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Rheumatoid arthritis biomarkers

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https://www.readbyqxmd.com/read/28549731/clinical-and-sonographic-biomarkers-of-structural-damage-progression-in-ra-patients-in-clinical-remission-a-prospective-study-with-12-months-follow-up
#1
Julio Ramírez, José Antonio Narváez, Virginia Ruiz-Esquide, Javier Hernández-Gañán, Andrea Cuervo, José Inciarte-Mundo, Maria Victoria Hernández, Miguel Sampayo-Cordero, José Luis Pablos, Raimon Sanmartí, Juan D Cañete
OBJECTIVE: To determine clinical and sonographic biomarkers predicting structural damage progression at 12 months of follow-up as measured by magnetic resonance imaging (MRI) in rheumatoid arthritis (RA) patients in clinical remission. PATIENTS AND METHODS: We included patients with RA in clinical remission, defined as 28-joint disease activity score (DAS28)-erythrocyte sedimentation rate (ESR) <2.6 for >6 months. Ultrasound scans of both hands and knees and MRI of the dominant hand were performed at baseline and at 12 months...
May 1, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28545509/ultrasound-detected-bone-erosion-is-a-relapse-risk-factor-after-discontinuation-of-biologic-disease-modifying-antirheumatic-drugs-in-patients-with-rheumatoid-arthritis-whose-ultrasound-power-doppler-synovitis-activity-and-clinical-disease-activity-are-well
#2
Shin-Ya Kawashiri, Keita Fujikawa, Ayako Nishino, Akitomo Okada, Toshiyuki Aramaki, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Akinari Mizokami, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Kiyoshi Aoyagi, Takahiro Maeda, Atsushi Kawakami
BACKGROUND: In the present study, we explored the risk factors for relapse after discontinuation of biologic disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) whose ultrasound power Doppler (PD) synovitis activity and clinical disease activity were well controlled. METHODS: In this observational study in clinical practice, the inclusion criteria were based on ultrasound disease activity and clinical disease activity, set as low or remission (Disease Activity Score in 28 joints based on erythrocyte sedimentation rate <3...
May 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28545499/pre-silencing-of-genes-involved-in-the-electron-transport-chain-etc-pathway-is-associated-with-responsiveness-to-abatacept-in-rheumatoid-arthritis
#3
C Derambure, G Dzangue-Tchoupou, C Berard, N Vergne, M Hiron, M A D'Agostino, P Musette, O Vittecoq, T Lequerré
BACKGROUND: In the current context of personalized medicine, one of the major challenges in the management of rheumatoid arthritis (RA) is to identify biomarkers that predict drug responsiveness. From the European APPRAISE trial, our main objective was to identify a gene expression profile associated with responsiveness to abatacept (ABA) + methotrexate (MTX) and to understand the involvement of this signature in the pathophysiology of RA. METHODS: Whole human genome microarrays (4 × 44 K) were performed from a first subset of 36 patients with RA...
May 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28526580/biomarkers-for-rheumatoid-arthritis-from-molecular-processes-to-diagnostic-applications-current-concepts-and-future-perspectives
#4
REVIEW
Britt Nakken, Gábor Papp, Vidar Bosnes, Margit Zeher, György Nagy, Peter Szodoray
Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory processes, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) or immune processes including autoantibodies, such as rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPA)...
May 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28516086/can-synovial-pathobiology-integrate-with-current-clinical-and-imaging-prediction-models-to-achieve-personalized-health-care-in-rheumatoid-arthritis
#5
REVIEW
Frances Claire Humby, Farida Al Balushi, Gloria Lliso, Alberto Cauli, Costantino Pitzalis
Although great progress has been made in the past decade toward understanding the pathogenesis of rheumatoid arthritis (RA), clinicians remain some distance from a goal of personalized health care. The capacity to diagnose RA early, predict prognosis, and moreover predict response to biologic therapies has been a research focus for many years. How currently available clinical prediction models can facilitate such goals is reviewed in this article. In addition, the role of current imaging techniques in this regard is also discussed...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28507178/anti-carbamylated-protein-antibodies-are-detectable-in-various-connective-tissue-diseases
#6
Shuichiro Nakabo, Hajime Yoshifuji, Motomu Hashimoto, Yoshitaka Imura, Ran Nakashima, Kosaku Murakami, Nobuo Kuramoto, Shinji Ito, Junko Satoh, Masao Tanaka, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura
OBJECTIVE: Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA. METHODS: The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA...
May 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28502137/angiopoietin-2-as-a-biomarker-for-echocardiographic-abnormalities-and-carotid-atherosclerosis-in-rheumatoid-arthritis-patients
#7
Hanan Omar, Ahmed Tageldien Abdellah, Housseini Abdalla, Samah Ismail Nasef, Hamdy Omar
Atherosclerosis and cardiovascular diseases (CVD) are increasingly recognised complications of rheumatoid arthritis (RA). Angiopoietin 2 (Ang-2) levels have been associated with clinically overt CVD in general population; we assessed serum Ang-2 levels and its correlation with Echocardiographic abnormalities and carotid intima-media thickness in RA patients. 44 RA patients without clinically overt CVD and 44 healthy controls were assessed by questionnaire and clinical examination. Disease activity score (DAS-28) was calculated...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28495399/evaluation-of-toll-like-receptor-gene-family-variants-as-prognostic-biomarkers-in-rheumatoid-arthritis
#8
Silvia Torices, Lorena Alvarez-Rodríguez, Ignacio Varela, Pedro Muñoz, Alejandro Balsa, M López-Hoyos, Víctor Martinez-Taboada, Jose L Fernández-Luna
Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main feature is persistent joint inflammation. Toll-like receptors (TLRs) play critical roles in the activation of innate and adaptive immune responses, and influence the activity of NFκB, a key player in chronic inflammation. We aimed at investigating the association of TLR allelic variants with susceptibility and severity of RA through a systematic, high-throughput, analysis of TLR genes. All coding exons and flanking regions of nine members of the TLR family (TLR1-9) were analyzed in 66 patients with RA and 30 healthy controls by next generation sequencing...
May 7, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28494794/juvenile-idiopathic-arthritis-in-relation-to-perinatal-and-maternal-characteristics-a-case-control-study
#9
Samantha W Bell, Susan Shenoi, J Lee Nelson, Parveen Bhatti, Beth A Mueller
BACKGROUND: Existing data on associations between maternal and early childhood exposures and juvenile idiopathic arthritis (JIA) risk is scant and inconsistent with previous studies showing potential role for prematurity, number of siblings and infections. We explored JIA and International League of Associations for Rheumatology (ILAR) JIA categories in relation to selected infant (birthweight, size-for-gestational-age, gestational age), and maternal (parity, delivery type, prior fetal loss) characteristics that may be markers for exposures related to two pathways (hygiene hypothesis, microchimerism) potentially associated with autoimmune disorder occurrence...
May 11, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28494030/antibody-nanoparticle-conjugates-to-enhance-the-sensitivity-of-elisa-based-detection-methods
#10
Margaret M Billingsley, Rachel S Riley, Emily S Day
Accurate antigen detection is imperative for clinicians to diagnose disease, assess treatment success, and predict patient prognosis. The most common technique used for the detection of disease-associated biomarkers is the enzyme linked immunosorbent assay (ELISA). In an ELISA, primary antibodies are incubated with biological samples containing the biomarker of interest. Then, detectible secondary antibodies conjugated with horseradish peroxidase (HRP) bind the primary antibodies. Upon addition of a color-changing substrate, the samples provide a colorimetric signal that directly correlates to the targeted biomarker concentration...
2017: PloS One
https://www.readbyqxmd.com/read/28490909/determining-early-referral-criteria-for-patients-with-suspected-inflammatory-arthritis-presenting-to-primary-care-physicians-a-cross-sectional-study
#11
Hani Almoallim, Nahid Janoudi, Suzan M Attar, Mohammed Garout, Shereen Algohary, Muhammad Irfanullah Siddiqui, Hanan Alosaimi, Ashraf Ibrahim, Amira Badokhon, Zaki Algasemi
OBJECTIVE: Early diagnosis and initiation of treatment for inflammatory arthritis can greatly improve patient outcome. We aimed to provide standardized and validated criteria for use by primary care physicians (PCPs) in the identification of individuals requiring referral to a rheumatologist. PATIENTS AND METHODS: We analyzed the predictive value of a wide variety of demographic variables, patient-reported complaints, physical examination results, and biomarkers in order to identify the most useful factors for indicating a requirement for referral...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28490445/serological-epithelial-component-proteins-identify-intestinal-complications-in-crohn-s-disease
#12
Yunki Y Yau, Rupert Wl Leong, Aviv Pudipeddi, Diane Redmond, Valerie C Wasinger
Crohns Disease (CD) is a relapsing inflammation of the gastrointestinal tract that affects a young working age population and is increasing in developing countries. Half of all sufferers will experience stricturing or fistulizing intestinal complications that require extensive surgical interventions and neither genes nor clinical risk factors can predict this debilitating natural history. We applied discovery and verification phase studies as part of an NCI-FDA modelled biomarker pipeline to identify differences in the low-mass (<25kDa) blood-serum proteome between CD behavioural phenotypes...
May 10, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28488248/response-to-treatment-with-tnf%C3%AE-inhibitors-in-rheumatoid-arthritis-is-associated-with-high-levels-of-gm-csf-and-gm-csf-t-lymphocytes
#13
Jonas Bystrom, Felix I Clanchy, Taher E Taher, Mohammed M Al-Bogami, Hawzheen A Muhammad, Saba Alzabin, Pamela Mangat, Ali S Jawad, Richard O Williams, Rizgar A Mageed
Biologic TNFα inhibitors are a mainstay treatment option for patients with rheumatoid arthritis (RA) refractory to other treatment options. However, many patients either do not respond or relapse after initially responding to these agents. This study was carried out to identify biomarkers that can distinguish responder from non-responder patients before the initiation of treatment. The level of cytokines in plasma and those produced by ex vivo T cells, B cells and monocytes in 97 RA patients treated with biologic TNFα inhibitors was measured before treatment and after 1 and 3 months of treatment by multiplex analyses...
May 9, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28473207/quantification-of-cartilage-oligomeric-matrix-protein-comp-and-a-comp-neoepitope-in-synovial-fluid-of-patients-with-different-joint-disorders-by-novel-automated-assays
#14
P Lorenzo, A Aspberg, T Saxne, P Önnerfjord
OBJECTIVE: To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial fluid and to investigate their diagnostic potential in different joint conditions. METHODS: Two sandwich immunoassays were developed for the quantification of COMP and a COMP neoepitope, using an automated analyser (IDS-iSYS, Immunodiagnostic Systems, Boldon, UK). Assay performance was evaluated in terms of sensitivity, recovery, linearity, and intra- and inter-assay precision...
May 2, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28470264/reconstruction-and-analysis-of-the-lncrna-mirna-mrna-network-based-on-competitive-endogenous-rna-reveal-functional-lncrnas-in-rheumatoid-arthritis
#15
Hui Jiang, Rong Ma, Shubiao Zou, Yongzhong Wang, Zhuqing Li, Weiping Li
Rheumatoid arthritis (RA) is an autoimmune disease with an unknown etiology, occurring in approximately 1.0% of general population. More and more studies have suggested that long non-coding RNAs (lncRNAs) could play important roles in various biological processes and be associated with the pathogenesis of different kinds of diseases including RA. Although a large number of lncRNAs have been found, our knowledge of their function and physiological/pathological significance is still in its infancy. In order to reveal functional lncRNAs and identify the key lncRNAs in RA, we reconstructed a global triple network based on the competitive endogenous RNA (ceRNA) theory using the data from National Center for Biotechnology Information Gene Expression Omnibus and our previous paper...
May 4, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28460767/predictors-of-endothelial-dysfunction-and-atherosclerosis-in-rheumatoid-arthritis-in-indian-population
#16
Inderjeet Verma, Ashit Syngle, Pawan Krishan
OBJECTIVE: Cardiovascular (CV) disease is leading cause of mortality in rheumatoid arthritis (RA). Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated with atherosclerosis and is therefore an early feature in atherogenesis. Biomarkers for rapid evolution of CV complications would be highly desirable for risk stratification. Finally, predictive biomarkers for cardiovascular risk would allow tailoring therapy to the individual. We assessed endothelial function and atherosclerosis utilizing carotid intima-media thickness (CIMT) in RA in context of clinical and laboratory markers in Indian RA population...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28460627/synovial-fluid-and-serum-concentrations-of-inflammatory-markers-in-rheumatoid-arthritis-psoriatic-arthritis-and-osteoarthitis-a-systematic-review
#17
Emma Altobelli, Paolo Matteo Angeletti, Domenico Piccolo, Rossella De Angelis
The aim of this review is to investigate systematically the presence of the most extensively studied synovial fluid (SF) and/or serum markers in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and osteoarthritis (OA) their associations and correlations with laboratory and clinical data, with a view to providing insights for future research. Papers were selected using the PRISMA flow-chart. Search of the electronic databases according to the above criteria found a total of 55 papers. Examination led to the exclusion of 39 papers...
April 27, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28426445/small-dense-ldl-an-update
#18
Philipp A Gerber, Dragana Nikolic, Manfredi Rizzo
PURPOSE OF REVIEW: In this review, we summarize the latest findings on small, dense LDL (sdLDL) atherogenic particles, including their associations with other biomarkers. RECENT FINDINGS: Increased sdLDL levels have been reported not only in different metabolic disorders such as diabetes, obesity and metabolic syndrome, but also in patients with rheumatoid and psoriatic arthritis as well as hypothyroidism. A wide range of lipid-lowering, as well as other drug classes, including novel antidiabetic agents and nutraceuticals, exert favourable effects on these atherogenic particles...
April 19, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28425787/defining-the-proteomic-landscape-of-rheumatoid-arthritis-progress-and-prospective-clinical-applications
#19
Lucía Lourido, Francisco J Blanco, Cristina Ruiz-Romero
The heterogeneity of Rheumatoid Arthritis (RA) and the absence of clinical tests accurate enough to identify the early stages of this disease have hampered its management. Therefore, proteomics research is increasingly focused on the discovery of novel biological markers, which would not only be able make an early diagnosis, but also to gain insight into the different pathological mechanisms underlying the heterogeneity of RA and also to stratify patients, which is critical to enabling effective treatments...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28422773/infections-in-rheumatoid-arthritis
#20
Fabiola Atzeni, Ignazio Francesco Masala, Manuela di Franco, Piercarlo Sarzi-Puttini
PURPOSE OF REVIEW: The purpose of this review is to provide an update concerning recent advances in the evidence- based study of serious infections in patients with rheumatoid arthritis (RA) treated with biological drugs or conventional disease-modifying antirheumatic drugs (DMARDs), concentrating on studies published in the last 18 months. RECENT FINDINGS: New studies have further strengthened existing evidence relating the use of biological drugs to serious infections...
April 18, 2017: Current Opinion in Rheumatology
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