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https://www.readbyqxmd.com/read/29331535/estrogen-deprivation-aggravates-cardiometabolic-dysfunction-in-obese-insulin-resistant-rats-through-the-impairment-of-cardiac-mitochondrial-dynamics
#1
Wanitchaya Minta, Siripong Palee, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkum, Sasiwan Kerdpoo, Wasana Pratchayasakul, Sirinart Kumfu, Siriporn C Chattipakorn, Nipon Chattipakorn
The incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, suggesting estrogen has a vital role in their prevention. Mitochondrial dynamics are known to play an important role in the maintenance of cardiac physiological function. However, the effects of estrogen deprivation on cardiometabolic status and cardiac mitochondrial dynamics under conditions of obese-insulin resistance have never been investigated. We hypothesized that estrogen deprivation aggravates cardiac dysfunction through increased cardiac mitochondrial fission in obese-insulin resistant rats...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29315516/strong-coupling-between-slow-oscillations-and-wide-fast-ripples-in-children-with-epileptic-spasms-investigation-of-modulation-index-and-occurrence-rate
#2
Yasushi Iimura, Kevin Jones, Lynne Takada, Itsuki Shimizu, Misaki Koyama, Kyoko Hattori, Yushi Okazawa, Yutaka Nonoda, Eishi Asano, Tomoyuki Akiyama, Cristina Go, Ayako Ochi, O Carter Snead, Elizabeth J Donner, James T Rutka, James M Drake, Hiroshi Otsubo
OBJECTIVE: Epileptic spasms (ES) often become drug-resistant. To reveal the electrophysiological difference between children with ES (ES+) and without ES (ES-), we compared the occurrence rate (OR) of high-frequency oscillations (HFOs) and the modulation index (MI) of coupling between slow and fast oscillations. In ES+, we hypothesized that (1) pathological HFOs are more widely distributed and (2) slow oscillations show stronger coupling with pathological HFOs than in ES-. METHODS: We retrospectively reviewed 24 children with drug-resistant multilobar onset epilepsy, who underwent intracranial video electroencephalography prior to multilobar resections...
January 6, 2018: Epilepsia
https://www.readbyqxmd.com/read/29276865/high-frequency-oscillatory-ventilation-versus-conventional-mechanical-ventilation-in-pediatric-acute-respiratory-distress-syndrome-a-randomized-controlled-study
#3
Ahmed El-Nawawy, Azza Moustafa, Hassan Heshmat, Ahmed Abouahmed
El-Nawawy A, Moustafa A, Heshmat H, Abouahmed A. High frequency oscillatory ventilation versus conventional mechanical ventilation in pediatric acute respiratory distress syndrome: A randomized controlled study. Turk J Pediatr 2017; 59: 130-143. The aim of this prospective randomized study is to compare the outcomes of the early use of either high frequency oscillation (HFO) or conventional mechanical ventilation (CMV) in patients with pediatric acute respiratory distress syndrome (PARDS). We allocated two hundred PARDS patients over 5 years in 1:1 ratio to either mode...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29244226/high-frequency-oscillations-are-not-better-biomarkers-of-epileptogenic-tissues-than-spikes
#4
Nicolas Roehri, Francesca Pizzo, Stanislas Lagarde, Isabelle Lambert, Anca Nica, Aileen McGonigal, Bernard Giusiano, Fabrice Bartolomei, Christian-George Bénar
OBJECTIVE: High-frequency oscillations (HFOs) in intracerebral EEG (stereoelectroencephalography, SEEG) are considered as better biomarkers of epileptogenic tissues than spikes. How this can be applied at the patient level remains poorly understood. We investigated how well the HFOs and the spikes can predict epileptogenic regions with a large spatial sampling at the patient level. METHODS: We analyzed non-REM sleep SEEG recordings sampled at 2,048Hz of thirty patients...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29175154/immature-status-epilepticus-in-vitro-models-reveal-differences-in-cholinergic-control-and-hfo-properties-of-adult-ca3-interictal-discharges-in-temporal-vs-septal-hippocampus
#5
Apostolos Mikroulis, Christos Panagiotis Lisgaras, Caterina Psarropoulou
We have earlier demonstrated that a Status Epilepticus (SE) during CNS development has long lasting effects on cholinergic neurotransmission, detectable in vitro and in vivo. In this work, we aimed to localize changes in temporal (T) vs septal (S) hippocampus and to correlate adult CA3 interictal epileptiform discharge (IED) frequency changes to those of Ripples (R) and Fast Ripples (FR) of the High Frequency Oscillations (HFOs). Spontaneous IEDs were induced by bathing slices in Mg2+-free ACSF or in 4-Aminopyridine (4-AP, 50µM) and data were analyzed separately for each model...
November 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/29171950/-evolocumab-repatha%C3%A2-a-human-monoclonal-antibody-against-pcsk9-protein-as-potent-cholesterol-lowering-therapy
#6
C Wallemacq
Evolocumab is a fully human monoclonal antibody (mAb) targeting ProProtein Convertase Subtilisin/Kexin 9 (PCSK9). PCSK9 is a circulating enzyme secreted by the liver and plays a key role in the LDL-Receptors (LDL-R) turnover. Binding of PCSK9 on the extracellular part of LDL-R is responsible for its degradation in the lysosome instead of its recycling to the cell surface, thereby producing a reduction in the number of LDL-R on the cell surface, a decreased LDL-C uptake and increased levels of LDL-C. Inhibiting PCSK9 is a new way to markedly reduce LDL-C...
November 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29159434/mineralogical-and-geochemical-characterization-of-waste-rocks-from-a-gold-mine-in-northeastern-thailand-application-for-environmental-impact-protection
#7
Thitiphan Assawincharoenkij, Christoph Hauzenberger, Karl Ettinger, Chakkaphan Sutthirat
Waste rocks from gold mining in northeastern Thailand are classified as sandstone, siltstone, gossan, skarn, skarn-sulfide, massive sulfide, diorite, and limestone/marble. Among these rocks, skarn-sulfide and massive sulfide rocks have the potential to generate acid mine drainage (AMD) because they contain significant amounts of sulfide minerals, i.e., pyrrhotite, pyrite, arsenopyrite, and chalcopyrite. Moreover, both sulfide rocks present high contents of As and Cu, which are caused by the occurrence of arsenopyrite and chalcopyrite, respectively...
November 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29113719/utilization-of-independent-component-analysis-for-accurate-pathological-ripple-detection-in-intracranial-eeg-recordings-recorded-extra-and-intra-operatively
#8
Shoichi Shimamoto, Zachary J Waldman, Iren Orosz, Inkyung Song, Anatol Bragin, Itzhak Fried, Jerome Engel, Richard Staba, Ashwini Sharan, Chengyuan Wu, Michael R Sperling, Shennan A Weiss
OBJECTIVE: To develop and validate a detector that identifies ripple (80-200 Hz) events in intracranial EEG (iEEG) recordings in a referential montage and utilizes independent component analysis (ICA) to eliminate or reduce high-frequency artifact contamination. Also, investigate the correspondence of detected ripples and the seizure onset zone (SOZ). METHODS: iEEG recordings from 16 patients were first band-pass filtered (80-600 Hz) and Infomax ICA was next applied to derive the first independent component (IC1)...
October 25, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29111591/magnetoencephalographic-imaging-of-ictal-high-frequency-oscillations-80-200%C3%A2-hz-in-pharmacologically-resistant-focal-epilepsy
#9
Jayabal Velmurugan, Srikantan S Nagarajan, Narayanan Mariyappa, Shankar G Ravi, Kandavel Thennarasu, Ravindranadh C Mundlamuri, Kenchaiah Raghavendra, Rose Dawn Bharath, Jitender Saini, Arimappamagan Arivazhagan, Jamuna Rajan, Anita Mahadevan, Malla B Rao, Parthasarathy Satishchandra, Sanjib Sinha
OBJECTIVE: Specificity of ictal high-frequency oscillations (HFOs) in identifying epileptogenic abnormality is significant, compared to the spikes and interictal HFOs. The objectives of the study were to detect and to localize ictal HFOs by magnetoencephalography (MEG) for identifying the seizure onset zone (SOZ), evaluate the cortical excitability from preictal to ictal transition, and establish HFO concordance rates with other modalities and postsurgical resection. METHODS: Sixty-seven patients with drug-resistant epilepsy had at least 1 spontaneous seizure each during MEG acquisition, and analysis was carried out on 20 seizures from 20 patients...
November 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/29102181/microwave-digestion-assisted-hfo-biochar-adsorption-to-recover-phosphorus-from-swine-manure
#10
Tao Zhang, Haoyu Xu, Huanhuan Li, Xinyue He, Yuanji Shi, Andrea Kruse
A sustainable management option for dealing with waste straw is to pyrolyze it to create biochar, which can then be used as a sorbent in pollution treatments, such as the recovery of phosphorus (P) from swine manure. However, the inability to directly capture soluble organic P (OP) and sparingly soluble P and the low selectivity of biochar remain key issues in this process. To overcome these, we investigated a microwave (MW) digestion pretreatment with a HFO/biochar adsorption process. The MW digestion-assisted treatment showed good performance for the solubilization of OP and sparingly soluble P...
October 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29099197/electronic-stopping-of-slow-protons-in-oxides-scaling-properties
#11
D Roth, B Bruckner, G Undeutsch, V Paneta, A I Mardare, C L McGahan, M Dosmailov, J I Juaristi, M Alducin, J D Pedarnig, R F Haglund, D Primetzhofer, P Bauer
Electronic stopping of slow protons in ZnO, VO_{2} (metal and semiconductor phases), HfO_{2}, and Ta_{2}O_{5} was investigated experimentally. As a comparison of the resulting stopping cross sections (SCS) to data for Al_{2}O_{3} and SiO_{2} reveals, electronic stopping of slow protons does not correlate with electronic properties of the specific material such as band gap energies. Instead, the oxygen 2p states are decisive, as corroborated by density functional theory calculations of the electronic densities of states...
October 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29079354/effect-of-luting-agent-on-the-load-to-failure-and-accelerated-fatigue-resistance-of-lithium-disilicate-laminate-veneers
#12
Marco M M Gresnigt, Mutlu Özcan, Marco Carvalho, Priscilla Lazari, Marco S Cune, Peywand Razavi, Pascal Magne
OBJECTIVE: The aim of this study was to investigate the influence of the luting agent on the application of laminate veneers (LVs) in an accelerated fatigue and load-to-failure test after thermo-cyclic aging. METHODS: Sound maxillary central incisors (N=40) were randomly divided into four groups to receive LVs (Li2Si2O5) that were adhesively bonded: Group CEMF: Adhesive cement (Variolink Esthetic LC), fatigue test; Group CEMLF: Adhesive cement, load-to-failure test; Group COMF: Resin composite (Enamel HFO), fatigue test; Group COMLF: Resin composite, load-to-failure test...
December 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29062105/resection-of-high-frequency-oscillations-predicts-seizure-outcome-in-the-individual-patient
#13
Tommaso Fedele, Sergey Burnos, Ece Boran, Niklaus Krayenbühl, Peter Hilfiker, Thomas Grunwald, Johannes Sarnthein
High frequency oscillations (HFOs) are recognized as biomarkers for epileptogenic brain tissue. A remaining challenge for epilepsy surgery is the prospective classification of tissue sampled by individual electrode contacts. We analysed long-term invasive recordings of 20 consecutive patients who subsequently underwent epilepsy surgery. HFOs were defined prospectively by a previously validated, automated algorithm in the ripple (80-250 Hz) and the fast ripple (FR, 250-500 Hz) frequency band. Contacts with the highest rate of ripples co-occurring with FR over several five-minute time intervals designated the HFO area...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29060055/a-novel-hfo-based-method-for-unsupervised-localization-of-the-seizure-onset-zone-in-drug-resistant-epilepsy
#14
Paige M Murphy, Adam J von Paternos, Sabato Santaniello
High frequency oscillations (HFOs) are potential biomarkers of epileptic areas. In patients with drug-resistant epilepsy, HFO rates tend to be higher in the seizure onset zone (SOZ) than in other brain regions and the resection of HFO-generating areas positively correlates with seizure-free surgery outcome. Nonetheless, the development of robust unsupervised HFO-based tools for SOZ localization remains challenging. Current approaches predict the SOZ by processing small samples of intracranial EEG (iEEG) data and applying patient-specific thresholds on the HFO rate...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28992690/atmospheric-chemistry-of-e-and-z-cf3ch%C3%A2-chf-hfo-1234ze-oh-reaction-kinetics-as-a-function-of-temperature-and-uv-and-ir-absorption-cross-sections
#15
María Antiñolo, Iván Bravo, Elena Jiménez, Bernabé Ballesteros, José Albaladejo
We report here the rate coefficients for the OH reactions (kOH) with E-CF3CH═CHF and Z-CF3CH═CHF, potential substitutes of HFC-134a, as a function of temperature (263-358 K) and pressure (45-300 Torr) by pulsed laser photolysis coupled to laser-induced fluorescence techniques. For the E-isomer, the existing discrepancy among previous results on the T dependence of kOH needs to be elucidated. For the Z-isomer, this work constitutes the first absolute determination of kOH. No pressure dependence of kOH was observed, while kOH exhibits a non-Arrhenius behavior: kOH(E) = [Formula: see text] and kOH(Z) = [Formula: see text] cm(3) molecule(-1) s(-1), where uncertainties are 2σ...
October 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28987533/joint-approximate-diagonalization-of-eigenmatrices-jade-as-a-high-throughput-approach-for-analysis-of-hyphenated-and-comprehensive-two-dimensional-gas-chromatographic-data
#16
Maryam Zarghani, Hadi Parastar
The objective of the present work is development of joint approximate diagonalization of eigenmatrices (JADE) as a member of independent component analysis (ICA) family, for the analysis of gas chromatography-mass spectrometry (GC-MS) and comprehensive two-dimensional gas chromatography-mass spectrometry (GC×GC-MS) data to address incomplete separation problem occurred during the analysis of complex sample matrices. In this regard, simulated GC-MS and GC×GC-MS data sets with different number of components, different degree of overlap and noise were evaluated...
September 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28981989/consecutive-transformations-of-tetrafluoropropenes-hydrogermylation-and-catalytic-c-f-activation-steps-at-a-lewis-acidic-aluminium-fluoride
#17
Thomas Braun, Gisa Meißner, Erhard Kemnitz, Konrad Kretschmar
Functionalization reactions of the refrigerants HFO 1234yf (2,3,3,3-tetrafluoropropene) and HFO-1234ze (1,3,3,3-tetrafluoropropene) were developed. The selectivity and reactivity towards CF3 groups of C-F activation reactions can be controlled by either employing a germane or silane as hydrogen source. Unique transformations were designed to accomplish consecutive hydrogermylation and C-F activation steps. This allows for an unprecedented transformation of an olefinic C-F bond into a C-H bond by heterogeneous catalysis...
October 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28922535/power-and-coherence-of-cortical-high-frequency-oscillations-during-wakefulness-and-sleep
#18
Matías Cavelli, Daniel Rojas-Líbano, Natalia Schwarzkopf, Santiago Castro-Zaballa, Joaquín Gonzalez, Alejandra Mondino, Noelia Santana, Luciana Benedetto, Atilio Falconi, Pablo Torterolo
Recently, a novel type of fast cortical oscillatory activity that occurs between 110 and 160 Hz (high-frequency oscillations (HFO)) was described. HFO are modulated by the theta rhythm in hippocampus and neocortex during active wakefulness and REM sleep. As theta-HFO coupling increases during REM, a role for HFO in memory consolidation has been proposed. However, global properties such as the cortex-wide topographic distribution and the cortico-cortical coherence remain unknown. In this study, we recorded the electroencephalogram during sleep and wakefulness in the rat and analyzed the spatial extent of the HFO band power and coherence...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28860077/the-cs-algorithm-a-novel-method-for-high-frequency-oscillation-detection-in-eeg
#19
Jan Cimbálník, Angela Hewitt, Greg Worrell, Matt Stead
BACKGROUND: High frequency oscillations (HFOs) are emerging as potentially clinically important biomarkers for localizing seizure generating regions in epileptic brain. These events, however, are too frequent, and occur on too small a time scale to be identified quickly or reliably by human reviewers. Many of the deficiencies of the HFO detection algorithms published to date are addressed by the CS algorithm presented here. NEW METHOD: The algorithm employs novel methods for: 1) normalization; 2) storage of parameters to model human expertise; 3) differentiating highly localized oscillations from filtering phenomena; and 4) defining temporal extents of detected events...
August 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28794978/localization-of-beta-and-high-frequency-oscillations-within-the-subthalamic-nucleus-region
#20
B C M van Wijk, A Pogosyan, M I Hariz, H Akram, T Foltynie, P Limousin, A Horn, S Ewert, P Brown, V Litvak
Parkinsonian bradykinesia and rigidity are typically associated with excessive beta band oscillations in the subthalamic nucleus. Recently another spectral peak has been identified that might be implicated in the pathophysiology of the disease: high-frequency oscillations (HFO) within the 150-400 Hz range. Beta-HFO phase-amplitude coupling (PAC) has been found to correlate with severity of motor impairment. However, the neuronal origin of HFO and its usefulness as a potential target for deep brain stimulation remain to be established...
2017: NeuroImage: Clinical
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