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Rheumatoid arthritis biomarkers

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https://www.readbyqxmd.com/read/28426445/small-dense-ldl-an-update
#1
Philipp A Gerber, Dragana Nikolic, Manfredi Rizzo
PURPOSE OF REVIEW: In this review, we summarize the latest findings on small, dense LDL (sdLDL) atherogenic particles, including their associations with other biomarkers. RECENT FINDINGS: Increased sdLDL levels have been reported not only in different metabolic disorders such as diabetes, obesity and metabolic syndrome, but also in patients with rheumatoid and psoriatic arthritis as well as hypothyroidism. A wide range of lipid-lowering, as well as other drug classes, including novel antidiabetic agents and nutraceuticals, exert favourable effects on these atherogenic particles...
April 19, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28425787/defining-the-proteomic-landscape-of-rheumatoid-arthritis-progress-and-prospective-clinical-applications
#2
Lucía Lourido, Francisco J Blanco, Cristina Ruiz-Romero
The heterogeneity of Rheumatoid Arthritis (RA) and the absence of clinical tests accurate enough to identify the early stages of this disease have hampered its management. Therefore, proteomics research is increasingly focused on the discovery of novel biological markers, which would not only be able make an early diagnosis, but also to gain insight into the different pathological mechanisms underlying the heterogeneity of RA and also to stratify patients, which is critical to enabling effective treatments...
April 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28422773/infections-in-rheumatoid-arthritis
#3
Fabiola Atzeni, Ignazio Francesco Masala, Manuela di Franco, Piercarlo Sarzi-Puttini
PURPOSE OF REVIEW: The purpose of this review is to provide an update concerning recent advances in the evidence- based study of serious infections in patients with rheumatoid arthritis (RA) treated with biological drugs or conventional disease-modifying antirheumatic drugs (DMARDs), concentrating on studies published in the last 18 months. RECENT FINDINGS: New studies have further strengthened existing evidence relating the use of biological drugs to serious infections...
April 18, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28413615/mean-platelet-volume-mpv-as-an-indicator-of-%C3%A2-disease-activity-and-severity-in-lupus
#4
Abidullah Khan, Iqbal Haider, Maimoona Ayub, Salman Khan
Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study...
2017: F1000Research
https://www.readbyqxmd.com/read/28413214/circulating-biomarkers-for-predicting-infliximab-response-in-rheumatoid-arthritis-a-systematic-bioinformatics-analysis
#5
Qiu-Lan Huang, Fu-Jiang Zhou, Cheng-Bin Wu, Chao Xu, Wen-Ying Qian, De-Ping Fan, Xu-Shan Cai
BACKGROUND Infliximab shows good efficacy in treating refractory rheumatoid arthritis (RA). However, many patients responded poorly and related studies were inconsistent in predictive biomarkers. This study aimed to identify circulating biomarkers for predicting infliximab response in RA. MATERIAL AND METHODS Public databases of Gene Expression Omnibus (GEO) and ArrayExpress were searched for related microarray datasets, focused on the response to infliximab in RA. All peripheral blood samples were collected before infliximab treatment and gene expression profiles were measured using microarray...
April 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28411808/validation-of-a-new-method-by-nano-liquid-chromatography-on-chip-tandem-mass-spectrometry-for-combined-quantitation-of-c3f-and-the-v65-vitronectin-fragment-as-biomarkers-of-diagnosis-and-severity-of-osteoarthritis
#6
Gaël Cobraiville, Marianne Fillet, Mohammed Sharif, Khadija Ourradi, Gwenaël Nys, Michel G Malaise, Dominique de Seny
Microfluidic liquid chromatography coupled to a nanoelectrospray source ion trap mass spectrometry was used for the absolute and simultaneous quantitation of C3f and the V65 vitronectin fragment in serum. The method was first carefully optimized and then validated in serum biological matrix. Stable isotopes for the two biomarkers of interest were used as stable isotope labeled peptide standards. A weighted 1/x(2) quadratic regression for C3f and a weighted 1/x quadratic regression for the V65 vitronectin peptide were selected for calibration curves...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411167/mast-cells-in-rheumatoid-arthritis-friends-or-foes
#7
REVIEW
Felice Rivellese, Alessandra Nerviani, Francesca Wanda Rossi, Gianni Marone, Marco Matucci-Cerinic, Amato de Paulis, Costantino Pitzalis
Mast cells are tissue-resident cells of the innate immunity, implicated in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). They are present in synovia and their activation has been linked to the potentiation of inflammation in the course of RA. However, recent investigations questioned the role of mast cells in arthritis. In particular, animal models generated conflicting results, so that many of their pro-inflammatory, i.e. pro-arthritogenic functions, even though supported by robust experimental evidences, have been labelled as redundant...
April 11, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28409894/genomic-responses-of-mouse-synovial-fibroblasts-during-tnf-driven-arthritogenesis-greatly-mimic-those-of-human-rheumatoid-arthritis
#8
Evangelos Ntougkos, Panagiotis Chouvardas, Fani Roumelioti, Caroline Ospelt, Mojka Frank-Bertoncelj, Andrew Filer, Christopher D Buckley, Steffen Gay, Christoforos Nikolaou, George Kollias
OBJECTIVE: Aberrant activation of synovial fibroblasts (SFs) is a key determinant in the pathogenesis of rheumatoid arthritis (RA). We aimed to produce a map of gene expression and epigenetic changes occurring in this cell type during disease progression in the human TNF-transgenic model of arthritis, and identify commonalities with human SFs. METHODS: We used deep sequencing to probe the transcriptome, the methylome and the chromatin landscape of cultured mouse arthritogenic SFs at three stages of disease, as well as SFs stimulated with human TNF...
April 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28408110/evaluation-of-the-activity-of-rheumatoid-arthritis-in-clinical-practice-agreement-between-self-rated%C3%A2-clinimetric%C3%A2-evaluation-and-clinical-evaluation-with-activity-indexes-das28-cdai-and-sdai
#9
Gabriel Horta-Baas, Arturo Pérez Bolde-Hernández, María Fernanda Hernández-Cabrera, Imelda Vergara-Sánchez, María Del Socorro Romero-Figueroa
INTRODUCTION AND OBJECTIVE: To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with laboratory studies (DAS28 and SDAI) or without them (CDAI). The objective was to analyze the concordance between self-rated clinimetric evaluation and clinimetric evaluation performed by the physician...
April 10, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28395950/prevalence-of-metabolic-syndrome-in-algerian-rheumatoid-arthritis-patients-correlation-with-disease-activity-and-functional-status
#10
Samy Slimani, Abdelmalek Abbas, Amina Ben Ammar, Fadia Rahal, Imene Khider, Khireddine Khelif, Aicha Ladjouze-Rezig
BACKGROUND: There is evidence that rheumatoid arthritis (RA) patients have an over-risk of cardiovascular disease. This may be mainly due to an increase in the prevalence of metabolic syndrome (MetS). The prevalence of MetS among adults in Algeria is 19.1%. OBJECTIVES: The aim of the study was to evaluate the prevalence of MetS among RA patients in Algeria. Another aim was to evaluate the relationship between MetS, inflammation biomarkers and disease scores. METHODS: The study was performed on a cohort of 249 patients meeting the ACR/EULAR criteria for RA, followed in 11 Algerian centers...
April 1, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28393498/the-impact-of-obesity-and-adiposity-on-inflammatory-markers-in-patients-with-rheumatoid-arthritis
#11
Michael D George, Jon T Giles, Patricia P Katz, Bryant R England, Ted R Mikuls, Kaleb Michaud, Alexis R Ogdie-Beatty, Said Ibrahim, Grant W Cannon, Liron Caplan, Brian C Sauer, Joshua F Baker
BACKGROUND: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are important disease activity biomarkers in rheumatoid arthritis (RA). This study aimed to determine to what extent obesity biases these biomarkers. METHODS: Body mass index (BMI) associations with CRP and ESR were assessed in two RA cohorts - 1) the cross-sectional Body Composition (BC) cohort (N = 451) including whole-body DXA measures of fat mass index, and 2) the longitudinal Veterans Affairs Rheumatoid Arthritis (VARA) registry (N = 1652), using multivariable models stratified by sex...
April 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28392862/role-of-lncrna-af085935-il-10-and-il-17-in-rheumatoid-arthritis-patients-with-chronic-hepatitis-c
#12
Dina Sabry, Azza Elamir, Rania Hosny Mahmoud, Ahmed Ali Abdelaziz, Wael Fathy
BACKGROUND: The current study aimed at testing the effect of corticosteroid therapy on serum levels of interleukin-10 (IL-10) and IL-17 as well as lncRNA-AF085935 in patients of rheumatoid arthritis (RA) associated with hepatitis C virus (HCV) and evaluating the usefulness of using these parameters to predict the therapeutic efficacy of steroids in these patients. METHODS: Thirty healthy control subjects and 65 chronic HCV patients with RA were included in our study...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28388908/evaluation-of-antigen-induced-synovitis-in-a-porcine-model-immunological-arthroscopic-and-kinetic-studies
#13
Francisco-Javier Vela, Francisco-Miguel Sánchez-Margallo, Rebeca Blázquez, Verónica Álvarez, Raquel Tarazona, M Teresa Mangas-Ballester, Alejandro Cristo, Javier G Casado
BACKGROUND: Synovitis is an inflammation-related disease linked to rheumatoid arthritis, osteoarthritis, infections and trauma. This inflammation is accompanied by immune cells infiltration which initiates an inflammatory response causing pain, discomfort and affecting the normal joint function. The treatment of synovitis is based on the administration of anti-inflammatory drugs or biological agents such as platelet rich plasma and mesenchymal stem cells. However, the evaluation and validation of more effective therapies of synovitis requires the establishment of clinically relevant animal models...
April 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28386136/assessment-of-anti-carp-antibodies-disease-activity-and-quality-of-life-in-rheumatoid-arthritis-patients-on-conventional-and-biological-disease-modifying-antirheumatic-drugs
#14
Sudhir Kumar, Ghanshyam Pangtey, Rachna Gupta, Harmeet Singh Rehan, Lalit Kumar Gupta
OBJECTIVE: Good biomarkers are important to guide decisions in the clinical management of rheumatoid arthritis (RA). RA patients harbor antibodies directed against carbamylated proteins which may predict joint damage. This study investigated whether antibodies against carbamylated proteins (anti-CarP) may serve as surrogate prognostic markers. MATERIAL AND METHODS: Fifty-three patients with a diagnosis of rheumatoid arthritis according to ACR 1987 criteria were included...
2017: Reumatologia
https://www.readbyqxmd.com/read/28386080/differential-activation-of-endocrine-immune-networks-by-arthritis-challenge-insights-from-colony-specific-responses
#15
Tamara S Bodnar, Matthew D Taves, Katie M Lavigne, Todd S Woodward, Kiran K Soma, Joanne Weinberg
Rheumatoid arthritis (RA) is a chronic inflammatory condition with variable clinical presentation and disease progression. Importantly, animal models of RA are widely used to examine disease pathophysiology/treatments. Here, we exploited known vendor colony-based differences in endocrine/immune responses to gain insight into inflammatory modulators in arthritis, utilizing the adjuvant-induced arthritis (AA) model. Our previous study found that Sprague-Dawley (SD) rats from Harlan develop more severe AA, have lower corticosteroid binding globulin, and have different patterns of cytokine activation in the hind paw, compared to SD rats from Charles River...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28384040/ctla-4-49-g-a-polymorphism-confers-autoimmune-disease-risk-an-updated-meta-analysis
#16
Ke Wang, Qin Zhu, Yunjie Lu, Hao Lu, Feng Zhang, Xuehao Wang, Ye Fan
BACKGROUND: Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a pivotal role in immune homeostasis. Dysregulated expression of CTLA-4 leads to many autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes (T1D). There has been a controversial association between the CTLA-4 +49 G/A SNP (rs231775) and autoimmune diseases. Therefore, this meta-analysis was performed to assess the link between rs231775 and autoimmune disease risk. MATERIALS AND METHODS: We retrieved the available studies from PUBMED and EMBASE through February, 2016 and then performed meta-analyses that included all populations, as well as by ethnicity...
April 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28379711/screening-and-validation-of-novel-biomarkers-in-osteoarticular-pathologies-by-comprehensive-combination-of-protein-array-technologies
#17
Álvaro Sierra-Sánchez, Diego Garrido-Martín, Lucía Lourido, María González-González, Paula Díez, Cristina Ruiz-Romero, Ronald Sjöber, Conrad Droste, Javier De Las Rivas, Peter Nilsson, Francisco Blanco, Manuel Fuentes
Osteoarthritis (OA) is one of the most prevalent articular diseases. The identification of proteins closely associated with the diagnosis, progression, prognosis, and treatment response is dramatically required for this pathology. In this work, differential serum protein profiles have been identified in OA and rheumatoid arthritis (RA) by antibody arrays containing 151 antibodies against 121 antigens in a cohort of 36 samples. Then the identified differential serum protein profiles have been validated in a larger cohort of 282 samples...
April 17, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28376912/head-to-head-comparison-of-aggressive-conventional-therapy-and-three-biological-treatments-and-comparison-of-two-de-escalation-strategies-in-patients-who-respond-to-treatment-study-protocol-for-a-multicenter-randomized-open-label-blinded-assessor-phase-4-study
#18
Daniel Glinatsi, Marte S Heiberg, Anna Rudin, Dan Nordström, Espen A Haavardsholm, Bjorn Gudbjornsson, Mikkel Østergaard, Till Uhlig, Gerdur Grondal, Kim Hørslev-Petersen, Ronald van Vollenhoven, Merete L Hetland
BACKGROUND: New targeted therapies and improved treatment strategies have dramatically improved the outcomes of patients with rheumatoid arthritis (RA). However, it is unknown whether different early aggressive interventions can induce stable remission or a low-active disease state that can be maintained with conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy, and whether they differ in efficacy and safety. The Nordic Rheumatic Diseases Strategy Trials And Registries (NORD-STAR) study will assess and compare (1) the proportion of patients who achieve remission in a head-to-head comparison between csDMARD plus glucocorticoid therapy and three different biological DMARD (bDMARD) therapies with different modes of action and (2) two de-escalation strategies in patients who respond to first-line therapy...
April 4, 2017: Trials
https://www.readbyqxmd.com/read/28376065/chikungunya-virus-and-autoimmunity
#19
Amir Tanay
PURPOSE OF REVIEW: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. Fever, rash and severe arthralgia are the hallmarks of chikungunya fever (CHIKF), the disease caused by this virus. The acute course of the disease usually lasts few weeks to months. Chronic, relapsing or persistent arthralgia and arthritis have been described mimicking rheumatoid arthritis (RA), requiring immunosuppressive drugs.The purpose of this review is to characterize both the chronic clinical course of CHIKF-associated arthritis and the immunological pathogenic mechanisms involved...
April 1, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28373027/omics-approaches-to-identify-potential-biomarkers-of-inflammatory-diseases-in-the-focal-adhesion-complex
#20
Johanne Brooks, Alastair Watson, Tamas Korcsmaros
Inflammatory diseases such as inflammatory bowel disease (IBD) require recurrent invasive tests, including blood tests, radiology, and endoscopic evaluation both to diagnose and assess disease activity, and to determine optimal therapeutic strategies. Simple 'bedside' biomarkers could be used in all phases of patient management to avoid unnecessary investigation and guide further management. The focal adhesion complex (FAC) has been implicated in the pathogenesis of multiple inflammatory diseases, including IBD, rheumatoid arthritis, and multiple sclerosis...
March 31, 2017: Genomics, Proteomics & Bioinformatics
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