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JOURNAL ARTICLE
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer.
Shih-Chieh Lin, Chung-Yang Kao, Hui-Ju Lee, Chad J Creighton, Michael M Ittmann, Shaw-Jenq Tsai, Sophia Y Tsai, Ming-Jer Tsai
Although early detection and treatment of prostate cancer (PCa) improves outcomes, many patients still die of metastatic PCa. Here, we report that metastatic PCa exhibits reduced levels of the microRNAsmiR-101 and miR-27a. These micro-RNAs (miRNAs) negatively regulate cell invasion and inhibit the expression of FOXM1 and CENPF, two master regulators of metastasis in PCa. Interestingly, the repression of FOXM1 and CENPF by these miRNAs occurs through COUP-TFII, a member of the orphan nuclear receptors family...
April 25, 2016: Nature Communications
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