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https://www.readbyqxmd.com/read/28239378/enterococcus-durans-ep1-a-promising-anti-inflammatory-probiotic-able-to-stimulate-siga-and-to-increase-faecalibacterium-prausnitzii-abundance
#1
Paula Carasi, Silvia María Racedo, Claudine Jacquot, Anne Marie Elie, María de Los Ángeles Serradell, María C Urdaci
Enterococcus species, principally Enterococcus faecium are used as probiotics since a long time with preference in animal applications but safety considerations were updated and also new uses as probiotics can be envisaged. Fifteen Enterococcus strains isolated from different foods were identified and analyzed for virulence factors and antibiotic resistance. Three Enterococcus durans strains were selected to study their immunomodulatory properties on PBMC and Caco2 cells. Two strains presented a profile toward a mild inflammatory Th1 response considering TNF-α/IL-10 and IL-1β/IL-10 cytokines ratios...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28228073/principal-physicochemical-methods-used-to-characterize-dendrimer-molecule-complexes-used-as-genetic-therapy-agents-nanovaccines-or-drug-carriers
#2
Rodríguez Fonseca Rolando Alberto, Rodrigues Joao, Muñoz-Fernández María de Los Angeles, Martínez Muñoz Alberto, Fragoso Vázquez Manuel Jonathan, Correa Basurto José
Nanomedicine is the application of nanotechnology to medicine. This field is related to the study of nanodevices and nanomaterials applied to various medical uses, such as in improving the pharmacological properties of different molecules. Dendrimers are synthetic nanoparticles whose physicochemical properties vary according to their chemical structure. These molecules have been extensively investigated as drug nanocarriers to improve drug solubility and as sustained-release systems. New therapies such as gene therapy and the development of nanovaccines can be improved by the use of dendrimers...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28223907/comparative-bioavailability-and-utilization-of-particular-forms-of-b12-supplements-with-potential-to-mitigate-b12-related-genetic-polymorphisms
#3
REVIEW
Cristiana Paul, David M Brady
CONTEXT: Three natural forms of vitamin B12 are commercially available: methylcobalamin (MeCbl), adenosylcobalamin (AdCbl), and hydroxycobalamin (OHCbl), all of which have been shown in clinical studies to improve vitamin B12 status. They are bioidentical to the B12 forms occurring in human physiology and animal foods. In contrast, cyanocobalamin (CNCbl), a synthetic B12 compound used for food fortification and in some supplements, occurs only in trace amounts in human tissues as a result of cyanide intake from smoking or other sources...
February 2017: Integrative Medicine
https://www.readbyqxmd.com/read/28221729/risk-of-metastasis-and-orbital-recurrence-in-advanced-retinoblastoma-eyes-treated-with-systemic-chemoreduction-versus-primary-enucleation
#4
Jesse L Berry, Kaitlin Kogachi, Hassan A Aziz, Kathleen McGovern, Emily Zolfaghari, A Linn Murphree, Rima Jubran, Jonathan W Kim
BACKGROUND: The purpose of this study was to evaluate the risk of metastatic disease and orbital recurrence in advanced retinoblastoma treated with systemic chemoreduction versus primary enucleation. METHODS: A retrospective review of patients with Group D/E retinoblastoma was conducted with data collection from 1995 to 2015. Overall, 345 eyes (294 patients) were included (165 Group D and 180 Group E). Primary outcome measures were orbital recurrence and metastatic disease...
April 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28218380/increase-in-physical-activity-after-resurfacing-hip-arthroplasty-is-associated-with-calcar-and-acetabular-bone-mineral-density-changes
#5
Davey M J M Gerhardt, Gerjon Hannink, Ton Rijnders, Job L C van Susante
PURPOSE: Bone preservation is an important advantage of the resurfacing hip arthroplasty (RHA) concept. We hypothesised that patients' increase in physical activity level after RHA would positively relate with periprosthetic bone mineral density (BMD) changes and thus facilitate bone preservation. METHODS: BMD-changes were prospectively recorded in 38 patients after RHA. Dual-energy absorptiometry was used to quantify BMD-changes in 6 periprosthetic regions of interest preoperatively, at 6 months, 1, 2 and 3 years postoperative...
February 15, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28216756/outcome-of-anatomic-locking-plate-in-extraarticular-distal-humeral-shaft-fractures
#6
Deepak Jain, Gurpreet S Goyal, Rajnish Garg, Pankaj Mahindra, Mohammad Yamin, Harpal S Selhi
BACKGROUND: Extraarticular fractures of distal humerus are challenging injuries to treat because of complex anatomy and fracture patterns. Functional bracing may not provide adequate stability in these injuries and operative treatment with intramedullary nails or conventional plates also has the limitation of inadequate fixation in the short distal fragment. The 3.5 mm precontoured single column locking plate (extraarticular distal humerus plate [EADHP]) has been introduced to overcome this problem...
January 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28215899/-18-f-fluorodeoxyglucose-positron-emission-tomography-cortical-metabolic-activity-associated-with-distinct-agitation-behaviors-in-alzheimer-disease
#7
Gali H Weissberger, Rebecca J Melrose, Theresa A Narvaez, Dylan Harwood, Mark A Mandelkern, David L Sultzer
OBJECTIVE: This study aimed to investigate the neurobiologic correlates of two distinct clusters of agitation symptoms to identify the unique biologic substrates underlying agitated behaviors. METHODS: Eighty-eight outpatients with mild to moderate Alzheimer disease (AD) were recruited from the VA Greater Los Angeles Healthcare System Geropsychiatry Outpatient Program. A cross-sectional investigation was conducted of the relationship between cerebral glucose metabolism measured via (18)F-fluorodeoxyglucose positron emission tomography and agitated symptoms from the Neuropsychiatric Inventory (NPI) in patients with AD...
January 31, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28215114/arthroscopic-extended-rotator-interval-release-for-treating-refractory-adhesive-capsulitis
#8
Ming-Jr Tsai, Wei-Pin Ho, Chih-Hwa Chen, Tsai-Hsueh Leu, Tai-Yuan Chuang
PURPOSE: To present the clinical results of arthroscopic extended rotator interval release with a stretching program for treating refractory adhesive capsulitis. STUDY DESIGN: Case series; level of evidence, 4. METHODS: Arthroscopy-assisted extended rotator interval tissue release including anterior capsular was performed in 26 patients with refractory adhesive capsulitis. All rotator interval tissues, except the medial sling of the biceps, were excised and the excursion of the subscapularis tendon was restored and freely mobilized...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28214705/home-and-away-area-socioeconomic-disadvantage-and-obesity-risk
#9
Rachel Tolbert Kimbro, Gregory Sharp, Justin T Denney
Although residential context is linked to obesity risk, less is known about how the additional places where we work, shop, play, and worship may influence that risk. We employ longitudinal data from the Los Angeles Family and Neighborhood Survey (LAFANS) to derive time-weighted measures of exposure to home and activity space contexts to ascertain the impacts of each on obesity risk for adults. Results show that increased exposure to socioeconomic disadvantage in the residential neighborhood significantly increases obesity risk, and although activity space disadvantage does not directly influence obesity, it reduces the association between residential disadvantage and obesity...
February 16, 2017: Health & Place
https://www.readbyqxmd.com/read/28213859/recurrence-in-localized-renal-cell-carcinoma-a-systematic-review-of-contemporary-data
#10
REVIEW
Jacqueline M Speed, Quoc-Dien Trinh, Toni K Choueiri, Maxine Sun
PURPOSE OF REVIEW: Patients with localized renal cell carcinoma (RCC) are at risk of recurrence. The purpose of this review was to characterize the literature on recurrence rates and risk factors after diagnosis of localized RCC. RECENT FINDINGS: Our search revealed that existing data examining the prevalence of recurrence rates predominantly originates from cohorts of patients diagnosed and treated in the 1980s to 1990s, and may therefore not be as useful for counseling for current patients today...
February 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28209594/adolescents-and-young-adults-with-acute-lymphoblastic-leukemia-and-acute-myeloid-leukemia-impact-of-care-at-specialized-cancer-centers-on-survival-outcome
#11
Julie Wolfson, Can-Lan Sun, Laura Wyatt, Wendy Stock, Smita Bhatia
Background: Adolescents and young adults (AYA; 15-39 years) with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) experience inferior survival when compared with children. Impact of care at NCI-designated Comprehensive Cancer Centers (CCC) or Children's Oncology Group sites (COG) on survival disparities remains unstudied.Methods: Using the Los Angeles cancer registry, we identified 1,870 ALL or AML patients between 1 and 39 years at diagnosis. Cox regression analyses assessed risk of mortality; younger age + CCC/COG served as the referent group...
February 16, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28207380/turning-the-curve-on-obesity-prevalence-among-fifth-graders-in-the-los-angeles-unified-school-district-2001-2013
#12
Amanda Kamali, Heena Hameed, Margaret Shih, Paul Simon
INTRODUCTION: After multiple decades of increasing childhood obesity prevalence in the United States, findings from recent studies suggest that prevalence has leveled or is decreasing in some populations. However, demographic and socioeconomic disparities in prevalence remain and may be increasing. METHODS: To assess recent trends and disparities in childhood obesity prevalence in Los Angeles County, we analyzed data from 2001 through 2013 in fifth graders in the Los Angeles Unified School District (LAUSD)...
February 16, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28206778/personal-and-cultural-identity-development-in-recently-immigrated-hispanic-adolescents-links-with-psychosocial-functioning
#13
Alan Meca, Raha F Sabet, Colleen M Farrelly, Cynthia G Benitez, Seth J Schwartz, Melinda Gonzales-Backen, Elma I Lorenzo-Blanco, Jennifer B Unger, Byron L Zamboanga, Lourdes Baezconde-Garbanati, Simona Picariello, Sabrina E Des Rosiers, Daniel W Soto, Monica Pattarroyo, Juan A Villamar, Karina M Lizzi
OBJECTIVES: This study examined directionality between personal (i.e., coherence and confusion) and cultural identity (i.e., ethnic and U.S.) as well as their additive effects on psychosocial functioning in a sample of recently immigrated Hispanic adolescents. METHOD: The sample consisted of 302 recent (<5 years) immigrant Hispanic adolescents (53% boys; Mage = 14.51 years at baseline; SD = .88 years) from Miami and Los Angeles who participated in a longitudinal study...
February 16, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28196620/evaluation-of-online-and-in-person-nutrition-education-related-to-salt-knowledge-and-behaviors-among-special-supplemental-nutrition-program-for-women-infants-and-children-participants
#14
Lauren E Au, Shannon E Whaley, Klara Gurzo, Martha Meza, Nila J Rosen, Lorrene D Ritchie
BACKGROUND: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) differs from other federal nutrition programs in that nutrition education is a required component. WIC programs traditionally provide in-person education, but recently some WIC sites have started offering online education. Education focused on reducing salt intake is an important topic for WIC participants because a high-sodium diet has been associated with high blood pressure, and low-income populations are at increased risk...
February 9, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28192647/a-double-blind-randomized-multicenter-clinical-trial-investigating-the-efficacy-and-safety-of-esomeprazole-single-therapy-versus-mosapride-and-esomeprazole-combined-therapy-in-patients-with-esophageal-reflux-disease
#15
Ju Yup Lee, Sung Kook Kim, Kwang Bum Cho, Kyung Sik Park, Joong Goo Kwon, Jin Tae Jung, Eun Young Kim, Byung Ik Jang, Si Hyung Lee
Background/Aims: We aimed to evaluate the efficacy and safety of combination therapy in erosive reflux disease (ERD) patients by comparing endoscopic healing rate according to the Los Angeles classification for esomeprazole alone and esomeprazole plus mosapride. Methods: A total of 116 ERD patients were randomized to receive esomeprazole 40 mg once daily plus mosapride 5 mg 3 times daily (E+M group), or esomeprazole plus placebo (E only group) for 8 weeks. Patients recorded gastroesophageal reflux disease (GERD) symptom questionnaire at week 4 and 8...
February 13, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28190902/constraining-the-kinematics-of-metropolitan-los-angeles-faults-with-a-slip-partitioning-model
#16
S Daout, S Barbot, G Peltzer, M-P Doin, Z Liu, R Jolivet
Due to the limited resolution at depth of geodetic and other geophysical data, the geometry and the loading rate of the ramp-décollement faults below the metropolitan Los Angeles are poorly understood. Here we complement these data by assuming conservation of motion across the Big Bend of the San Andreas Fault. Using a Bayesian approach, we constrain the geometry of the ramp-décollement system from the Mojave block to Los Angeles and propose a partitioning of the convergence with 25.5 ± 0.5 mm/yr and 3...
November 16, 2016: Geophysical Research Letters
https://www.readbyqxmd.com/read/28190644/what-are-normal-metal-ion-levels-after-total-hip-arthroplasty-a%C3%A2-serologic-analysis-of-four-bearing-surfaces
#17
Brian T Barlow, Philippe A Ortiz, John W Boles, Yuo-Yu Lee, Douglas E Padgett, Geoffrey H Westrich
BACKGROUND: The recent experiences with adverse local tissue reactions have highlighted the need to establish what are normal serum levels of cobalt (Co), chromium (Cr), and titanium (Ti) after hip arthroplasty. METHODS: Serum Co, Cr, and Ti levels were measured in 80 nonconsecutive patients with well-functioning unilateral total hip arthroplasty and compared among 4 bearing surfaces: ceramic-on-ceramic (CoC); ceramic-on-polyethylene (CoP); metal-on-polyethylene (MoP), and dual mobility (DM)...
December 3, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28188689/sentinel-node-biopsy-for-prostate-cancer-report-from-a-consensus-panel-meeting
#18
Henk G van der Poel, Esther M Wit, Cenk Acar, Nynke S van den Berg, Fijs W B van Leeuwen, Renato A Valdes Olmos, Alexander Winter, Friedhelm Wawroschek, Fredrik Liedberg, Steven Maclennan, Thomas Lam
OBJECTIVE: To explore the evidence and knowledge gaps in sentinel node biopsy (SNB) in prostate cancer by a consensus panel of experts. METHODS: A two-round Delphi survey among experts was followed by a consensus panel meeting of 16 experts in February 2016. Agreement voting was performed using the RAND/University of California, Los Angeles Appropriateness Methodology on 150 statements in 9 domains. The disagreement index based on the interpercentile range-adjusted for symmetry score was used to assess consensus and non-consensus among panel members RESULTS: Consensus was obtained on 91 of 150 (61%) statements...
February 10, 2017: BJU International
https://www.readbyqxmd.com/read/28185723/hiv-testing-preferences-among-msm-members-of-an-lgbt-community-organization-in-los-angeles
#19
Alexandra Medline, Joseph Daniels, Robert Marlin, Sean Young, Greg Wilson, Emily Huang, Jeffrey D Klausner
Lack of regular HIV testing puts African American, Asian, and Latino men who have sex with men (MSM) at high risk for HIV infection. Rapid self-testing may be an effective option for these men. We explored acceptability, preferences, and usability of HIV self-test kits with MSM of color using semi-structured focus groups to discuss HIV testing history, reasons for testing, and self-testing preferences. Participants (n = 21) lived in Los Angeles, identified as MSM of color, and were 18-35 years of age. Discussions were audio-recorded, transcribed, and analyzed using grounded theory...
January 12, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28182592/transmission-behaviors-and-prevalence-of-chlamydia-and-gonorrhea-among-adult-film-performers
#20
Marjan Javanbakht, M Claire Dillavou, Robert W Rigg, Peter R Kerndt, Pamina M Gorbach
BACKGROUND: Adult film work involves multiple sex partners, unprotected intercourse and frequent oral/rectal contact. Data on sexual networks and sexual behaviors of adult film performers (AFP) are limited. METHODS: From August 2012 to May 2013, AFPs in Los Angeles, CA, seeking care at 2 clinics that provide sexually transmitted infections (STIs) testing to performers were offered urogenital, pharyngeal, and rectal chlamydia/gonorrhea testing. Participants were 18 years or older and performed in at least 1 adult film scene within the past year...
March 2017: Sexually Transmitted Diseases
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