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Rheumatoid arthritis biomarkers

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https://www.readbyqxmd.com/read/28796299/complement-c3-and-fatty-liver-disease-in-rheumatoid-arthritis-patients-a-cross-sectional-study
#1
Francesco Ursini, Emilio Russo, Daniele Mauro, Ludovico Abenavoli, Giorgio Ammerata, Alfonso Serrao, Rosa Daniela Grembiale, Giovambattista De Sarro, Ignazio Olivieri, Salvatore D'Angelo
BACKGROUND: Recent evidence suggested a potential role of complement fraction C3 as a biomarker of non-alcoholic fatty liver disease (NAFLD) in the general population. Aim of the present study was to evaluate the performance of C3 for prediction of NAFLD in RA patients. MATERIALS AND METHODS: For the present study, consecutive RA patients were recruited. NAFLD was diagnosed according to predefined ultrasonographic (US) criteria. For comparison, the hepatic steatosis index (HSI) was calculated...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28793911/igg-fc-galactosylation-predicts-response-to-methotrexate-in-early-rheumatoid-arthritis
#2
Susanna L Lundström, Aase H Hensvold, Dorothea Rutishauser, Lars Klareskog, A Jimmy Ytterberg, Roman A Zubarev, Anca I Catrina
BACKGROUND: Methotrexate (MTX) is the standard first-line therapy in rheumatoid arthritis (RA) with variable clinical efficacy that is difficult to predict. The glycosylation status of immunoglobulin G (IgG) is altered in RA and influenced by MTX treatment. We aimed to further investigate if IgG glycosylation in untreated early RA can predict therapeutic response to MTX. METHODS: We used a shotgun proteomic approach to screen for the Fc glycopeptides in the serum of 12 control subjects and 59 untreated patients with early RA prior to and following MTX initiation...
August 9, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28792533/increased-amount-of-phosphorylated-proinflammatory-osteopontin-in-rheumatoid-arthritis-synovia-is-associated-to-decreased-tartrate-resistant-acid-phosphatase-5b-5a-ratio
#3
Jani Luukkonen, Laia Mira Pascual, Christina Patlaka, Pernilla Lång, Sanna Turunen, Jussi Halleen, Tomi Nousiainen, Maarit Valkealahti, Juha Tuukkanen, Göran Andersson, Petri Lehenkari
BACKGROUND: Osteopontin (OPN) is an immunoregulatory protein which production increases in both rheumatoid arthritis (RA) and osteoarthritis (OA). Phosphorylated osteopontin (Phospho-OPN) is known to increase macrophage and osteoclast activation, this process is controlled by extracellular tartrate-resistant acid phosphatase (TRAcP), also a biomarker for RA. Here, we evaluated the phosphorylation status of OPN in RA and OA synovia, as well as its correlation with TRAcP isoforms. METHODS: Synovial tissue and fluid were obtained from 24 RA (14 seropositive and 10 seronegative) and 24 OA patients...
2017: PloS One
https://www.readbyqxmd.com/read/28790437/meniscal-ossicles-as-micro-ct-imaging-biomarker-in-a-rodent-model-of-antigen-induced-arthritis-a-synchrotron-based-x-ray-pilot-study
#4
Sandro Donato, Serena Pacilè, Federico Colombo, Chiara Garrovo, Simeone Dal Monego, Paolo Macor, Giuliana Tromba, Stefania Biffi
It is increasingly recognized that early detection of bone erosion plays an important role in the overall evaluation of rheumatoid arthritis and in the choice of the correct treatment approach. Since an appropriate use of imaging biomarkers in preclinical settings offers the prospect of smaller and optimized sample size, in the present study we define an anatomical imaging biomarker that could be objectively measured from micro-CT imaging data as an indicator of bone erosion in arthritis process. The well-characterized antigen-induced arthritis (AIA) model in rats was used...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782994/serum-mir-210-and-mir-155-expression-levels-as-novel-biomarkers-for-rheumatoid-arthritis-diagnosis
#5
R S Abdul-Maksoud, A M Sediq, Aaa Kattaia, Wsh Elsayed, N Ezzeldin, S M Abdel Galil, R A Ibrahem
BACKGROUND: MicroRNAs play a crucial role in the regulation of immune response. We hypothesised roles for serum miR-210 and miR-155 in the diagnosis of rheumatoid arthritis (RA) and relationships with the clinical and laboratory variables including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibodies, tumour necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β). METHODS: MiR-210 and miR-155 levels were identified by real-time polymerase chain reaction (PCR)...
August 7, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28763759/metabolomics-analysis-of-danggui-sini-decoction-on-treatment-of-collagen-induced-arthritis-in-rats
#6
Bang Cheng, Hua Zheng, Fang Wu, Jinxia Wu, Xuwen Liu, Chaoling Tang, Shiyin Lu, Zhaoni Chen, Fangming Song, Junxiang Ruan, Hongye Zhang, Hui Song, Wei Liu, Hongwei Guo, Yonghong Liang, Zhiheng Su
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent joint inflammation leading to bone and cartilage damage and even disability. However, the pathogenesis of RA is multi-factorial and to a large degree, remains unknown. Danggui Sini decoction (DSD), a traditional Chinese medicine (TCM) formula, has been widely used as a remedy for rheumatoid arthritis (RA) in recent years. In our study, (1)H-nuclear magnetic resonance ((1)H NMR) based metabolomics analysis of 7 potential biomarkers, including taurine (1), urea (2), betaine (3), pyruvate (4), hippurate (5), succinate (6) and acetone (7) was performed to investigate the progression of RA and assess the efficacy of DSD in collagen-induced arthritis (CIA) rats...
July 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28752573/adiponectin-exerts-a-potent-anti-arthritic-effect-and-insulin-resistance-in-collagen-induced-arthritic-rats
#7
Dongke Wu, Binghong Hua, Zishui Fang, Jiankun Liu, Ningning Liu, Yunqing Ma
AIM: Previous research has shown that adiponectin (AD) induces severe insulin resistance (IR) and exhibits pro-inflammatory effect, so it could serve as a useful risk biomarker in rheumatoid arthritis (RA). The present study aims to evaluate the effect of AD on IR and anti-arthritis in collagen-induced arthritic (CIA) rats. METHOD: After immunization with bovine type II collagen (CII), Wistar rats were administered with AD (60 μg/kg/day) or saline into the ankle joint cavity of the left hind leg for 15 days...
July 27, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28748366/clinical-features-of-psoriatic-arthritis-a-comprehensive-review-of-unmet-clinical-needs
#8
REVIEW
Angela McArdle, Stephen Pennington, Oliver FitzGerald
Psoriatic arthritis (PsA) is a form of inflammatory arthritis (IA) affecting approximately 0.25% of the population. It is a heterogeneous disorder associated with joint damage, disability, disfiguring skin disease and in severe cases, premature mortality. Inherently irreversible and frequently progressive, the process of joint damage begins at, or before, the clinical onset of disease. Early recognition and intervention is thus crucial to patient outcome. At disease onset, however, PsA often resembles other forms of arthritis-especially rheumatoid arthritis (RA)...
July 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28743354/analysis-of-four-serum-biomarkers-in-rheumatoid-arthritis-association-with-extra-articular-manifestations-in-patients-and-arthralgia-in-relatives
#9
Flávia R Nass, Thelma L Skare, Isabela Goeldner, Renato Nisihara, Iara T Messias-Reason, Shirley R R Utiyama
OBJECTIVES: To evaluate the frequency of four serum biomarkers in RA patients and their relatives and identify possible associations with clinical findings of the disease. METHODS: This was a transversal analytical study. Anti-cyclic citrullinated peptide (anti-CCP), anti-mutated citrullinated vimentin (anti-MCV) and IgA-rheumatoid factor (RF) were determined by ELISA and IgM-RF by latex agglutination in 210 RA patients, 198 relatives and 92 healthy controls from Southern Brazil...
July 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28740485/tuftsin-phosphorylcholine-maintains-normal-gut-microbiota-in-collagen-induced-arthritic-mice
#10
Hila Ben-Amram, Tomer Bashi, Nir Werbner, Hadar Neuman, Mati Fridkin, Miri Blank, Yehuda Shoenfeld, Omry Koren
Rheumatoid arthritis (RA) is characterized by chronic autoinflammation of the joints, with a prevalence of about 1% in Western populations. Evidence in recent years has linked RA to changes in the gut microbiota (dysbiosis). Interestingly, helminths have been shown to have therapeutic activity in RA. Specifically, a glycoprotein containing phosphorylcholine (PC) extracted from helminths was found to have immunomodulatory activity. We have previously developed a novel chimeric compound composed of tuftsin-PC (TPC) that attenuates the joint destruction in mice with collagen-induced arthritis (CIA)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28736274/biomarkers-as-a-treatment-guide-in-rheumatoid-arthritis
#11
Tsutomu Takeuchi
It is anticipated that biomarkers support rheumatologists to judge a group of patients that can improve the diagnosis and prognosis, and further facilitate appropriate and precise treatment with targeted therapy. In particular, biomarkers for predicting and monitoring response to biological disease modifying anti-rheumatic drugs (DMARDs) are demanding. Given the mechanism action of biological DMARDs is much more simple than the conventional synthetic DMARDs, a variety of approaches to find such biomarkers has been taken recent years...
July 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28735350/inflammatory-joint-disorders-and-neutrophilic-dermatoses-a-comprehensive-review
#12
REVIEW
Massimo Cugno, Roberta Gualtierotti, Pier Luigi Meroni, Angelo Valerio Marzano
Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and psoriasis, and rare diseases like neutrophilic dermatoses. The latter are clinically characterised by polymorphic lesions, including pustules, bullae, abscesses, papules, nodules, plaques and ulcers, and histologically by neutrophil-rich inflammatory infiltrates...
July 22, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28722123/value-of-biomarkers-in-the-prevention-of-rheumatoid-arthritis
#13
A Finckh, D Alpizar-Rodriguez, P Roux-Lombard
Recent diagnostic advances allow to identify persons in a pre-symptomatic stage of rheumatoid arthritis (RA), opening the way for a preventive therapeutic intervention, which may potentially be curative. We review and discuss existing biomarkers predictive of future onset of RA. A responsible use of biomarkers in clinical settings will require an integration of blood-based tests, imaging techniques, clinical history, environmental risk factors, and family history.
July 19, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28720095/fibrocyte-measurement-in-peripheral-blood-correlates-with-number-of-cultured-mature-fibrocytes-in-vitro-and-is-a-potential-biomarker-for-interstitial-lung-disease-in-rheumatoid-arthritis
#14
Søren Andreas Just, Hanne Lindegaard, Eva Kildall Hejbøl, Jesper Rømhild Davidsen, Niels Bjerring, Søren Werner Karlskov Hansen, Henrik Daa Schrøder, Inger Marie Jensen Hansen, Torben Barington, Christian Nielsen
BACKGROUND: Interstitial lung disease (ILD) can be a severe extra-articular disease manifestation in Rheumatoid Arthritis (RA). A potential role of fibrocytes in RA associated ILD (RA-ILD) has not previously been described. We present a modified faster method for measuring circulating fibrocytes, without intracellular staining. The results are compared to the traditional culture method, where the number of monocytes that differentiate into mature fibrocytes in vitro are counted. The results are following compared to disease activity in patients with severe asthma, ILD, RA (without diagnosed ILD) and RA with verified ILD (RA-ILD)...
July 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28713940/a-novel-method-to-identify-hub-pathways-of-rheumatoid-arthritis-based-on-differential-pathway-networks
#15
Shi-Tong Wei, Yong-Hua Sun, Shi-Hua Zong
The aim of the current study was to identify hub pathways of rheumatoid arthritis (RA) using a novel method based on differential pathway network (DPN) analysis. The present study proposed a DPN where protein‑protein interaction (PPI) network was integrated with pathway‑pathway interactions. Pathway data was obtained from background PPI network and the Reactome pathway database. Subsequently, pathway interactions were extracted from the pathway data by building randomized gene‑gene interactions and a weight value was assigned to each pathway interaction using Spearman correlation coefficient (SCC) to identify differential pathway interactions...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28711880/the-relationship-between-synovial-pathobiology-and-magnetic-resonance-imaging-abnormalities-in-rheumatoid-arthritis-a-systematic-review
#16
Frances Humby, Arti Mahto, Muaaze Ahmed, Andrew Barr, Stephen Kelly, Maya Buch, Costantino Pitzalis, Philip G Conaghan
OBJECTIVE: Magnetic resonance imaging (MRI) has been increasingly recognized as a critical tool for the assessment of patients with rheumatoid arthritis (RA) and is able to reliably identify synovitis, bone marrow edema, bone erosion, and joint space narrowing (JSN)/cartilage loss. Understanding the exact relationship between each MRI feature and local synovial pathobiology is critical to dissect disease pathogenesis as well as develop future predictive models. METHODS: A systematic review was performed of the current published literature examining the relationship between MRI abnormalities and synovial pathobiology in patients with RA...
July 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28711147/future-directions-of-genomics-research-in-rheumatic-diseases
#17
REVIEW
Yukinori Okada, Toshihiro Kishikawa, Saori Sakaue, Jun Hirata
Recent developments in human genome genotyping and sequencing technologies, such as genome-wide association studies and whole-genome sequencing analyses, have successfully identified several risk genes of rheumatic diseases. Fine-mapping studies using the HLA imputation method revealed that classical and non-classical HLA genes contribute to the risk of rheumatic diseases. Integration of human disease genomics with biological, medical, and clinical databases should contribute to the elucidation of disease pathogenicity and novel drug discovery...
August 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28702930/personalized-medicine-in-rheumatology-the-paradigm-of-serum-autoantibodies
#18
REVIEW
Silvia Sirotti, Elena Generali, Angela Ceribelli, Natasa Isailovic, Maria De Santis, Carlo Selmi
The sequencing of the human genome is now well recognized as the starting point of personalized medicine. Nonetheless, everyone is unique and can develop different phenotypes of the same disease, despite identical genotypes, as well illustrated by discordant monozygotic twins. To recognize these differences, one of the easiest and most familiar examples of biomarkers capable of identifying and predicting the outcome of patients is represented by serum autoantibodies. In this review, we will describe the concept of personalized medicine and discuss the predictive, prognostic and preventive role of antinuclear antibodies (ANA), anti-citrullinated peptide antibodies (ACPA), rare autoantibodies and anti-drug antibodies (ADA), to evaluate how these can help to identify different disease immune phenotypes and to choose the best option for treating and monitoring rheumatic patients in everyday practice...
December 2017: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/28701761/antigen-specific-immunotherapies-in-rheumatic-diseases
#19
REVIEW
Judit Pozsgay, Zoltán Szekanecz, Gabriella Sármay
The main goal of antigen-specific immunotherapy (ASI) in autoimmune and rheumatic diseases is to reprogramme or remove autoreactive cells and/or induce immune tolerance to self-antigens. Current therapies in these diseases either treat symptoms or slow down disease progression but are not yet curative or preventative - disease-specific treatments are urgently needed. In contrast to the nonspecific treatments in current use that induce generalized immune suppression, which is associated with several adverse effects including increased risk of infections, ASIs target a restricted subset of B cells or T cells, and thus do not compromise systemic immunity and host defence...
July 13, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28701760/synovial-tissue-research-a-state-of-the-art-review
#20
REVIEW
Carl Orr, Elsa Sousa, David L Boyle, Maya H Buch, Christopher D Buckley, Juan D Cañete, Anca I Catrina, Ernest H S Choy, Paul Emery, Ursula Fearon, Andrew Filer, Danielle Gerlag, Frances Humby, John D Isaacs, Søren A Just, Bernard R Lauwerys, Benoit Le Goff, Antonio Manzo, Trudy McGarry, Iain B McInnes, Aurélie Najm, Constantino Pitzalis, Arthur Pratt, Malcolm Smith, Paul P Tak, Rogier Thurlings, João E Fonseca, Douglas J Veale
The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the use of arthroscopic and ultrasonographic technologies that enable easier visualization and improve the reliability of synovial biopsies. Rapid progress has been made in using synovial tissue to study disease pathogenesis, to stratify patients, to discover biomarkers and novel targets, and to validate therapies, and this progress has been facilitated by increasingly diverse and sophisticated analytical and technological approaches...
August 2017: Nature Reviews. Rheumatology
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