keyword
https://read.qxmd.com/read/38527610/prevalence-of-apical-periodontitis-in-patients-with-autoimmune-liver-diseases-under-immune-suppressants-and-immune-modulators-a-cross-sectional-study
#21
JOURNAL ARTICLE
Francesca Ideo, Sadia Niazi, Luchino Chessa, Michela Miglianti, Giulia Bardini, Francesco Mannocci, Elisabetta CottiDDS
INTRODUCTION: Autoimmune liver diseases (ALDs) are chronic conditions generated by an immune-mediated auto-aggressive inflammatory reaction in genetically susceptible individuals. The purpose of this study was to evaluate the prevalence of AP in patients suffering from ALDs, in treatment with the immune-suppressants glucocorticoids, azathioprine, and/or ursodeoxycholic acid. METHODS: The ALDs group included 46 patients (11 men and 35 women, average age: 57.9 ± 11...
March 23, 2024: Journal of Endodontics
https://read.qxmd.com/read/38527237/explaining-the-variability-of-alzheimer-disease-fluid-biomarker-concentrations-in-memory-clinic-patients-without-dementia
#22
JOURNAL ARTICLE
Vincent Bouteloup, Isabelle Pellegrin, Bruno Dubois, Genevieve Chene, Vincent Planche, Carole Dufouil
BACKGROUND AND OBJECTIVES: Patients' comorbidities can affect Alzheimer disease (AD) blood biomarker concentrations. Because a limited number of factors have been explored to date, our aim was to assess the proportion of the variance in fluid biomarker levels explained by the clinical features of AD and by a large number of non-AD-related factors. METHODS: MEMENTO enrolled 2,323 individuals with cognitive complaints or mild cognitive impairment in 26 French memory clinics...
April 23, 2024: Neurology
https://read.qxmd.com/read/38526161/genetic-factors-associated-with-age-related-macular-degeneration-modulating-plasma-inflammatory-biomarker-levels-in-patients-with-aids
#23
JOURNAL ARTICLE
Efe Sezgin, Michael F Schneider, Peter W Hunt, Gabriele Beck-Engeser, Gabriele C Ambayac, Douglas A Jabs
INTRODUCTION: Patients with the acquired immunodeficiency syndrome (AIDS) have an increased prevalence and incidence of intermediate-stage age-related macular degeneration (AMD). Several elevated plasma inflammatory biomarkers are associated with increased incidence of intermediate-stage AMD in this population. We evaluated the association between AMD risk alleles and plasma inflammatory biomarker levels in persons with AIDS. MATERIALS AND METHODS: Cryopreserved plasma specimens of 229 non-Hispanic White and 252 non-Hispanic blacks from the Longitudinal Study of the Ocular Complications of AIDS cohort were assayed for plasma levels of soluble tumor necrosis factor receptor (sTNFR) 2, interleukin (IL)-18, C × 3motif chemokine ligand 1 (CX3CL1), C-reactive protein (CRP), and soluble CD14 (sCD14)...
March 25, 2024: Ophthalmic Genetics
https://read.qxmd.com/read/38524267/can-we-achieve-pain-stratification-in-musculoskeletal-conditions-implications-for-clinical-practice
#24
REVIEW
Nidhi Sofat, Andrew Lambarth
In the last few years there has been an increased appreciation that pain perception in rheumatic and musculoskeletal diseases (RMDs) has several mechanisms which include nociceptive, inflammatory, nociplastic and neuropathic components. Studies in specific patient groups have also demonstrated that the pain experienced by people with specific diagnoses can present with distinctive components over time. For example, the pain observed in rheumatoid arthritis has been widely accepted to be caused by the activation of nociceptors, potentiated by the release of inflammatory mediators, including prostaglandins, leukotrienes and cytokine networks in the joint environment...
2024: Front Pain Res (Lausanne)
https://read.qxmd.com/read/38523882/do-serological-tests-eliminate-the-need-for-endoscopic-biopsy-for-the-diagnosis-of-symptomatic-patients-with-celiac-disease-a-retrospective-study-with-review-of-literature
#25
JOURNAL ARTICLE
Mohammad Hossein Anbardar, Neda Soleimani, Ehsan Torabi Dashtaki, Naser Honar, Mozhgan Zahmatkeshan, Sahand Mohammadzadeh
Background: Celiac disease is one of the most common genetic allergies worldwide. The prevalence of celiac disease in Iran is similar to or even higher than the global prevalence. Celiac disease is a chronic inflammatory disease that affects the small intestine. Affected patients are allergic to gluten protein that exists in some grains, such as wheat and barley. Methods: Serological endomysial IgA antibody (EMA-AB) and tissue transglutaminase IgA antibody (TTG-IgA) tests were performed on 114 patients aged the ages of 0-18 years with histopathological findings of celiac disease...
October 2023: Middle East Journal of Digestive Diseases
https://read.qxmd.com/read/38522483/microbiome-interactions-with-different-risk-factors-in-development-of-myocardial-infarction
#26
REVIEW
Manisha Bijla, Sunil Kumar Saini, Ajai Pathak, Kamal Prakash Bharadwaj, Katyayani Sukhavasi, Ayurshi Patil, Diksha Saini, Rakesh Yadav, Shalini Singh, Christiaan Leeuwenburgh, Pramod Kumar
Among all non-communicable diseases, Cardiovascular Diseases (CVDs) stand as the leading global cause of mortality. Within this spectrum, Myocardial Infarction (MI) strikingly accounts for over 15 % of all deaths. The intricate web of risk factors for MI, comprising family history, tobacco use, oral health, hypertension, nutritional pattern, and microbial infections, is firmly influenced by the human gut and oral microbiota, their diversity, richness, and dysbiosis, along with their respective metabolites...
March 22, 2024: Experimental Gerontology
https://read.qxmd.com/read/38521068/the-central-role-of-natural-killer-cells-in-mediating-acute-myocarditis-after-mrna-covid-19-vaccination
#27
JOURNAL ARTICLE
Hing Wai Tsang, Mike Yat Wah Kwan, Gilbert T Chua, Sabrina Siu Ling Tsao, Joshua Sung Chih Wong, Keith Tsz Suen Tung, Godfrey Chi Fung Chan, Kelvin Kai Wang To, Ian Chi Kei Wong, Wing Hang Leung, Patrick Ip
BACKGROUND: Vaccine-related acute myocarditis is recognized as a rare and specific vaccine complication following mRNA-based COVID-19 vaccinations. The precise mechanisms remain unclear. We hypothesized that natural killer (NK) cells play a central role in its pathogenesis. METHODS: Samples from 60 adolescents with vaccine-related myocarditis were analyzed, including pro-inflammatory cytokines, cardiac troponin T, genotyping, and immunophenotyping of the corresponding activation subsets of NK cells, monocytes, and T cells...
March 15, 2024: Med
https://read.qxmd.com/read/38520607/additional-data-in-expanded-patient-populations-and-new-indications-support-the-practice-of-biosimilar-to-biosimilar-switching
#28
JOURNAL ARTICLE
Hillel P Cohen, Wolfram Bodenmueller
As of 31 December, 2023, 31 observational studies have been published, including a total of 6081 patients who underwent a switch from one biosimilar to another biosimilar of the same reference biologic. Most studies evaluated infliximab, while a smaller number evaluated adalimumab, rituximab or etanercept. Indications studied now include sarcoidosis, as well as the indications previously reported of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis/ankylosing spondylitis and inflammatory bowel disease (Crohn's disease and ulcerative colitis)...
March 23, 2024: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://read.qxmd.com/read/38520496/the-causal-effect-of-inflammatory-proteins-and-immune-cell-populations-on-diabetic-nephropathy-evidence-from-mendelian-randomization
#29
JOURNAL ARTICLE
Yi Ren, Honggang Zhang
BACKGROUND: Diabetic nephropathy (DN) is one of the diabetic microvascular complications with complex pathophysiology, and exploring the landscape of immune dysregulation in DN is valuable for pathogenesis and disease treatment. We crystallized possible inflammatory exposures into 91 circulating inflammatory proteins and 109 blood immune cells; and assessed the causal relationship between inflammation and DN using Mendelian randomization (MR). METHODS: Based on publicly available genetic data, we explored causal associations between inflammation and DN risk by two-sample MR analysis...
March 23, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38519926/inflammatory-cytokines-mediating-the-effect-of-oral-lichen-planus-on-oral-cavity-cancer-risk-a-univariable-and-multivariable-mendelian-randomization-study
#30
JOURNAL ARTICLE
Tao Zheng, Chengyong Liu, Yetong Wang, Han Zhou, Rong Zhou, Xuan Zhu, Zibing Zhu, Yisi Tan, Zhengrui Li, Xufeng Huang, Jin Tan, Keke Zhu
BACKGROUND: While observational studies and experimental data suggest a link between oral lichen planus (OLP) and oral cavity cancer (OCC), the causal relationship and the role of inflammatory cytokines remain unclear. METHODS: This study employed a univariable and multivariable Mendelian Randomization (MR) analysis to investigate the causal relationship between OLP and the risk of OCC. Additionally, the potential role of inflammatory cytokines in modulating this association was explored...
March 22, 2024: BMC Oral Health
https://read.qxmd.com/read/38519640/genetic-contribution-to-microglial-activation-in-schizophrenia
#31
JOURNAL ARTICLE
Marja Koskuvi, Elina Pörsti, Tristen Hewitt, Noora Räsänen, Ying-Chieh Wu, Kalevi Trontti, Amanda McQuade, Shringaa Kalyanaraman, Ilkka Ojansuu, Olli Vaurio, Tyrone D Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, Taisia Rolova, Šárka Lehtonen, Jari Tiihonen, Jari Koistinaho
Several lines of evidence indicate the involvement of neuroinflammatory processes in the pathophysiology of schizophrenia (SCZ). Microglia are brain resident immune cells responding toward invading pathogens and injury-related products, and additionally, have a critical role in improving neurogenesis and synaptic functions. Aberrant activation of microglia in SCZ is one of the leading hypotheses for disease pathogenesis, but due to the lack of proper human cell models, the role of microglia in SCZ is not well studied...
March 22, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38518902/microarray-analysis-of-trna-derived-small-rna-tsrna-in-lps-challenged-macrophages-treated-with-metformin
#32
JOURNAL ARTICLE
Huan Lin, Hongao Deng, Zhengying Jiang, Peng Hua, Shiqiang Hu, Haiyong Ao, Meiling Zhong, Mingzhuo Liu, Guanghua Guo
Metformin, a widely used anti-diabetic drug, has demonstrated its efficacy in addressing various inflammatory conditions. tRNA-derived small RNA (tsRNA), a novel type of small non-coding RNA, exhibits diverse regulatory functions and holds promise as both a diagnostic biomarker and a therapeutic target for various diseases. The purpose of this study is to investigate whether the abundance of tsRNAs changed in LPS versus LPS + metformin-treated cells, utilizing microarray technology. Firstly, we established an in vitro lipopolysaccharide (LPS)-induced inflammation model using RAW264...
March 20, 2024: Gene
https://read.qxmd.com/read/38518214/risk-factors-for-lichen-sclerosus-a-case-control-study-of-43-000-finnish-women
#33
JOURNAL ARTICLE
Pia Halonen, Oskari Heikinheimo, Kishor Hadkhale, Mika Gissler, Eero Pukkala, Maija Jakobsson
OBJECTIVES: Lichen sclerosus (LS) is an inflammatory skin disease probably arising from an interplay of genetics, local irritation, and autoimmune processes. We identified potential risk factors for the disease using data from nationwide Finnish registries. METHODS: We identified all women diagnosed with LS within specialized health care during 1998-2016 (n = 10,692) and selected 3 age-matched population control women for each case. We calculated odds ratios (ORs) for possible risk factors using conditional logistic regression...
April 1, 2024: Journal of Lower Genital Tract Disease
https://read.qxmd.com/read/38518097/spondyloarthritis-in-first-degree-relatives-and-spouses-of-patients-with-inflammatory-bowel-disease-a-nationwide-population-based-cohort-study-from-sweden
#34
JOURNAL ARTICLE
Sarita Shrestha, Judith S Brand, Mehdi Osooli, Carl Eriksson, Ida Schoultz, Johan Askling, Tine Jess, Scott Montgomery, Ola Olén, Jonas Halfvarson
BACKGROUND AND AIMS: Register-based research suggests a shared pathophysiology between inflammatory bowel disease [IBD] and spondyloarthritis [SpA], but the role of familial [genetic and environmental] factors in this shared susceptibility is largely unknown. We compared the risk of SpA in first-degree relatives [FDRs] and spouses of IBD patients with FDRs and spouses of matched population-based reference individuals. METHODS: We identified 147,080 FDRs and 25,945 spouses of patients with incident IBD [N=39,203] during 2006-2016 and 1,453,429 FDRs and 258,098 spouses of matched reference individuals [N=390,490], by linking nationwide Swedish registers and gastrointestinal biopsy data...
March 22, 2024: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38517544/occurrence-of-mucosa-affecting-diseases-of-the-upper-airways-in-middle-ear-cholesteatoma-patients-a-nationwide-case-control-study
#35
JOURNAL ARTICLE
Agnes Modée Borgström, Hanna Mogensen, Cecilia Engmér Berglin, Johan Knutsson, Åsa Bonnard
PURPOSE: Exploring a possible link between upper airway inflammation and the development of cholesteatoma by studying the association between mucosa-affecting diseases of the upper airways and cholesteatoma surgery. METHODS: This is a nationwide case-control study of 10,618 patients who underwent surgery for cholesteatoma in Sweden between 1987 and 2018. The cases were identified in the National Patient Register and 21,235 controls matched by age, sex and place of residency were included from national population registers...
March 22, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38517358/cms121-a-novel-approach-to-mitigate-aging-related-obesity-and-metabolic-dysfunction
#36
JOURNAL ARTICLE
Alcir L Dafre, Saadia Zahid, Jessica Jorge Probst, Antonio Currais, Jingting Yu, David Schubert, Pamela Maher
BACKGROUND: Modulated by differences in genetic and environmental factors, laboratory mice often show progressive weight gain, eventually leading to obesity and metabolic dyshomeostasis. Since the geroneuroprotector CMS121 has a positive effect on energy metabolism in a mouse model of type 2 diabetes, we investigated the potential of CMS121 to counteract the metabolic changes observed during the ageing process of wild type mice. METHODS: Control or CMS121-containing diets were supplied ad libitum for 6 months, and mice were sacrificed at the age of 7 months...
March 20, 2024: Aging
https://read.qxmd.com/read/38517042/investigating-the-association-between-the-tissue-expression-of-mirna-101-jak2-stat3-with-tnf-%C3%AE-il-6-il-1%C3%AE-and-il-10-cytokines-in-the-ulcerative-colitis-patients
#37
JOURNAL ARTICLE
Qazaleh Voshagh, Amir Anoshiravani, Amin Karimpour, Golnaz Goodarzi, Sadra Samavarchi Tehrani, Ozra Tabatabaei-Malazy, Ghodratollah Panahi
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease caused by numerous factors, such as immune system dysfunction and genetic factors. MicroRNAs (miRNAs) play a crucial role in UC pathogenesis, particularly via the JAK-STAT pathway. Our aim was to investigate the association between miRNA-101 and JAK2-STAT3 signaling pathway with inflammatory cytokines in UC patients. METHODS: We enrolled 35 UC patients and 35 healthy individuals as the control group, referred to Shariati Hospital, Tehran, Iran...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38517029/sorghum-phytonutrients-and-their-health-benefits-a-systematic-review-from-cell-to-clinical-trials
#38
REVIEW
Lívia de Lacerda de Oliveira, Lúcio Flávio de Alencar Figueiredo
Sorghum is key for global food security due to its genetic variability, resilience, and rich phytonutrient content, which are linked to numerous health benefits. A systematic review assessed the health effects of sorghum by analyzing cell (n = 22), animal (n = 20), and human (n = 7) studies across antioxidant, anti-inflammatory, obesity, cancer, cardiovascular, and diabetes outcomes. This review, involving 42 papers and 177 researchers from 12 countries, collected data from sorghum accessions (acc) and significant effects...
March 22, 2024: Journal of Food Science
https://read.qxmd.com/read/38516776/circular-rnas-and-the-regulation-of-gene-expression-in-diabetic-nephropathy-review
#39
JOURNAL ARTICLE
Maximo Berto Martinez Benitez, Yussel Pérez Navarro, Elisa Azuara-Liceaga, Angeles Tecalco Cruz, Jesús Valdés Flores, Lilia Lopez-Canovas
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38516478/the-role-of-gut-microbiome-in-the-pathogenesis-and-the-treatment-of-inflammatory-bowel-diseases
#40
REVIEW
Andrea Vidal-Gallardo, Juan E Méndez Benítez, Leticia Flores Rios, Luis F Ochoa Meza, Rodrigo A Mata Pérez, Edgar Martínez Romero, Andres M Vargas Beltran, Jose L Beltran Hernandez, Douglas Banegas, Brenda Perez, Marily Martinez Ramirez
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a chronic condition characterized by inflammation of the gastrointestinal tract. Its exact cause is unknown, but it's thought to result from a dysregulated immune response influenced by various factors, including changes in the intestinal microbiota, diet, lifestyle, and genetics. The gut microbiome, consisting of diverse microorganisms, plays a crucial role in maintaining physiological balance, with its disruption leading to inflammatory responses typical of IBD...
February 2024: Curēus
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