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https://www.readbyqxmd.com/read/28916029/oral-mucosa-biology-and-salivary-biomarkers
#1
Rosie Qin, Andrea Steel, Nasim Fazel
Although the surfaces of both the skin and oral mucosa are protected by squamous epithelial cells and fall within the scope of dermatologic practice, the oral cavity contains highly specialized structures and functions distinct from other skin biology and pathologic conditions and are also the purview of clinicians who care for patients with skin and mucosal diseases. We describe the distinct features of the tongue, mucosa, and salivary glands. In particular, we examine the composition and function of the saliva, with special focus on salivary biomarkers...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28901380/expression-of-cd19-cd24highcd38high-b-cells-il%C3%A2-10-and-il%C3%A2-10r-in-peripheral-blood-from-patients-with-systemic-lupus-erythematosus
#2
Tao Wang, Zhijun Li, Xingfu Li, Linjie Chen, Hao Zhao, Chao Jiang, Lijun Song
The present study aimed to examine the status and clinical significance of cluster of differentiation (CD) 19+CD24highCD38high regulatory B cells (Bregs), serum interleukin (IL)‑10, serum transforming growth factor (TGF)‑β and IL‑10 receptor (IL‑10R) expression in peripheral blood from patients with systemic lupus erythematosus (SLE). A total of 56 patients with SLE and 35 healthy individuals were recruited to the present study. The SLE disease activity index (SLEDAI) was calculated, and other laboratory parameters were measured...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28898254/serum-levels-of-adiponectin-and-leptin-as-biomarkers-of-proteinuria-in-lupus-nephritis
#3
Valeria Diaz-Rizo, David Bonilla-Lara, Laura Gonzalez-Lopez, Dalia Sanchez-Mosco, Nicte S Fajardo-Robledo, Edsaul E Perez-Guerrero, N Alejandra Rodriguez-Jimenez, A Miriam Saldaña-Cruz, M Luisa Vazquez-Villegas, Eduardo Gomez-Bañuelos, Monica Vazquez-Del Mercado, E German Cardona-Muñoz, David Cardona-Muller, Xochitl Trujillo, Miguel Huerta, Mario Salazar-Paramo, Jorge I Gamez-Nava
INTRODUCTION: There are controversial results about the role of serum leptin and adiponectin levels as biomarkers of the severity of proteinuria in lupus nephritis. OBJECTIVE: The aim of this study was to evaluate the relationship between serum leptin and adiponectin levels with severity of proteinuria secondary to lupus nephritis (LN). METHODS: In a cross-sectional study, 103 women with systemic lupus erythematosus (SLE) were evaluated for kidney involvement...
2017: PloS One
https://www.readbyqxmd.com/read/28884017/development-and-validation-of-an-impedance-biosensor-for-point-of-care-detection-of-vascular-cell-adhesion-molecule-1-toward-lupus-diagnostics
#4
Anjan Panneer Selvam, Andi Wangzhou, Michael Jacobs, Tianfu Wu, Chandra Mohan, Shalini Prasad
AIM: Systemic lupus erythematosus is an autoimmune disease that requires chronic monitoring. In this study, we demonstrate a proof-of-concept study of a highly attractive noninvasive strategy for monitoring systemic lupus erythematosus through biomarker quantification. RESULTS: This sensor technology requires 50 μl of urine to detect and quantify vascular cell adhesion molecule-1 in 15 min. The sensor used nonfaradaic detection to demonstrate performance with and without detection antibody...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28883515/factor-xa-mediates-calcium-flux-in-endothelial-cells-and-is-potentiated-by-igg-from-patients-with-lupus-and-or-antiphospholipid-syndrome
#5
Bahar Artim-Esen, Natalia Smoktunowicz, Thomas McDonnell, Vera M Ripoll, Charis Pericleous, Ian Mackie, Eifion Robinson, David Isenberg, Anisur Rahman, Yiannis Ioannou, Rachel C Chambers, Ian Giles
Factor (F) Xa reactive IgG isolated from patients with antiphospholipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects compared to systemic lupus erythematosus (SLE) non APS IgG. FXa signalling via activation of protease-activated receptors (PAR) leads to increased intracellular calcium (Ca(2+)). Therefore, we measured alterations in Ca(2+) levels in human umbilical vein endothelial cells (HUVEC) following FXa-mediated PAR activation and investigated whether FXa reactive IgG from patients with APS or SLE/APS- alter these responses...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865500/-determinant-factors-of-morbidity-in-patients-with-systemic-lupus-erythematosus
#6
Margarida Jacinto, Eliana Silva, Nuno Riso, Maria Francisca Moraes-Fontes
INTRODUCTION: Severity in systemic lupus erythematosus may vary from mild to even fatal consequences. There are no biomarkers to predict the disease's prognosis. The Systemic Lupus International Collaborating Clinics/ Systemic Damage Index defines systemic lupus erythematosus disease severity and is found to predict prognosis. OBJECTIVE: To test damage determinants in a single-centre systemic lupus erythematosus cohort. MATERIAL AND METHODS: Retrospectively followed systemic lupus erythematosus female patients (defined by the identification of at least four systemic lupus erythematosus American College of Rheumatology criteria - fulfillment 100%, n = 76) over the past five years...
May 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28862243/association-of-anti-clic2-and-anti-hmgb1-autoantibodies-with-higher-disease-activity-in-systemic-lupus-erythematosus-patients
#7
C S Syahidatulamali, W G Wan Syamimee, Y Nor Azwany, K K Wong, C H Che Maraina
BACKGROUND: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by numerous autoantibodies. In this study, we investigated the presence of anti-chloride intracellular channel 2 (anti-CLIC2) and anti-high mobility group box 1 (anti-HMGB1) autoantibodies in SLE patients (n = 43) versus healthy controls ([HCs] n = 43), and their association with serological parameters (antinuclear antibody [ANA], anti-double-stranded DNA [anti-dsDNA], and C-reactive protein [CRP]) and disease activity using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score (active or inactive)...
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28859328/are-interferon-related-biomarkers-advantageous-for-monitoring-disease-activity-in-systemic-lupus-erythematosus-a-longitudinal-benchmark-study
#8
Thomas Rose, Andreas Grützkau, Jens Klotsche, Philipp Enghard, Alexandra Flechsig, Johannes Keller, Gabriela Riemekasten, Andreas Radbruch, Gerd-Rüdiger Burmester, Thomas Dörner, Falk Hiepe, Robert Biesen
Objective: To determine the clinical value of six traditional and three IFN-related biomarkers in monitoring disease activity (DA) in SLE. Methods: Prospective longitudinal study of IFNα, IFNγ-inducible protein 10 (IP-10) and sialic acid-binding Ig-like lectin 1 (SIGLEC1) vs antibodies against dsDNA (ELISA and Farr radioimmunoassay), dsDNA-complexed nucleosomes (anti-dsDNA-NcX: ELISA), nucleosomes (ANuA: ELISA) and complement C3/C4 for correlation with DA (measured by BILAG 2004 index) in 26 SLE patients (77 visits)...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28841837/decreased-ex-vivo-production-of-interferon-gamma-is-associated-with-severity-and-poor-prognosis-in-patients-with-lupus
#9
Sung Soo Ahn, Eun Seong Park, Joo Sung Shim, Sang-Jun Ha, Beom Seok Kim, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
BACKGROUND: Lupus pathogenesis is closely associated with interferon gamma (IFN-γ), which plays a central role in innate and adaptive immunity. The aim of this study was to evaluate the ex vivo production of IFN-γ after stimulation of peripheral blood mononuclear cells with phytohemagglutinin (PHA) in patients with lupus, according to disease activity. METHODS: This study included 118 patients with lupus who had undergone IFN-γ-releasing assays (IGRAs) to screen for tuberculosis...
August 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28840341/usefulness-of-neutrophil-to-lymphocyte-ratio-as-a-biomarker-for-diagnosing-infections-in-patients-with-systemic-lupus-erythematosus
#10
Hyoun-Ah Kim, Ju-Yang Jung, Chang-Hee Suh
Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have been investigated as disease activity markers for systemic lupus erythematosus (SLE). Hence, we investigated the clinical significance of these parameters in diagnosing infection in patients with SLE. In total, 120 patients with SLE, who were admitted to hospital due to disease flares or infection, were recruited for the study. Of the 120 patients, 60 had a concurrent infection (SLE with infection), while the remaining 60 patients were admitted with a flare without any evidence of infection (SLE with flare)...
August 24, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28829212/targeting-methionine-cycle-as-a-potential-therapeutic-strategy-for-immune-disorders
#11
Heng Li, Huimin Lu, Wei Tang, Jianping Zuo
Methionine cycle plays an essential role in regulating many cellular events, especially transmethylation reactions, incorporating the methyl donor S-adenosylmethionine (SAM). The transmethylations and substances involved in the cycle have shown complicated effects and mechanisms on immunocytes developments and activations, and exert crucial impacts on the pathological processes in immune disorders. Areas covered: Methionine cycle has been considered as an effective means of drug developments. This review discussed the role of methionine cycle in immune responses and summarized the potential therapeutic strategies based on the cycle, including SAM analogs, methyltransferase inhibitors, S-adenosylhomocysteine hydrolase (SAHH) inhibitors, adenosine receptors specific agonists or antagonists and homocysteine (Hcy)-lowering reagents, in treating human immunodeficiency virus (HIV) infections, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), systemic sclerosis (SSc) and other immune disorders...
August 22, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28798699/schizophrenia-or-atypical-lupus-erythematosus-with-predominant-psychiatric-manifestations-over-25%C3%A2-years-case-analysis-and-review
#12
Axel Mack, Christiane Pfeiffer, E Marion Schneider, Karl Bechter
We observed a case over 25 years of relapsing-remitting schizophrenic spectrum disorder, varying regarding the main symptomatology between more depressive or more schizoaffective or rather typical schizophrenic syndrome. Diseased phases were repeatedly accompanied by minor skin lesions, which were initially classified as mixed tissue disorder. Psychotic phases were waxing-waning over years. During one later relapse, skin involvement was severe, classified to likely represent an allergic reaction to psychopharmaca; this generalized exanthema remitted rapidly with cortisone treatment and azathioprine...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28770613/novel-biomarkers-for-systemic-lupus-erythematosus
#13
Jinrong Zeng, Haijing Wu, Ming Zhao, Qianjin Lu
Systemic lupus erythematosus (SLE) is a complex and highly heterogeneous disease. By now, no novel drug has been approved by the US FDA in the past 50 years, except Belimumab, a monoclonal antibody to inhibit B-cell activating factor. The stagnating drug development of lupus may be due to our limited understanding of disease etiopathogenesis and the extreme heterogeneity of patient population. Thus, the individualized treatment for SLE becomes necessary. Recently, biomarkers have shown potential in individualized treatment...
August 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28755405/serum-ifn-%C3%AE-predicts-the-therapeutic-effect-of-mesenchymal-stem-cells-transplantation-in-systemic-lupus-erythematosus-patients
#14
Dandan Wang, Shiying Wang, Saisai Huang, Zhuoya Zhang, Xinran Yuan, Xuebing Feng, Liwei Lu, Lingyun Sun
Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) show immunoregulatory properties on various immune cells and display therapeutic effects on various autoimmune diseases such as systemic lupus erythematosus (SLE). The aim of this study was to investigate the effect of the SLE environment on UC MSCs and to identify a potential serum biomarker to predict the therapeutic effect. UC MSCs were cocultured with peripheral blood mononuclear cells (PBMCs) from active lupus patients, and the proliferation, apoptosis and surface markers of UC MSCs were observed...
September 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28754791/association-analysis-of-the-mhc-in-lupus-nephritis
#15
Ricong Xu, Qibin Li, Rongjun Liu, Juan Shen, Ming Li, Minghui Zhao, Meng Wang, Qijun Liao, Haiping Mao, Zhijian Li, Na Zhou, Peiran Yin, Yue Li, Xueqing Tang, Tian Wu, Zhong Zhong, Yan Wang, Zhen Ai, Ou Wang, Nan Chen, Xiaoqin Yang, Junbin Fang, Ping Fu, Jieruo Gu, Kun Ye, Jian Chen, Lie Dai, Huafeng Liu, Zhangsuo Liu, Yunhua Liao, Jianxin Wan, Guohua Ding, Jinghong Zhao, Hao Zhang, Shuxia Fu, Liangdan Sun, Xuejun Zhang, Huanming Yang, Jian Wang, Jun Wang, Jianjun Liu, Yingrui Li, Xueqing Yu
Lupus nephritis (LN) is one of the most prevalent and serious complications of SLE, with significant effects on patient and renal survival. Although a large number of genetic variants associated with SLE have been identified, biomarkers that correlate with LN are extremely limited. In this study, we performed a comprehensive sequencing analysis of the whole MHC region in 1331 patients with LN and 1296 healthy controls and validated the independent associations in another 950 patients with LN and 1000 controls...
July 28, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28752494/epigenetics-in-sle
#16
REVIEW
Christian Michael Hedrich
PURPOSE OF REVIEW: Systemic lupus erythematosus is a severe autoimmune/inflammatory condition of unknown pathophysiology. Though genetic predisposition is essential for disease expression, risk alleles in single genes are usually insufficient to confer disease. Epigenetic dysregulation has been suggested as the missing link between genetic risk and the development of clinically evident disease. RECENT FINDINGS: Over the past decade, epigenetic events moved into the focus of research targeting the molecular pathophysiology of SLE...
September 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28745510/statistical-models-for-the-analysis-of-isobaric-tags-multiplexed-quantitative-proteomics
#17
Gina D'Angelo, Raghothama Chaerkady, Wen Yu, Deniz Baycin Hizal, Sonja Hess, Wei Zhao, Kristen Lekstrom, Xiang Guo, Wendy I White, Lorin Roskos, Michael A Bowen, Harry Yang
Mass spectrometry is being used to identify protein biomarkers that can facilitate development of drug treatment. Mass spectrometry-based labeling proteomic experiments result in complex proteomic data that is hierarchical in nature often with small sample size studies. The generalized linear model (GLM) is the most popular approach in proteomics to compare protein abundances between groups. However, GLM does not address all the complexities of proteomics data such as repeated measures and variance heterogeneity...
August 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28741130/epigenetic-involvement-in-etiopathogenesis-and-implications-in-treatment-of-systemic-lupus-erythematous
#18
REVIEW
Arron Munggela Foma, Saeed Aslani, Jafar Karami, Ahmadreza Jamshidi, Mahdi Mahmoudi
BACKGROUND: Recent researches in the field of genetics have extended our knowledge through the discovery of genetic factors associated with autoimmune diseases (AID). Genetics by itself, however, cannot elucidate all the uncertainties encountered in the etiopathology of AID. On the other hand, incomplete harmony in the prevalence of AID in identical twins suggests that non-genetic factors may play an important role in determining the disease susceptibility. Besides, epigenetics, which is defined by changes in gene expression without a corresponding change in the DNA sequences, has come in to provide new awareness in the disease etiopathology by bridging the genetic and epigenetic factors...
July 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28718063/new-insights-on-platelets-and-platelet-derived-microparticles-in-systemic-lupus-erythematosus
#19
REVIEW
Marc Scherlinger, Vanja Sisirak, Christophe Richez, Estibaliz Lazaro, Pierre Duffau, Patrick Blanco
PURPOSE OF REVIEW: Current knowledge on the role of platelets and platelet-derived microparticles (PMPs) on the immune system has been fast-growing. Systemic lupus erythematosus (SLE) is a systemic auto-immune disorder characterized by a loss of tolerance toward nuclear auto-antigens. Although recent studies allowed a better understanding of SLE pathogenesis, there is an urgent need for the development of new treatments and the identification of new biomarkers to assess the disease activity...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28711993/clinical-risk-assessment-in-the-antiphospholipid-syndrome-current-landscape-and-emerging-biomarkers
#20
REVIEW
Shruti Chaturvedi, Keith R McCrae
PURPOSE OF REVIEW: Laboratory criteria for the classification of antiphospholipid syndrome include the detection of a lupus anticoagulant and/or anticardiolipin and anti-β2-glycoprotein I antibodies. However, the majority of patients who test positive in these assays do not have thrombosis. Current risk-stratification tools are largely limited to the antiphospholipid antibody profile and traditional thrombotic risk factors. RECENT FINDINGS: Novel biomarkers that correlate with disease activity and potentially provide insight into future clinical events include domain 1 specific anti-β2GPI antibodies, antibodies to other phospholipids or phospholipid/protein antigens (such as anti-PS/PT), and functional/biological assays such as thrombin generation, complement activation, levels of circulating microparticles, and annexin A5 resistance...
July 2017: Current Rheumatology Reports
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