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Charalampia Kyriakou, Ariane Boumendil, Herve Finel, NNNorbert Schmitz, Niels Smedegaard Andersen, Didier Blaise, Patrice Chevallier, Paul Browne, Ram Malladi, Dietger Niederwieser, Antonio Pagliuca, Frank Kroschinsky, Silvia Montoto, Peter Dreger
BACKGROUND: More than 60% of patients with non-Hodgkin lymphoma (NHL) are over 60 years old at presentation. The purpose of this study was to compare the potential risks and benefits of allogeneic HSCT in elderly patients with NHL with younger patients in a large sample taking also into account comorbidity information. METHODS: Eligible were all patients >=18 years who had received an alloHCT from a matched sibling or unrelated donor for NHL between 2003 and 2013 and were registered with the EBMT...
September 13, 2018: Biology of Blood and Marrow Transplantation
João R Pereira, Diana Araújo, Ana C Marques, Luísa A Neves, Christian Grandfils, Chantal Sevrin, Vítor D Alves, Elvira Fortunato, Maria A M Reis, Filomena Freitas
Pseudomonas chlororaphis subsp. aurantiaca (DSM 19603) was grown on crude glycerol from biodiesel production to produce a medium-chain-length polyhydroxyalkanoate (mcl-PHA), composed of 3-hydroxydodecanoate (43 ± 1.8 mol%), 3-hydroxydecanoate (29 ± 3.1 mol%), 3-hydroxytetradecanoate (12 ± 0.4 mol%), 3-hydroxyoctanoate (10 ± 1.5 mol%) and 3-hydroxyhexanoate (6 ± 0.3 mol%). The biopolymer had an average molecular weight of 1.1 × 105  Da, with a polydispersity index of 1...
September 13, 2018: International Journal of Biological Macromolecules
Peipei Wang, Dapeng Wei, Hongmei Zhang, Jiao Chen, Dingding Zhang, Suthakar Ganapathy, Pauline Isakson, Changyan Chen, Tongbo Zhu
Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant disease with 5-year survival rate of less than 6%. Activating mutations of Kras ( mu-Kras ) are often detected in most of PDAC patients. Although it has been known that oncogenic Kras is the driver of pancreatic cancer initiation and development, the underlying mechanisms by which mu-Kras promotes PDAC remain poorly understood. Here, we identify that PKCι is one of the crucial factors for supporting the survival of pancreatic cancer cells expressing mu-Kras ...
August 28, 2018: Oncotarget
Natasha Catherine Edwin, Brad Kahl
Mantle cell lymphoma is an incurable, moderately aggressive B cell lymphoma. While a small proportion of patients with indolent disease can be managed expectantly, most patients require treatment. The therapeutic approach is driven by physician recommendation, patient choice, age, fitness and comorbidities. Young, fit patients often receive combination chemoimmunotherapy, including high dose cytarabine, with autologous stem cell transplant. Recent data has indicated benefit from maintenance rituximab following autologous stem cell transplant...
September 2018: Best Practice & Research. Clinical Haematology
Mohammad Javed Ali, Ashapogu Venugopal, Kavyashree Sakharayapatna Ranganath, Medicharla V Jagannadham, Siva Kumar Nadimpalli
PURPOSE: Glycoproteins play an important role in human mucosal defenses and immunity-related cell-to-cell interactions. The aim of the present study is to investigate the presence and patterns of lacrimal sac glycoproteins involved in defense mechanisms with a special reference to prolactin-inducible protein (PIP). METHODS: The study was performed on healthy lacrimal sacs obtained from exenteration samples immediately after surgery and frozen at -80 degrees for subsequent analysis...
September 13, 2018: Orbit
Ye Li, Xinxin Wang, Jiali Ren, Xiaoshan Wu, Guoqing Li, Zhipeng Fan, Chunmei Zhang, Ang Li, Songlin Wang
Signal transduction between different organs is crucial in the normal development of the human body. As an important medium for signal communication, exosomes can transfer important information, such as microRNAs (miRNAs), from donors to receptors. MiRNAs are known to fine-tune a variety of biological processes, including maxillofacial development; however, the underlying mechanism remains largely unknown. In the present study, transient apoptosis was found to be due to the expression of a miniature swine maxillofacial-specific miRNA, ssc-mir-133b...
2018: Bone Research
Qing Zhao, Xiaofeng Zhang, Haifeng Cai, Pei Zhang, Dong Kong, Xiaosong Ge, Min Du, Rong Liang, Wenxia Dong
Triple negative breast cancer (TNBC) accounts for about 10-15% of all breast cancers. It is a heterogeneous disease, characterized by early relapse, aggressive behavior, and poor prognosis, when compared to other breast cancer subtypes. Interestingly, most of the heat shock protein 90 (Hsp90) client proteins are oncoproteins, and some are closely related to the key factors that promote the progression of TNBC. Anacardic acid (AA), which is commonly seen in natural plants of Anacardiaceae, exhibits potent Hsp90 ATPase inhibition activity...
2018: American Journal of Translational Research
Fu-Dong Shi, Daniel Edward Hess, Jin-Zeng Zuo, Shi-Jie Liu, Xue-Chen Wang, Yong Zhang, Xiao-Guang Meng, Ze-Jun Cui, Shao-Ping Zhao, Chang-Jiang Li, Wan-Ning Hu
The ipsilateral peroneus longus tendon (PLT) was utilized as an autograft for anterior cruciate ligament (ACL) reconstruction of patients with acute ACL rupture and grade III medial collateral ligament (MCL) injury. We investigated the efficacy and safety of this alternative autograft compared with autologous hamstring tendon (HT). Biomechanical testing of the graft options was performed and compared with the native ACL. Thirty-eight patients with acute ACL ruptures and grade III MCL injuries were treated with ACL reconstruction with a doubled autologous PLT or quadrupled autologous HT...
September 11, 2018: Journal of Knee Surgery
Aloran Mazumder, Jin-Young Lee, Oualid Talhi, Claudia Cerella, Sébastien Chateauvieux, Anthoula Gaigneaux, Che Ry Hong, Hyoung Jin Kang, Youngjo Lee, Kyu-Won Kim, Dong-Wook Kim, Hee-Young Shin, Mario Dicato, Khaldoun Bachari, Artur M S Silva, Barbora Orlikova-Boyer, Marc Diederich
We synthetized and investigated here the anti-leukemic potential of the novel cytostatic bis(4-hydroxycoumarin) derivative OT-55 which complied with the Lipinski's rule of 5 and induced differential toxicity in various chronic myeloid leukemia (CML) cell models. OT-55 triggered ER stress leading to canonical, caspase-dependent apoptosis and release of danger associated molecular patterns. Consequently, OT-55 promoted phagocytosis of OT-55-treated CML cells by both murine and human monocyte-derived macrophages...
September 8, 2018: Cancer Letters
Jatin R Verma, Danielle S G Harte, Ume-Kulsoom Shah, Huw Summers, Catherine A Thornton, Shareen H Doak, Gareth J S Jenkins, Paul Rees, John W Wills, George E Johnson
Use of imaging flow cytometry to assess induced DNA damage via the cytokinesis block micronucleus (CBMN) assay has thus far been limited to radiation dosimetry in human lymphocytes using high end, 'ImageStream X' series imaging cytometers. Its potential to enumerate chemically induced DNA damage using in vitro cell lines remains unexplored. In the present manuscript, we investigate the more affordable FlowSight® imaging cytometry platform to assess in vitro micronucleus (MN) induction in the human lymphoblastoid TK6 and metabolically competent MCL-5 cells treated with Methyl Methane Sulfonate (MMS) (0-5 µg/ml), Carbendazim (0-1...
September 11, 2018: Mutagenesis
Emanuele Cencini, Anna Sicuranza, Alberto Fabbri, Ilaria Ferrigno, Luigi Rigacci, Maria C Cox, Donatella Raspadori, Monica Bocchia
Bendamustine is used in combination with rituximab (BR) to treat indolent non-Hodgkin lymphomas (iNHL) and mantle cell lymphoma (MCL). The variability in treatment efficacy and toxicity could be related to single nucleotide polymorphisms (SNPs) in immune response genes. We would like to show a correlation between SNPs and treatment outcome in iNHL and MCL patients receiving BR. We investigated some SNPs that had already been associated with NHL outcome. Samples were genotyped for the IL2 (rs2069762), IL10 (rs1800890, rs10494879), VEGFA (rs3025039), IL8 (rs4073), CFH (rs1065489) and MTHFR (rs1801131) SNPs by allelic discrimination assays...
September 11, 2018: British Journal of Haematology
Debashri Manna, Rajabrata Bhuyan, Forid Saikh, Somnath Ghosh, Jayasri Basak, Rita Ghosh
1,4-Dihydropyridines (1,4-DHPs) are important as a class of heterocyclic compounds that exhibit wide range of biological actions. Many of its derivatives are already characterized as medicinally important drugs and used worldwide. In this study, we have screened some novel Hantzsch 1,4-DHP compounds using both in silico (QSAR and Pharmacophore) and in vitro (cytotoxic screening). 1,4-DHP showed selective cytotoxicity against five human cancerous cell lines; A375, A549, HeLa, HepG2 and SH-SY5Y but limited effect towards normal skin keratinocyte (HaCaT), lung fibroblast (WL-38) and healthy peripheral blood mononuclear cells...
September 10, 2018: Apoptosis: An International Journal on Programmed Cell Death
Yu-Cheng Chou, Meng-Ya Chang, Hsu-Tung Lee, Chiung-Chyi Shen, Tomor Harnod, Yea-Jiuan Liang, Rick Sai-Chuen Wu, Kuang-Chi Lai, Fei-Ting Hsu, Jing-Gung Chung
Phenethyl isothiocyanate (PEITC) from cruciferous vegetables can inhibit the growth of various human cancer cells. In previous studies, we determined that PEITC inhibited the in vitro growth of human glioblastoma GBM 8401 cells by inducing apoptosis, inhibiting migration and invasion, and altering gene expression. Nevertheless, there are no further in vivo reports disclosing whether PEITC can suppress the growth of glioblastoma. Therefore, in this study we investigate the anti-tumor effects of PEITC in a xenograft model of glioblastoma in nude mice...
September 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Abid R Mattoo, Alex Joun, J Milburn Jessup
MCL-1, a member of the anti-apoptotic BCL2 family, is a pro-survival protein with an essential DNA repair function. This study aims to test whether inhibition of protein synthesis by mTOR complex (mTORC) inhibitors depletes MCL-1, suppresses Homologous Recombination (HR) repair and sensitizes cancer cells to PARP inhibitors. Treatment with Everolimus decreases MCL-1 in colorectal carcinomas (CRC) and small cell lung cancer (SCLC) cells but not glioblastoma multiforme (GBM) cells with a PTEN mutational background...
September 10, 2018: Molecular Cancer Research: MCR
Lee B Sims, Hunter A Miller, Michael E Halwes, Jill M Steinbach-Rankins, Hermann B Frieboes
The secreted mucus layer in the vaginal epithelium presents a formidable barrier to the transport of active agents for the prevention and treatment of female reproductive tract (FRT) infections. Nanoparticle-mediated drug delivery has been proposed to help facilitate the transport and release of active agents through the cervicovaginal mucus (CVM) and underlying mucosa. However, both nanoparticles (NPs) and free active agents face a variety of challenges, often requiring the administration of high localized doses to circumvent leakage and poor penetration to targeted intravaginal tissue compartments...
September 6, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Atanu Maity, Sarmistha Majumdar, Shubhra Ghosh Dastidar
The proteins of Bcl-2 family, which are promising anti-cancer-drug targets, have substantial similarity in primary sequence and share homologous domains as well as similar structural folds. In spite of similarities in sequence and structures, the members of its pro- and anti- apoptotic subgroups form complexes with different type of partners with discriminating binding affinities. Understanding the origin of this discrimination is very important for designing ligands that can either selectively target a protein or could be made broad ranged as necessary...
August 23, 2018: Computational Biology and Chemistry
Benjawan Wudtiwai, Pornsiri Pitchakarn, Ratana Banjerdpongchai
Anoikis-resistance is a critical step in cancer progression, especially during the process of metastasis. During this phase, the cancer phenotype that causes cell survival in detachment conditions, drug resistance, and epithelial-to-mesenchymal transition (EMT) is altered. Inhibition of anoikis-resistance can potentially be the molecular target in cancer therapy. Alpha-mangostin, an active compound in Garcinia mangostana, has been reported for its cell-death induction and its chemosensitizing and anti-metastatic properties in many cancer cell types, such as ovarian cancer, lung cancer, and hepatocellular carcinoma...
September 6, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Muhammed H Rahaman, Yingyi Yu, Longjin Zhong, Julian Adams, Frankie Lam, Peng Li, Ben Noll, Robert Milne, Jun Peng, Shudong Wang
Acute myeloid leukemia (AML) is the most common form of acute leukemia with dismal long-term prognosis with age. The most aggressive subtype of AML is MLL-AML that is characterized by translocations of the mixed-lineage leukemia gene (MLL) and resistance to conventional chemotherapy. Cyclin dependent kinase 9 (CDK9) plays a crucial role in the MLL-driven oncogenic transcription, and hence, inhibiting activity of CDK9 has been proposed as a promising strategy for treatment of AML. We investigated the therapeutic potential of CDKI-73, one of the most potent CDK9 inhibitors, against a panel of AML cell lines and samples derived from 97 patients...
September 8, 2018: Investigational New Drugs
Aleš Obr, Vit Prochazka, Tomas Papajik, Pavel Klener, Andrea Janikova, David Salek, David Belada, Robert Pytlík, Alice Sykorova, Heidi Mocikova, Martin Simkovic, Vit Campr, Jitka Dlouha, Tomas Furst, Marek Trněný
We analyzed 495 MCL patients from the Czech Lymphoma Study Group data registry. With the median follow-up of 4.4 years, 51.7% patients progressed or relapsed and 34.1% died. Five-year overall survival reached 65.3% and five-year progression free survival 44.1% of the patients. Maintenance rituximab (MR) after first line therapy improved overall and progression free survival compared to the patients under observation only (both p < .001). Elevated beta-2-microglobulin (p = .003), presence of systemic symptoms (p = ...
September 6, 2018: Leukemia & Lymphoma
Ning Li, Qingyu Zhang, Zhenbin Jia, Xiaohong Yang, Haitao Zhang, Hui Luo
The anti-lung cancer activity of volatile oil from Alpinia officinarum (VOAO) and the underlying mechanism has not been studied. Herein, VOAO was extracted by steam distillation and its components were identified by GC-MS analysis. Cells viability was measured by an MTT assay and the cell survival capacity was tested via a colony formation assay. Apoptosis cells were detected using the Annexin V-FITC/PI method. Hoechst 33342 cell unclear staining was employed to evaluate the nuclear morphology change. The mitochondrial membrane potential was detected by a JC-1 staining assay...
September 6, 2018: Food & Function
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