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peptide self-assembly

Noam Brown, Jiangtao Lei, Chendi Zhan, Linda J W Shimon, Lihi Adler-Abramovich, Guanghong Wei, Ehud Gazit
Self-assembly is a process of key importance in natural systems and in nanotechnology. Peptides are attractive building blocks due to their relative facile synthesis, biocompatibility and other unique properties. Diphenylalanine (FF) and its derivatives are known to form nanostructures of various architectures and remarkable characteristics. The larger triphenylalanine (FFF) was found to self-assemble as efficiently as FF, forming related but distinct architectures of plate-like and spherical nanostructures...
March 20, 2018: ACS Nano
Myeongsang Lee, Jae In Kim, Sungsoo Na, Kilho Eom
Amyloid β (Aβ) aggregates, which are a hallmark for neurodegenerative disease, are formed through a self-assembly process such as aggregation of Aβ peptide chains. This aggregation process depends on the solvent conditions under which the proteins are aggregated. Nevertheless, the underlying mechanism of the ionic effect on the formation and stability of amyloid aggregates has not been fully understood. Here, we report how metal ions play a role in the formation and stability of Aβ aggregates at different length scales, i...
March 20, 2018: Physical Chemistry Chemical Physics: PCCP
Ganesh R Kokil, Rakesh N Veedu, Bao Tri Le, Grant A Ramm, Harendra S Parekh
Despite advancements in the development of high generation cationic-dendrimer systems for delivery of nucleic acid-based therapeutics, commercially available chemical agents suffer from major drawbacks such as cytotoxicity while being laborious and costly to synthesize. To overcome the aforementioned limitations, low-generation cationic peptide asymmetric dendrimers with side arm lipid (cholic and decanoic acid) conjugation were designed, synthesized and systematically screened for their ability to self-assemble into micelles using dynamic light scattering...
March 19, 2018: Scientific Reports
Davoud Mozhdehi, Kelli M Luginbuhl, Joseph R Simon, Michael Dzuricky, Rüdiger Berger, H Samet Varol, Fred C Huang, Kristen L Buehne, Nicholas R Mayne, Isaac Weitzhandler, Mischa Bonn, Sapun H Parekh, Ashutosh Chilkoti
Post-translational modification of proteins is a strategy widely used in biological systems. It expands the diversity of the proteome and allows for tailoring of both the function and localization of proteins within cells as well as the material properties of structural proteins and matrices. Despite their ubiquity in biology, with a few exceptions, the potential of post-translational modifications in biomaterials synthesis has remained largely untapped. As a proof of concept to demonstrate the feasibility of creating a genetically encoded biohybrid material through post-translational modification, we report here the generation of a family of three stimulus-responsive hybrid materials-fatty-acid-modified elastin-like polypeptides-using a one-pot recombinant expression and post-translational lipidation methodology...
March 19, 2018: Nature Chemistry
Carl Peter J Maury
A crucial stage in the origin of life was the emergence of the first molecular entity that was able to replicate, transmit information, and evolve on the early Earth. The amyloid world hypothesis posits that in the pre-RNA era, information processing was based on catalytic amyloids. The self-assembly of short peptides into β-sheet amyloid conformers leads to extraordinary structural stability and novel multifunctionality that cannot be achieved by the corresponding nonaggregated peptides. The new functions include self-replication, catalytic activities, and information transfer...
March 17, 2018: Cellular and Molecular Life Sciences: CMLS
Luiz Filipe Barbosa-Martins, Jossaria Pereira de Sousa, Aline Rogéria Freire de Castilho, Julia Puppin-Rontani, Robert P W Davies, Regina Maria Puppin-Rontani
Bonding to demineralized dentin of a diseased tooth has shown to be a significant clinical issue. This study evaluated the effect of 0.2% NaF-(NaF), MI Paste™-(CPP-ACP) and the self-assembling peptide 'P11 - 4 ' (Ace-QQRFEWEFEQQ-NH2 ) contained in Curodont™ Repair, have on microtensile bond strength-(µTBS) of two different adhesive systems (Adper™ Single Bond-(SB) or Clearfil™ SE Bond (CSE)) and wettability of demineralized dentin slices after remineralising agents were applied. The highest µTBS were found for the demineralized dentin-(DD) treated with CPP-ACP; both adhesives systems (p < 0...
March 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Katarina Ulicna, Zuzana Bednarikova, Wei-Tse Hsu, Martina Holztragerova, Josephine W Wu, Slavka Hamulakova, Steven S-S Wang, Zuzana Gazova
Amyloid aggregates of proteins are one of the most abundant and important naturally occurring self-associated assemblies. Formation of poly/peptide amyloid aggregates is also associated with the widely spread diseases, so called amyloidosis, which include Alzheimer's disease, diabetes mellitus and lysozyme amyloidosis. These disorders are still incurable and novel therapeutical approaches are focused on using small molecules for inhibition of amyloid aggregation. We have observed effect of three structurally distinct groups of tacrine/acridone - coumarin heterodimers on hen egg white (HEW) lysozyme fibrillization in vitro...
March 9, 2018: Colloids and Surfaces. B, Biointerfaces
Weibing Dong, Ziang Liu, Liying Sun, Cui Wang, Yue Guan, Xiaoman Mao, Dejing Shang
The threshold hydrophobicity and amphipathic structure of the peptidic chain are important for the biological function of antimicrobial peptides. Chensinin-1b exhibits broad-spectrum bactericidal activity with no hemolytic activity but has almost no anticancer ability against the selected cancer cell lines. In this study, the conjugation of aliphatic acid was designed with different lengths of N-terminal of chensinin-1b, the antimicrobial activity of the resulting lipo-chensinin-1b was examined, in which OA-C1b showed much stronger activity than those of cheninin-1b and the other two lipopeptides...
March 10, 2018: European Journal of Medicinal Chemistry
Dongni Wu, Shuangying Zhang, Yuyuan Zhao, Ningjian Ao, Seeram Ramakrishna, Liumin He
RADA16-I (Ac-(RADA)4 -CONH2 ) is a widely investigated self-assembling peptide (SAP) in the biomedical field. It can undergo ordered self-assembly to form stable secondary structures, thereby further forming a nanofiber hydrogel. The modification of RADA16-I with functional peptide motifs has become a popular research topic. Researchers aim to exhibit particular biomedical signaling, and subsequently, further expand its applications. However, only a few fundamental reports are available on the influences of the peptide motifs on self-assembly mechanisms of designer functional RADA16-I SAPs...
March 16, 2018: Biomedical Materials
Niloy Kundu, Debasis Banik, Nilmoni Sarkar
Amphiphiles are class of molecules which are known to assemble into a variety of nanostructures. The understanding and applications of self-assembled systems are based on what has been learned from biology. Among the vast number of self-assemblies, in this article, we have described the formation, characterization and dynamics of two important biologically inspired assemblies, vesicles and fibrils. Vesicles, which can be classified into several categories depending on the sizes and components, are of great interest due to their potential application in drug delivery and as nanoscale reactor...
March 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Antonella Accardo, Carlo Diaferia, Nicole Balasco, Teresa Sibillano, Cinzia Giannini, Luigi Vitagliano, Giancarlo Morelli
Over the years, a large number of multidisciplinary investigations has unveiled that the self-assembly of short peptides and even of individual amino acids can generate a variety of different biomaterials. In this framework, we have recently reported that polyethylene glycol (PEG) conjugates of short homopeptides, containing aromatic amino acids such as phenylalanine (Phe, F) and naphthylalanine (Nal), are able to form elongated fibrillary aggregates having interesting chemical and physical properties. We here extend these analyses characterizing the self-assembling propensity of PEG6-W4, a PEG adduct of the tetra-tryptophan (W4) sequence...
March 15, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Hui Sun, Yuanxiu Hong, Yuejing Xi, Yijie Zou, Jingyi Gao, Jianzhong Du
Antimicrobial peptides (AMPs) have been attracting much attention due to their excellent antimicrobial efficiency and low rate in driving antimicrobial resistance (AMR) which has been increasing globally to alarming levels. Conjugation of AMPs into functional polymers not only preserves excellent antimicrobial activities but reduces the toxicity and offers more functionalities, which brings new insight towards developing multifunctional biomedical materials such as hydrogels, polymer vesicles, polymer micelles, etc...
March 14, 2018: Biomacromolecules
Jie Li, Domenico Bullara, Xuewen Du, Hongjian He, Stavroula Sofou, Ioannis G Kevrekidis, Irving R Epstein, Bing Xu
Recent studies have demonstrated that enzyme-instructed self-assembly (EISA) in extra- or intracellular environments can serve as a multistep process for controlling cell fate. There is little knowledge, however, about the kinetics of EISA in the complex environments in or around cells. Here we design and synthesize three dipeptidic precursors (LD-1-SO3, DL-1-SO3, DD-1-SO3), consisting of diphenylalanine (L-Phe-D-Phe, D-Phe-L-Phe, D-Phe-D-Phe, respectively) as the backbone, which are capped by 2-(naphthalen-2-yl)acetic acid at the N-terminal and by 2-(4-(2-aminoethoxy)-4-oxobutanamido)ethane-1-sulfonic acid at the C- 2 terminal...
March 14, 2018: ACS Nano
Nicole L Ing, Ryan K Spencer, Son H Luong, Hung D Nguyen, Allon I Hochbaum
Examples of long-range electronic conductivity are rare in biological systems. The observation of micrometer-scale electronic transport through protein wires produced by bacteria is therefore notable, providing an opportunity to study fundamental aspects of conduction through protein-based materials and natural inspiration for bioelectronics materials. Borrowing sequence and structural motifs from these conductive protein fibers, we designed self-assembling peptides that form electronically conductive nanofibers under aqueous conditions...
March 14, 2018: ACS Nano
Pramod Gavel, Dharm Dev, Hamendra Singh Parmar, Sheetal Bhasin, Apurba K Das
Here, we report the self-assembly of Amoc (9-anthracenemethoxycarbonyl)-capped dipeptides, which self-assemble to form injectable, self-healable and shape-memory hydrogels with inherent antibacterial properties. Amoc-capped dipeptides self-assemble to form nanofibrillar networks, which are established by several spectroscopic and microscopic techniques. The inherent antibacterial properties of hydrogels are evaluated using two Gram-positive Staphylococcus aureus, Bacillus subtilis and three Gram-negative Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi bacteria...
March 14, 2018: ACS Applied Materials & Interfaces
Nazario Martin, Alicia López-Andarias, Javier López-Andarias, Carmen Atienza, Francisco J Chichón, José L Carrascosa
Supramolecular chemistry has evolved from the traditional focus on thermodynamic on-pathways to the complex study of kinetic off-pathways, which are strongly dependent of the environmental conditions. Moreover, the control over pathway complexity allows obtaining nanostructures that are inaccessible through spontaneous thermodynamic processes. Here, we present a family of peptide-based π-extended tetrathiafulvalene (exTTF) molecules which show two self-assembly pathways leading to two distinct J-aggregates, namely metastable (M) and thermodynamic (T), with different spectroscopic, chiroptical and electrochemical behavior...
March 14, 2018: Chemistry: a European Journal
Swapnil C Kohale, Subha Pratihar, William L Hase
Classical chemical dynamics simulation results are presented for the thermal desorption kinetics and energetics of protonated dialanine ions (ala2 -H+ ) physisorbed on/in a perfluorinated self-assembled monolayer (F-SAM) surface. Previously developed analytic potentials were used for the F-SAM and the ala2 -H+ /F-SAM intermolecular interaction, and the AMBER valence force field was used for ala2 -H+ . The activation energy, Ea = 13.2 kcal/mol, determined from the simulations is consistent with previous simulations of the ala2 -H+ /F-SAM binding energy...
March 13, 2018: Journal of Physical Chemistry Letters
Yujuan Chen, Fengjiao Yuan, Xian Jiang, Qing Lv, Na Luo, Changyang Gong, Chunting Wang, Li Yang, Gu He
Recently, tumor immunotherapy has achieved great progress in the treatment of hematological and solid neoplasms. The DC vaccines, KLH-conjugated vaccines or glycosylated peptide vaccines can efficiently induce immune responses against tumors. In the current study, we have discovered cholesteryl PADRE-EGFRvIII epitope-conjugated lipopeptide self-assembled micelles as a potential self-adjuvant vaccine against cutaneous melanoma. The lipopeptide vaccines were synthesized using a standard solid phase peptide synthesis method, and these vaccines could elicit both a humoral and a cellular immune response to EGFRvIII positive melanoma cells...
March 12, 2018: Biomaterials Science
Therese W Herling, Aviad Levin, Kadi L Saar, Christopher M Dobson, Tuomas P J Knowles
The self-assembly of proteins into supramolecular structures and machinery underpins biological activity in living systems. Misassembled, misfolded and aggregated protein structures can, by contrast, have deleterious activity and such species are at the origin of a number of disease states ranging from cancer to neurodegenerative disorders. In particular, the formation of highly ordered protein aggregates, amyloid fibrils, from normally soluble peptides and proteins, is the common pathological hallmark of a range a group of over fifty protein misfolding disorders...
March 12, 2018: Lab on a Chip
Markus Schlee, Florian Rathe, Claudine Bommer, Frank Bröseler, Lucy Kind
BACKGROUND: Patient reported dentin hypersensitivity [DHS] pain is a common finding linked with periodontal disease. This pilot clinical study investigates a novel therapeutic regimen using self-assembling peptide matrix [SAPM] gel (test) and compare it to the use of an 8% arginine and calcium carbonate [ACC] toothpaste (control) for treatment of DHS. METHODS: 50 patients with history of Supportive Periodontal Therapy [SPT] were enrolled in the prospective, randomized monocentric clinical study, of which 45 (test: N = 22; control: N = 23) fulfilled all the study visits...
March 5, 2018: Journal of Periodontology
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