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Cerebral blood flow

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https://www.readbyqxmd.com/read/28732352/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#1
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28730950/statistical-analysis-plan-for-the-head-position-in-stroke-trial-headpost-an-international-cluster-cross-over-randomized-trial
#2
Laurent Billot, Mark Woodward, Hisatomi Arima, Maree L Hackett, Paula Muñoz Venturelli, Pablo M Lavados, Alejandro Brunser, Bin Peng, Liying Cui, Lily Song, Stephane Heritier, Stephen Jan, Sandy Middleton, Verónica V Olavarría, Joyce Lim, Thompson Robinson, Octavio Pontes-Neto, Caroline Watkins, Craig S Anderson
Background There is evidence to indicate that the lying flat head position increases cerebral blood flow and oxygenation in patients with acute ischemic stroke, but how these physiological effects translate into clinical outcomes is uncertain. The Head Position in Stroke Trial aims to determine the comparative effectiveness of lying flat (0°) compared to sitting up (≥30°) head positioning, initiated within 24 h of hospital admission for patients with acute stroke. Design An international, pragmatic, cluster-randomized, crossover, open, blinded outcome assessed clinical trial...
August 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28730452/transcranial-color-doppler-in-stroke-free-adult-patients-with-sickle-cell-disease
#3
G Graziadei, F M Casoni, F Annoni, I Cortinovis, P Ridolfi, I Gandolfi, A Marcon, E Di Pierro, M D Cappellini
The threshold velocity ≥200 cm/s at transcranial Doppler (TCD) evaluation is a useful cut-off for preventing the stroke (STOP trial) in pediatric patients with sickle cell disease (SCD), term including different types of sickle genotypes. Scanty data are available for adult SCD patients. We compared intracranial blood flow velocities between adult SCD patients and controls using transcranial color Doppler (TCCD), measuring the peak of systolic velocity (PSV) with the insonation angle correction and the pulsatility index (PI), an indicator of endothelial elasticity...
July 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28729429/brain-perfusion-imaging-under-acetazolamide-challenge-for-detection-of-impaired-cerebrovascular-reserve-capacity-positive-findings-with-o-15-water-pet-in-patients-with-negative-tc-99m-hmpao-spect
#4
Güliz Acker, Catharina Lange, Imke Schatka, Andreas Pfeifer, Marcus A Czabanka, Peter Vajkoczy, Ralph Buchert
Cerebrovascular reserve capacity (CVRC) is an important parameter for treatment decisions in chronic cerebrovascular diseases. It can be assessed by measuring the acetazolamide-induced change of regional cerebral blood flow using single photon emission computed tomography (SPECT) with Tc-99m-labeled hexamethylpropyleneamine oxime (HMPAO) or positron emission tomography (PET) with O-15-water. Methods: Our database was searched for patients with moyamoya vasculopathy (MMV) or atherosclerotic cerebrovascular disease who had underwent O-15-water PET after normal Tc-99m-HMPAO SPECT with respect to CVRC...
July 20, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28729160/echo-time-dependence-of-the-bold-response-transients-a-window-into-brain-functional-physiology
#5
Martin Havlicek, Dimo Ivanov, Benedikt A Poser, Kamil Uludag
The blood oxygenation level-dependent (BOLD) fMRI response to neuronal activation results from a complex interplay of induced metabolic and vascular changes. Thus, its transients, such as initial overshoot and post-stimulus undershoot, provide a window into the dynamic relationships of the underlying physiological variables. In this study, we propose multi-echo fMRI as a tool to investigate the physiological underpinnings of the BOLD signal, in particular, and brain functional physiology, in general. In the human visual cortex at 3 T, we observed that the BOLD response is nonlinearly dependent on echo-time (TE) and the amount of nonlinearity varies during the entire time-course...
July 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28727580/increase-in-intracranial-pressure-by-application-of-a-rigid-cervical-collar-a-pilot-study-in-healthy-volunteers
#6
Iscander M Maissan, Rein Ketelaars, Boris Vlottes, Sanne E Hoeks, Dennis den Hartog, Robert J Stolker
OBJECTIVES: Rigid cervical collars are known to increase intracranial pressure (ICP) in severe traumatic brain injury (TBI). Cerebral blood flow might decrease according to the Kellie Monroe doctrine. For this reason, the use of the collar in patients with severe TBI has been abandoned from several trauma protocols in the Netherlands. There is no evidence on the effect of a rigid collar on ICP in patients with mild or moderate TBI or indeed patients with no TBI. As a first step we tested the effect in healthy volunteers with normal ICPs and intact autoregulation of the brain...
July 19, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28722696/hematocrit-and-serum-hemoglobin-do-not-influence-values-in-computed-tomography-perfusion-of-patients-with-acute-ischemic-stroke
#7
Grzegorz Marek Karwacki, Matthias Richard Benz, Anthony Joseph Tyndall, Stephan Ulmer
OBJECTIVE: There is a correlation between both serum hemoglobin (HGB) and hematocrit (HCT) and attenuation values of vessels in noncontrast-enhanced computed tomography (NECT), which could influence calculated perfusion maps in CT perfusion. METHODS: We retrospectively included 45 patients, who presented with acute new neurological symptoms and underwent NECT and CT perfusion (128-row multi detector scanner, coverage: 6.9 cm craniocaudally; 80 kV; 200 mAs; temporal resolution: 2 seconds using 40 mL Ultravist 370 at a flow rate of 5 mL/s) on admission and a follow-up MRI within 1 week of admission...
July 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28722518/effects-of-pentoxifylline-on-hemodynamic-hemorheological-and-microcirculatory-parameters-in-young-shrs-during-arterial-hypertension-development
#8
Mark B Plotnikov, Oleg I Aliev, Alexander Y Shamanaev, Anastasia V Sidekhmenova, Yana Anfinogenova, Anna M Anishchenko, Tatiana I Fomina, Alexander M Arkhipov
The most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats...
July 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28721902/permeability-of-brain-tumor-vessels-induced-by-uniform-or-spatially-microfractionated-synchrotron-radiation-therapies
#9
Audrey Bouchet, Marine Potez, Nicolas Coquery, Claire Rome, Benjamin Lemasson, Elke Bräuer-Krisch, Chantal Rémy, Jean Laissue, Emmanuel L Barbier, Valentin Djonov, Raphael Serduc
PURPOSE: To compare the blood-brain barrier permeability changes induced by synchrotron microbeam radiation therapy (MRT, which relies on spatial fractionation of the incident x-ray beam into parallel micron-wide beams) with changes induced by a spatially uniform synchrotron x-ray radiation therapy. METHODS AND MATERIALS: Male rats bearing malignant intracranial F98 gliomas were randomized into 3 groups: untreated, exposed to MRT (peak and valley dose: 241 and 10...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28720742/-two-cases-of-ruptured-blood-blister-like-aneurysm-treated-with-x-ray-angiography-perfusion-xap-analysis
#10
Shoichi Tani, Hirotoshi Imamura, Katsunori Asai, Kampei Shimizu, Hidemitsu Adachi, So Tokunaga, Takayuki Funatsu, Mikiya Beppu, Keita Suzuki, Hiromasa Adachi, Tomohiro Okuda, Yuichi Matsui, Yasunori Yoshida, Shuhei Kawabata, Ryo Akiyama, Kazufumi Horiuchi, Nobuyuki Sakai
Two cases of ruptured blood blister-like internal carotid artery aneurysms for which low flow bypass was sufficient to attain successful treatment of trapping are reported. In the acute stage of rupture, it is troublesome to perform accurate examinations of tolerance to ischemia like balloon occlusion test(BOT)for estimating the required amount of bypass flow. In our cases, X-ray angiography perfusion(XAP)analysis was introduced, which could be performed in a couple dozen seconds without room-to-room transfer of patients, following the ordinary examination of diagnostic digital subtraction angiography...
July 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28720528/postoperative-dilatation-of-superficial-temporal-artery-associated-with-transient-neurological-symptoms-after-direct-bypass-surgery-for-moyamoya-angiopathy
#11
Daizo Ishii, Takahito Okazaki, Toshinori Matsushige, Katsuhiro Shinagawa, Nobuhiko Ichinose, Shigeyuki Sakamoto, Kaoru Kurisu
OBJECTIVE: In moyamoya angiopathy (MMA), transient neurological symptoms (TNS) are occasionally observed after superficial temporal artery (STA)-middle cerebral artery (MCA) direct bypass surgery. The purpose of this study was to investigate the correlation between TNS and postoperative MR images, as well as perform a perfusion study. METHODS: A total of 52 hemispheres in 33 consecutive patients with MMA were reviewed. TNS were defined as reversible neurological dysfunction without any apparent intracranial infarction or hemorrhage...
July 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28720078/characteristics-of-cardio-cerebrovascular-modulation-in-patients-with-generalized-anxiety-disorder-an-observational-study
#12
Zhen-Ni Guo, Liangshu Feng, Xiuli Yan, Le Yang, Shuo Huang, Yingqi Xing, Yi Yang
BACKGROUND: Generalized anxiety disorder (GAD) has been shown in previous studies to display abnormal cerebral blood flow velocity (CBFV); however, the characteristics of cardio-cerebrovascular modulation are unknown. We aimed to analyze cardio-cerebrovascular modulation using parameters from a supine-to-standing test. METHODS: There are 2 parts to this study; in Part 1, 125 participants with Hamilton Anxiety scale scores ≥14 were enrolled, and 33 age- and sex-matched medically and psychiatrically healthy volunteers were recruited as control participants...
July 18, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28719802/cerebral-hypoperfusion-is-not-associated-with-an-increase-in-%C3%AE-amyloid-pathology-in-middle-aged-or-elderly-people
#13
O Hansson, S Palmqvist, H Ljung, T Cronberg, D van Westen, R Smith
INTRODUCTION: It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans. METHODS: Cerebral blood flow and β-amyloid ((18)F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of precerebral arteries resulting in chronic and uneven hypoperfusion...
July 15, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28719038/static-cerebrovascular-pressure-autoregulation-remains-intact-during-deep-hypothermia
#14
Dheeraj Goswami, Katherine McLeod, Samantha Leonard, Kathleen Kibler, Ronald Blaine Easley, Charles D Fraser, Dean Andropoulos, Ken Brady
BACKGROUND: Clinical studies measuring cerebral blood flow in infants during deep hypothermia have demonstrated diminished cerebrovascular pressure autoregulation. The coexistence of hypotension in these cohorts confounds the conclusion that deep hypothermia impairs cerebrovascular pressure autoregulation. AIM: We sought to compare the lower limit of autoregulation and the static rate of autoregulation between normothermic and hypothermic piglets. METHODS: Twenty anesthetized neonatal piglets (5-7 days old; 10 normothermic and 10 hypothermic to 20°C) had continuous measurements of cortical red cell flux using laser Doppler flowmetry, while hemorrhagic hypotension was induced without cardiopulmonary bypass...
July 18, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28717076/increase-in-the-regional-cerebral-blood-flow-following-waon-therapy-in-patients-with-chronic-fatigue-syndrome-a-pilot-study
#15
Takao Munemoto, Yuji Soejima, Akinori Masuda, Yoshiaki Nakabeppu, Chuwa Tei
Objective Chronic fatigue syndrome (CFS) is a complex disorder, with no consensus on therapeutic options. However, Waon therapy has been reported to be an effective treatment. The purpose of this study was to evaluate changes in the cerebral blood flow (CBF) before and after Waon therapy in CFS patients and to investigate the correlation between such changes and the therapeutic efficacy of Waon therapy. Methods Eleven patients (2 men and 9 women, mean age 27 years old) diagnosed with CFS participated in the study...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28715004/an-implantable-multimodal-sensor-for-oxygen-neurotransmitters-and-electrophysiology-during-spreading-depolarization-in-the-deep-brain
#16
Caddy N Hobbs, Justin A Johnson, Matthew D Verber, R Mark Wightman
Brain tissue injury is often accompanied by spreading depolarization (SD) events, marked by widespread cellular depolarization and cessation of neuronal firing. SD recruits viable tissue into the lesion, making it a focus for intervention. During SD, drastic fluctuations occur in ion gradients, extracellular neurotransmitter concentrations, cellular metabolism, and cerebral blood flow. Measuring SD requires a multimodal approach to capture the array of changes. However, the use of multiple sensors can inflict tissue damage...
July 17, 2017: Analyst
https://www.readbyqxmd.com/read/28713328/recovery-from-unrecognized-sleep-loss-accumulated-in-daily-life-improved-mood-regulation-via-prefrontal-suppression-of-amygdala-activity
#17
Yuki Motomura, Shingo Kitamura, Kyoko Nakazaki, Kentaro Oba, Ruri Katsunuma, Yuri Terasawa, Akiko Hida, Yoshiya Moriguchi, Kazuo Mishima
Many modern people suffer from sleep debt that has accumulated in everyday life but is not subjectively noticed [potential sleep debt (PSD)]. Our hypothesis for this study was that resolution of PSD through sleep extension optimizes mood regulation by altering the functional connectivity between the amygdala and prefrontal cortex. Fifteen healthy male participants underwent an experiment consisting of a baseline (BL) evaluation followed by two successive interventions, namely, a 9-day sleep extension followed by one night of total sleep deprivation (TSD)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28712093/neurobiological-effect-of-selective-brain-cooling-after-concussive-injury
#18
Alexa Walter, Katie Finelli, Xiaoxiao Bai, Brian Johnson, Thomas Neuberger, Peter Seidenberg, Timothy Bream, Mark Hallett, Semyon Slobounov
The search for effective treatment facilitating recovery from concussive injury, as well as reducing risk for recurrent concussion is an ongoing challenge. This study aimed to determine: a) feasibility of selective brain cooling to facilitate clinical symptoms resolution, and b) biological functions of the brain within athletes in acute phase of sports-related concussion. Selective brain cooling for 30 minutes using WElkins sideline cooling system was administered to student-athletes suffering concussive injury (n=12; tested within 5±3 days) and those without history of concussion (n=12)...
July 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28712063/resisting-sleep-pressure-impact-on-resting-state-functional-network-connectivity
#19
Laura Tüshaus, Joshua Henk Balsters, Anthony Schläpfer, Daniel Brandeis, Ruth O'Gorman Tuura, Peter Achermann
In today's 24/7 society, sleep restriction is a common phenomenon which leads to increased levels of sleep pressure in daily life. However, the magnitude and extent of impairment of brain functioning due to increased sleep pressure is still not completely understood. Resting state network (RSN) analyses have become increasingly popular because they allow us to investigate brain activity patterns in the absence of a specific task and to identify changes under different levels of vigilance (e.g. due to increased sleep pressure)...
July 15, 2017: Brain Topography
https://www.readbyqxmd.com/read/28711736/two-dose-investigation-of-the-5-ht-agonist-psilocybin-on-relative-and-global-cerebral-blood-flow
#20
Candace R Lewis, Katrin H Preller, Rainer Kraehenmann, Lars Michels, Philipp Stämpfli, Franz X Vollenweider
Psilocybin, the active compound in psychedelic mushrooms, is an agonist of various serotonin receptors. Seminal psilocybin positron emission tomography (PET) research suggested regional increases in glucose metabolism in frontal cortex (hyperfrontality). However, a recent arterial spin labeling (ASL) study suggests psilocybin may lead to hypo-perfusion in various brain regions. In this placebo-controlled, double-blind study we used pseudo-continuous ASL (pCASL) to measure perfusion changes, with and without adjustment for global brain perfusion, after two doses of oral psilocybin (low dose: 0...
July 12, 2017: NeuroImage
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