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Rheumatoid arthritis biomarkers

Rajalingham Sakthiswary, Shamala Rajalingam, Heselynn Hussein, Radhika Sridharan, Abdul Wahab Asrul
The aim of the study is to investigate the correlation of serum cartilage oligomeric matrix protein (COMP) levels with articular cartilage damage based on sonographic knee cartilage thickness (KCT) and disease activity in rheumatoid arthritis (RA). A total of 61 RA patients and 27 healthy controls were recruited in this study. Serum samples were obtained from all subjects to determine the serum COMP levels. All subjects had bilateral ultrasound scan of their knees. The KCT was based on the mean of measurements at three sites: the medial condyle, lateral condyle and intercondylar notch...
September 9, 2017: Clinical Rheumatology
Marina Lipina, Maxim Makarov, Sergey Makarov, Alexander Novikov
PURPOSE: In order to test the validity of the selected surgical technique as a way to manage persistent synovitis of the knee joint, as well as to slow down the cartilage and bone destruction, we studied the dynamics of biomarkers of inflammatory conditions, and bone and cartilage destruction after total arthroscopic synovectomy (TAS) of the knee joint. METHODS: The sampling comprised 124 RA patients (158 knees) who had undergone the TAS procedure between 2003 and 2015...
September 9, 2017: International Orthopaedics
Jiaqi Ren, Lin Sun, Jinxia Zhao
The antibody against peptidylarginine deiminase (PAD) 4 is a biomarker that might be helpful in the diagnosis of rheumatoid arthritis (RA). We aim to estimate the diagnostic value of anti-PAD4 antibody for RA by meta-analysis. We searched PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for studies published in any languages in March 1, 2017 that evaluated the diagnostic accuracy of the anti-PAD4 antibody for the diagnosis of RA. The articles that detected the anti-PAD4 antibody by enzyme-linked immunosorbent assay (ELISA) and used healthy donors or patients without arthritis or arthralgia as controls were included for meta-analysis...
September 8, 2017: Clinical Rheumatology
Robin M Ten Brinck, Hanna W van Steenbergen, Lukas Mangnus, Leonie E Burgers, Monique Reijnierse, Tom Wj Huizinga, Annette Hm van der Helm-van Mil
INTRODUCTION: A phase of arthralgia may precede the emergence of rheumatoid arthritis (RA). Although several studies have focused on biomarkers, the relevance of this phase for patients is less studied. It is unknown if patients already have functional limitations and if this is correlated to the extent of subclinical inflammation. Therefore, we assessed functional disability in patients with clinically suspect arthralgia (CSA), its association with MRI-detected subclinical inflammation and its course during progression to clinical arthritis...
2017: RMD Open
Jorge I Gamez-Nava, David Bonilla-Lara, Juan M Ponce-Guarneros, J Alejandro Zuñiga-Mora, Edsaul E Perez-Guerrero, Jessica D Murillo-Vazquez, Itzel N Becerra-Alvarado, N Alejandra Rodriguez-Jimenez, A Miriam Saldaña-Cruz, M Luisa Vazquez-Villegas, Erika Y Vera-Navarrete, Fabiola Gonzalez-Ponce, Laura Gonzalez-Lopez
The objective of this study was to investigate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting short-term therapeutic response to methotrexate (MTX) in rheumatoid arthritis (RA). Patients with active RA, with Disease Activity Score-28 joints (DAS-28) >3.2, starting oral MTX, were included. We measured at baseline, 3 and 6 mo: DAS-28, Health Assessment Questionnaire-Disability Index (HAQ-DI), patient's perception of disease severity, morning stiffness and pain, as well as modifications in sTREM-1 levels...
January 1, 2017: Innate Immunity
Chen-Chung Liao, Yu-Sheng Chang, Chao-Wen Cheng, Wei-Ming Chi, Kai-Leun Tsai, Wei-Jung Chen, Ting-Shuan Kung, Chih-Chun Tai, Yi-Fang Lin, Hung-Tse Lin, Yi-Ying Lu, Ching-Yu Lin
This study identified and validated four differentially expressed novel malondialdehyde (MDA)-modified peptide adducts and evaluated autoantibodies against native and MDA-modified peptides among Taiwanese women patients with rheumatoid arthritis (RA), osteoarthritis (OA) and healthy controls (HCs). Ig kappa chain C region(76-99), alpha-1-antitrypsin(284-298), alpha-2-macroglobulin(824-841), and apolipoprotein B-100(4022-4040) exhibiting 2-fold differences in relative modification ratios were identified by concanavalin A (Con A) affinity chromatography, 1D SDS-PAGE, in-gel digestion, nano-LC/MS/MS and nano-LC/MS using pooled serum-derived Con A-captured proteins from 9 RA and 9 age-matched HCs...
September 1, 2017: Journal of Proteomics
Tuija Väänänen, Katriina Vuolteenaho, Hannu Kautiainen, Riina Nieminen, Timo Möttönen, Pekka Hannonen, Markku Korpela, Markku J Kauppi, Kari Laiho, Oili Kaipiainen-Seppänen, Riitta Luosujärvi, Tea Uusitalo, Toini Uutela, Marjatta Leirisalo-Repo, Eeva Moilanen
OBJECTIVE: YKL-40, a chitinase-like glycoprotein associated with inflammation and tissue remodeling, is produced by joint tissues and recognized as a candidate auto-antigen in rheumatoid arthritis (RA). In the present study, we investigated YKL-40 as a potential biomarker of disease activity in patients with early RA at baseline and during intensive treatment aiming for early remission. METHODS: Ninety-nine patients with early DMARD-naïve RA participated in the NEO-RACo study...
2017: PloS One
Nisha Nair, Anthony G Wilson, Anne Barton
Rheumatoid arthritis (RA) is a complex disease affecting approximately 0.5-1% of the population. While there are effective biologic therapies, in up to 40% of patients, disease activity remains inadequately controlled. Therefore, identifying factors that predict, prior to the initiation of therapy, which patients are likely to respond best to which treatment is a research priority and DNA methylation is increasingly being explored as a potential theranostic biomarker. DNA methylation is thought to play a role in RA disease pathogenesis and in mediating the relationship between genetic variants and patient outcomes...
September 2017: Pharmacogenomics
Gianfranco Ferraccioli, Elisa Gremese
The analysis of BAFF receptors before and after B cell depletion therapy (BCDT) might offer a clue to understand whether some B cell subsets, may represent useful biomarkers of biological and clinical response. Among the BAFF receptors, the AA have shown in a cohort of rheumatoid arthritis (RA) patients, by FACS analysis of the MFI (median fluorescence intensity) that TACI, and BCMA, do not change whereas BR3, the most important, appears to be decreased either before as well as after BCDT, in all B cells subsets but not in Plasmablasts, the subset more important and depleted by BCDT ...
August 23, 2017: Clinical and Experimental Immunology
Won-Seok Lee, Ji-Hyeon Jeong, Eun-Gyeong Lee, Yun Jung-Choi, Jin-Hee Kim, Hang-Rae Kim, Wan-Hee Yoo
Tacrolimus is an immunosuppressive drug that inhibits the release of inflammatory cytokines involved in rheumatoid arthritis development by blocking T cell activation. "Endoplasmic reticulum stress," an imbalance between protein folding load and capacity leading to the accumulation of unfolded proteins in the endoplasmic reticulum lumen, has been implicated in rheumatoid arthritis and other inflammatory and metabolic diseases. We aimed to investigate the effect of tacrolimus on endoplasmic reticulum stress-mediated osteoclastogenesis and inflammation and elucidate the underlying mechanisms...
August 22, 2017: Cell Biology International
Jana Hurnakova, Hana Hulejova, Jakub Zavada, Petra Hanova, Martin Komarc, Herman Mann, Martin Klein, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Jiri Vencovsky, Karel Pavelka, Ladislav Senolt
BACKGROUND: Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity. OBJECTIVES: In the current study, we investigated whether calprotectin is a better biomarker than CRP for predicting clinical activity and ultrasound parameters in patients with RA. METHODS: A total of 160 patients with RA underwent clinical (swollen joint count-SJC, tender joint count-TJC, Disease Activity Score-DAS28, Clinical Disease Activity Index-CDAI, and simplified Disease Activity Index-SDAI) and ultrasound (German US7) examination...
2017: PloS One
Heng Li, Huimin Lu, Wei Tang, Jianping Zuo
Methionine cycle plays an essential role in regulating many cellular events, especially transmethylation reactions, incorporating the methyl donor S-adenosylmethionine (SAM). The transmethylations and substances involved in the cycle have shown complicated effects and mechanisms on immunocytes developments and activations, and exert crucial impacts on the pathological processes in immune disorders. Areas covered: Methionine cycle has been considered as an effective means of drug developments. This review discussed the role of methionine cycle in immune responses and summarized the potential therapeutic strategies based on the cycle, including SAM analogs, methyltransferase inhibitors, S-adenosylhomocysteine hydrolase (SAHH) inhibitors, adenosine receptors specific agonists or antagonists and homocysteine (Hcy)-lowering reagents, in treating human immunodeficiency virus (HIV) infections, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), systemic sclerosis (SSc) and other immune disorders...
August 22, 2017: Expert Opinion on Therapeutic Targets
Tetsuro Sugiura, Mikio Kamioka, Shigeo Yamanaka, Taisuke Hisahara, Yoko Hirakawa, Yoshihisa Matsumura
Activity of rheumatoid arthritis (RA) has been evaluated by various biomarkers including matrix metalloproteinase (MMP)-3, but the relationship between the levels of biomarkers and elevation of pulmonary artery systolic pressure (PAs) has not been evaluated in detail. We sought to determine the utility of MMP-3 with other biomarkers for the prediction of PAs in patients with RA. Blood samples for biomarkers and echocardiography were obtained in 100 consecutive patients with RA. PAs was measured by continuous-wave Doppler echocardiography and was correlated with laboratory findings...
August 21, 2017: Heart and Vessels
Stefania L Magda, Raluca I Mincu, Maria Florescu, Andrea O Ciobanu, Gabriela F Udrea, Mircea Cinteza, Dragos Vinereanu
BACKGROUND AND PURPOSE: Rheumatoid arthritis (RA) causes frequently cardiovascular complications, probably determined by early atherosclerosis in connection to chronic systemic inflammation. Purpose of our study was to assess subclinical cardiac and vascular dysfunction, and to evaluate the mechanisms of ventriculo-arterial interaction, in patients with correctly treated RA vs. normal subjects. METHODS: We evaluated 46 subjects (55±10 years, 2 men): 29 patients with seropositive treated RA (mean duration of 11±9 years), without documented cardiovascular or pulmonary disease, and 17 control subjects, matched for age, sex, and distribution of conventional major risk factors...
December 2016: Mædica
Fabiola Atzeni, Rossella Talotta, Ignazio F Masala, Sara Bongiovanni, Laura Boccassini, Piercarlo Sarzi-Puttini
Biomarkers are important for guiding the clinical and therapeutic management of all phases of rheumatoid arthritis because they can help to predict disease development in subjects at risk, improve diagnosis by closing the serological gap, provide prognostic information that is useful for making therapeutic choices and assessing treatment responses and outcomes, and allow disease activity and progression to be monitored. Various biomarkers can be used to identify subjects susceptible to the disease and those with pre-clinical rheumatoid arthritis before the onset of symptoms such as rheumatoid factor and anti-citrullinated protein antibodies...
August 2017: Israel Medical Association Journal: IMAJ
Francesco Ursini, Emilio Russo, Daniele Mauro, Ludovico Abenavoli, Giorgio Ammerata, Alfonso Serrao, Rosa Daniela Grembiale, Giovambattista De Sarro, Ignazio Olivieri, Salvatore D'Angelo
BACKGROUND: Recent evidence suggested a potential role of complement fraction C3 as a biomarker of non-alcoholic fatty liver disease (NAFLD) in the general population. Aim of the present study was to evaluate the performance of C3 for prediction of NAFLD in RA patients. MATERIALS AND METHODS: For the present study, consecutive RA patients were recruited. NAFLD was diagnosed according to predefined ultrasonographic (US) criteria. For comparison, the hepatic steatosis index (HSI) was calculated...
August 10, 2017: European Journal of Clinical Investigation
Susanna L Lundström, Aase H Hensvold, Dorothea Rutishauser, Lars Klareskog, A Jimmy Ytterberg, Roman A Zubarev, Anca I Catrina
BACKGROUND: Methotrexate (MTX) is the standard first-line therapy in rheumatoid arthritis (RA) with variable clinical efficacy that is difficult to predict. The glycosylation status of immunoglobulin G (IgG) is altered in RA and influenced by MTX treatment. We aimed to further investigate if IgG glycosylation in untreated early RA can predict therapeutic response to MTX. METHODS: We used a shotgun proteomic approach to screen for the Fc glycopeptides in the serum of 12 control subjects and 59 untreated patients with early RA prior to and following MTX initiation...
August 9, 2017: Arthritis Research & Therapy
Jani Luukkonen, Laia Mira Pascual, Christina Patlaka, Pernilla Lång, Sanna Turunen, Jussi Halleen, Tomi Nousiainen, Maarit Valkealahti, Juha Tuukkanen, Göran Andersson, Petri Lehenkari
BACKGROUND: Osteopontin (OPN) is an immunoregulatory protein which production increases in both rheumatoid arthritis (RA) and osteoarthritis (OA). Phosphorylated osteopontin (Phospho-OPN) is known to increase macrophage and osteoclast activation, this process is controlled by extracellular tartrate-resistant acid phosphatase (TRAcP), also a biomarker for RA. Here, we evaluated the phosphorylation status of OPN in RA and OA synovia, as well as its correlation with TRAcP isoforms. METHODS: Synovial tissue and fluid were obtained from 24 RA (14 seropositive and 10 seronegative) and 24 OA patients...
2017: PloS One
Sandro Donato, Serena Pacilè, Federico Colombo, Chiara Garrovo, Simeone Dal Monego, Paolo Macor, Giuliana Tromba, Stefania Biffi
It is increasingly recognized that early detection of bone erosion plays an important role in the overall evaluation of rheumatoid arthritis and in the choice of the correct treatment approach. Since an appropriate use of imaging biomarkers in preclinical settings offers the prospect of smaller and optimized sample size, in the present study we define an anatomical imaging biomarker that could be objectively measured from micro-CT imaging data as an indicator of bone erosion in arthritis process. The well-characterized antigen-induced arthritis (AIA) model in rats was used...
August 8, 2017: Scientific Reports
R S Abdul-Maksoud, A M Sediq, Aaa Kattaia, Wsh Elsayed, N Ezzeldin, S M Abdel Galil, R A Ibrahem
BACKGROUND: MicroRNAs play a crucial role in the regulation of immune response. We hypothesised roles for serum miR-210 and miR-155 in the diagnosis of rheumatoid arthritis (RA) and relationships with the clinical and laboratory variables including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibodies, tumour necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β). METHODS: MiR-210 and miR-155 levels were identified by real-time polymerase chain reaction (PCR)...
August 7, 2017: British Journal of Biomedical Science
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