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J R Griswold, D G Medvedev, J W Engle, R Copping, J M Fitzsimmons, V Radchenko, J C Cooley, M E Fassbender, D L Denton, K E Murphy, A C Owens, E R Birnbaum, K D John, F M Nortier, D W Stracener, L H Heilbronn, L F Mausner, S Mirzadeh
Actinium-225 and (213)Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of (225)Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of (225)Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL)...
September 28, 2016: Applied Radiation and Isotopes
Gregory S Antonarakis, Bryan D Tompson, David M Fisher
OBJECTIVE:   Maxillary growth in patients with cleft lip and palate is highly variable. The authors' aim was to investigate associations between preoperative cleft lip measurements and maxillary growth determined cephalometrically in patients with complete unilateral cleft lip and palate (cUCLP). DESIGN:   Retrospective cross-sectional study. PATIENTS:   Children with cUCLP. METHODS:   Preoperative cleft lip measurements were made at the time of primary cheiloplasty and available for each patient...
November 2016: Cleft Palate-craniofacial Journal
Aatekah Owais, Benjamin Schwartz, David G Kleinbaum, Parminder S Suchdev, A S G Faruque, Sumon K Das, Aryeh D Stein
The association between suboptimal infant feeding practices and growth faltering is well-established. However, most of this evidence comes from cross-sectional studies. To prospectively assess the association between suboptimal infant feeding practices and growth faltering, we interviewed pregnant women at 28-32 weeks' gestation and followed-up their offspring at postnatal months 3, 9, 16 and 24 months in rural Bangladesh. Using maternal recall over the past 24 hours, exclusive breastfeeding (EBF) status at 3 months, age at complementary feeding (CF) initiation, and receipt of minimum acceptable diet (MAD; as defined by WHO) at 9 months were assessed...
2016: PloS One
B C C Khoo, J K Brown, R L Prince
OBJECTIVES: In recent years quantitative computed tomography (QCT) has allowed precise non-invasive, three dimensional, in vivo measurement of hip structure in large numbers of individuals. The effects of ageing on proximal femur structure are reported and implications for the prevention of hip prosthesis loosening and hip fracture considered. DESIGN, SETTING AND PARTICIPANTS: An observational cross-sectional study of proximal femur QCT in 719 unselected female European descent aged 20 to 89 years recruited from US and Australian populations...
2016: PloS One
Daniel Schwarzkopf, Hendrik Rüddel, Daniel O Thomas-Rüddel, Jörg Felfe, Bernhard Poidinger, Claudia T Matthäus-Krämer, Christiane S Hartog, Frank Bloos
OBJECTIVES: Perceiving nonbeneficial treatment is stressful for ICU staff and may be associated with burnout. We aimed to investigate predictors and consequences of perceived nonbeneficial treatment and to compare nurses and junior and senior physicians. DESIGN: Cross-sectional, multicenter paper-pencil survey on personal and work-related characteristics, perceived nonbeneficial treatment, burnout, and intention to leave the job. SETTING: Convenience sample of 23 German ICUs...
October 21, 2016: Critical Care Medicine
Milly Marston, Jessica Nakiyingi-Miiro, Sylvia Kusemererwa, Mark Urassa, Denna Michael, Constance Nyamukapa, Simon Gregson, Basia Zaba, Jeffrey W Eaton
OBJECTIVES: To estimate the relationship between HIV natural history and fertility by duration of infection in East and Southern Africa before the availability of antiretroviral therapy, and assess potential biases in estimates of age-specific sub-fertility when using retrospective birth histories in cross-sectional studies. DESIGN: Pooled analysis of prospective population-based HIV cohort studies in Masaka (Uganda) Kisesa (Tanzania), and Manicaland (Zimbabwe)...
October 20, 2016: AIDS
Erin M Warshaw, Solveig L Hagen, Denis Sasseville, Howard I Maibach, Joel G DeKoven, Donald V Belsito, Joseph F Fowler, Kathryn A Zug, James S Taylor, C G Toby Mathias, Anthony F Fransway, Vincent A DeLeo, James G Marks, Melanie D Pratt, Matthew J Zirwas, Frances J Storrs
BACKGROUND: Contact dermatoses are common in mechanic and repair occupations. OBJECTIVES: This study aimed to (1) estimate the prevalence of occupationally related contact dermatitis among mechanics/repairers patch tested from 1998 to 2014 by the North American Contact Dermatitis Group, (2) characterize responsible allergens and irritants, and their sources, and (3) compare results among 3 occupational subgroups (mechanics, electrical/electronic, and other). METHODS: A cross-sectional analysis of patients patch tested by the North American Contact Dermatitis Group between 1998 and 2014...
October 21, 2016: Dermatitis
Jari E Kaikkonen, Peter Würtz, Emmi Suomela, Miia Lehtovirta, Antti J Kangas, Antti Jula, Vera Mikkilä, Jorma S A Viikari, Markus Juonala, Tapani Rönnemaa, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Pasi Soininen, Mika Ala-Korpela, Olli T Raitakari
: Non-alcoholic fatty liver is associated with obesity-related metabolic disturbances, but little is known about the metabolic perturbations preceding fatty liver disease. We performed comprehensive metabolic profiling to assess how circulating metabolites, such as lipoprotein lipids, fatty acids, amino acids and glycolysis-related metabolites, reflect the presence of and future risk for fatty liver in young adults. Sixty-eight lipids and metabolites were quantified by nuclear magnetic resonance metabolomics in the population-based Young Finns Study from serum collected in 2001 (n=1,575), 2007 (n=1,509) and 2011 (n=2,002)...
October 24, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Peter de Jonge, Annelieke M Roest, Carmen C W Lim, Silvia E Florescu, Evelyn J Bromet, Dan J Stein, Meredith Harris, Vladimir Nakov, Jose Miguel Caldas-de-Almeida, Daphna Levinson, Ali O Al-Hamzawi, Josep Maria Haro, Maria Carmen Viana, Guilherme Borges, Siobhan O'Neill, Giovanni de Girolamo, Koen Demyttenaere, Oye Gureje, Noboru Iwata, Sing Lee, Chiyi Hu, Aimee Karam, Jacek Moskalewicz, Viviane Kovess-Masfety, Fernando Navarro-Mateu, Mark Oakley Browne, Marina Piazza, José Posada-Villa, Yolanda Torres, Margreet L Ten Have, Ronald C Kessler, Kate M Scott
CONTEXT: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. OBJECTIVE: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions. DESIGN AND SETTING: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3...
October 24, 2016: Depression and Anxiety
Xiaolei Song, Guanyang Zou, Wen Chen, Siqi Han, Xia Zou, Li Ling
OBJECTIVE: To describe the self-reported health status and service utilization of employed, retired and unemployed migrants in Guangzhou, a mega-city in southern China. METHODS: Cross-sectional study adapted from National Health Service Survey between September and December in 2014. Based on the distribution of occupation of migrants, multi-stage sampling was used to recruit individuals. Logistic regression was applied to explore the factors influencing their service utilization...
October 24, 2016: Tropical Medicine & International Health: TM & IH
Jennie Johnstone, Robin Parsons, Fernando Botelho, Jamie Millar, Shelly McNeil, Tamas Fulop, Janet E McElhaney, Melissa K Andrew, Stephen D Walter, P J Devereaux, Mehrnoush Malek, Ryan R Brinkman, Jonathan Bramson, Mark Loeb
OBJECTIVES: To determine whether immune phenotypes associated with immunosenescence are predictive of frailty and mortality within 1-year in elderly nursing home residents. DESIGN: Cross sectional study of frailty; prospective cohort study of mortality. SETTING: Thirty-two nursing homes in four Canadian cities between September 2009 and October 2011. PARTICIPANTS: Nursing home residents aged 65 and older (N = 1,072, median age 86, 72% female)...
October 24, 2016: Journal of the American Geriatrics Society
Jamie Perin, John S Preisser
Alternating logistic regressions is an estimating equations procedure used to model marginal means of correlated binary outcomes while simultaneously specifying a within-cluster association model for log odds ratios of outcome pairs. A recent generalization of alternating logistic regressions, known as orthogonalized residuals, is extended to incorporate finite sample adjustments in the estimation of the log odds ratio model parameters for when there is a moderately small number of clusters. Bias adjustments are made both in the sandwich variance estimators and in the estimating equations for the association parameters...
October 24, 2016: Biometrics
Jeri W Nieves, Chris Gennings, Pam Factor-Litvak, Jonathan Hupf, Jessica Singleton, Valerie Sharf, Björn Oskarsson, J Americo M Fernandes Filho, Eric J Sorenson, Emanuele D'Amico, Ray Goetz, Hiroshi Mitsumoto
Importance: There is growing interest in the role of nutrition in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS). Objective: To evaluate the associations between nutrients, individually and in groups, and ALS function and respiratory function at diagnosis. Design, Setting, and Participants: A cross-sectional baseline analysis of the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, 2013, at 16 ALS clinics throughout the United States among 302 patients with ALS symptom duration of 18 months or less...
October 24, 2016: JAMA Neurology
Verónica Rubio González, Susana Redondo Martín, Gema Ruíz López Del Prado, Mª Fe Muñoz Moreno, Alexander Velázquez Miranda
OBJECTIVE: Household Survey on Alcohol and Other Drugs shows the progressive increase in the consumption of hypnotics, alone or in combination with other substances. The aim of the research was to obtain information about the consumption of hypnotics and sedatives in population of Castilla y León treated in emergency medical services of four monitored hospitals between 2009-2013, describing clinical and epidemiological characteristics of the emergencies and what drugs were consumed, to provide information for future interventions...
October 24, 2016: Revista Española de Salud Pública
Zengchun Ye, Qunzi Zhang, Yan Li, Cheng Wang, Jun Zhang, Xinxin Ma, Hui Peng, Tanqi Lou
Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to our hospital. Patients were divided into two groups: hyperhomocysteinemia and normohomocysteinemia. Multivariable linear regression analyses were used to evaluate the association between plasma homocysteine and renal/cardiovascular parameters...
October 20, 2016: Nutrients
Ricardo Dias de Castro, Marianne de Lucena Rangel, Marcos André Azevedo da Silva, Brunna Thaís Lucwu de Lucena, Alessandro Leite Cavalcanti, Paulo Rogério Ferreti Bonan, Julyana de Araújo Oliveira
The Specialized Dental Clinics (SDCs) represent the first government initiative in Latin America aimed at providing specialized oral health services. This study sought to evaluate the organizational accessibility to specialized oral health care services in Brazil and to understand the factors that may be associated with accessibility from the user's perspective. This epidemiological, cross-sectional and quantitative study was conducted by means of interviews with individuals who sought specialized public oral health services in the city of João Pessoa, Paraíba, Brazil, and consisted of a sample of 590 individuals...
October 19, 2016: International Journal of Environmental Research and Public Health
Ye Chang, Yuan Li, Xiaofan Guo, Dongxue Dai, Yingxian Sun
In 2010, the American Heart Association has proposed a new concept "ideal cardiovascular health" (CVH) based on seven CVH metrics: smoking, body mass index, physical activity, diet score, total cholesterol, blood pressure, and fasting plasma glucose. We aimed to determine the association of CVH with atherogenic index of plasma (AIP), a strong marker for atherosclerosis (AS). This cross-sectional study was conducted in the rural areas of northeast China and 11,113 middle-aged subjects were enrolled. Seven CVH metrics were classified into ideal, intermediate, and poor groups...
October 19, 2016: International Journal of Environmental Research and Public Health
Mieun Gwon, Young Jin Tak, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Dong Wook Jeong, Yu Hyeon Yi, Seung Hoon Lee, Hye Rim Hwang, Youngin Lee
Hypovitaminosis D and stress are common problems among the elderly. The aim of this cross-sectional nationally representative study was to evaluate the association between hypovitaminosis D and stress perception using large-scale nationally representative data from the Korea National Health and Nutrition Examination Survey (2012-2013). In our study, a total of 1393 elders (≥65 years old) were included to evaluate the association between hypovitaminosis D and stress perception. Serum 25-hydroxyvitamin D levels were determined using radioimmunoassay, and perceived stress status was assessed by a self-reporting questionnaire...
October 19, 2016: Nutrients
Alfred Chikweto, Ravindra N Sharma, Keshaw P Tiwari, Shiv K Verma, Rafael Calero-Bernal, Tiantian Jiang, Chunlei Su, Oliver C Kwok, Jitender P Dubey
The objectives of the present cross sectional study were to isolate and genotype Toxoplasma gondii in free-range chickens from Grenada, West Indies. Using the modified agglutination test, antibodies to T. gondii were found in 39 (26.9%) of 145 free-range chickens with titers of 25 in 7chickens; 50 in 6 chickens; 100 in 2 chickens; 200 or higher in 24 chickens. The hearts of the 39 seropositive chickens were bioassayed in mice; viable T. gondii was isolated from 20 and further propagated in cell culture. Genotyping of T...
October 24, 2016: Journal of Parasitology
Antonia G Zogka, Abdelwahid Mellouki, Manolis N Romanias, Yuri Bedjanian, Mahmoud Idir, Benoit Grosselin, Veronique Daele
The rate coefficients for the reactions of OH and Cl with 1-methoxy 2-propyl acetate (MPA) in the gas phase were measured using absolute and relative methods. The kinetic study on the OH-reaction was conducted in the temperature (263-373) K and pressure (1-760) Torr ranges using the pulsed laser photolysis-laser induced fluorescence technique, a low pressure fast flow tube reactor-quadrupole mass spectrometer and an atmospheric simulation chamber-GC/FID. The derived Arrhenius expression is kMPA+OH(T)=(2.01±0...
October 24, 2016: Journal of Physical Chemistry. A
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