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Karina C Lopes, Aloysio da S Ferrão-Filho, Everton G N Dos Santos, Rodolfo A Cunha, Cláudia P Santos
The cyanobacterium Cylindrospermopsis raciborskii is an invasive species in water supply reservoirs worldwide, which can produces cylindrospermopsins and saxitoxins. In the wild, guppy (Poecilia vivipara) can be exposed to cyanotoxins, but those born and reared in laboratory are free of this contact. The aim of this paper was to comparatively measure the locomotor activity of 'wild' and 'lab' P. vivipara before and after exposure to crude extracts of two different cultures of C. raciborskii (CYRF-01), a saxitoxin-procucer strain...
February 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
Anne E Marsden, Kevin Grudzinski, Jakob M Ondrey, Cindy R DeLoney-Marino, Karen L Visick
Vibrio fischeri, a marine bacterium and symbiont of the Hawaiian bobtail squid Euprymna scolopes, depends on biofilm formation for successful colonization of the squid's symbiotic light organ. Here, we investigated if culture conditions, such as nutrient and salt availability, affect biofilm formation by V. fischeri by testing the formation of wrinkled colonies on solid media. We found that V. fischeri forms colonies with more substantial wrinkling when grown on the nutrient-dense LBS medium containing NaCl relative to those formed on the more nutrient-poor, seawater-salt containing SWT medium...
2017: PloS One
Seigo Yamashita, Frédéric Sacher, Darren A Hooks, Benjamin Berte, Jean-Marc Sellal, Antonio Frontera, Nora Al Jefairi, Yuki Komatsu, Sana Amraoui, Arnaud Denis, Nicolas Derval, Maxime Sermesant, François Laurent, Michel Montaudon, Mélèze Hocini, Michel Haïssaguerre, Pierre Jaïs, Hubert Cochet
BACKGROUND: Scar-related ventricular tachycardia (VT) arises from specific substrate according to etiology. OBJECTIVE: The purpose of this study was to evaluate the relationship between wall thinning (WT) on multidetector computed tomography (MDCT) and local abnormal ventricular activity (LAVA) in patients with ischemic cardiomyopathy (ICM), postmyocarditis (PMC), and dilated cardiomyopathy (DCM). METHODS: Forty-two patients (40 male, age 58 ± 13 years, 22 ICM, 11 PMC, 9 DCM) underwent MDCT before a combined endo-/epicardial VT ablation procedure...
February 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Can Tepeköylü, Uwe Primessnig, Leo Pölzl, Michael Graber, Daniela Lobenwein, Felix Nägele, Elke Kirchmair, Elisabeth Pechriggl, Michael Grimm, Johannes Holfeld
Shock wave treatment (SWT) was shown to induce regeneration of ischaemic myocardium via Toll-like receptor 3 (TLR3). The antimicrobial peptide LL37 gets released by mechanical stress and is known to form complexes with nucleic acids thus activating Toll-like receptors. We suggested that SWT in the acute setting prevents from the development of heart failure via RNA/protein release. Myocardial infarction in mice was induced followed by subsequent SWT. Heart function was assessed 4 weeks later via transthoracic echocardiography and pressure-volume measurements...
December 20, 2016: Journal of Cellular and Molecular Medicine
Deepak Ranjan Nayak, Ratnakar Dash, Banshidhar Majhi
This paper presents an automatic classification system for segregating pathological brain from normal brains in magnetic resonance imaging scanning. The proposed system employs contrast limited adaptive histogram equalization scheme to enhance the diseased region in brain MR images. Two-dimensional stationary wavelet transform is harnessed to extract features from the preprocessed images. The feature vector is constructed using the energy and entropy values, computed from the level-2 SWT coefficients. Then, the relevant and uncorrelated features are selected using symmetric uncertainty ranking filter...
October 24, 2016: CNS & Neurological Disorders Drug Targets
Yajuan Hao, Qiangqiang Tang, Xiaohong Li, Meirong Zhang, Yingbo Wan, Lai Feng, Ning Chen, Zdeněk Slanina, Ludwik Adamowicz, Filip Uhlík
It has been proposed that the fullerene formation mechanism involves either a top-down or bottom-up pathway. Despite different starting points, both mechanisms approve that particular fullerenes or metallofullerenes are formed through a consecutive stepwise process involving Stone-Wales transformations (SWTs) and C2 losses or additions. However, the formation pathway has seldomly been defined at the atomic level due to the missing-link fullerenes. Herein, we present the isolation and crystallographic characterization of two isomeric clusterfullerenes Sc2O@C2v(3)-C78 and Sc2O@D3h(5)-C78, which are closely related via a single-step Stone-Wales (SW) transformation...
November 7, 2016: Inorganic Chemistry
Mariana Gomez-Smith, Sudhir Karthikeyan, Matthew S Jeffers, Rafal Janik, Lynsie A Thomason, Bojana Stefanovic, Dale Corbett
Many promising findings from pre-clinical research have failed to translate to the clinic due to their inability to incorporate human disease co-morbidity. A variety of rodent diets and feeding durations are currently used in models of human metabolic syndrome, obesity and diabetes. One model, the Cafeteria (CAF) diet, makes use of grocery store-purchased food items that more closely approximate the human ultra-processed diet than commercial high-fat or high-sugar rodent diets. The present study describes the development of metabolic syndrome in rats fed a CAF diet as well as the recovery of metabolic syndrome following a healthy "lifestyle" change...
December 1, 2016: Physiology & Behavior
Can Tepeköylü, Daniela Lobenwein, Anja Urbschat, Michael Graber, Elisabeth Judith Pechriggl, Helga Fritsch, Patrick Paulus, Michael Grimm, Johannes Holfeld
BACKGROUND: Shock wave therapy (SWT) has been shown to induce angiogenesis in ischemic muscle. However, the mechanism of action remains unknown. Macrophages are crucial for angiogenic responses after ischemic injury. The M2 macrophage subset enables tissue repair and induces angiogenesis. We hypothesized that the angiogenic effects of SWT are at least partly caused by enhanced macrophage recruitment. METHODS: C57BL/6 mice were subjected to hind limb ischemia with subsequent SWT or sham treatment...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
Jing Sun, Li Zhang, Yujun He, Kun Zhang, Liping Wu, Yongsheng Fan, Zhijun Xie
Traditional Chinese Medicine (TCM) is increasingly getting clinical application worldwide. But its theory like QI-Blood is still abstract. Actually, Qi deficiency and blood deficiency, which were treated by Si-Jun-Zi-Tang (SJZT) and Si-Wu-Tang (SWT) respectively, have characteristic clinical manifestations. Here, we analyzed targets of the ingredients in SJZT and SWT to unveil potential biologic mechanisms between Qi deficiency and blood deficiency through biomedical approaches. First, ingredients in SWT and SJZT were retrieved from TCMID database...
September 28, 2016: Scientific Reports
Vaughan Hoefler, Hiroko Nagaoka, Craig S Miller
OBJECTIVES: A systematic review was performed to compare the long-term survival of deep dentine caries-affected permanent teeth treated with partial-caries-removal (PCR) versus similar teeth treated with stepwise-caries-removal techniques (SWT). DATA: Clinical studies investigating long-term PCR and SWT outcomes in unrestored permanent teeth with deep dentine caries were evaluated. Failures were defined as loss of pulp vitality or restorative failures following treatment...
November 2016: Journal of Dentistry
Lill-Heidi Johansson, Gerrit Timmerhaus, Sergey Afanasyev, Sven Martin Jørgensen, Aleksei Krasnov
Smoltification and seawater adaptation of Atlantic salmon are associated with profound alterations in the endocrine status, osmoregulation and behaviour. Little is known about immunological changes during smoltification, although increased incidences of infectious diseases after seawater transfer (SWT) may indicate weakened protection. We report microarray gene expression analyses in farmed Atlantic salmon during smoltification stimulated with constant light and early seawater adaptation (one and three weeks after SWT)...
November 2016: Fish & Shellfish Immunology
Peter G Erdmann, Laurien L Teunissen, Leonard H van den Berg, Nicolette C Notermans, Carin D Schröder, Bart C Bongers, Nico L U van Meeteren
PURPOSE: This study assessed the validity of the shuttle walk test (SWT) to evaluate walking ability in patients with polyneuropathy. METHODS: Forty-one patients with chronic idiopathic axonal polyneuropathy (CIAP) and 49 patients with multifocal motor neuropathy (MMN) performed both the 10-meter walk test (10MWT) and the SWT. Face validity was assessed by evaluating whether patients considered both tests to reflect their walking ability (Likert scale: 1 = not at all, 10 = very well)...
September 6, 2016: Disability and Rehabilitation
Saleha Khatun, Ruhi Mahajan, Bashir I Morshed
Electroencephalogram (EEG) is a technique for recording the asynchronous activation of neuronal firing inside the brain with non-invasive scalp electrodes. Artifacts, such as eye blink activities, can corrupt these neuronal signals. While ocular artifact (OA) removal is well investigated for multiple channel EEG systems, in alignment with the recent momentum toward minimalistic EEG systems for use in natural environments, we investigate unsupervised and effective removal of OA from single-channel streaming raw EEG data...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Fabrício Motteran, Juliana K Braga, Edson L Silva, Maria Bernadete A Varesche
This study evaluates the kinetics of methane production and degradation of standard linear alkylbenzene sulfonate (LAS) (50 ± 3.5 mg/L) and LAS from laundry wastewater (85 ± 2.1 mg/L) in anaerobic batch reactors at 30°C with different sources of inoculum. The inocula were obtained by auto-fermentation (AFM) and UASB reactors from wastewater treatment of poultry slaughterhouse (SGH), swine production (SWT) and wastewater treatment thermophilic of sugarcane industry (THR). The study was divided into three phases: synthetic substrate (Phase I), standard LAS (Phase II) and LAS from laundry wastewater (Phase III)...
December 5, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Davi Farias de Araújo, Antônio Pinto de Melo Neto, Ítalo Sérgio Cavalcante Oliveira, Beatriz Soares Brito, Ineusi Teixeira de Araújo, Ingrid Sousa Barros, José Wellington Oliveira Lima, Wagner Goes Horta, Francisco de Assis Aquino Gondim
BACKGROUND: Recent studies have reported that peripheral neuropathy (PN) is common in patients with Parkinson's disease (PD) and raised the possibility that levodopa neurotoxicity is the main culprit. METHODS: We evaluated the presence of large & small (autonomic) fiber PN in 54 consecutive patients with PD or parkinsonism in a tertiary outpatient clinic from Brazil. Initial PN screening consisted of history/neurological exam and skin wrinkling test (SWT). In addition, we also performed Nerve conduction studies/Electromyography (NCS/EMG) in all patients with PN signs/symptoms and/or abnormal SWT...
August 17, 2016: BMC Neurology
Hui-Fang Chiu, Ying-Hua Wu, You-Cheng Shen, Shing-Jung Wang, Kamesh Venkatakrishnan, Chin-Kun Wang
BACKGROUND: Si-Wu-Tang (SWT) is used to treat various gynecological disorders in Chinese medicine. This study investigated the antioxidant and physiological effects of SWT on the skin and liver in healthy adults. METHODS: This randomized, crossover, double-blind, placebo-controlled clinical trial was conducted at Chung Shan Medical University Hospital in December 2008. Participants with uncontrolled diabetes, heart disease, liver disease, kidney disease, cancer, and pregnancy were excluded...
2016: Chinese Medicine
Roger E Peverill, Bon Chou, Lesley Donelan, Philip M Mottram, John S Gelman
BACKGROUND: The transmitral E wave and the peak velocity of early diastolic mitral annular motion (e`) both decrease with age, but the mechanisms underlying these age-related changes are incompletely understood. This study investigated the possible contributions of blood pressure (BP) and left ventricular end-diastolic length (LVEDL) to age-related reductions in E and e`. METHODS: The study group were 82 healthy adult subjects <55 years of age who were not obese or hypertensive...
2016: PloS One
Jonathan Caron, Pierre-Antoine Michel, Jean-Claude Dussaule, Christos Chatziantoniou, Pierre Ronco, Jean-Jacques Boffa
Low-energy extracorporeal shock wave therapy (SWT) has been shown to improve myocardial dysfunction, hind limb ischemia, erectile function, and to facilitate cell therapy and healing process. These therapeutic effects were mainly due to promoting angiogenesis. Since chronic kidney diseases are characterized by renal fibrosis and capillaries rarefaction, they may benefit from a proangiogenic treatment. The objective of our study was to determine whether SWT could ameliorate renal repair and favor angiogenesis in L-NAME-induced hypertensive nephropathy in rats...
June 2016: Physiological Reports
Cordula Werner, Manuela Byhahn, Stefan Hesse
PURPOSE: In order to promote alertness and awareness in patients with severe disorders of consciousness (DOC) frontal near infrared laser stimulation (N-LT) or transcranial focused shock wave therapy (F-SWT) might be an option. The study compared both techniques in severe chronic DOC patients. METHODS: Sixteen DOC patients were allocated to two groups (A and B). A three week baseline either followed a frontal N-LT (0,1 mJ/mm2, 10 min per session), five times a week over four weeks (group A), or a F-SWT (0,1 mJ/mm2, 4000 stimuli per session) three times a week over four weeks (group B)...
April 11, 2016: Restorative Neurology and Neuroscience
Johan Larsson, Michael Miller, Eva Ekvall Hansson
Vestibular asymmetry is a common cause of dizziness in the elderly, for whom it precipitates the risk of falling. Previous studies have shown that those with vestibular asymmetry displayed an altered variability in double support time (DST) compared to controls. However, swing time (SwT) variability findings are conflicting. In this study, we investigated if vestibular asymmetry might be causally connected to increased DST variability. We studied a group of eight elderly fallers with wrist fractures across three months, during which time four of them regained vestibular symmetry while four others developed an asymmetry...
March 2016: Gait & Posture
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