acid templates on which amino-acylated adapters assembled...
November 8, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29120632/is-spa-an-implicit-treatment-of-the-non-polar-component-to-solvation-for-simulating-molecular-aggregation
#16
Peter T Lake, Martin McCullagh
Non-polar solute-solvent interactions are the driving force for aggregation in important chemical and biological phenomena including protein-folding, peptide self-assembly and oil-water emulsion formation. Currently, the most accurate and computationally efficient description of these processes requires an explicit treatment of all solvent and solute atoms. Previous computationally feasible implicit solvent models, such as solute surface area approaches, are unsuccessful at capturing aggregation features including both structural and energetic trends while more theoretically rigorous approaches, such as Reference Interaction Site Model (RISM), are accurate but extremely computationally demanding...
November 9, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29120326/the-liquid-structure-of-elastin
#17
Sarah Rauscher, Régis Pomès
The protein elastin imparts extensibility, elastic recoil, and resilience to tissues including arterial walls, skin, lung alveoli, and the uterus. Elastin and elastin-like peptides are hydrophobic, disordered, and undergo liquid-liquid phase separation upon self-assembly. Despite extensive study, the structure of elastin remains controversial. We use molecular dynamics simulations on a massive scale to elucidate the structural ensemble of aggregated elastin-like peptides. Consistent with the entropic nature of elastic recoil, the aggregated state is stabilized by the hydrophobic effect...
November 9, 2017: ELife
https://www.readbyqxmd.com/read/29118336/self-assembling-dipeptide-antibacterial-nanostructures-with-membrane-disrupting-activity
#18
Lee Schnaider, Sayanti Brahmachari, Nathan W Schmidt, Bruk Mensa, Shira Shaham-Niv, Darya Bychenko, Lihi Adler-Abramovich, Linda J W Shimon, Sofiya Kolusheva, William F DeGrado, Ehud Gazit
Peptide-based supramolecular assemblies are a promising class of nanomaterials with important biomedical applications, specifically in drug delivery and tissue regeneration. However, the intrinsic antibacterial capabilities of these assemblies have been largely overlooked. The recent identification of common characteristics shared by antibacterial and self-assembling peptides provides a paradigm shift towards development of antibacterial agents. Here we present the antibacterial activity of self-assembled diphenylalanine, which emerges as the minimal model for antibacterial supramolecular polymers...
November 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29117575/self-assembling-peptide-hydrogel-enables-instant-epicardial-coating-of-the-heart-with-mesenchymal-stromal-cells-for-the-treatment-of-heart-failure
#19
Yuki Ichihara, Masahiro Kaneko, Kenichi Yamahara, Marinos Koulouroudias, Nobuhiko Sato, Rakesh Uppal, Kenji Yamazaki, Satoshi Saito, Ken Suzuki
Transplantation of mesenchymal stromal cells (MSCs) is an emerging therapy for the treatment of heart failure. However, the delivery method of MSC is currently suboptimal. The use of self-assembling peptide hydrogels, including PuraMatrix(®) (PM; 3-D Matrix, Ltd), has been reported for clinical hemostasis and in research models. This study demonstrates the feasibility and efficacy of an advanced approach for MSC-therapy, that is coating of the epicardium with the instantly-produced PM hydrogel incorporating MSCs (epicardial PM-MSC therapy)...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29117531/charge-influences-substrate-recognition-and-self-assembly-of-hydrophobic-fg-sequences
#20
Wesley G Chen, Jacob Witten, Scott C Grindy, Niels Holten-Andersen, Katharina Ribbeck
The nuclear pore complex controls the passage of molecules via hydrophobic phenylalanine-glycine (FG) domains on nucleoporins. Such FG domains consist of repeating units of FxFG, FG, or GLFG sequences, many of which are interspersed with highly charged amino acid sequences. Despite the high density of charge in certain FG domains, if and how charge influences FG-domain self-assembly and selective binding of nuclear transport receptors is largely unexplored. Using rationally designed short peptide sequences, we determined that the charge type and identity of amino acids surrounding FG sequences impact the structure and selectivity of FG-based gels...
November 7, 2017: Biophysical Journal
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