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Rheumatoid arthritis biomarkers

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https://www.readbyqxmd.com/read/29323343/targeting-lymphatic-function-as-a-novel-therapeutic-intervention-for-rheumatoid-arthritis
#1
REVIEW
Echoe M Bouta, Richard D Bell, Homaira Rahimi, Lianping Xing, Ronald W Wood, Clifton O Bingham, Christopher T Ritchlin, Edward M Schwarz
Although clinical outcomes for patients with rheumatoid arthritis (RA) have greatly improved with the use of biologic and conventional DMARDs, approximately 40% of patients do not achieve primary clinical outcomes in randomized trials, and only a small proportion achieve lasting remission. Over the past decade, studies in murine models point to the critical role of the lymphatic system in the pathogenesis and therapy of inflammatory-erosive arthritis, presumably by the removal of catabolic factors, cytokines and inflammatory cells from the inflamed synovium...
January 11, 2018: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29321815/circulating-plasma-microrna-profiling-in-patients-with-polymyositis-dermatomyositis-before-and-after-treatment-mirna-may-be-associated-with-polymyositis-dermatomyositis
#2
Takuya Hirai, Keigo Ikeda, Hiroshi Tsushima, Maki Fujishiro, Kunihiro Hayakawa, Yuko Yoshida, Shinji Morimoto, Ken Yamaji, Yoshinari Takasaki, Kenji Takamori, Naoto Tamura, Iwao Sekigawa
Background: MicroRNAs (miRNAs) are involved in the regulation of key biological processes and have been implicated in various diseases, including autoimmune disorders. The pathogenesis of polymyositis (PM) and dermatomyositis (DM) is considered to be mediated by autoimmune reactions. To determine miRNA role in the development and progression of PM and DM, we performed plasma miRNA profiling in PM/DM patients before and after treatment. Methods: Total RNA was isolated from plasma of 10 patients before and after treatment with prednisolone, or, in case of prednisolone resistance or complications, with the combination of calcineurin inhibitors (cyclosporine or tacrolims) and/or pulse intravenous cyclophosphamide...
2018: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29320550/longitudinal-micro-ct-as-an-outcome-measure-of-interstitial-lung-disease-in-tnf-transgenic-mice
#3
Richard D Bell, Christopher Rudmann, Ronald W Wood, Edward M Schwarz, Homaira Rahimi
INTRODUCTION: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a debilitating condition with poor survival prognosis. High resolution computed tomography (CT) is a common clinical tool to diagnose RA-ILD, and is increasingly being adopted in pre-clinical studies. However, murine models recapitulating RA-ILD are lacking, and CT outcomes for inflammatory lung disease have yet to be formally validated. To address this, we validate μCT outcomes for ILD in the tumor necrosis factor transgenic (TNF-Tg) mouse model of RA...
2018: PloS One
https://www.readbyqxmd.com/read/29305563/arterial-stiffness-association-with-chronic-inflammatory-disorders-in-the-uk-biobank-study
#4
Alex Dregan
OBJECTIVE: The present study tested the hypothesis that arterial stiffness will be elevated across overall and specific inflammatory disorders compared with an inflammation-free comparison group. METHODS: Adults (n=171 125) aged 40-70 years from the UK Biobank who were cardiovascular disease (CVD) free and who had their arterial stiffness assessed at the time of study recruitment between 2006 and 2010 were included. The main exposure was represented by a global measure of chronic inflammatory disorders...
January 4, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29290168/the-economic-burden-of-acpa-positive-status-among-patients-with-rheumatoid-arthritis
#5
Jason Shafrin, Mahlet Gizaw Tebeka, Kwanza Price, Chad Patel, Kaleb Michaud
BACKGROUND: Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA diagnosis and prognosis. Furthermore, treatment efficacy has been shown to vary by ACPA-positive status. However, it is not clear if the economic burden of patients with RA varies by ACPA status. OBJECTIVE: To determine if the economic burden of RA varies by patient ACPA status...
January 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29288974/jobelyn%C3%A2-attenuates-inflammatory-responses-and-neurobehavioural-deficits-associated-with-complete-freund-adjuvant-induced-arthritis-in-mice
#6
Osarume Omorogbe, Abayomi M Ajayi, Benneth Ben-Azu, Ejiroghene E Oghwere, Adaeze Adebesin, Adegbuyi O Aderibigbe, Olajuwon Okubena, Solomon Umukoro
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the physical and psychosocial wellbeing of the patients and a major cause of work disability. Current drugs for its treatment only provide palliative effect, as cure for the disease still remains elusive. Jobelyn® (JB), a potent anti-oxidant and anti-inflammatory dietary supplement obtained from Sorghum bicolor, has been claimed to relieve arthritic pain. Thus, this study was designed to evaluate its effect on inflammatory and biochemical changes as well as neurobehavioural deficits associated with complete Freund-adjuvant (CFA)-induced arthritis in mice...
December 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29287749/phase-1b-study-of-the-safety-pharmacokinetics-and-disease-related-outcomes-of-the-matrix-metalloproteinase-9-inhibitor-andecaliximab-in-patients-with-rheumatoid-arthritis
#7
David L Gossage, Blanka Cieslarová, Sophe Ap, Hao Zheng, Yan Xin, Preeti Lal, Guang Chen, Victoria Smith, John S Sundy
PURPOSE: Andecaliximab (GS-5745) is a highly selective monoclonal antibody against matrix metalloproteinase-9 (MMP9), a proteolytic enzyme implicated in the pathogenesis of rheumatoid arthritis (RA). This study assessed the safety and pharmacokinetic (PK) parameters of andecaliximab in patients with RA and evaluated the effects of andecaliximab treatment on exploratory disease biomarkers. METHODS: In this double-blind, Phase 1b trial, patients with active RA were randomized (4:1) to receive 400-mg andecaliximab or placebo every 2 weeks for a total of 3 intravenous infusions...
December 26, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29287311/hypomethylation-of-cyp2e1-and-dusp22-promoters-associated-with-disease-activity-and-erosive-disease-among-rheumatoid-arthritis-patients
#8
Amanda Mok, Brooke Rhead, Calliope Holingue, Xiaorong Shao, Hong L Quach, Diana Quach, Elizabeth Sinclair, Jonathan Graf, John Imboden, Thomas Link, Ruby Harrison, Vladimir Chernitskiy, Lisa F Barcellos, Lindsey A Criswell
OBJECTIVE: Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). This study aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with four clinical outcomes among RA patients. METHODS: Peripheral blood samples were taken from 63 patients in the University of California, San Francisco RA cohort (all satisfied ACR classification criteria; 57 were seropositive). Cells were FACS-sorted into four immune cell subpopulations (CD14+ monocytes, CD19+ B cells, CD4+ naïve T cells, and CD4+ memory T cells) per individual, and 229 epigenome-wide DNA methylation profiles were generated using Illumina HumanMethylation450 BeadChips...
December 29, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29282619/dickkopf-1-protein-circulating-levels-as-a-possible-biomarker-of-functional-disability-and-chronic-damage-in-patients-with-rheumatoid-arthritis
#9
Ana M Santos, Eugenia-Lucía Saldarriaga, Rodrigo Giraldo-Bustos, Jesus Giovanny Ballesteros-Muñoz, Juan C Rueda, Francy-Milena Cuervo, José-Ignacio Angarita, Andrés Y Vásquez, Sofía Arias-Correal, Camilo A González, Pedro Santos-Moreno, John Londono
Rheumatoid arthritis (RA) is an inflammatory disease characterized by joint destruction, deformity, lower functionality, and decrease in life expectancy. Wingless signaling pathway (Wnt) has been recently involved in bone homeostasis. Studies suggest that overexpression of the pathway inhibitors, like the Dickkopf 1 protein (DKK1), has been implicated in bone destruction. The objective of this study is to compare circulating levels of DKK1 in different groups of patients with disease activity (remission, low, moderate, high activity,) and functionality status...
December 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29273071/profiling-micrornas-in-individuals-at-risk-of-progression-to-rheumatoid-arthritis
#10
L Ouboussad, L Hunt, E M A Hensor, J L Nam, N A Barnes, P Emery, M F McDermott, M H Buch
BACKGROUND: Individuals at risk of rheumatoid arthritis (RA) demonstrate systemic autoimmunity in the form of anti-citrullinated peptide antibodies (ACPA). MicroRNAs (miRNAs) are implicated in established RA. This study aimed to (1) compare miRNA expression between healthy individuals and those at risk of and those that develop RA, (2) evaluate the change in expression of miRNA from "at-risk" to early RA and (3) explore whether these miRNAs could inform a signature predictive of progression from "at-risk" to RA...
December 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29249121/matrix-metalloproteinase-1-a-better-biomarker-for-squamous-cell-carcinoma-by-multiple-microarray-analyses
#11
Li-Qiang Zheng, Rui Wang, Su-Min Chi, Cheng-Xin Li
BACKGROUND: The present study aimed to validate MMP1 role in the development of squamous cell carcinoma (SCC) by bioinformatics methods. METHODS: Gene expression data of 10 GSE series (5 HNSCCs and 5 cSCCs) were obtained from the Gene Expression Omnibus (GEO) database and used to identify differentially expressed genes (DEGs). RESULTS: Higher expression of MMP1 was found rank number one in 9/10 GSE series of SCC. MMP1 was mainly focused on Gene Ontology (GO) terms of collagen catabolic process, extracellular matrix disassembly...
December 15, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29246875/proteomics-analysis-reveals-differential-pattern-of-widespread-protein-expression-and-novel-role-of-histidine-rich-glycoprotein-and-lipopolysaccharide-binding-protein-in-rheumatoid-arthritis
#12
Doojin Kim, Sora Mun, Jiyeong Lee, Arum Park, AeEun Seok, Yeon-Tae Chun, Hee-Gyoo Kang
Rheumatoid factor (RF) is an auto-antibody against antigen-antibody immune complexes. RF is valuable as a biomarker for the screening of autoimmune and infectious diseases. However, it is suggested that RF would be a more powerful biomarker when used complementarily with RF-correlated proteins. In this study, we utilized a proteomic approach to analyze global protein expression in RF-low and RF-high subjects using high-performance liquid chromatography tandem mass spectrometry. Histidine-rich glycoprotein (HRG) and lipopolysaccharide-binding protein (LBP) were found to be differentially expressed between RF-low and RF-high subjects (cut-off >2-fold, p<0...
December 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29226640/association-of-paraoxonase-1-polymorphism-and-serum-25-hydroxyvitamin-d-with-the-risk-of-cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#13
Sawsan O Khoja, Yasser El Miedany, Archana P Iyer, Sami M Bahlas, Khadijah S Balamash, Mohamed F Elshal
BACKGROUND: Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality that are not accounted for by traditional risk factors alone. Paraoxonase 1 (PON1) and 25-hydroxyvitamin D have been shown to be involved in the pathogenesis of CV diseases. Objective: This study aimed to investigate PON1 gene polymorphism and serum 25-hydroxyvitamin D concentrations in RA patients, and to determine their association with CV risk in RA. METHODS: Serum samples from 46 RA patients and 45 healthy controls were tested for PON1 R192Q genotypes and serum vitamin D concentrations...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29221595/genetic-and-environmental-risk-factors-for-rheumatoid-arthritis
#14
REVIEW
Kevin D Deane, M Kristen Demoruelle, Lindsay B Kelmenson, Kristine A Kuhn, Jill M Norris, V Michael Holers
Multiple genetic and environmental factors have been associated with an increased risk for rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female sex, a family history of RA, the genetic factor the "shared epitope," and exposure to tobacco smoke. There is also renewed interest in mucosal inflammation and microbial factors as contributors to the development of RA. However, the identification of a "preclinical" period of RA that can be defined as local or systemic autoimmunity as measured by autoantibodies and other biomarkers prior to the development of clinically apparent synovitis suggests that the risk factors for RA are acting long prior to first clinical evidence of IA...
February 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29221579/biomarkers-in-connective-tissue-diseases
#15
REVIEW
Neelakshi R Jog, Judith A James
Autoimmune connective tissue diseases are clinically variable, making biomarkers desirable for assessing future disease risk, supporting early and accurate diagnosis, monitoring disease activity and progression, selecting therapeutics, and assessing treatment response. Because of their correlations with specific clinical characteristics and often with disease progression, autoantibodies and other soluble mediators are considered potential biomarkers. Additional biomarkers might reflect downstream pathologic processes or appear because of ongoing inflammation and damage...
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29220376/c5a-and-c5ar-are-elevated-in-joints-of-rheumatoid-and-psoriatic-arthritis-patients-and-c5ar-blockade-attenuates-leukocyte-migration-to-synovial-fluid
#16
Lars Hornum, Anker Jon Hansen, Ditte Tornehave, Marianne Scheel Fjording, Paula Colmenero, Inger Falbe Wätjen, Niels Henrik Søe Nielsen, Henning Bliddal, Else Marie Bartels
Complement activation correlates to rheumatoid arthritis disease activity, and increased amounts of the complement split product C5a is observed in synovial fluids from rheumatoid arthritis patients. Blockade of C5a or its receptor (C5aR) is efficacious in several arthritis models. The aim of this study was to investigate the role of C5a and C5aR in human rheumatoid arthritis and psoriatic arthritis-both with respect to expression and function. Synovial fluid, blood and synovial samples were obtained from rheumatoid arthritis, psoriatic arthritis and osteoarthritis patients as a less inflammatory arthritis type, and blood from healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/29204090/autoantibodies-c-reactive-protein-erythrocyte-sedimentation-rate-and-serum-cytokine-profiling-in-monitoring-of-early-treatment
#17
Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka-Bykowska, Jacek Witkowski, Ewa Bryl
Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods: The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29202618/synovial-fluid-proteomics-in-the-pursuit-of-arthritis-mediators-an-evolving-field-of-novel-biomarker-discovery
#18
Shalini M Mahendran, Katerina Oikonomopoulou, Eleftherios P Diamandis, Vinod Chandran
Synovial fluid (SF) is a protein-rich fluid produced into the joint cavity by cells of the synovial membrane. Due to its direct contact with articular cartilage, surfaces of the bone, and the synoviocytes of the inner membrane, it provides a promising reflection of the biochemical state of the joint under varying physiological and pathophysiological conditions. This property of SF has been exploited within numerous studies in search of unique biomarkers of joint pathologies with the ultimate goal of developing minimally invasive clinical assays to detect and/or monitor disease states...
December 4, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29196243/clinical-and-immunological-aspects-of-anti-peptidylarginine-deiminase-type-4-anti-pad4-autoantibodies-in-rheumatoid-arthritis
#19
REVIEW
Zyanya Reyes-Castillo, José Francisco Muñoz-Valle, Mara A Llamas-Covarrubias
Rheumatoid arthritis (RA) is the most common rheumatic autoimmune disease worldwide, which causes progressive joint damage and can lead to functional disability. Despite prominent advances in RA diagnosis and treatment during the last 20years, there is still a need for novel biomarkers that aid in diagnosis and prognosis of this heterogeneous disease. Citrullination is a key post-translational modification implicated on anti-citrullinated protein/peptide antibodies (ACPA) production in RA, catalyzed by human peptidylarginine deiminases (PADs)...
December 2, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29194108/epigenetics-of-inflammatory-arthritis
#20
Deepa Hammaker, Gary S Firestein
PURPOSE OF REVIEW: Aberrant epigenetic changes in DNA methylation, histone marks, and noncoding RNA expression regulate the pathogenesis of many rheumatic diseases. The present article will review the recent advances in the epigenetic profile of inflammatory arthritis and discuss diagnostic biomarkers and potential therapeutic targets. RECENT FINDINGS: Methylation signatures of fibroblast-like synoviocytes not only distinguish rheumatoid arthritis (RA) and osteoarthritis (OA), but also early RAs from late RAs or juvenile idiopathic arthritis...
November 30, 2017: Current Opinion in Rheumatology
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