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peptide self-assembly

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https://www.readbyqxmd.com/read/28544846/genomic-dna-interactions-mechanize-peptidotoxin-mediated-anti-cancer-nanotherapy
#1
Santosh K Misra, Aaron S Schwartz-Duval, Dipanjan Pan
Host defense peptides (HDPs) are a class of evolutionarily conserved substances of the innate immune response that has been identified as major players in the defense system in many living organisms. Some of the HDPs are also referred as peptidotoxins which offer immense potential for anti-cancer therapy. However, their therapeutic potential is yet to be fully translated mainly due to their off-target toxicity. Here we show that their nano-enabled delivery may become beneficial in controlling their delivery in intra-cellular space...
May 25, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28544138/inhibition-of-the-aggregation-and-toxicity-of-the-minimal-amyloidogenic-fragment-of-tau-by-its-pro-substituted-analogs
#2
Marina Chemerovski-Glikman, Moran Frenkel-Pinter, Amjaad Abu-Mokh, Ragad Mdah, Ehud Gazit, Daniel Segal
Inhibiting the toxic aggregation of amyloid-β and the tau protein, the key pathological agents involved in Alzheimer's, is a leading approach in modulating disease progression. Using an aggregative tau-derived model peptide, Ac-PHF6-NH2, we show that substitution of its amino acids with Proline, a known efficient β-breaker, reduces its self-assembly. This effect is attributed to the steric hindrance created by the Proline substitution, which results in disruption of the β-sheet formation process. Moreover, several of the Proline-substituted peptides inhibit the aggregation of Ac-PHF6-NH2 amyloidogenic peptide...
May 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28544124/secondary-structure-driven-self-assembly-of-reactive-polypept-o-ides-controlling-size-shape-and-function-of-core-cross-linked-nanostructures
#3
Kristina Klinker, Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz
Achieving precise control over morphology and function of polymeric nanoparticles during self-assembly remains a challenge in material as well as bio-medical sciences, especially when all these properties can be controlled independently. Herein, we report on nanostructures derived from amphiphilic block copolypept(o)ides by secondary structure directed self-assembly, presenting a strategy to adjust core polarity separately from particle preparation in a bio-reversible fashion. The peptide-inherent process of secondary structure-formation allows for the synthesis of spherical and worm-like core cross-linked architectures from the same block copolymer, introducing a simple yet powerful approach to versatile peptide-based nanoparticles...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28537734/can-simple-interaction-models-explain-sequence-dependent-effects-in-peptide-homodimerization
#4
David J Smith, M Scott Shell
The development of rapid methods to explain and predict peptide interactions, aggregation, and self-assembly has become important to understanding amyloid disease pathology, the shelf stability of peptide therapeutics, and the design of novel peptide materials. While experimental aggregation databases have been used to develop correlative and statistical models, molecular simulations offer atomic-level details that potentially provide greater physical insight and allow one to single out the most explanatory simple models...
May 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28537604/multiscale-simulations-for-understanding-the-evolution-and-mechanism-of-hierarchical-peptide-self-assembly
#5
Chengqian Yuan, Shukun Li, Qianli Zou, Ying Ren, Xuehai Yan
Hierarchical self-assembly, abundant in biological systems, has been explored as an effective bottom-up method to fabricate highly ordered functional superstructures from elemental building units. Biomolecules, especially short peptides consisting of several amino acids, are a type of elegant building blocks due to their advantages of structural, mechanical, and functional diversity as well as high biocompatibility and biodegradability. The hierarchical self-assembly of peptides is a spontaneous process spanning multiple time and length scales under certain thermodynamics and kinetics conditions...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28537502/suitability-of-different-natural-and-synthetic-biomaterials-for-dental-pulp-tissue-engineering
#6
Kerstin M Galler, Ferdinand Brandl, Susanne Kirchhof, Matthias Widbiller, Andreas Eidt, Wolfgang Buchalla, Achim Goepferich, Gottfried Schmalz
Dental pulp tissue engineering is possible after insertion of pulpal stem cells combined with a scaffold into empty root canals. Commonly used biomaterials are collagen or poly(lactic) acid, which are either difficult to modify or to insert into such a narrow space. New hydrogel scaffolds with bioactive, specifically tailored functions could optimize the conditions to engineer dental pulp. Different synthetic and natural hydrogels were tested for their suitability to engineer dental pulp. Two functionalized modifications of polyethylene glycol were developed in this study and compared to a self-assembling peptide as well as to collagen and fibrin...
May 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28537313/control-of-the-hierarchical-assembly-of-%C3%AF-conjugated-optoelectronic-peptides-by-ph-and-flow
#7
Rachael A Mansbach, Andrew L Ferguson
Self-assembled nanoaggregates of π-conjugated peptides possess optoelectronic properties due to electron delocalization over the conjugated peptide groups that make them attractive candidates for the fabrication of bioelectronic materials. We present a computational and theoretical study to resolve the microscopic effects of pH and flow on the non-equilibrium morphology and kinetics of early-stage assembly of an experimentally-realizable optoelectronic peptide that displays pH triggerable assembly. Employing coarse-grained molecular dynamics simulations, we probe the effects of pH on growth kinetics and aggregate morphology to show that control of the peptide protonation state by pH can be used to modulate the assembly rates, degree of molecular alignment, and resulting morphologies within the self-assembling nanoaggregates...
May 24, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28535062/supramolecular-hydrogel-formation-in-a-series-of-self-assembling-lipopeptides-with-varying-lipid-chain-length
#8
Valeria Castelletto, Amanpreet Kaur, Radoslaw M Kowalczyk, Ian W Hamley, Mehedi Reza, Janne Ruokolainen
The self-assembly in aqueous solution of three lipopeptides comprising a bioactive motif conjugated at the N terminus to dodecyl, tetradecyl or hexadecyl lipid chains has been examined. The bioactive motif is the peptide block YEALRVANEVTLN; a C-terminal fragment of the lumican proteoglycan. This study was motivated by our previous studies on the hexadecyl homologue C16-YEALRVANEVTLN which showed aggregation into β-sheet structures above a critical aggregation concentration (cac), but most remarkably we found that these aggregates were stable to dilution below the cac...
May 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28532113/nanofibers-of-human-tropoelastin-inspired-peptides-structural-characterization-and-biological-properties
#9
Valeria Secchi, Stefano Franchi, Marco Fioramonti, Giovanni Polzonetti, Giovanna Iucci, Brigida Bochicchio, Chiara Battocchio
Regenerative medicine is taking great advantage from the use of biomaterials in the treatments of a wide range of diseases and injuries. Among other biomaterials, self-assembling peptides are appealing systems due to their ability to spontaneously form nanostructured hydrogels that can be directly injected into lesions. Indeed, self-assembling peptide scaffolds are expected to behave as biomimetic matrices able to surround cells, to promote specific interactions, and to control and modify cell behavior by mimicking the native environment as well...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530745/self-assembling-peptide-and-protein-amyloids-from-structure-to-tailored-function-in-nanotechnology
#10
REVIEW
Gang Wei, Zhiqiang Su, Nicholas P Reynolds, Paolo Arosio, Ian W Hamley, Ehud Gazit, Raffaele Mezzenga
Self-assembled peptide and protein amyloid nanostructures have traditionally been considered only as pathological aggregates implicated in human neurodegenerative diseases. In more recent times, these nanostructures have found interesting applications as advanced materials in biomedicine, tissue engineering, renewable energy, environmental science, nanotechnology and material science, to name only a few fields. In all these applications, the final function depends on: (i) the specific mechanisms of protein aggregation, (ii) the hierarchical structure of the protein and peptide amyloids from the atomistic to mesoscopic length scales and (iii) the physical properties of the amyloids in the context of their surrounding environment (biological or artificial)...
May 22, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28530133/efficacy-of-a-self-assembling-peptide-hydrogel-spg-178-gel-for-bone-regeneration-and-three-dimensional-osteogenic-induction-of-dental-pulp-stem-cells
#11
Jun Tsukamoto, Keiko Naruse, Yusuke Nagai, Shuhei Kan, Nobuhisa Nakamura, Masaki Hata, Maiko Omi, Tatsuhide Hayashi, Tatsushi Kawai, Tatsuaki Matsubara
The aim of this study was to assess the efficacy of a self-assembling peptide hydrogel as a scaffold for bone regeneration. We used a neutral and injectable self-assembling peptide hydrogel, SPG-178-Gel. Bone defects (5 mm in diameter) in rat calvarial bones were filled with a mixture of alpha-modified Eagle's medium and the peptide hydrogel. Three weeks after surgery, soft X-ray and micro-computed tomography (micro-CT) images of the gel-treated bones showed new bone formations in the periphery and in central areas of the defects...
May 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28528863/cross-linking-of-a-biopolymer-peptide-co-assembling-system
#12
Karla E Inostroza-Brito, Estelle C Collin, Anna Poliniewicz, Sherif Elsharkawy, Alistair Rice, Armando E Del Río Hernández, Xin Xiao, José Rodríguez-Cabello, Alvaro Mata
The ability to guide molecular self-assembly at the nanoscale into complex macroscopic structures could enable the development of functional synthetic materials that exhibit properties of natural tissues such as hierarchy, adaptability, and self-healing. However, the stability and structural integrity of these kinds of materials remains a challenge for many practical applications. We have recently developed a dynamic biopolymer-peptide co-assembly system with the capacity to grow and undergo morphogenesis into complex shapes...
May 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28525280/self-healing-self-assembled-%C3%AE-sheet-peptide-poly-%C3%AE-glutamic-acid-hybrid-hydrogels
#13
David E Clarke, E Thomas Pashuck, Sergio Bertazzo, Jonathan V M Weaver, Molly M Stevens
Self-assembled biomaterials are an important class of materials that can be injected and formed in situ. However, they often are not able to meet the mechanical properties necessary for many biological applications, losing mechanical properties at low strains. We synthesized hybrid hydrogels consisting of a poly(γ-glutamic acid) polymer network physically cross-linked via grafted self-assembling β-sheet peptides to provide non-covalent cross-linking through β-sheet assembly, reinforced with a polymer backbone to improve strain stability...
May 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28522213/harnessing-self-assembled-peptide-nanoparticles-in-epitope-vaccine-design
#14
REVIEW
Manica Negahdaripour, Nasim Golkar, Nasim Hajighahramani, Sedigheh Kianpour, Navid Nezafat, Younes Ghasemi
Vaccination has been one of the most successful breakthroughs in medical history. In recent years, epitope-based subunit vaccines have been introduced as a safer alternative to traditional vaccines. However, they suffer from limited immunogenicity. Nanotechnology has shown value in solving this issue. Different kinds of nanovaccines have been employed, among which virus-like nanoparticles (VLPs) and self-assembled peptide nanoparticles (SAPNs) seem very promising. Recently, SAPNs have attracted special interest due to their unique properties, including molecular specificity, biodegradability, and biocompatibility...
May 15, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28522193/ph-triggered-re-assembly-of-nanosphere-to-nanofiber-the-role-of-peptide-conformational-change-for-enhanced-cancer-therapy
#15
Peiqing Liang, Junjiong Zheng, Shulin Dai, Jiayu Wang, Zhaoqing Zhang, Ting Kang, Changyun Quan
pH-triggered conformational change and subsequent re-assembly of nanostructures provide a new strategy in nanomedicine for controlled drug release and enhanced therapy. Here, we reported the development of a novel pH-responsive nano-assembly as a drug carrier from peptide amphiphile (PA) consisting of mimicking peptide and stearic acid moieties. The mimicking peptide is a basic 17-amino acid peptide derived from antennapedia homeodomain, and undergoes a conformational transition of the secondary structure from β-sheet at pH7...
May 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28520402/catch-and-release-engineered-allosterically-regulated-%C3%AE-roll-peptides-enable-on-off-biomolecular-recognition
#16
Beyza Bulutoglu, Kevin Dooley, Géza R Szilvay, Mark Blenner, Scott Banta
Alternative scaffolds for biomolecular recognition are being developed to overcome some of the limitations associated with immunoglobulin domains. The repeat-in-toxin (RTX) domain is a repeat protein sequence that reversibly adopts the β-roll secondary structure motif specifically upon calcium binding. This conformational change was exploited for controlled biomolecular recognition. Using ribosome display, an RTX peptide library was selected to identify binders to a model protein, lysozyme, exclusively in the folded state of the peptide...
May 18, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28518205/self-assembly-of-amphiphilic-tripeptides-with-sequence-dependent-nanostructure
#17
Jugal Kishore Sahoo, Calvin Nazareth, Michael A VandenBerg, Matthew J Webber
Supramolecular chemistry enables the creation of a diversity of nanostructures and materials. Many of these have been explored for applications as biomaterials and therapeutics. Among them, self-assembling peptides have been broadly applied. The structural diversity afforded from the library of amino acid building blocks has enabled control of emergent properties across length-scales. Here, we report on a family of amphiphilic tripeptides with sequence-controlled nanostructure. By altering one amino acid in these peptides, we can produce a diversity of nanostructures with different aspect-ratio and geometry...
May 18, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28515315/the-c-terminal-peptide-of-aquifex-aeolicus-riboflavin-synthase-directs-encapsulation-of-native-and-foreign-guests-by-a-cage-forming-lumazine-synthase
#18
Yusuke Azuma, Reinhard Zschoche, Donald Hilvert
Encapsulation of specific enzymes in self-assembling protein cages is a hallmark of bacterial compartments that function as counterparts to eukaryotic organelles. The cage-forming enzyme lumazine synthase (LS) from Bacillus subtilis (BsLS), for example, encapsulates riboflavin synthase (BsRS), enabling channeling of lumazine from the site of its generation to the site of its conversion to vitamin B2. Elucidating the molecular mechanisms underlying the assembly of these supramolecular complexes could help inform new approaches for metabolic engineering, nanotechnology, and drug delivery...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28513074/%C3%AE-myrtoxin-mp1a-is-a-helical-heterodimer-from-the-venom-of-the-jack-jumper-ant-with-antimicrobial-membrane-disrupting-and-nociceptive-activities
#19
Zoltan Dekan, Stephen J Heady, Martin Scanlon, Brian A Baldo, Tzong-Hsien Lee, Marie-Isabel Aguilar, Jennifer R Deuis, Irina Vetter, Alysha G Elliott, Maite Amado, Matthew A Cooper, Dianne Alewood, Paul Francis Alewood
Δ-Myrtoxin-Mp1a (Mp1a), a 49-residue heterodimeric peptide from the venom of Myrmecia pilosula is comprised of a 26-mer A chain and a 23-mer B chain connected by two disulfide bonds in an antiparallel arrangement. Combination of the individual synthetic chains via aerial oxidation remarkably resulted in the self-assembly of Mp1a as a homogenous product without the need for directed disulfide bond formation. NMR analysis revealed a well-defined, unique structure containing a pair of antiparallel α-helices...
May 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28509927/tuning-morphological-architectures-generated-through-living-supramolecular-assembly-of-a-helical-foldamer-end-capped-with-two-complementary-nucleobases
#20
Giulia Marafon, Ileana Menegazzo, Marta De Zotti, Marco Crisma, Claudio Toniolo, Alessandro Moretto
Two appropriately functionalized nucleobases, thymine and adenine, have been covalently linked at the N- and C-termini, respectively, of two α-aminoisobutyric acid-rich helical peptide foldamers, aiming at driving self-assembly through complementary recognition. A crystal-state analysis (by X-ray diffraction) on the shorter, achiral foldamer 1 unambiguously shows that adeninethymine base pairing, through Watson-Crick intermolecular H-bonding, does take place between either end of each peptide molecule. In the crystals, π-stacking between base pairs is also observed...
May 16, 2017: Soft Matter
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